A brief exploration of the physical properties of single living cells under dynamic loading conditions.

Introduction: Single living cells exhibit both active biological functions and material-like mechanical behaviors. While extensive research has focused on static or quasi-static loading, the purely mechanical properties under high-rate impact remain underexplored. Investigating cell responses to dynamic loading can isolate rapid deformation characteristics, potentially clarifying how life activities modulate mechanical behavior.

Distinctive function of Tetraspanins: Implication in viral infections.

Harboring four transmembrane domains in their structural hallmark, Tetraspanins (Tspans) are a family of glycoproteins with pivotal functions in a variety of biological and cellular processes. Through interacting laterally with each other or specific membrane proteins, Tspans organize tetraspanin-enriched microdomains (TEMs), modulating cellular signaling, adhesion, fusion, and proliferation. An abundance of evidence has identified the multiple functions in the progression of cancer as well as the underlying molecular mechanisms.

Augmentation of antiviral immune response induced by perturbation of CD82 under microgravity condition.

Exposure to microgravity has become the primary factor threatening astronauts' health. Immunity is dysregulated rapidly following spaceflight, and reactivation of latent virus has been observed. However, systematic studies and molecular mechanisms of the adverse impact of microgravity on the antiviral immune response are still elusive.