Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations.

To gain molecular and mechanistic insights into initiation of the RAS-RAF signaling cascade, we developed and used a combination of multiscale simulation and experimental approaches. The influence and impact of the membrane on RAS and RAF proteins is a factor we are just beginning to understand and appreciate in more detail. Molecular simulation is an ideal methodology to further study this complicated relationship between the membrane and associated proteins.

Genetic Mapping of a QTL Controlling Fruit Size in Melon ( L.).

Fruit size is an important agronomic trait affecting the yield and commercial value of melon and a key trait selected for during domestication. In this study, two respective melon accessions (large-fruited M202008 and small-fruited M202009) were crossed, and developed biparental mapping populations of the F generation (160 and 382 plants) were checked across two subsequent experimental years (2023 and 2024). The phenotypic characterization and genetic inheritance analysis showed that melon fruit size is modulated by quantitative genetics.

Identification of brevis radix (BRX) family genes in tomato (Solanum lycopersicum) and the function of SlBRX5 and SlBRX7 under cold stress.

The BRX gene family is a group of plant-specific transcription factors that play a role in phytohormone signaling and regulates root elongation and stress tolerance in plants. In this study, ten BRX genes were identified in the tomato genome-wide. The structure, chromosomal localization, collinearity of the SlBRX family genes in tomato, and the physicochemical properties, conserved motifs, and phylogeny of SlBRX family proteins were characterized.

Concept Lens: Visual Comparison and Evaluation of Generative Model Manipulations.

Generative models are becoming a transformative technology for the creation and editing of images. However, it remains challenging to harness these models for precise image manipulation. These challenges often manifest as inconsistency in the editing process, where both the type and amount of semantic change, depend on the image being manipulated.

Genome-wide analysis of KCS genes in tomato and functional characterization of SlKCS8 and SlKCS10 in drought tolerance.

KCS, an endogenous cellular enzyme, catalyzes the elongation of fatty acid chains and plays a crucial role in the biosynthesis of plant epidermal wax. Through processes such as transfer, decarboxylation, and fixation, it contributes to plant growth and adaptation to abiotic and biotic stresses. However, the mechanism by which KCS genes participate in the response of tomato plants to driught remains unclear.

"Understanding Robustness Lottery": A Geometric Visual Comparative Analysis of Neural Network Pruning Approaches.

Deep learning approaches have provided state-of-the-art performance in many applications by relying on large and overparameterized neural networks. However, such networks are very brittle and are difficult to deploy on resource-limited platforms. Model pruning, i.

Impact of root distribution patterns on the elastic deformation resistance capacity and pore water development in root reinforced soil.

Shallow soils are highly vulnerable to the combined impacts of various factors, including vehicle loading, precipitation, and groundwater. The slope soil at the roadside is inevitably subjected to long-term cyclic loading from traffic. Previous studies have demonstrated that ecological engineering measures can effectively mitigate soil deformation and reduce pore water pressure development, thereby preventing soil erosion and landslides.

Corrigendum to "Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury"[J Ginseng Res 48(6), November 2024, 592-602].

[This corrects the article DOI: 10.1016/j.jgr.

Endoscopic maxillary sinus drainage combined with buccal fat pad flaps for repairing large oroantral fistulas in patients with odontogenic maxillary sinusitis.

Background: Oroantral fistula (OAF) is a pathological channel formed between the oral cavity and the maxillary sinus. A large size of OAF (≥5 mm) increases the risk of surgical failure, and an optimal surgical approach should be cautiously selected.

Objective: This study aims to characterize the application of nasal endoscopy and buccal fat pad (BFP) flaps to repair large OAFs in patients with odontogenic maxillary sinusitis (OMS).

Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury.

Background: Ischemic stroke is a devastating disease that can result in permanent disability and death, and angiogenesis plays a critical role in the recovery and survival of patients and animal models of ischemic stroke. Panax notoginseng has been used as a key herb in the treatment of stroke diseases due to its effect in promoting blood circulation and removing blood stasis. However, the role of Panax notoginseng saponins, in promoting angiogenesis is unclear.

miR-PC-3p-241582_34 Contributes to the Infection of by Regulating the Expression of in .

is a recurring pest in the maize seedling stage under the wheat-maize no-tillage direct seeding system in China's summer maize region. Our previous research identified a highly pathogenic to , which spore wall protein plays an important role in the infection process. However, the regulatory mechanism of this spore wall protein is still unclear.

Protective effects and mechanisms of HuDiChangRong capsule on TNBS-induced ulcerative colitis in mice.

Ethnopharmacological Relevance: UC, characterized by chronic inflammation primarily affecting the colon and rectum, follows a protracted relapsing course marked by inflammation and an abundance of free radicals at the onset. Hudichangrong Capsule (HDCRC), a traditional Chinese medicinal formula, has long been employed in the treatment of UC and chronic bacillary dysentery, exhibiting positive therapeutic outcomes and a high rate of cure in clinical practice.

Aim Of The Study: The precise mechanism underlying its efficacy for UC remains elusive.

Influence of biopolymer-vegetation interaction on soil hydro-mechanical properties under climate change: A review.

Soil reinforcement using eco-friendly biopolymer and vegetation has been increasingly popular in geotechnical engineering. However, research is still in its early stages due to complex biochemical interactions between biopolymers and plants. Moreover, under the increasing climate change, extreme weather poses severe challenges to the effectiveness of biopolymer-vegetation on soil treatment.

Anti-LSSDS pharmacological components identification of YuHuangLian based on the combination of spectrum-effect analysis and network pharmacology as well as molecular docking.

This research aimed to investigate the pharmacological components for liver stagnation and spleen deficiency syndrome (LSSDS) of Evodia rutaecarpa (also called Yu HuangLian [YHL]) by exploring the spectrum-effect relationship between fingerprints and pharmacological actions. The fingerprints of 17 batches of YHL with different preparation conditions according to Box-Behnken Design were generated and analyzed to identify the common peaks by HPLC and FT-IR. Vasoactive intestinal peptide (vip), substance P, and 5-HT levels in colon sample were measured by ELISA.

Crosstalk among Oxidative Stress, Autophagy, and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells: A Mixed Computational and Experimental Study.

Objective: Brain microvascular endothelial cells (BMECs) were found to shift from their usually inactive state to an active state in ischemic stroke (IS) and cause neuronal damage. Ginsenoside Rb1 (GRb1), a component derived from medicinal plants, is known for its pharmacological benefits in IS, but its protective effects on BMECs have yet to be explored. This study aimed to investigate the potential protective effects of GRb1 on BMECs.

The Relationship Between Stressful Life Events and Depressive Symptoms in College Students: mediation by Parenting Style and Gender's Moderating Effect.

Aim: Stressful life events have a significant impact on the mental health of college students. Depression, as a prevalent psychological issue, has garnered attention in the field of college student mental health and is closely linked to it. Additionally, parenting style is identified as an important factor influencing the development of college students' mental health.

Advancements in research on the effects of panax notoginseng saponin constituents in ameliorating learning and memory disorders.

Learning and memory disorder is a cluster of symptoms caused by neuronal aging and other diseases of the central nervous system (CNS). Panax notoginseng saponins (PNS) are a series of saponins derived from the natural active ingredients of traditional Chinese medicine (TCM) that have neuroprotective effects on the central nervous system. In this paper, we review the ameliorative effects and mechanisms of Panax notoginseng saponin-like components on learning and memory disorders to provide valuable references and insights for the development of new drugs for the treatment of learning and memory disorders.

A Visual Comparison of Silent Error Propagation.

High-performance computing (HPC) systems play a critical role in facilitating scientific discoveries. Their scale and complexity (e.g.

Influence of root distribution patterns on soil dynamic characteristics.

Slopes along the highway and railway routes are subjected to not only static loads but also dynamic loads generated by vehicles and trains. The induced excessive deformation potentially poses a threat to slope stability. In terms of the extensive application of ecological slope protection, plants play a critical role in slope stability, as the roots can enhance the shear strength of the soil.

Development of Whole Genome SNP-CAPS Markers and Preliminary QTL Mapping of Fruit Pedicel Traits in Watermelon.

Fruit pedicel (FP) is an important determinant of premium fruit quality that directly affects commercial market value. However, in-depth molecular and genetic basis of pedicel-related traits has not been identified in watermelon. Herein, a quantitative trait locus (QTL) mapping strategy was used to identify the potential genetic regions controlling FP traits based on newly derived whole-genome single nucleotide polymorphism based cleaved amplified polymorphism sequence (SNP-CAPS) markers.

Identification of Candidate Chromosome Region Related to Melon ( L.) Fruit Surface Groove Trait Through Biparental Genetic Mapping and Genome-Wide Association Study.

The melon fruit surface groove (fsg) not only affects peel structure and causes stress-induced fruit cracking but also fits consumers' requirements in different regions. In this study, genetic inheritance analysis of three F populations derived from six parental lines revealed that the fsg trait is controlled by a simple recessive inherited gene. Through bulked segregant analysis sequencing (BSA-seq), the locus was detected in an 8.

Attribution-Driven Explanation of the Deep Neural Network Model via Conditional Microstructure Image Synthesis.

The materials science community has been increasingly interested in harnessing the power of deep learning to solve various domain challenges. However, despite their effectiveness in building highly predictive models, e.g.

Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.

RAS is a signaling protein associated with the cell membrane that is mutated in up to 30% of human cancers. RAS signaling has been proposed to be regulated by dynamic heterogeneity of the cell membrane. Investigating such a mechanism requires near-atomistic detail at macroscopic temporal and spatial scales, which is not possible with conventional computational or experimental techniques.

, a Novel Causal Agent of Maize Ear Rot and Its Sensitivity to Fungicides.

Ear rot is one of the most prevalent and destructive diseases of maize. During field surveys, it was found that a Penicillium ear rot broke out in some areas of Shanxi, Shaanxi, Hebei, and Tianjin in China, with an incidence of 3 to 90%. A sp.