Daptomycin-Loaded Nano-Drug Delivery System Based on Biomimetic Cell Membrane Coating Technology: Preparation, Characterization, and Evaluation.

Staphylococcus aureus () is a clinically significant pathogenic bacterium. Daptomycin (DAP) is a cyclic lipopeptide antibiotic used to treat infections caused by multidrug-resistant Gram-positive bacteria, including . However, DAP currently faces clinical limitations due to its short half-life, toxic side effects, and increasingly severe drug resistance issues.

Difenoconazole-Loaded Nanostructured Lipid Carriers: Preparation, Characterization, and Evaluation.

: Difenoconazole (DFC) is a broad-spectrum fungicide. However, its application is limited due to poor aqueous solubility. Drugs with low solubility can be better absorbed using nanostructured lipid carriers (NLCs).

Ecosystem impact and dietary exposure of polychlorinated biphenyls (PCBs) and heavy metals in Chinese mitten crabs (Eriocheir sinensis) and their farming areas in Jiangsu, China.

This study investigated the presence of 18 dioxin-like and non-dioxin-like polychlorinated biphenyls (dl- and ndl-PCBs), heavy metals (Cd, Hg, Pb, and As) in Chinese mitten crabs (Eriocheir sinensis) and their distribution in Jiangsu, China. Risk assessment and source apportionment were employed for evaluating the eco-toxicological impact and human exposure. It was found that the compositions of PCBs varied spatially, suggesting different sources of pollutants, whilst PCB 28, 105, 114, and 126 were consistently found in all sample types, suggesting a common pollution source remained, and the bio-accumulation process was in effect.

Transfer and Metabolism of Triadimefon Residues from Rape Flowers to Apicultural Products.

This paper presents a study on the transfer and metabolism of triadimefon residues from rape flowers to apicultural products. In the field trials, honeybee colonies were placed in four rape greenhouses treated with triadimefon on standard dosage. Apicultural products (pollen, honey, and royal jelly) were collected on a regular basis.

Transfer Assessment of Carbendazim Residues from Rape Flowers to Apicultural Products.

Carbendazim is usually used to control the of rapes during the flowering period. This paper presents a study on transfer assessment of carbendazim residues from rape flowers to apicultural products. In the field trials, the rapes were sprayed with carbendazim on standard dosage.

Determination of atomoxetine in human plasma by a high performance liquid chromatographic method with ultraviolet detection using liquid-liquid extraction.

A HPLC method with UV detection (210 nm) was developed and validated for the quantification of atomoxetine, a new medication for the treatment of attention deficit/hyperactivity disorder, in human plasma. Following a two-step liquid-liquid extraction with diethyl ether, the analyte and internal standard (maprotiline) were separated using an isocratic mobile phase of acetonitrile/phosphate buffer (39/61, v/v, pH 6.6) on a reverse phase Inertsil C(18) column.