Daptomycin-Loaded Nano-Drug Delivery System Based on Biomimetic Cell Membrane Coating Technology: Preparation, Characterization, and Evaluation.

Staphylococcus aureus () is a clinically significant pathogenic bacterium. Daptomycin (DAP) is a cyclic lipopeptide antibiotic used to treat infections caused by multidrug-resistant Gram-positive bacteria, including . However, DAP currently faces clinical limitations due to its short half-life, toxic side effects, and increasingly severe drug resistance issues.

STAFNet: an adaptive multi-feature learning network via spatiotemporal fusion for EEG-based emotion recognition.

Introduction: Emotion recognition using electroencephalography (EEG) is a key aspect of brain-computer interface research. Achieving precision requires effectively extracting and integrating both spatial and temporal features. However, many studies focus on a single dimension, neglecting the interplay and complementarity of multi-feature information, and the importance of fully integrating spatial and temporal dynamics to enhance performance.

A Novel Multi-Feature Fusion Network With Spatial Partitioning Strategy and Cross-Attention for Armband-Based Gesture Recognition.

Effectively integrating the time-space-frequency information of multi-modal signals from armband sensor, including surface electromyogram (sEMG) and accelerometer data, is critical for accurate gesture recognition. Existing approaches often neglect the abundant spatial relationships inherent in multi-channel sEMG signals obtained via armband sensors and face challenges in harnessing the correlations across multiple feature domains. To address this issue, we propose a novel multi-feature fusion network with spatial partitioning strategy and cross-attention (MFN-SPSCA) to improve the accuracy and robustness of gesture recognition.

Effects of Emotional Olfactory Stimuli on Modulating Angry Driving Based on an EEG Connectivity Study.

Effectively regulating anger driving has become critical in ensuring road safety. The existing research lacks a feasible exploration of anger-driving regulation. This paper delves into the effect and neural mechanisms of emotional olfactory stimuli (EOS) on regulating anger driving based on EEG.

The kidney antifibrotic effects of 5,7,3',4',5'-pentamethoxyflavone from in streptozotocin-induced diabetic rats: and experiments.

Context: The antidiabetic effects of flavonoids have been reported, but it is still unclear whether 5,7,3',4',5'-pentamethoxyflavone, isolated from Benth. (Fabaceae), also exhibits such properties.

Objective: To isolate 5,7,3',4',5'-pentamethoxyflavone from using high-speed countercurrent chromatography and examine its potential in treating diabetic nephropathy.

Melatonin regulates cancer migration and stemness and enhances the anti-tumour effect of cisplatin.

Melatonin, a lipophilic hormone released from the pineal gland, has oncostatic effects on various types of cancers. However, its cancer treatment potential needs to be improved by deciphering its corresponding mechanisms of action and optimising therapeutic strategy. In the present study, melatonin inhibited gastric cancer cell migration and soft agar colony formation.

Hapten designs based on aldicarb for the development of a colloidal gold immunochromatographic quantitative test strip.

The common carbamate insecticide aldicarb is considered one of the most acutely toxic pesticides. Herein, rational design was used to synthesize two haptens with spacers of different carbon chain lengths. The haptens were then used to immunize mice.

A Decision Tree Model for Analysis and Judgment of Lower Limb Movement Comfort Level.

To address the problem of ambiguity and one-sidedness in the evaluation of comprehensive comfort perceptions during lower limb exercise, this paper deconstructs the comfort perception into two dimensions: psychological comfort and physiological comfort. Firstly, we designed a fixed-length weightless lower limb squat exercise test to collect original psychological comfort data and physiological comfort data. The principal component analysis and physiological comfort index algorithm were used to extract the comfort index from the original data.

[Fatigue analysis of upper limb rehabilitation based on surface electromyography signal and motion capture].

At present, fatigue state monitoring of upper limb movement generally relies solely on surface electromyographic signal (sEMG) to identify and classify fatigue, resulting in unstable results and certain limitations. This paper introduces the sEMG signal recognition and motion capture technology into the fatigue state monitoring process and proposes a fatigue analysis method combining an improved EMG fatigue threshold algorithm and biomechanical analysis. In this study, the right upper limb load elbow flexion test was used to simultaneously collect the biceps brachii sEMG signal and upper limb motion capture data, and at the same time the Borg Fatigue Subjective and Self-awareness Scale were used to record the fatigue feelings of the subjects.

Discovery and biological evaluation of proteolysis targeting chimeras (PROTACs) as an EGFR degraders based on osimertinib and lenalidomide.

Epidermal growth factor receptor (EGFR) is one of the important and valuable drug targets. Overexpression of EGFR is associated with the development of many types of cancer. In this study, three PROTACs small molecules (16a-16c) were designed, synthesized and evaluated for their cytotoxicity against the growth in different NSCLC cell line and the degradation effect.