Van der Waals Magnetic Tunnel Junctions Based on Two-Dimensional 1T-VSe and Rotationally Aligned h-BN Monolayer.

Magnetic tunnel junctions (MTJs) are pivotal for spintronic applications such as magneto resistive memory and sensors. Two-dimensional van der Waals heterostructures offer a promising platform for miniaturizing MTJs while enabling the twist-angle engineering of their properties. Here, we investigate the impact of twisting the insulating barrier layer on the performance of a van der Waals MTJ with the structure graphene/1T-VSe/h-BN/1T-VSe/graphene, where 1T-VSe serves as the ferromagnetic electrodes and the monolayer h-BN acts as the tunnel barrier.

Specific Pathogen Free Ten Gene-Edited Donor Pigs for Xenotransplantation.

Xenotransplantation has entered the clinical phase in an effort to address the global organ shortage. However, recent clinical studies have revealed that current xenografts from gene-edited (GE) pigs still pose risk of immune rejection and biosafety concerns. In this study, we successfully produced a large batch of 582 GE cloned donor (GEC) pigs with 10-(GTKO/CMAHKO/β4GalNT2KO/hCD46/hCD55/ hCD59/hTBM/ hEPCR/hCD39/hCD47) gene edits via gene editing and somatic cell cloning technologies, and successfully obtained the F1 generation.

Synergizing Ferroptosis Suppressor Protein 1 Gene Silencing and Photodynamic Therapy Based on Photosensitive Lipid Nanoparticles for Colon Cancer Immunotherapy.

Metastasis and immune escape play crucial roles in the progression of colon cancer. Current chemotherapy and immunotherapy treatments have limited effectiveness in reversing the immunologically cold microenvironment. Therefore, it is essential to investigate efficient strategies to enhance the antitumor immunity.

Targeted therapy in acute myeloid leukemia: Resistance and overcoming strategy.

Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by uncontrolled proliferation of immature myeloid blasts, leading to hematopoietic suppression and bone marrow failure. Advances in understanding the pathogenesis of AML have fueled the development of precision medicine approaches, with notable successes in targeting specific mutant proteins (e.g.

Multi-Omics Analysis Provides New Insights into the Interplay Between Gut Microbiota, Fatty Acid Metabolism, and Immune Response in Cultured and Wild from the Yangtze River Area in China.

To elucidate the interactions among fatty acid metabolism, immune status, and gut microbiota, both cultured and wild from the Yangtze River were examined in China. The results demonstrated that wild exhibited markedly higher lipid and docosahexaenoic acid (DHA) contents, a greater ratio of total ω-3 PUFAs to total ω-6 PUFAs, and more active antioxidant enzymes compared to cultured . However, the shear force, water-holding capacity, and total n-6 PUFA content were lower in wild .

Heat stress targets and degrades BCR::ABL1 oncoproteins to overcome drug-resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia.

BCR::ABL1 oncofusion protein drives Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL), making it a critical therapeutic target. Tyrosine kinase inhibitors (TKIs) targeting BCR::ABL1 have revolutionized the treatment of Ph+ ALL patients. However, mutations in the kinase domain of BCR::ABL1 commonly impair the sensitivity to TKIs, resulting in drug resistance and poor prognosis in Ph+ ALL.

Nuclear receptors in metabolism and diseases: Mechanistic and therapeutic insights.

Nuclear receptors (NRs) are ligand-activated transcription factors that function as metabolic sensors, integrating endogenous and xenobiotic signals to regulate gene networks controlling metabolism, immunity, and cellular homeostasis. Recent studies elucidated the pivotal roles of NRs (e.g.

Enhancement of 3-MA in Paclitaxel Treatment of MDA-MB-231 Tumor-Bearing Nude Mice and Its Mechanisms.

Triple-negative breast cancer (TNBC) poses significant challenges due to its high aggressiveness, poor prognosis, and the lack of effective targeted therapies. Paclitaxel (PTX) is a chemotherapeutic agent commonly used in the treatment of TNBC; however, its efficacy is often compromised by drug resistance mediated by autophagy. This study investigated the synergistic effects of the autophagy inhibitor 3-methyladenine (3-MA) and PTX in a TNBC nude mouse model.

Arsenic trioxide could promote SARS-CoV-2 NSP12 protein degradation.

The global dissemination and infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become a worldwide crisis with staggering confirmed cases and death tolls. Although prophylactic vaccines are widely applied to curb the spread of the virus, these protections are greatly weakened by the emergence of SARS-CoV-2 variants. Non-structural protein 12 (NSP12) of SARS-CoV-2 is an RNA-dependent RNA polymerase that plays an essential role in viral replication and transcription, representing a promising target for drug development.

Evidence summary for the management of sleep disorders after malignant tumor surgery.

Introduction: This study aimed to extract, evaluate, and summarize the evidence related to the management of sleep disorders after malignant tumor surgery, providing a reference for evidence-based clinical practice.

Methods: A systematic and hierarchical search strategy was used to identify relevant evidence from authoritative databases and resources. Following the "6S" evidence pyramid model, we conducted a comprehensive review of the following databases: BMJ Best Practice, CINAHL, Cochrane Library, Clinical Trials, Embase, PubMed, UpToDate, Web of Science, Guidelines International Network, National Guideline Clearinghouse, and the National Guidelines Database.

Hydrochemical Characteristics, Controlling Factors, and High Nitrate Hazards of Shallow Groundwater in an Urban Area of Southwestern China.

Groundwater nitrate (NO) contamination has emerged as a critical global environmental issue, posing serious human health risks. This study systematically investigated the hydrochemical processes, sources of NO pollution, the impact of land use on NO pollution, and drinking water safety in an urban area of southwestern China. Thirty-one groundwater samples were collected and analyzed for major hydrochemical parameters and dual isotopic composition of NO (δN-NO and δO-NO).

A New Comprehensive Platform for Profile-Mode-Based Untargeted Metabolomics for Efficient Data Mining to Improve Compound Extraction and Identification.

The profile mode of ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) is commonly utilized in metabolomics for its ability to comprehensively retain compound information in mass spectra. However, current data-analysis methods have not been optimized for the entire profile-mode-based untargeted metabolomics. To address this issue, we developed a set of novel algorithms, including centroiding transformation, extracted ion chromatogram construction, and feature extraction.

Celastrol Induces Ferroptosis by Regulating CERKL to Exert Anti-Gastric Cancer Effect.

Gastric cancer is a significant global health issue. Celastrol, a natural compound, has shown antitumor potential, but its molecular mechanism in gastric cancer remains unclear. In this study, we treated HGC-27 cells with celastrol and employed CCK8, colony formation, and Transwell assays, revealing its inhibitory effect on cell proliferation and migration.

Flavokawain B ameliorates depressive-like behaviors by inhibiting neddylation in the ventral hippocampus.

Depression is a widespread and serious mental illness. Recent evidence suggests that post-translational modifications, particularly neddylation, play a significant role in the pathophysiology of mood disorders. Neddylation, similar to ubiquitination, involves the attachment of NEDD8 to target proteins, regulating their function.

Exploring Dynamics in Post-stroke Motor Rehabilitation: A Systematic Review of Implementation Barriers and Facilitators using the COM-B Model.

PurposeThis systematic review aimed to identify barriers and facilitators in post-stroke motor rehabilitation across patient, caregiver, and healthcare professional levels, employing the capability, opportunity, motivation, behavior (COM-B) model and the theoretical domains framework (TDF).Materials and MethodsA systematic search of PubMed, EMBASE, Cochrane Library, Web of Science, and CINAHL, following PRISMA guidelines, covered literature until January 20, 2025. Studies reporting qualitative, quantitative, or mixed-methods data on post-stroke motor rehabilitation barriers and facilitators were included.

Global, regional, and national burden of ischemic heart disease attributable to metabolic risks: a systematic analysis of Global Burden of Disease 2021.

Background: Ischemic heart disease (IHD) represents the most significant disease burden among all cardiovascular diseases (CVDs). The increasing prevalence of metabolic risks in the 21 century has a profound impact on the disease burden associated with IHD. We analyzed the global, regional, and national burdens of IHD attributable to metabolic risks from 1990 to 2021.

Jasmonate pathway regulates sphingolipid desaturation during cold stress.

In response to chilling, plants undergo a variety of metabolic changes, including structural modifications of sphingolipids, which have an important but poorly understood effect on cold tolerance. Here, we used biochemical, molecular, cell biological, and genetic approaches to investigate the mechanism of cold-induced sphingolipid regulation. Chilling stress affected sphingolipid metabolism in Arabidopsis thaliana, resulting in increased long-chain base (LCB) unsaturation by promoting the expression of the sphingoid LCB ∆8 desaturase gene SLD1.

Mutation in the Unrearranged Allele Confers Resistance to Arsenic Trioxide in Acute Promyelocytic Leukemia.

Arsenic trioxide (ATO) is able to selectively target and degrade the disease-causing PML::RARα (P/R) oncoprotein in acute promyelocytic leukemia (APL) for curing the disease. However, some relapsed patients develop resistance to ATO due to mutations in the promyelocytic leukemia (PML) part of the fusion gene. A relapsed APL patient had shown resistance to ATO and chemotherapy and was identified to harbor a point mutation (A216V) in the unrearranged allele rather than the fusion gene.

Risk factors for postoperative hypothermia in non-cardiac surgery patients: a systematic review and meta-analysis.

Background: Postoperative hypothermia seems to be a common problem in surgical patients but is easily ignored. This study aimed to identify risk factors for postoperative hypothermia in non-cardiac surgery patients.

Methods: We searched databases including PubMed, Embase, Web of Science, Cochrane Library, CINAHL, VIP, Wan Fang, CNKI, and CBM from inception to April 2025.

Association between lean body mass and osteoarthritis: a cross-sectional study from the NHANES 2007-2018.

The prevention of osteoarthritis through controlling body measurements has received increasing attention in recent years, but the relationship between lean body mass (LBM) and osteoarthritis remains unclear. Hence, we explored this association through the data from the National Health and Nutrition Examination Survey (2007-2018). The present study enrolled 31,172 participants.

Mitigating gastrointestinal side effects of risedronate sodium: A study on Bletilla striata polysaccharide microneedle patches.

Risedronate sodium (RIS) is a primary treatment for postmenopausal osteoporosis, but oral administration requires patients to remain upright to prevent side effects like esophagitis, gastritis, and ulcers, which can be difficult for those with fatigue or bone pain. This study developed RIS-loaded Bletilla striata polysaccharide microneedles (RIS-BMNs) with sufficient mechanical strength for effective skin penetration and drug delivery. Franz diffusion cell experiments showed that RIS-BMNs achieved 3 times higher in vitro transdermal absorption than the RIS solution and 2.

Correlation of Parkinson's disease severity and F-FDG and F-FP-DTBZ PET.

Background: Positron emission tomography (PET) using the tracer F-fluorodeoxyglucose (F-FDG) and [F] 9-fluoropropyl-(+)-dihydrotetrabenazine (F-FP-DTBZ) is widely utilized to measure metabolic activity and dopaminergic integrity in neurodegenerative diseases such as Parkinson's disease (PD). Previous studies employing F-FDG PET have primarily focused on motor or non-motor symptoms, rather than the severity of PD. This study aimed to measure the glucose metabolism of F-FDG and the dopaminergic function of F-FP-DTBZ across various Hoehn-Yahr (H&Y) stages, analyzing the correlation between metabolic activity, dopaminergic function, and H&Y stages to monitor the severity of PD.

Conditional Binding of Arsenic Trioxide (ATO) to Cysteine-Rich Zinc Finger Motifs within RBCC Domain of PML Protein.

The arsenic trioxide (ATO)-based cure of acute promyelocytic leukemia is attributed to PML/RARα oncoprotein degradation through binding of its RBCC domain (i.e., consist of RING, B-box1, B-box2, and Coiled-coil) with arsenic.

Pacific sub-decadal sea surface temperature variations contributed to recent Aantarctic Sea ice decline trend.

Total sea ice extent (SIE) across the Southern Ocean increased from 1979-2014, but declined rapidly after 2016. Significant sea ice decline has emerged since the peak of SIE in 2014, coincident with Pacific sub-decadal sea surface temperature (SST) trends resembling a strong La Niña-like cold condition and the negative phase of the interdecadal Pacific oscillation (IPO). Previous studies suggest that the warm subsurface Southern Ocean was an important driver of the low sea ice in spring 2016 and the sustained low sea ice state since.