Serrodyne-Enabled Dual Electro-Optic Comb Interferometry for High-Precision Absolute Ranging and Integration-Ready Metrology.

Optical frequency combs (OFCs) have revolutionized precision metrology, enabling highly precise frequency and distance measurements. Dual electro-optic frequency comb ranging systems traditionally rely on acousto-optic modulators (AOMs) to shift the local oscillator frequency, mitigating frequency degeneracy but restricting tuning flexibility, response speed, and power efficiency. Here, an AOM-free dual electro-optic frequency comb ranging system is introduced, employing a serrodyne-modulated electro-optic modulator (EOM) for frequency shifting, achieving superior phase coherence and high-precision distance measurement.

miR-769-5p has diagnostic value in acute kidney injury in intensive care unit patients and mediates disease development by targeting SIRT6.

Background: This investigation was designed to assess the diagnostic value of miR-769-5p in acute renal injury (AKI) among intensive care unit (ICU) patients and explore its mechanism by targeting silent information regulator 6 (SIRT6).

Methods: 80 sepsis patients without AKI and 82 with sepsis-induced AKI (S-AKI) were enrolled. HK-2 cells were induced with lipopolysaccharide (LPS) to construct an in vitro cell model.

Laparoscopic cholecystectomy for duplication of the gallbladder: A case report.

Introduction: Gallbladder duplication is a rare anomaly among clinical gallbladder diseases, with an incidence of approximately 1: 4000 worldwide. Abnormal embryonic development can lead to gallbladder duplication and alterations in the morphology of these structures. Currently, laparoscopic cholecystectomy remains the preferred treatment for gallbladder duplication.

Chromosome-Level Genome Assembly and Annotation of the Amur Rat Snake Elaphe schrenckii.

The Amur rat snake (Elaphe schrenckii), a widely distributed colubrid species in Northeast Asia, plays a critical role in controlling rodent and mouse populations in the wild. Despite its ecological and evolutionary significance, genomic resources for this nonvenomous species have been limited. In this study, we present a high-quality, chromosome-level genome assembly of E.

Maintaining Grain Boundary Segregation-Induced Strengthening Effect in Extremely Fine Nanograined Metals.

Reinforcing grain boundaries through solute segregation is a promising strategy to strengthen nanograined metals. However, maintaining strengthening in extremely fine nanograined metals poses challenges due to grain size reduction and grain boundary structural changes from excessive segregation. This study employs hybrid Monte Carlo/Molecular Dynamics simulations to investigate the interplay between solute concentration, grain boundary structure, deformation mechanism, and strength in Zr-segregated nanograined Cu.

PCR array analysis reveals a novel expression profile of ferroptosis-related genes in idiopathic pulmonary fibrosis.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible, and fatal disease characterized by progressive interstitial lung fibrosis. Given its insidious onset and poor outcome, there is an urgent need to elucidate the molecular mechanisms underlying IPF and identify effective therapeutic targets and diagnosis and prognosis biomarkers. Ferroptosis is an iron-dependent form of programmed cell death that occurs as lipid peroxides accumulate.

Association between drinking patterns and diabetic kidney disease in United States adults: a cross-sectional study based on data from NHANES 1999-2016.

Objective: This cross-sectional study aimed to investigate the association between drinking patterns and prevalence of diabetic kidney disease (DKD) among adults in the United States.

Methods: Data were analyzed from the NHANES surveys conducted between 1999 and 2016, including 26,473 participants. Drinking patterns were categorized by frequency (weekly, monthly, or yearly) and quantity (light, moderate, or heavy, based on daily consumption).

Authenticating the Geographical Origin of Jingbai Pear in Northern China by Multiple Stable Isotope and Elemental Analysis.

The Jingbai pear is one of the best pear species in China with high quality and nutrition values which are closely linked to its geographical origin. With the purpose of discriminating the PGI Mentougou Jingbai pear from three other producing regions, the stable isotope ratios and elemental profiles of the pears ( = 52) and the corresponding soils and groundwater were determined using isotope ratio mass spectrometry (IRMS) and inductively coupled plasma mass spectrometry (ICP-MS), respectively. The results revealed that δN, δO, and Li were significantly different ( < 0.

A Novel Multi-Feature Fusion Network With Spatial Partitioning Strategy and Cross-Attention for Armband-Based Gesture Recognition.

Effectively integrating the time-space-frequency information of multi-modal signals from armband sensor, including surface electromyogram (sEMG) and accelerometer data, is critical for accurate gesture recognition. Existing approaches often neglect the abundant spatial relationships inherent in multi-channel sEMG signals obtained via armband sensors and face challenges in harnessing the correlations across multiple feature domains. To address this issue, we propose a novel multi-feature fusion network with spatial partitioning strategy and cross-attention (MFN-SPSCA) to improve the accuracy and robustness of gesture recognition.

Effects of Emotional Olfactory Stimuli on Modulating Angry Driving Based on an EEG Connectivity Study.

Effectively regulating anger driving has become critical in ensuring road safety. The existing research lacks a feasible exploration of anger-driving regulation. This paper delves into the effect and neural mechanisms of emotional olfactory stimuli (EOS) on regulating anger driving based on EEG.

Gaussian Particle Filtering for Nonlinear Systems With Heavy-Tailed Noises: A Progressive Transform-Based Approach.

The Gaussian particle filter (GPF) is a type of particle filter that employs the Gaussian filter approximation as the proposal distribution. However, the linearization errors are introduced during the calculation of the proposal distribution. In this article, a progressive transform-based GPF (PT-GPF) is proposed to solve this problem.

Development and testing of alginate/CNporphyrin bead as a self-initiated Fenton photocatalyst for highly efficient atrazine removal.

Fenton reaction has been widely used for efficient treatment of organic wastewater. However, its applications are limited by such key factors as pH < 3. In this study, we developed, tested, and optimized an alginate/CNporphyrin bead (CNpor-SA) as a recyclable photocatalyst in a photocatalysis-self-Fenton process to overcome these limitations.

MgH@Mg(BH) Core-Shell-like Nanostructures: Synthesis, Hydrolysis Performance, and Promotion Mechanism.

The hydrolysis of hydrides, represented by MgH, delivers substantial capacity and presents an appealing prospect for an on-site hydrogen supply. However, the sluggish hydrolysis kinetics and low hydrogen yield of MgH caused by the formation of a passivation Mg(OH) layer hinder its practical application. Herein, we present a dual strategy encompassing microstructural design and compounding, leading to the successful synthesis of a core-shell-like nanostructured MgH@Mg(BH) composite, which demonstrates excellent hydrolysis performance.

ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension.

Background: Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells plays a pivotal role in the initiation and progression of pulmonary hypertension (PH). ErbB3 (human epidermal growth factor receptor 3), also recognized as HER3, is a member of the ErbB family of receptor tyrosine kinases.

ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through 1-methyladenosine modification of circCDK17.

Pulmonary hypertension (PH) is an extremely malignant pulmonary vascular disease of unknown etiology. ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine, thereby affecting RNA expression. However, the role of ADAR1 in PH development remains unclear.

Amorphous Thickness-Dependent Strengthening-Softening Transition in Crystalline-Amorphous Nanocomposites.

Core-shell crystalline-amorphous nanocomposites, featuring nanograins surrounded by thick amorphous boundaries, are promising nanoarchitectures for achieving exceptional strength through cooperative strengthening effects. However, a comprehensive understanding of the influence of characteristic sizes, particularly the amorphous thickness, on codeformation strengthening is still lacking, limiting the attainment of the strength limit. Here, we employ molecular dynamics simulations to investigate Cu-CuTa crystalline-amorphous nanocomposites with varying grain sizes and amorphous thicknesses.

Transparent Oil-Water Separating Hydrophobic Sponge Prepared from a Pickering High Internal Phase Emulsion Stabilized by Octadecyltrichlorosilane Grafting Carbon Nanotubes.

Increasingly, oil spills and industrial discharges are wreaking havoc on the water environment; in order to efficiently separate oil and water from sewage containing oil or organic solvents, a novel porous polymer (P(EHA--BA)) was prepared by Pickering high internal phase emulsion (HIPE) template method. To obtain polyHIPE with better oil/water separation capacities, octadecyltrichlorosilane (OTS)-modified carbon nanotubes (CNTs) and surfactants were used as costabilizers for HIPE, which improved the stability of HIPE as well as the mechanical properties and the separation efficiency of polyHIPE. In the presence of 1 wt % OTS-CNT adding in the oil phase, 1%OTS-CNT polyHIPE has high porosity (92.

MiR-423-5p promotes Müller cell activation via targeting NGF signaling in diabetic retinopathy.

Aims: Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and one of the major causes of visual impairment and blindness in industrialized countries. The early neuro-glial perturbations, especially retinal Müller cells (rMC) activation, intimately associated with the vascular alterations. MicroRNAs (miRNAs) have been reported to play critical roles in the progression of DR.

Entropy-Stabilized Layered KNiFeMgTiMnO as a High-Rate and Stable Cathode for Potassium-Ion Batteries.

Mn-based layered oxides have been considered the most promising cathode candidates for cost-effective potassium-ion batteries (PIBs). Herein, equiatomic constituents of Ni, Fe, Mg, and Ti have been introduced into the transition metal layers of Mn-based layered oxide to design a high-entropy KNiFeMgTiMnO (HE-KMO, = 1.17R).

Acetylation halts missense mutant p53 aggregation and rescues tumor suppression in non-small cell lung cancers.

mutations are ubiquitous with tumorigenesis in non-small cell lung cancers (NSCLC). By analyzing the TCGA database, we reported that missense mutations are correlated with chromosomal instability and tumor mutation burden in NSCLC. The inability of wild-type nor mutant p53 expression can't predict survival in lung cancer cohorts, however, an examination of primary NSCLC tissues found that acetylated p53 did yield an association with improved survival outcomes.

MOF@Polydopamine-incorporated membrane with high permeability and mechanical property for efficient fouling-resistant and oil/water separation.

Metal organic frameworks (MOFs) have demonstrated great potential for their favorable impacts on the performance of water treatment membranes. Herein, the novel nanoparticles based on both nanoporous MOFs and organic PDA layer was exploited as a novel dopant for the fabrication of PES ultrafiltration (UF) membranes. The PDA was synthesized via oxidative self-polymerization under alkaline conditions and formed adhesive coatings on dispersed MOF.

Plasma-microbubble treatment and sustainable agriculture application of diclofenac-contaminated wastewater.

The demand for efficient wastewater treatment is becoming increasingly urgent due to the rising threat of pharmaceutical residues in water. As a sustainable advanced oxidation process, cold plasma technology is a promising approach for water treatment. However, the adoption of the technology encounters several challenges, including the low treatment efficiency and the potentially unknown environmental impact.

Deficiency of HtrA3 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via TGF-β1/Smad Signaling Pathway.

Purpose: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by excessive extracellular matrix deposition. No effective treatments are currently available for IPF. High-temperature requirement A3 (HtrA3) suppresses tumor development by antagonizing transforming growth factor β (TGF-β) signaling; however, little is known about the role of HtrA3 in IPF.

The positive regulatory loop of TCF4N/p65 promotes glioblastoma tumourigenesis and chemosensitivity.

Background: NF-κB signaling is widely linked to the pathogenesis and treatment resistance in cancers. Increasing attention has been paid to its anti-oncogenic roles, due to its key functions in cellular senescence and the senescence-associated secretory phenotype (SASP). Therefore, thoroughly understanding the function and regulation of NF-κB in cancers is necessary prior to the application of NF-κB inhibitors.