Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Although the pathogenesis of seropositive rheumatoid arthritis (RA) remains unclear, studies suggest that pulmonary inflammation-related biological mechanisms play a significant role in its development. This review thoroughly explores the mechanisms underlying early pulmonary lesions in seropositive RA, focusing on the mucosal barrier hypothesis, neutrophil extracellular traps, pathogenic microbial infections like COVID-19, Vitamin D, the microbiome and gut-lung axis, inhalation exposures and chronic pulmonary diseases. This study seeks to provide novel insights and theoretical foundations for the prevention and treatment of seropositive rheumatoid arthritis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141282 | PMC |
| http://dx.doi.org/10.3389/fimmu.2025.1530753 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Are we screening effectively? A systematic review and meta-analysis of proposed risk factors for rheumatoid arthritis-associated interstitial lung disease screening.
Scand J Rheumatol
September 2025
REMEDY Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway.
Objectives: To systematically review and meta-analyse the risk factors proposed by the American College of Rheumatology and American College of Chest Physicians as screening tools for rheumatoid arthritis-associated interstitial lung disease (RA-ILD), focusing exclusively on studies using high-resolution computed tomography (HRCT) in prospectively collected data from unselected RA patients.
Method: A comprehensive search was conducted to identify studies evaluating RA-ILD risk factors. Selection criteria included studies using HRCT in prospective, unselected RA cohorts.
Expanded senescent CD8 T-cells in IMID patients are associated with distinct inflammatory cytokines.
Clin Exp Immunol
September 2025
Rheumatology Department, Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1184, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (APHP), CEA , FHU CARE, Le Kremlin Bicêtre, France.
Introduction: Immunosenescence remodels immune functions and was first described with aging. It is present in 25% of cancer patients but has also been described in patients with Immune-mediated inflammatory diseases (IMIDs). This study aims at quantifying cells exhibiting a phenotype of senescence in CD4+ (T4sen) and CD8+ (T8sen) T cells, analyzing its potential drivers and the effect of anti-TNF treatment in a prospective cohort of patients with rheumatoid arthritis (RA), spondyloarthritis (SpA) and Sjögren disease (SjD).
View Article and Find Full Text PDFFactors influencing delayed attainment of low disease activity in rheumatoid arthritis patients continuing targeted therapy.
Korean J Intern Med
September 2025
Hanyang University Institute for Rheumatology Research, Seoul, Korea.
Background/aims: To identify factors associated with achieving low disease activity (LDA) after 48 weeks of targeted therapy in patients with rheumatoid arthritis (RA) despite not meeting treat-to-target (T2T) criteria at week 24.
Methods: Data were collected from a multicenter, prospective observational cohort of Korea patients with RA receiving targeted therapy between April 2020 and July 2023. Patients who continued their initial targeted therapy despite not achieving LDA at week 24 were assigned to the LDA and non-LDA groups at week 48.
MRI-Negative Transverse Myelitis Revealing Seropositive Rheumatoid Arthritis in a Young Woman.
Cureus
August 2025
Neurology, Palmetto General Hospital, Miami, USA.
Transverse myelitis (TM) is an inflammatory disorder of the spinal cord often associated with autoimmune diseases, such as systemic lupus erythematosus (SLE) or neuromyelitis optica spectrum disorder (NMOSD); however, it is rarely linked to rheumatoid arthritis (RA). We present the case of a 28-year-old woman with subacute ascending numbness, lancinating pain, and bilateral lower extremity weakness resulting in significant functional impairment. Despite upper motor neuron signs on examination and supportive cerebrospinal fluid findings, including elevated gamma globulins and positive myelin basic protein, spinal MRI remained negative.
View Article and Find Full Text PDFCaplan syndrome in the 21st century: Cavitary nodules and delayed rheumatoid arthritis.
Occup Med (Lond)
September 2025
Department of Internal Diseases, Occupational Diseases Unit, Ministry of Health Ankara Etlik City Hospital, Ankara, Turkey.
Caplan syndrome, a rare condition characterized by the coexistence of pneumoconiosis and rheumatoid arthritis in individuals exposed to inorganic dust, remains a relevant diagnostic consideration in the 21st century. We present a case of a 41-year-old former coal miner who developed multiple cavitary pulmonary nodules years after leaving the mining sector, initially mimicking pulmonary malignancy. Extensive diagnostic work-up, including positron emission tomography-computed tomography, bronchoscopy and lung biopsy, eventually led to the diagnosis of Caplan syndrome, with seropositive rheumatoid arthritis emerging 8 years after exposure cessation.
View Article and Find Full Text PDF