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Article Abstract
Introduction: Immune thrombocytopenia (ITP) is the most common bleeding disorder in children. Tfh cells play a crucial role in the pathogenesis of ITP by promoting the production of anti-platelet autoantibodies. Recent studies have shown that CXCR5 T cells not only possess "Tfh-like" cell functions but also can induce Tfh cell differentiation. However, it remains unknown whether CXCR5 T cells are involved in the pathogenesis of ITP. This study aims to investigate the role of CXCR5 T cells in children with newly diagnosed ITP (nITP).
Methods: A total of 96 children with nITP and 48 healthy children were enrolled in this study. FCM was used to compare the frequencies of circulating CXCR5 T cells and circulating Tfh cells, as well as the levels of ICOS and CD40l on circulating CXCR5 T cells in both groups. The correlation between circulating CXCR5 T cells and platelets as well as circulating Tfh cells were further analyzed.
Results: Compared with healthy controls, the frequency of circulating CXCR5 T cells was higher in children with nITP, and it was negatively correlated with platelet count. The levels of ICOS and CD40l on circulating CXCR5 T cells in children with nITP were also higher. Children with nITP had a higher frequency of circulating Tfh cells, which was positively correlated with circulating CXCR5 T cells.
Conclusions: The excessive activation and proliferation of CXCR5 T cells may contribute to the pathogenesis of nITP in children. Therefore, it can be used as a target for the immunotherapy of pediatric ITP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375633 | PMC |
| http://dx.doi.org/10.3389/fped.2025.1646877 | DOI Listing |
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