An Analysis of the Different Salt-Tolerance Mechanisms in Rice Cultivars Induced by Cerium Oxide Nanoparticles.

Cerium oxide nanoparticles (CeONPs) can boost crops' salt tolerance, yet their regulatory mechanisms in rice cultivars with contrasting salt tolerance remain unclear. This study investigated the regulatory differences in poly (acrylic acid)-coated nanoceria (PNC)-primed in salt-sensitive (Huanghuazhan, H) and salt-tolerant (Xiangliangyou900, X) rice. The results showed that PNC priming improved salt tolerance in two cultivars, but the underlying mechanisms differed.

Quercetin inhibits the cAMP/PKA/CREB/glycolysis axis to exert anti-acute lymphoblastic leukemia effects.

Acute lymphoblastic leukemia (ALL), an aggressive hematologic malignancy with high incidence and treatment resistance, demands novel therapeutic approaches. Enhanced glycolysis is a hallmark of metabolic reprogramming in ALL. Quercetin (Que) demonstrates broad antitumor effects by inhibiting glycolysis and cell proliferation.

Effect of Transcutaneous Electrical Acupoint Stimulation at the Sanyinjiao Point on Preventing Bladder Spasm after Transurethral Laser Prostatectomy.

Background: Bladder spasm is a common complication after transurethral laser prostatectomy. Herein, we aimed to assess the effect of transcutaneous electrical acupoint stimulation (TEAS) at the Sanyinjiao point on relieving bladder spasm after transurethral laser prostatectomy.

Methods: The medical data of patients undergoing transurethral laser prostatectomy were retrospectively collected from May 2021 to May 2024.

An Emerging Trend of At-Home Uroflowmetry-Designing a New Vibration-Based Uroflowmeter with Artificial Intelligence Pattern Recognition of Uroflow Curves and Comparing with Other Technologies.

: For aging men experiencing lower urinary tract symptoms (LUTS), bladder diaries (BD) and uroflowmetry (UFM) are commonly used non-invasive diagnostic tools. However, bladder diaries often suffer from subjectivity and incomplete data, while traditional hospital-based uroflowmetry lacks convenience and repeatability. Therefore, there is a growing need for a user-friendly, artificial intelligence (AI)-powered at-home uroflow monitoring solution.

Visual outcomes with two posterior chamber phakic intraocular lenses in myopic patients: a contralateral eye study.

Purpose: Assess the efficacy, safety, and visual quality of two posterior chamber phakic intraocular lenses (PIOL) for myopia correction.

Methods: In this randomized double-blind prospective controlled trial, 38 eyes of 19 myopic patients received phakic refractive (PR) IOL in one eye and implantable collamer lens (EVO ICL) in the opposite eye and were followed up for 1 year. Uncorrected distance visual acuity, corrected distance visual acuity, vault, disk halo size, contrast sensitivity, higher-order aberrations, retinal imaging quality, intraocular scattering, and subjective glare/halo perception were measured.

Stabilizing mechanisms enable dioecious trees to maintain synchrony in spring budburst under climate warming.

Climate change could reduce dioecious plant fitness if the phenology of males and females responds differently to temperature. However, the extent to which spring phenological responses to climate differ between sexes in wind-pollinated dioecious trees remains poorly understood. Here, we combined ground observations with climate-controlled experiments to investigate sexual differences in spring budburst in Ginkgo biloba, Fraxinus chinensis, and Eucommia ulmoides.

Biological mechanisms of pulmonary inflammation and its association with seropositive rheumatoid arthritis.

Although the pathogenesis of seropositive rheumatoid arthritis (RA) remains unclear, studies suggest that pulmonary inflammation-related biological mechanisms play a significant role in its development. This review thoroughly explores the mechanisms underlying early pulmonary lesions in seropositive RA, focusing on the mucosal barrier hypothesis, neutrophil extracellular traps, pathogenic microbial infections like COVID-19, Vitamin D, the microbiome and gut-lung axis, inhalation exposures and chronic pulmonary diseases. This study seeks to provide novel insights and theoretical foundations for the prevention and treatment of seropositive rheumatoid arthritis.

The Opportunities and Challenges in the Molecular Mechanism Research of Congenital Heart Disease: A Review.

Background: Advanced molecular mechanism research incorporated with multidisciplinary collaborations on congenital heart disease has prompted new insight into its cause, development, and outcomes.

Summary: This literature review aims to comprehensively examine the genetic molecular mechanisms of congenital heart disease and explain current prospects and challenges in this field. Through a systematic exploration of etiology, embryology, clinical outcomes, algorithms, and ethics, we seek to shed light on the path toward improved diagnostics, treatments, and outcomes for patients.

Assessing the effectiveness of travel control measures in preventing imported COVID-19 cases reveals the critical role of travel volume.

Background: Although travel control measures have played a key role in mitigating COVID-19 spread in certain regions, few empirical observational studies have specifically quantified their effectiveness in preventing the importation of infectious cases into communities. In Hong Kong, layered policies (e.g.

Concept Lens: Visual Comparison and Evaluation of Generative Model Manipulations.

Generative models are becoming a transformative technology for the creation and editing of images. However, it remains challenging to harness these models for precise image manipulation. These challenges often manifest as inconsistency in the editing process, where both the type and amount of semantic change, depend on the image being manipulated.

Nuclear shuttling of CDC4 mediated broad-spectrum antiviral activity against diverse coronaviruses.

Pandemics of coronavirus (CoV)-related infection have been a major issue since the outbreaks of SARS, MERS and COVID-2019 in the past decades, leading a substantial threat to public health. Porcine deltacoronavirus (PDCoV), a new swine coronavirus, causes enteropathogenic disease characterized by acute diarrhoea, vomiting and dehydration in suckling piglets and poses potential risks of cross-species transmission. Here we reveal a novel function of CDC4 protein in restricting PDCoV infection.

Gentle fundal pressure to facilitate vaginal delivery: A randomized clinical trial.

Introduction: Fundal pressure during the second stage of labor is widely practiced but understudied. Violent fundal pressure can cause maternal and fetal injuries. Many providers believe the maneuver is effective.

Incorporating Drought Thresholds Improves Model Predictions of Autumn Phenology in Tropical and Subtropical Forests.

Drought dramatically influences vegetation phenology, thereby impacting terrestrial carbon and water cycles. However, the mechanisms by which drought drives changes in autumn phenology remain unclear, hindering the accurate simulation of these processes in phenology models. In this study, we employed ridge regression analysis to quantify the dynamic effects of intensifying drought on the end-of-photosynthetic-growing-season (EOPS) and identified the drought threshold at which the vegetation's response to drought shifts.

Metagenomic analysis reveals soil microbiome responses to microplastics and ZnO nanoparticles in an agricultural soil.

Both microplastics (MPs) and engineered nanoparticles are pervasive emerging contaminants that can produce combined toxicity to terrestrial ecosystems, yet their effects on soil microbiomes remain inadequately understood. Here, metagenomic analysis was employed to investigate the impacts of three common MPs [i.e.

The relationship between renal function indicators and preeclampsia in the second trimester of pregnancy: a retrospective study.

Background: To investigate the relationship between serum renal function indicators and preeclampsia (PE) in pregnant women at second trimester of pregnancy, determine the optimal critical values of the above indicators, and further identify the independent risk factors of PE.

Methods: We assessed the renal function indicators in second trimesters of 137 pregnant women with PE and 137 normal pregnant women who delivered at Shijiazhuang Fourth Hospital between January 2020 to December 2022. Paired -tests, paired Mann-Whitney U tests, and Chi-square tests were used to evaluate differences of clinical data between the two groups.

Long-Term Evaluation of Central and Peripheral Lens Densities Post Implantation of Implantable Collamer Lens V4c.

Purpose: This study aimed to analyze the impact of long-term ICL implantation on lens density, focusing on the relationship between the anterior subcapsule, anterior lens density, and implantable collamer lenses (ICL) position after ICL V4c implantation.

Methods: This retrospective study included 145 eyes with ICL V4c implantation and average follow-up of 4.2 years (range: 3-8 years).

General lightweight framework for vision foundation model supporting multi-task and multi-center medical image analysis.

The foundation model, trained on extensive and diverse datasets, has shown strong performance across numerous downstream tasks. Nevertheless, its application in the medical domain is significantly hindered by issues such as data volume, heterogeneity, and privacy concerns. Therefore, we propose the Vision Foundation Model General Lightweight (VFMGL) framework, which facilitates the decentralized construction of expert clinical models for various medical tasks.

The Evolution of Uroflowmetry and Bladder Diary and the Emerging Trend of Using Home Devices From Hospital to Home.

Although uroflowmetry and bladder diaries are widely used for noninvasive evaluation of lower urinary tract symptoms, they still have limitations in diagnostic capability and users' convenience. The aim of this paper is to discuss potential solutions by reviewing (1) the evolution and current clinical use of uroflowmetry and bladder diary, including clinical guidelines, daily practice applications, and their historical development; (2) a growing trend toward using home devices with various technologies; and (3) a comprehensive comparison of the strengths and weaknesses of these home devices. In our opinion, the following points can be highlighted: (1) the emerging trend of using home devices can enhance diagnostic capabilities through repeated measurements and the convenience of at-home testing and (2) home devices, which provide both frequency-volume and uroflowmetry information, have the potential to transform the management of lower urinary tract symptoms.

Durable suppression of seizures in a preclinical model of KCNT1 genetic epilepsy with divalent small interfering RNA.

Objective: Gain-of-function variants in the KCNT1 gene, which encodes a sodium-activated potassium ion channel, drive severe early onset developmental epileptic encephalopathies including epilepsy of infancy with migrating focal seizures and sleep-related hypermotor epilepsy. No therapy provides more than sporadic or incremental improvement. Here, we report suppression of seizures in a genetic mouse model of KCNT1 epilepsy by reducing Kcnt1 transcript with divalent small interfering RNA (siRNA), an emerging variant of oligonucleotide technology developed for the central nervous system.

NSUN6 inhibitor discovery guided by its mRNA substrate bound crystal structure.

NSUN6 preferentially catalyzes the methylation of cytosine nucleotides in mRNA substrates, which enhances transcription. Dysregulation of NSUN6 catalysis drives the oncogenesis of certain cancers. In this study, we determined the crystal structure of human NSUN6 in complex with its S-adenosyl-L-methionine analog and a bound NECT-2 3'-UTR RNA substrate at 2.

N-oxide-Functionalized Bipyridines as Strong Electron-Deficient Units to Construct High-Performance n-Type Conjugated Polymers.

Developing low-cost unipolar n-type organic thin-film transistors (OTFTs) is necessary for logic circuits. To achieve this objective, the usage of new electron-deficient building blocks with simple structure and easy synthetic route is desirable. Among all electron-deficient building units, N-oxide-functionalized bipyridines can be prepared through a simple oxidized transformation of bipyridines.

Preoperative discrimination of absence or presence of myometrial invasion in endometrial cancer with an MRI-based multimodal deep learning radiomics model.

Objective: Accurate preoperative evaluation of myometrial invasion (MI) is essential for treatment decisions in endometrial cancer (EC). However, the diagnostic accuracy of commonly utilized magnetic resonance imaging (MRI) techniques for this assessment exhibits considerable variability. This study aims to enhance preoperative discrimination of absence or presence of MI by developing and validating a multimodal deep learning radiomics (MDLR) model based on MRI.

Changes in relative peripheral refraction after implantable collamer lenses implantation.

Purpose: This study aimed to measure the changes in refraction difference value (RDV) in different parts of the retina before and after implantable collamer lenses (ICL) surgery.

Design: Prospective study.

Methods: This study included 40 eyes of 40 patients who underwent ICL implantation for myopia.

An antibody cocktail targeting two different CD73 epitopes enhances enzyme inhibition and tumor control.

CD73, an ectoenzyme responsible for adenosine production, is often elevated in immuno-suppressive tumor environments. Inhibition of CD73 activity holds great promise as a therapeutic strategy for CD73-expressing cancers. In this study, we have developed a therapeutic anti-human CD73 antibody cocktail, HB0045.

Investigation on the reliability calculation method of gravity dam based on CNN-LSTM and Monte Carlo method.

To improve the calculation accuracy of the Monte Carlo (MC) method and reduce the calculation time. Firstly, CNN and LSTM deep learning networks are introduced for designing nonlinear dynamic systems simulating dam stress. Then, spatial feature mining and sequence information extraction of nonlinear data of dam stress are carried out respectively, and a combined prediction model of dam stress depth (DS-FEM-CNN-LSTM) is proposed.