Towards Semantically Faithful Diffusion Representation for Generalizable Retinal Image Segmentation.

Retinal image segmentation is essential for analyzing retinal structures like vessels and diagnosing retinopathy. However, the inherent intricacy of the retina, along with annotation scarcity and data heterogeneity, presents prevalent challenges in creating accurate and generalizable deep learning models. Diffusion models, while initially developed for image generation, have recently shown great promise for visual perception by leveraging the learned internal representations.

Separation of Gas Mixture of H and CO by Nanopromoter-Enhanced Gas Hydrate Formation.

Traditional coal burning emits a large amount of pollutants, including sulfur dioxide (SO), nitrogen oxides, and carbon dioxide (CO), severely contaminating the environment and exacerbating global warming. In contrast, integrated gasification combined cycle (IGCC) technology, with highly efficient and clean characteristics, significantly reduces pollutant emissions and has a positive impact on environmental protection. It is a simple and effective method to obtain hydrogen (H) by purifying IGCC fuel gas with the main components of H and CO.

Deficiency of Rab26 causes behavioral defects in mice through impaired trafficking of serotonin (5-HT) transporter.

Rab proteins are key regulators of membrane trafficking. Dysregulated Rab proteins are associated with neurological diseases through the regulation of receptor endocytosis, recycling, and/or degradation. Rab26 is highly expressed in the brain, but its physiological function remains poorly elucidated.

Global patterns and trends in ischemic stroke burden attributable to particulate matter pollution: changes from 1990 to 2021 and projections from 2022 to 2050.

Background: Stroke was the third leading cause of global deaths in 2021, linked to air pollution, especially particulate matter (PMP). Research shows that ischemic strokes are more affected by air pollution than hemorrhagic strokes. This study aims to evaluate the disease burden, trends, and future projections of ischemic stroke associated with PMP using the latest data.

Recovery of Methane from Low-Concentration Coalbed Methane via Hydrate Formation Enhanced by -SO-Coated Nanopolymers.

Low-concentration coalbed methane (LCCBM) is an abundant unconventional natural gas resource, but the utilization efficiency of methane (CH) is very low. Sodium dodecyl sulfate (SDS) enhances hydration for CH recovery but generates foams during hydrate dissociation, limiting continuous production. To address this issue, the -SO group was fixed on the polystyrene nanopolymers (named -SO@PSNS) for enhancing hydration to recover CH from 21.

Investigating the perception dimensions of sports disciplines stigma in China: social identity and participation willingness.

Introduction: This study aims to explore the dimensions of stigma perception in sports disciplines, focusing on the impact these dimensions have on the public's willingness to participate in stigmatized sports. The research seeks to identify and analyze the dimensions of stigma, test hypotheses regarding their influence, and investigate the mediating role of social identity in this relationship.

Methods: The study was conducted in China using in-depth interviews with 36 sports enthusiasts, followed by a comprehensive questionnaire survey.

Enhanced accuracy and reduced complications: robot-assisted navigation for retrograde intramedullary nailing in distal femoral fractures.

Purpose: This research investigates the benefits of robot-assisted navigation systems in retrograde intramedullary nailing for distal femoral fractures and contrasts their outcomes with conventional surgical methods. This is a retrospective clinical study designed to compare the outcomes of these two approaches.

Methods: This study included 56 distal femoral fracture patients treated between February 2020 and May 2023.

Exploring the relationship between serum 25-hydroxyvitamin D levels and intestinal fungal communities and their metabolites in postmenopausal Chinese women.

Background: Research gaps persist in understanding the interactions between serum 25 (OH)D levels, intestinal fungi, and their metabolites in postmenopausal women.

Methods: This study, approved by the Ethics Committee of Zhongshan Hospital, Xiamen University, recruited postmenopausal women from Xiamen. Clinical assessments included Body Mass Index (BMI) calculations and blood tests for various bone-related markers using Roche's electrochemiluminescence system.

Abdominal bleeding secondary to isolated mesenteric injury following blunt abdominal trauma: A case report.

Rationale: Isolated mesenteric injury often results from traffic accidents causing blunt abdominal trauma, exhibit nonspecific symptoms and signs. Most mesenteric injuries occur concurrently with injuries to other organs, such as the liver and spleen. As a result, the incidence of isolated mesenteric injury is very low and often misdiagnosed.

ABVS breast tumour segmentation via integrating CNN with dilated sampling self-attention and feature interaction Transformer.

Given the rapid increase in breast cancer incidence, the Automated Breast Volume Scanner (ABVS) is developed to screen breast tumours efficiently and accurately. However, reviewing ABVS images is a challenging task owing to the significant variations in sizes and shapes of breast tumours. We propose a novel 3D segmentation network (i.

BMP9 enhances osteogenic differentiation in rheumatoid arthritis: a potential therapeutic approach.

Objective: Rheumatoid arthritis (RA) is a chronic inflammatory disorder that causes joint damage, including cartilage degradation and bone erosion. Bone morphogenetic protein 9 (BMP9), a member of the TGF-β superfamily, plays a key role in osteogenesis and tissue repair. However, its role in bone erosion and inflammation in RA remains underexplored.

Dual release scaffolds as a promising strategy for enhancing bone regeneration: an updated review.

Advancements in tissue regeneration, particularly bone regeneration is key area of research due to potential of novel therapeutic approaches. Efforts to reduce reliance on autologous and allogeneic bone grafts have led to the development of biomaterials that promote synchronized and controlled bone healing. However, the use of growth factors is limited by their short half-life, slow tissue penetration, large molecular size and potential toxicity.

FAMF-Net: Feature Alignment Mutual Attention Fusion With Region Awareness for Breast Cancer Diagnosis via Imbalanced Data.

Automatic and accurate classification of breast cancer in multimodal ultrasound images is crucial to improve patients' diagnosis and treatment effect and save medical resources. Methodologically, the fusion of multimodal ultrasound images often encounters challenges such as misalignment, limited utilization of complementary information, poor interpretability in feature fusion, and imbalances in sample categories. To solve these problems, we propose a feature alignment mutual attention fusion method (FAMF-Net), which consists of a region awareness alignment (RAA) block, a mutual attention fusion (MAF) block, and a reinforcement learning-based dynamic optimization strategy(RDO).

A Study of Sperm DNA Damage Mechanism Based on miRNA Sequencing.

To analyze the differential expression profiles of microRNAs (miRNAs) in spermatozoa of patients with sperm DNA damage and to investigate the role of miRNAs in sperm DNA damage. Male infertility patients with sperm DNA damage who attended the First Affiliated Hospital of Henan University of Chinese Medicine from October 2023 to December 2023 were selected and included in this study as a case group. Fertile healthy men who were seen at the health check-up center during the same period and diagnosed by examination were also included as a control group.

RILP Induces Cholesterol Accumulation in Lysosomes by Inhibiting Endoplasmic Reticulum-Endolysosome Interactions.

Endoplasmic reticulum (ER)-endolysosome interactions regulate cholesterol exchange between the ER and the endolysosome. ER-endolysosome membrane contact sites mediate the ER-endolysosome interaction. VAP-ORP1L (vesicle-associated membrane protein-associated protein- OSBP-related protein 1L) interaction forms the major contact site between the ER and the lysosome, which is regulated by Rab7.

[Comprehensive therapy of traditional Chinese medicine for erectile dysfunction with damp-heat stasis: A clinical observation of 103 cases].

Objective: To assess the clinical effect and safety of comprehensive therapy of traditional Chinese medicine (TCM) in the treatment of erectile dysfunction (ED) with damp-heat stasis.

Methods: We selected 108 cases of ED with damp-heat stasis meeting the inclusion criteria and treated with tadalafil (the control group, n = 54) or tadalafil + comprehensive TCM therapy (the trial group, n = 54) in the First Affiliated Hospital of Henan University of Chinese Medicine in the same period. After 8 weeks of treatment, we recorded the patients' scores on IIEF-5, TCM syndrome, erectile quality (EQS), 9-Item Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Scale 7 (GAD-7).

Targeting BRD4 to attenuate RANKL-induced osteoclast activation and bone erosion in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause destruction of cartilage and bone's extracellular matrix. Bromodomain 4 (BRD4), as a transcriptional and epigenetic regulator, plays a key role in cancer and inflammatory diseases. While, the role of BRD4 in bone destruction in RA has not been extensively reported.

Orphan drug policy analysis in China.

Rare diseases have various types, low incidence rates, complex conditions, and are often difficult to diagnose. Due to China's large population, there is a significant number of rare disease patients, but there is a shortage of orphan drugs. Consequently, these patients often find themselves in a situation where necessary medications are either unavailable or unaffordable.

Clinical Significance of a Novel Vasculogenic Mimicry-based Prognostic Model in Hepatocellular Carcinoma.

Background: Vasculogenic mimicry, a novel neovascularization pattern of aggressive tumors, is associated with poor clinical outcomes.

Objective: The aim of this research was to establish a new model, termed VC score, to predict the prognosis, Tumor Microenvironment (TME) components, and immunotherapeutic response in Hepatocellular Carcinoma (HCC).

Methods: The expression data of the public databases were used to develop the prognostic model.

Causal relationship between serum metabolites and juvenile idiopathic arthritis: a mendelian randomization study.

Background: Juvenile Idiopathic Arthritis (JIA) is a condition that occurs when individuals under the age of 16 develop arthritis that lasts for more than six weeks, and the cause is unknown. The development of JIA may be linked to serum metabolites. Nevertheless, the association between JIA pathogenesis and serum metabolites is unclear, and there are discrepancies in the findings across studies.

[Comparative study of minimally invasive titanium elastic nail and steel plate on the treatment of fracture of tibiofibular fracture in adults].

Objective: To compare the clinical outcomes of using elastic intramedullary nail and plate to fix fibular fracture.

Methods: The 60 patients with tibiofibular fractures admitted from January 2015 to December 2022 were divided into two groups:intramedullary nail group and plate group, 30 cases each, intramedullary nail group was treated with elastic intramedullary nail fixation group, plate group was treated with steel plate and screw fixation group. Intramedullary nail group, there were 18 males and 12 females, aged from 22 to 75 years old with an average of (39.