Atomic armor for thermal stability in nanoporous structures.

Nanoporous structures play a critical role in a wide range of applications, including catalysis, thermoelectrics, energy storage, gas adsorption, and thermal insulation. However, their thermal instability remains a persistent challenge. Inspired by the extraordinary resilience of tardigrades, an "atomic armor" strategy is introduced to enhance the stability of nanoporous structures.

CT Radiomics-based machine learning approach for the invasiveness of pulmonary ground-glass nodules prediction.

Objective: To develop and validate a machine learning model based on CT radiomics to improve the ability to differentiate pathological subtypes of pulmonary ground-glass nodules (GGN).

Methods: A retrospective analysis was conducted on clinical data and radiological images from 392 patients with lung adenocarcinoma at Binzhou Medical University Hospital between January 1, 2020 to May 31, 2023. All patients underwent preoperative thin-section chest CT scans and surgical resection.

Daptomycin-Loaded Nano-Drug Delivery System Based on Biomimetic Cell Membrane Coating Technology: Preparation, Characterization, and Evaluation.

Staphylococcus aureus () is a clinically significant pathogenic bacterium. Daptomycin (DAP) is a cyclic lipopeptide antibiotic used to treat infections caused by multidrug-resistant Gram-positive bacteria, including . However, DAP currently faces clinical limitations due to its short half-life, toxic side effects, and increasingly severe drug resistance issues.

The recent progress of tumor cell-derived exosomes in the pathogenesis, diagnosis and therapeutic strategies of tumors.

Exosomes are extracellular vesicles of nanoscale, which represent the characteristics of the cells of origin. Tumor cell-derived exosomes (TEXs) obtain the characteristics of the tumor cells, which meanwhile transfer the various substances from the tumor cells to regulate the other cells and microenvironments. TEXs play an important role in the pathogenesis of tumors, which can promote the progression, metastasis and recurrence of tumors.

Short-term effects of ambient air pollution on musculoskeletal diseases in Yangzhou during 2019-2022.

Background: Given the limited research on the association between air pollutants and musculoskeletal diseases (MDs), our study aimed to examine how exposure to air pollutants influenced the risk of developing musculoskeletal disorders.

Methods: We extracted daily air pollutants and musculoskeletal diseases data from 2019 to 2022 in Yangzhou. The combined effects of air pollutants particulate matte 2.

Ultralow loss and broadband hollow core anti-resonant fiber with nested waterdrop-shaped tube.

The hollow-core anti-resonant fiber (HC-ARF) has attracted a great deal of interest due to its unique fiber properties. However, it still is a challenging work to design a HC-ARF with simple structure that can further reduce the loss while maintaining wide bandwidth and good single-mode characteristics. Based on this, we proposed two kinds of single-layer nested waterdrop-shaped anti-resonance nodeless fibers (NWANFs), and implemented a comparative study with previously proposed nested anti-resonant nodeless fiber and nested elliptical anti-resonant nodeless fiber in terms of confinement loss (CL), total loss, bending loss, and single-mode characteristics.

Multiscale local sparsity and prior learning algorithm for Cherenkov-excited luminescence scanned tomography reconstruction.

Cherenkov-excited luminescence scanned tomography (CELST) is an emerging imaging technique and its potential applications during radiation therapy have just recently been explored. The aim of CELST is to recover the distribution of luminescent probes from emission photons. However, CELST images tend to suffer from low resolution and degraded image quality due to light multiple scattering and limited boundary measurements.

Ion Valency as a Molecular Switch for Salt-Resistant Underwater Adhesion.

Achieving underwater adhesion remains challenging due to the disruption of interfacial interactions by hydration layers and the ionic environment. This study shows how high adhesion in a saline environment can be achieved in adhesive peptide systems relying on π-π and cation-π interactions using multivalent ions. Monovalent ions (K) disrupt native peptide-peptide interactions, drastically reducing adhesion strength.

Gut-Vaginal Microbiome Crosstalk in Ovarian Cancer: Implications for Early Diagnosis.

Ovarian cancer remains a formidable global health burden, characterized by frequent late-stage diagnosis and elevated mortality rates attributable to its elusive pathogenesis and the critical lack of reliable early-detection biomarkers. Emerging investigations into the gut-vaginal microbiome axis have unveiled novel pathogenic mechanisms and potential diagnostic targets in ovarian carcinogenesis. This comprehensive review systematically examines the compositional alterations in and functional interplay between vaginal and intestinal microbial communities in ovarian cancer patients.

Chitosan-collagen composite biomaterials: Advances and insights into properties and biomedical applications.

Chitosan polysaccharides and collagen, derived from natural products, are important macromolecular compounds with extensive applications in many fields. In the past decade, substantial progress has been made in studying chitosan-collagen (CS-Col) composite biomaterials. Based on the morphology of materials, this work systematically reviews CS-Col composite biomaterials including nanoparticles, nanofibers, hydrogels, three-dimensional (3D) bioprinting scaffolds, films, and sponges.

Glimepiride overcomes acquired resistance to EGFR TKIs in lung cancer via the AMPK/ERK/MMP7 signaling pathway.

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) limits their clinical efficacy. Intratumoral heterogeneity and the coexistence of diverse resistance mechanisms make combination therapies focused on single molecules or pathways clinically ineffective. Here, our study demonstrated that glimepiride, a sulfonylurea drug, reversed and delayed acquired resistance to EGFR TKIs in lung cancer.

Comparison of laparoscopic verse open oesophagogastric devascularisation with splenectomy in portal hypertension: A meta-analysis.

To assess the efficacy and safety in treating portal hypertension by laparoscopic oesophagogastric devascularisation with splenectomy. I searched the randomised controlled trials about the efficacy and safety of laparoscopic oesophagogastric devascularisation with splenectomy in treating portal hypertension from PubMed (1998~2023.02), Wanfang Data (1990~2023.

Combining epidemiology, network toxicology and in vivo experimental validation to uncover takeout-mediated DEHP/MEHP toxicity in inflammatory bowel disease.

Background And Aims: Mono (2-ethylhexyl) phthalate (MEHP), the active metabolite of di-(2-ethylhexyl) phthalate (DEHP), is a widely used plasticizer in food packaging materials. While DEHP/MEHP has been linked to various health risks, the underlying mechanisms between DEHP/MEHP exposure and inflammatory bowel disease (IBD) remain poorly understood. This study aims to explore this relationship using a comprehensive approach integrating epidemiology, Mendelian randomization (MR), network toxicology, and animal experiments.

Integrated transcriptomic and proteomic profiling of colonic tissue in interleukin-10-deficient mice.

Interleukin (IL)-10, a prominent anti-inflammatory cytokine predominantly secreted by various immune cells, plays a crucial role in the pathophysiological mechanisms of inflammatory bowel disease (IBD). Mice deficient in IL-10 (IL-10) progressively develop features of idiopathic enterocolitis as they mature. To advance our understanding of the molecular mechanisms underpinning chronic enterocolitis in IL-10 mice, we performed an extensive analysis of the transcriptome and proteome of colonic tissue from these mice manifesting colitis.

Effects of coating on recovery of -derived phytase under different steam pelleting conditions.

The objective of this study was to evaluate the effect of coating on the recovery rate () of phytase activity during the steam conditioning-pelleting () process. A split-plot design was employed, with phytases assigned to the main plot and two conditioning temperatures (75 or 85 °C) assigned to the subplot. The whole plot was repeated four times.

Deep transfer learning radiomics combined with explainable machine learning for preoperative thymoma risk prediction based on CT.

Objective: To develop and validate a computerized tomography (CT)‑based deep transfer learning radiomics model combined with explainable machine learning for preoperative risk prediction of thymoma.

Methods: This retrospective study included 173 pathologically confirmed thymoma patients from our institution in the training group and 93 patients from two external centers in the external validation group. Tumors were classified according to the World Health Organization simplified criteria as low‑risk types (A, AB, and B1) or high‑risk types (B2 and B3).

Difenoconazole-Loaded Nanostructured Lipid Carriers: Preparation, Characterization, and Evaluation.

: Difenoconazole (DFC) is a broad-spectrum fungicide. However, its application is limited due to poor aqueous solubility. Drugs with low solubility can be better absorbed using nanostructured lipid carriers (NLCs).

Data-Augmented Deep Learning Algorithm for Accurate Control of Bioethanol Fermentation Using an Online Raman Analyzer.

Fed-batch fermentation has become the preferred strategy in many industrial biomanufacturing processes. However, a key challenge remains in optimizing the feeding strategy to achieve stable maximum yields. In this study, we present an online Raman spectroscopy-based monitoring and control system, using bioethanol production by Saccharomyces cerevisiae as a case study.

The impact of behavioral patterns on accelerated aging in the UK biobank.

Background: Biological Age Acceleration (BAA), as quantified by epigenetic clocks, is a well-established biomarker for mortality and age-related morbidity. This study aimed to investigate the independent and combined associations of sleep duration, sedentary behavior, and physical activity with BAA risk.

Methods: Leveraging the UK Biobank cohort, we conducted multiple linear regression analyses to assess the relationships between modifiable lifestyle factors and BAA.

A bifunctional UIO-66-NH@ RhB-based fluorescence and colorimetric dual-mode ratiometric sensor and hydrogel-based smart phone-assisted naked eye detection of perfluorooctanesulfonate (PFOS).

A bifunctional fluorescent and colorimetric sensor based on UiO-66-NH₂@RhB was developed for the highly sensitive detection of perfluorooctanesulfonate (PFOS), a persistent environmental pollutant. The sensing mechanism relies on the inner filter effect (IFE), where Rhodamine B (RhB) modulates the fluorescence of UiO-66-NH₂, enabling effective PFOS recognition. In the presence of PFOS, UiO-66-NH@RhB exhibits dual emissions in blue fluorescence at 448 nm and red fluorescence at 565 nm at a single excitation wavelength.

Mining Key Drought-Resistant Genes of Upland Cotton Based on RNA-Seq and WGCNA Analysis.

Cotton, as a globally important fiber crop, is significantly affected by drought stress during production. This study uses the drought-resistant variety Jin and the drought-sensitive variety TM-1 as test materials. Through multi-period drought stress treatments at 0 d, 7 d, 10 d, 15 d, and 25 d, combined with dynamic monitoring of physiological indicators, RNA sequencing, and weighted gene co-expression network analysis, the molecular mechanism of cotton drought resistance is systematically analyzed.

Fatty acid oxidation contributed to NLRP3 inflammasome activation caused by N-nitrosamines co-exposure.

Nitrosamines, as common environmental carcinogens, are closely related to the development of esophageal inflammation (EI). Studies have revealed that NLRP3 inflammasome activation was a key event in nitrosamine-induced EI. However, the involvement of fatty acid metabolism in nitrosamine-induced NLRP3 inflammasome activation has not been reported.

Assessing Coronary Microvascular Dysfunction Using Angiographic Frame Count in Patients With Angina and Nonobstructive Coronary Arteries.

Background: Coronary microvascular dysfunction (CMD) is underdiagnosed, mainly because of the low clinical adoption of wire-based invasive coronary function testing. Angiography-based, wireless methods might facilitate widespread assessment of CMD. To our knowledge, the diagnostic utility of angiographic Thrombolysis In Myocardial Infarction (TIMI) frame count and frame count reserve (FCR) in identifying CMD in patients with angina and nonobstructive coronary arteries (ANOCA) has never been explored.

Survey on diagnosis and treatment of cognitive impairment in Sichuan area in China.

Introduction: Dementia imposes significant economic and emotional burdens, with cognitive impairment in China expected to rise. However, diagnosis and treatment remain inadequately standardized. This study surveyed cognitive impairment diagnosis and treatment in Sichuan, China.