Exploring Phage Peptide Scaffolds: Tyrosinase-Mediated Cyclization for Selective Generation of Bioactive Cyclic Peptides.

Phage display is an ideal platform for selecting peptide hits and offers a diverse array of cyclic binders with high affinity. While many recently developed phage display platforms incorporate chemical strategies, the vast majority of these are detrimental to the phage life cycle due to cross-reactivity with the capsid protein. In contrast, enzyme catalysis, which combines high efficiency and biocompatibility, offers a promising approach for phage-based cyclic peptide display.

Genetic Prediction of Causal Association Between Celiac Disease and Thyroid Function: A Two-Sample Mendelian Randomized Study.

Aim: Observational studies have suggested an association between celiac disease and thyroid dysfunction, but their causal relationship has not yet been established.

Methods: Summary statistics for celiac disease were retrieved from the FinnGen Consortium, thyroid hormone and antibody data were obtained from the ThyroidOmics Consortium, and genetic variants associated with hyperthyroidism and hypothyroidism were sourced from the UK Biobank. MR statistical analyses used the inverse variance weighted algorithm, followed by various sensitivity analyses and reliability evaluations.

Metabolite Profiling of Clerodendranthus spicatus by UHPLC-Q-Orbitrap HRMS and Evaluation of Antioxidant and Tyrosinase Activation Activities.

Clerodendranthus spicatus (Thunb.) C.Y.

Clinical features and prognostic factors of salivary adenoid cystic and mucoepidermoid carcinomas.

Adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) are common malignant tumors of the salivary glands. This study aimed to compare ACC and MEC regarding clinical features and survival factors. Data from all ACC and MEC cases between 2000 and 2020 were extracted from the US National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database.

Laparoscopic cholecystectomy for duplication of the gallbladder: A case report.

Introduction: Gallbladder duplication is a rare anomaly among clinical gallbladder diseases, with an incidence of approximately 1: 4000 worldwide. Abnormal embryonic development can lead to gallbladder duplication and alterations in the morphology of these structures. Currently, laparoscopic cholecystectomy remains the preferred treatment for gallbladder duplication.

Prognostic and immune modulatory effects of ammonia-induced cell death in head and neck squamous cell carcinoma.

Background: Ammonia metabolism plays a crucial role in cancer progression and immune modulation. However, the prognostic relevance and immunological effects of ammonia-induced cell death (ACD) in HNSC remain insufficiently studied. ACD is a newly characterized form of regulated cell death caused by pathological ammonia accumulation, leading to mitochondrial dysfunction, oxidative stress, and DNA damage.

Dicyanoisophorone-based fluorescence probe for detection of Cu and its applications in living cells and mice.

Copper ion, as an essential metal element of human body, plays a critical role in the activation of numerous enzymes and are indispensable for maintaining normal physiological functions. So, it is of importance to develop an efficient analytical method for detecting Cu in biosystems. Herein, we designed and synthesized a highly sensitive and selective fluorescence probe (DBC) based on dicyanoisophorone skeleton for monitoring Cu.

Seasonality and Vertical Structure of Microbial Communities in Alpine Wetlands.

The soil microbial community plays a crucial role in the elemental cycling and energy flow within wetland ecosystems. The temporal dynamics and spatial distribution of soil microbial communities are central topics in ecology. While numerous studies have focused on wetland microbial community structures at low altitudes, microbial diversity across seasons and depths and their environmental determinants remain poorly understudied.

Efficacy and mechanisms of repeated closed-loop auditory exposure during slow-wave sleep for internet gaming disorder.

Internet Gaming Disorder (IGD) is marked by impaired psychological and social functioning but remains without effective treatments. Cue exposure therapy (CET) is typically administered during wakefulness to help extinguish addictive memories. However, recent studies suggest that sleep may be an optimal state for memory modulation.

Unveiling the enigma: understanding the complex disease course of granulomatous mastitis and seeking ways to shorten it.

Background: Granulomatous mastitis is an infrequent and intricate ailment. Limited knowledge exists regarding how granulomatous mastitis progresses and its impact on disease management. We aim to prospectively capture symptoms in the general population to accurately ascertain the duration of illness and the prevalence of long-lasting symptoms.

The Effect of Mattress Firmness on Sleep Architecture and PSG Characteristics.

Background: The influence of sleep environments on sleep quality is well-established; however, the specific role of mattress design remains underexplored. Existing studies focus primarily on ergonomic aspects, such as pressure relief and spinal support, yet lack conclusive evidence linking these features to improved sleep quality.

Objective And Methods: This study aimed to evaluate the effects of mattress firmness on sleep quality.

Unlocking the Potential of Thermal Post-Treatments: A Study on Odor Emission Control in Wood Particleboard.

wood particleboard (EPB), commonly used in indoor decoration, releases volatile organic compounds (VOCs) that can adversely affect indoor air quality and human health. This study systematically examined the VOC emission characteristics of EPB using headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography mass spectrometry (GC-MS). A total of 65 VOCs were identified, with medium-volatility organic compounds (MVOCs) accounting for 28 compounds, low-volatility organic compounds (LVOCs) for 26, and high-volatility organic compounds (HVOCs) for 11.

Association Between Estimated Glucose Disposal Rate and Stroke in Middle-Aged and Older Chinese Adults: A Nationwide Prospective Cohort Study.

Background: The estimated glucose disposal rate (eGDR) is recognized as a reliable marker of insulin resistance. However, the association between eGDR and the risk of stroke remains unclear.

Methods And Results: A total of 13 706 middle-aged and older participants were enrolled from CHARLS (China Health and Retirement Longitudinal Study).

Novel sesquiterpenoids from LP76, a predominant endophytic fungus from .

Two new sesquiterpenoids, designated as collcameins A () and B (), alongside four previously identified compounds (-), were successfully extracted from the solid-state fermentation of LP76, a predominant endophytic fungus found within its leaves of cultivated ancient tea tree. Their chemical structures were determined through various spectroscopic techniques and by comparing the results with available literature for elucidation. To clarify the stereochemical configurations of and , extra X-ray diffraction crystallography was employed, both featuring a rare presilphiperfolane-type architecture.

Managing Irinotecan-Induced Diarrhea: A Comprehensive Review of Therapeutic Interventions in Cancer Treatment.

Irinotecan (CPT-11), an inhibitor of DNA topoisomerase I, stands as a pivotal therapeutic agent in oncology. However, its use is primarily constrained by side effects such as neutropenia and the onset of delayed diarrhea. Despite the effective management of neutropenia, CPT-11-induced diarrhea (CID) is often severe, leading to hospitalization, dosage adjustments, and in some cases, treatment discontinuation, which can significantly impact therapeutic outcomes.

Composition, Antimicrobial, Anti-Inflammatory, and Potential Neuroprotective Activities of Volatile Oils in Solid Wood Boards from Different Tree Ages of .

The wood of (Japanese cedar or sugi) is widely used in building and adornment. This study aims to identify the composition of the volatile oils (VOs) extracted from solid wood boards by gas chromatography-mass spectroscopy, and to investigate their antimicrobial, anti-inflammatory, and potential neuroprotective activities. A total of 58 volatile organic compounds (VOCs) were identified in the VOs from solid wood boards with tree ages of 40, 50, and 60 years (VO-40, 50, and 60), with sandaracopimarinol (13.

Restoring turbid eutrophic shallow lakes to a clear-water state by combined biomanipulation and chemical treatment: A 4-hectare in-situ experiment in subtropical China.

While biomanipulation and chemical treatments have been applied to speed up the recovery of shallow eutrophic lakes through top-down and bottom-up effects, the efficacy of a combined approach has received less attention. We conducted a large-scale (4 ha) restoration experiment in an isolated part of Lake Yanglan, a shallow eutrophic lake in subtropical China. Here, lanthanum-modified bentonite and polyaluminium chloride were applied after fish removal, followed by transplantation of submerged macrophytes.

Antifungal Polyacetylenic Deoxyglycosides Isolated from Endophytic Fungus sp. VDL4 Associated with .

One novel C polyacetylene rhamnoside, 4,6,8-decatriyne-1--α-L-rhamnopyranoside, named xylariside A (), together with two novel C polyacetylene quinovopyranosides, 4,6,8-decatriyne-1--α-D-quinovopyranoside, xylariside B (), and 8-decaene-4,6-diyne-1--α-D-quinovopyranoside, xylariside C (), were obtained from the solid fermentation of sp. VDL4, an endophytic fungus isolated from wight (Ericaceae). Their chemical structures were elucidated through a combination of spectroscopic techniques.

[Early clinical outcomes of 3D-printed individualised customised prostheses in hip revision combined severe bone defect].

Objective: To explore the early clinical outcomes of 3D printed individualised customised prostheses for in hip revision in patients with combined severe bone defects.

Methods: Twenty-two patients from January 2021 to May 2023 underwent hip revision using 3D printed personalised customised prostheses were retrospective analyzed, including 10 males and 12 females, age 28 to 78 with a mean of (58.9±12.

Gegen Qinlian decoction remodels tumor immune microenvironment and inhibits aerobic glycolysis with the synergistic combination of CPT-11 chemotherapy in colorectal cancer therapy.

Ethnopharmacological Relevance: Although several traditional Chinese medicine formulas have demonstrated remarkable outcomes in suppressing the severe gastrointestinal toxicity induced by irinotecan (CPT-11), few studies have investigated whether enhanced anti-cancer efficacy and reduced intestinal toxicity can be achieved through co-administration. CPT-11, as a first-line drug for treating colorectal cancer, has the side effect of intestinal toxicity. Previous studies have primarily focused on using traditional Chinese medicine to alleviate diarrhea caused by CPT-11.

Unsupervised Learning-Derived Complex Metabolic Signatures Refine Cardiometabolic Risk.

Background: Cardiometabolic diseases have become a leading cause of morbidity and mortality globally. Nuclear magnetic resonance metabolomics represents a precise tool for assessing metabolic individuality.

Objectives: This study aimed to use unsupervised learning to decode plasma metabolomic profiles, providing new insights into the etiology of cardiometabolic diseases.

The impact of MTHFR and VDR polymorphisms on endometriosis susceptibility: Insights from a systematic review and meta-analysis.

The VDR and MTHFR polymorphisms have been linked to many gynecological and obstetrical diseases. However, there is still a pressing need for a systematic review and meta-analysis to synthesize the current evidence on the association between these variants and endometriosis risk. English and Chinese literature databases were systematically retrieved to find relevant research published up to August 1, 2024.

Contribution of Type 2 Diabetes Susceptible Gene GCKR Polymorphisms Rs780094 and Rs1260326 to Gestational Diabetes Mellitus: A Meta-Analysis.

Background: There is still no conclusive understanding of whether the glucokinase regulator (GCKR) gene rs780094 and rs1260326 polymorphisms predispose to gestational diabetes mellitus (GDM).

Objective: This systematic review and meta-analysis aimed to determine the effect of the GCKR polymorphisms on GDM susceptibility.

Methods: Seven literature databases were searched (from inception to February 17, 2024) to locate relevant studies included in further meta-analysis.

Genotypic diversity and biological characterization of Alphabaculovirus mabrassicae isolates from a wide host range.

Background: Baculoviruses are ideal biological insecticides, providing long-lasting pest control and environmental benefits. Alphabaculovirus mabrassicae stains, with their broad host range, have been effective in agricultural pest management. Various A.

ALDOA contributes to colorectal tumorigenesis and metastasis by targeting YAP.

Metabolic reprogramming is considered one of the hallmarks of cancer in which cancer cells reprogram some of their metabolic cascades, mostly driven by the specific chemical microenvironment in cancer tissues. The altered metabolic pathways are increasingly being considered as potential targets for cancer therapy. In this view, Aldolase A (ALDOA), a key glycolytic enzyme, has been validated as a candidate oncogene in several cancers.