Household adoption of domestic water filtration for combating waterborne diseases in developing countries.

Drinking contaminated water is a leading cause of several waterborne diseases. Domestic water filtration plants are treated as one of the possible alternative tools to combat the disease caused by contaminated drinking water. Little is known about the usage behaviour of households to use water filtration plants at the domestic level in combating waterborne disease.

Design, synthesis, and mechanism study of novel isoquinoline derivatives containing an oxime moiety as antifungal agents.

A series of novel isoquinoline derivatives 5a-5 s incorporating bioactive amide and oxime ester moieties were rationally designed and synthesized based-on isoquinoline alkaloid scaffolds through pharmacophore splicing strategy. Their structures were verified by H NMR, C NMR, IR and HRMS. The fungicidal bioassay indicated that most of the target compounds showed good to excellent inhibitory activity against five phytopathogenic fungi in vitro at a concentration of 50 mg/L.

Changes in attention deficit and adipokine levels in children with sleep-disordered breathing.

Background: Pediatric sleep-disordered breathing (SDB) may lead to attention deficits and abnormal changes in adipokine levels, potentially impacting overall health and development. This work aimed to investigate the relationship between obstructive sleep apnea (OSA) and attention-deficit hyperactivity disorder (ADHD).

Methods: A total of 111 children with OSA were included in the study and categorized into two groups based on the presence or absence of ADHD: the observation group (OG, n = 58) and the control group (CG, n = 53).

Identification of SfABCC2 as the critical receptor for Cry1Fa and Cry1Ab in Spodoptera frugiperda via CRISPR-mediated gene knockouts.

Insecticidal proteins from Bacillus thuringiensis (Bt) have been widely used to control major agricultural pests through genetically modified (GM) Bt crops. However, the development of resistance in target pests could undermine the effectiveness of Bt crops. Understanding the mechanisms of action of Bt insecticidal proteins and the resistance mechanisms in pests is crucial for developing effective resistance management strategies to sustain the use of Bt crops.

Fabrication and Performance Study of 3D-Printed Ceramic-in-Gel Polymer Electrolytes.

Solid-state electrolytes (SSEs) have emerged as a promising solution for next-generation lithium-ion batteries due to their excellent safety and high energy density. However, their practical application is still hindered by critical challenges such as their low ionic conductivity and high interfacial resistance at room temperature. The innovative application of 3D printing in the field of electrochemistry, particularly in solid-state electrolytes, endows energy storage devices with attractive characteristics.

LARS2 DNA methylation predicts the prognosis in colon cancer.

Colon cancer is a highly aggressive solid tumor. Because most studies have focused on the intrinsic oncogenic pathways of tumors, we focused on the relationship between DNA methylation genes in the tumor immune microenvironment and colon cancer prognosis. We download RNA-seq data from the TCGA dataset.

The Succession of Cervical Canal Microbiota in Endometrial Cancer and Cervical Cancer: A Clinical Metagenomics Study.

Objective: To define stage-specific cervical canal microbiota signatures across the continuum of gynecologic malignancies from benign endometrial cancer (BE)/cervical cancer precancerous lesions (CIN) to endometrial cancer (EC)/cervical cancers (CC), and to evaluate their potential as diagnostic biomarkers and therapeutic targets.

Methods: In the observational study, metagenomic sequencing was employed to investigate the cervical canal microbiota of 45 patients, including BE, EC, CIN, and CC. Specimen collection was performed by an experienced physician.

A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy.

Photodynamic immunotherapy is a promising strategy for cancer treatment. However, the dysfunctional tumor vasculature results in tumor hypoxia and the low efficiency of drug delivery, which in turn restricts the anticancer effect of photodynamic immunotherapy. In this study, we designed photosensitive lipid nanoparticles.

miRNA-548d-3p represses non-small cell lung cancer growth by perturbing DDX5-mediated pyroptosis through JAK2/STAT3 signaling.

Background: The function of microRNAs (miRNAs) in tumor development has been extensively characterized. Pyroptosis is a kind of programmed death, which can effectively hinder cancer development. However, there is still a large gap in the function of miRNAs in NSCLC pyroptosis.

Ligand substitution in organic-inorganic hybrid zinc iodides for second-harmonic generation.

Noncentrosymmetric metal halides are promising nonlinear optical (NLO) materials that have prospective applications in optical switching technologies. However, obtaining zinc halides with a large second harmonic generation (SHG) effect is of great challenge due to their ideal tetrahedral configurations. In this study, four organic-inorganic hybrid zinc iodides, namely, (HIm)[ZnI]·HO (1), (HIm)[ZnI(Im)] (2), ZnI(Im) (3), and [ZnI(Im)]I (4) where Im = imidazole, have been synthesized by a ligand substitution approach.

Dynamic changes of dental plaque and saliva microbiota in OSCC progression.

Objectives: To elucidate the changes in microbial composition and genomics in saliva and dental plaque during the progression of Oral Squamous Cell Carcinoma (OSCC), and to identify virulence factors and pathways associated with tumor differentiation in OSCC patients.

Materials And Methods: Using metagenomic sequencing, 64 saliva and dental plaque samples from OSCC patients at different stages of differentiation were examined.

Results: The results showed notable differences in the microbial composition and genomic profiles across ecological regions and differentiation degrees.

Preparation and Performance of PVDF-HFP/PAN-Based Gel Polymer Electrolytes.

Solid-state electrolytes are widely expected to enhance the performance of lithium-ion batteries, providing higher energy density and improved safety. However, challenges still need to be solved in their practical application due to low ionic conductivity and high interfacial resistance at room temperature. In this study, we successfully developed a high-performance gel polymer electrolyte (GPEs) by blending poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP) and polyacrylonitrile (PAN) through UV curing, cross-linking with ethoxylated trimethylolpropane triacrylate (ETPTA), and incorporating LiLaZrTaO (LLZTO).

A generalizable approach for programming protease-responsive conformationally inhibited artificial transcriptional factors.

Synthetic genetic circuits that harness programmable protein modules and artificial transcription factors (ATF) to devise event-triggerable cascaded pathways represent an essential class of tools for studying cell biology. Fine-tuning the general structural functionality of ATFs is important for constructing orthogonal and composable transcriptional regulators. Here, we report the design of a protease-responsive conformationally inhibited system (PRCIS).

Trilocked Photodynamic Senolytic Inducer Potentiating Immunogenic Senescent Cell Removal for Liver Fibrosis Resolution.

Liver fibrosis is a major global health problem without effective therapies, and targeted elimination of senescent cells is beneficial for hepatic function and organism survival. We report a new trilocked photodynamic senolytic inducer (PDSI) strategy for liver fibrosis resolution using a type-I photodynamic agent for immunogenic clearance of senescent cells. We demonstrate that this trilocked PDSI not only facilitates efficient production of superoxide anions (O) in lysosomes of senescent cells for photodynamic therapy, but also permits NIR fluorescence and photoacoustic (NIRF/PA) imaging of senescent cells.

Electrocatalytic CO Reduction to Alcohols: Progress and Perspectives.

Utilizing renewable electricity for the electrocatalytic conversion of CO into alcohols represents a promising avenue for generating value-added fuels and achieving carbon neutrality. Recently, there has been growing scientific interest in achieving high-efficiency conversion of CO to alcohols, with significant advancements made in mechanism understanding, reactor design, catalyst development, and more. Herein, a thorough examination of the latest advances in electrocatalytic CO reduction reaction (CORR) to alcohols is provided.

Can behavioural nudges promote reduced-salt dish orders on meal delivery apps?

Objectives: This study aimed to evaluate the effectiveness of educational health message and menu default options on a Meal Delivery App (MDA) in nudging consumers towards reduced-salt options in restaurants of China.

Study Design: We conducted a nudge-based intervention trial on an MDA named ELEME in China.

Methods: Along with a control group, five intervention groups were formed utilizing different combinations of the three nudging treatments, including setting up a salt submenu for "reduced salt" default, a salt submenu for "regular salt" default, and a conventional educational health message on the ordering page.

CMAB: A Multi-Attribute Building Dataset of China.

Rapidly acquiring three-dimensional (3D) building data, including geometric attributes like rooftop, height and orientations, as well as indicative attributes like function, quality, and age, is essential for accurate urban analysis, simulations, and policy updates. Current building datasets suffer from incomplete coverage of building multi-attributes. This paper presents the first national-scale Multi-Attribute Building dataset (CMAB) with artificial intelligence, covering 3,667 spatial cities, 31 million buildings, and 23.

SRSF9 mediates oncogenic RNA splicing of SLC37A4 via liquid-liquid phase separation to promote oral cancer progression.

Introduction: Oral cancer represents a significant proportion of head and neck malignancies, accounting for approximately 3 % of all malignant tumors worldwide.

Objectives: Alternative splicing (AS), a post-transcriptional regulatory mechanism, is increasingly linked to cancer development. The precise impact of AS on oral cancer progression is not well understood.

Beyond self-reports: serum cotinine reveals sex-and age-related differences of smoking on all-cause and disease-specific mortality.

Background: It is well-known that sex and age play critical roles in smoking-related diseases and mortality. However, quantification of the extent of smoking requires self-reports in these studies, which may yield only partially accurate results. This study investigated sex-and age-related differences in the association between smoking and all-cause, cardiovascular disease, and cancer mortality by measuring serum cotinine levels.

Measurement of urban vitality with time-lapsed street-view images and object-detection for scalable assessment of pedestrian-sidewalk dynamics.

Principles of dense, mixed-use environments and pedestrianisation are influential in urban planning practice worldwide. A key outcome espoused by these principles is generating "urban vitality", the continuous use of street sidewalk infrastructure throughout the day, to promote safety, economic viability and attractiveness of city neighbourhoods. Vitality is hypothesised to arise from a nearby mixture of primary uses, short blocks, density of buildings and population and a diversity in the age and condition of surrounding buildings.

Light-Driven Low-Temperature and Near-Unity Conversion of Ester on a Perovskite Derivative Photothermal Catalyst via Photon-Bismuth Triggered Hotspot.

Solar-driven photothermal chemical transformations are regarded as green processes to reduce energy consumption and are expected to utilize unique light-induced activation mechanisms to improve reaction kinetics. Halide perovskites and their derivatives, due to unique optoelectronic properties and compositional flexibility, are allowed for the precise regulation of energy band structures and surface electronic states, showing potentials as photoactivated catalysts with photo-thermal synergistic effects. However, the photothermal catalytic performance of halide perovskites is still unsatisfied with low conversion (<0.

Characteristics of the smallest brucellaphage with strong lytic ability.

Brucellosis is a globally prevalent zoonotic disease caused by spp. posing significant threats to animal and human health. In this study, a novel lytic brucellaphage designated Y17 was isolated from sheep fecal samples collected in Ludian County, Yunnan Province, China.

Functionalized Multichannel Fluorescence-Encoded Nanosystem on Erythrocyte-Coated Nanoparticles for Precise Cancer Subtype Discrimination.

Rapid and precise cancer subtype discrimination is essential for personalized oncology. Conventional diagnostic methods often lack sufficient accuracy and speed. Here, we introduce a multichannel fluorescence-encoded nanosystem based on erythrocyte-coated polydopamine nanoparticles (PDA@EM), functionalized with multiple resurfaced fluorescent proteins.