Graph-oriented Instruction Tuning of Large Language Models for Generic Graph Mining.

Graphs with abundant attributes are essential in modeling interconnected entities and enhancing predictions across various real-world applications. Traditional Graph Neural Networks (GNNs) often require re-training for different graph tasks and datasets. Although the emergence of Large Language Models (LLMs) has introduced new paradigms in natural language processing, their potential for generic graph mining-training a single model to simultaneously handle diverse tasks and datasets-remains under-explored.

Cellular senescence in kidney diseases.

Cellular senescence, stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stressors, has been highlighted as one of the most important mechanisms involved in kidney diseases. It not only serves as a fundamental biological process promoting normal organogenesis and successful wound repair but also contributes to organ dysfunction, tissue fibrosis, and the generalized aging phenotype. Moreover, senescent cells exhibit reduced regenerative capacity, which impairs renal function recovery from injuries.

Dihydroartemisinin Suppresses LOXL2-Mediated Glycerophospholipid Metabolic Reprogramming to Induce Cuproptosis in Colorectal Cancer Cells.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, second only to lung cancer. Dihydroartemisinin (DHA), a derivative of traditional Chinese medicine, has demonstrated anticancer properties; however, its role in modulating cuproptosis remains unclear. Lysyl oxidase-like 2 (LOXL2), a copper-dependent amine oxidase, has been implicated in cuproptosis regulation, though its mechanistic involvement requires further elucidation.

Iridium-Catalyzed Regio- and Enantioselective C7-Allylic Alkylation of 4-Aminoindoles.

The first iridium-catalyzed direct intermolecular indole C7-allylic alkylation of 4-aminoindoles and racemic branched allylic esters was reported. Various substituted substrates were applicable to give the corresponding C7-allylated products in moderate to high yields (43-80%) with high regio- and enantioselectivities (82-99% ee) under mild reaction conditions. Representative transformations of the vinyl group in the product were carried out to examine the utility of this protocol.

Relationship between first pass effect NLR and PLR in mechanical thrombectomy for acute anterior circulation large-vessel occlusion.

Purpose: The study investigated the correlation between the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) concerning the first-pass effect (FPE) observed during mechanical thrombectomy subsequent to acute ischemic stroke (AIS).

Methods: Patients diagnosed with AIS in the anterior circulation, who underwent mechanical thrombectomy between January 2020 and December 2022, were assessed. Various data were collected, including blood cell counts, general information, relevant surgical and clinical details, and functional outcomes determined by the Modified Rankin Scale (MRS) score ≤2 at 3 months.

Preferential Flow Drives Coupled Nitrogen Migration and Transformation in the Vadose Zone: Microbial Hotspots and Functional Gene Dynamics.

Preferential flow (Pf) in agricultural vadose zones poses environmental risks by accelerating transport of contaminants to groundwater while simultaneously functioning as biogeochemical hotspots. However, current research often simplifies vadose zone processes, overlooking the intricate coupling among pore structure, hydrological flow, and microbial communities in shaping nitrogen cycling. Field investigations in Northeast China identified significant differences between Pf zones and the soil matrix zones in terms of physical-chemical properties and molecular biological characteristics: Pf zones exhibited 26.

Angular distributions of single-photon and above-threshold detachment of sulfur hexafluoride anions in femtosecond laser fields.

We experimentally investigate the photodetachment of sulfur hexafluoride anions (SF6-) in 400 nm 35 fs laser fields using a home-built mass-selective anion source combined with electron velocity map imaging (VMI). The electron kinetic energy and the photoelectron angular distributions (PADs) are obtained from the VMI measurements. In addition to the single-photon detachment, two-photon above-threshold detachment (ATD), which is induced by strong laser fields with peak intensity higher than >1.

Revolutionizing Satellite Real-Time Air Pollution Alerts through New On-Orbit System-on-Chip Technology.

Exposure to abnormally high concentrations of particulate matter and ozone can cause severe harm to human health, highlighting the need for real-time satellite monitoring to enable rapid responses and timely warnings. However, the existing methods for on-orbit diagnostics under resource constraints are limited. This study presents SoC-POM (System-on-Chip for Particulate Matter and Ozone Monitoring), a real-time, on-orbit artificial intelligence algorithm embedded in satellites and designed to detect anomalous concentrations of PM, PM, and O.

A New Comprehensive Platform for Profile-Mode-Based Untargeted Metabolomics for Efficient Data Mining to Improve Compound Extraction and Identification.

The profile mode of ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) is commonly utilized in metabolomics for its ability to comprehensively retain compound information in mass spectra. However, current data-analysis methods have not been optimized for the entire profile-mode-based untargeted metabolomics. To address this issue, we developed a set of novel algorithms, including centroiding transformation, extracted ion chromatogram construction, and feature extraction.

Global bone cancer incidence and death rate analysis at 40 years.

Background: Bone cancer exhibits significant global disparities in incidence and mortality. Understanding these trends is essential for identifying high-risk populations and informing targeted interventions.

Methods: Using data from the Global Burden of Disease Study 2021 (GBD 2021) and the Cancer Incidence in Five Continents (CI5) database, this study analyzed bone cancer incidence (1993-2017) and mortality (1980-2021) trends.

Anti-TNFR2 antibody and HMGN1 combined with TIL cell therapy inhibits colorectal cancer progression by enhancing immune response.

Background: Immunotherapy utilizing tumor-infiltrating lymphocytes (TILs) has demonstrated exceptional effectiveness in the treatment of diverse solid tumors. However, existing procedures typically involve lymphodepleting chemotherapy using cyclophosphamide and high-dose IL-2 to support the proliferation and activity of reintroduced TILs, despite the common occurrence of systemic toxicity.

Methods: A CT26 colorectal cancer mouse model was established in this research.

Enhancing Semantic and Structure Modeling of Diseases for Diagnosis Prediction.

Electronic Health Records (EHRs) are valuable healthcare data, aiding researchers and doctors in improving diagnosis accuracy. Researchers have developed several predictive models by learning disease representations to forecast the potential diagnosis that patients may receive. However, existing studies usually ignore the fine-grained semantic and structure information in EHRs (e.

Miltirone enhances the chemosensitivity of gastric cancer cells to cisplatin by suppressing the PI3K/AKT signaling pathway.

Background: Gastric cancer (GC) is one of the most common malignant tumors with poor survival. Although cisplatin is a first-line chemotherapy drug for GC, it still has the potential to develop drug resistance and side effects. Miltirone, extracted from Chinese herb Salvia miltiorrhiza Bunge, has been reported to significantly inhibit some types of cancer.

Overestimated Myocardial Ischemia.

We introduced a case of a 69-year-old female patient with mitral valve prolapse with severe regurgitation who was transferred from the ICU to a regular ward after undergoing mitral valve replacement surgery. Routine ECG examination showed that the precordial leads were affected by the apical pulsation, leading to pseudo-ST segment depression and prolonged QT interval. In clinical practice, ECG artifacts caused by apical pulsation, if not carefully distinguished, may lead to unnecessary examinations and treatments for patients.

Intratumoral injection of R848 and poly(I:C) synergistically promoted antitumor immune responses by reprogramming macrophage polarization and activating DCs in lung cancer.

Introduction: Immunotherapy has rapidly become a primary treatment option for many lung cancer patients because of its success in treating this prevalent and deadly disease. However, the success of immunotherapy relies on overcoming the immunosuppressive tumor microenvironment, making remodeling this environment a potential strategy for lung cancer therapy. Research suggests that Toll-like receptor (TLR) agonists can impede tumor growth by promoting the conversion of tumor-associated macrophages into an M1-like state or enhancing dendritic cell development.

Tanshinone IIA Reverses Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells Impaired by Glucocorticoids via the ERK1/2-CREB Signaling Pathway.

Glucocorticoids-induced osteoporosis poses a critical health issue due to its detrimental impact on bone marrow mesenchymal stem cells (BMSCs); Tanshinone IIA (TSA) emerges as a promising therapeutic intervention, demonstrating its capacity to reverse osteogenic differentiation impairment. The aim is to determine whether TSA enhances the osteogenic differentiation of BMSCs damaged by dexamethasone (DEX) through the ERK1/2 -CREB signaling pathway. BMSCs were treated with varying concentrations of DEX (0.

Phenolics and Phenolic Glycosides from and Their Hepatoprotective Activities.

Thirty compounds including 13 new phenolic glycosides (-, -) and 17 known aromatic compounds and aromatic glycosides (-, -) were isolated from the roots of . The structures of the new phenolic glycosides were established by extensive NMR spectroscopic data analysis as well as chemical derivatization method. The isolated compounds were evaluated for their hepatoprotective activities using cell model of acetaminophen (APAP)-induced HepG2 cells.

Triangesinenolides A-C: Trimeric Phthalides with Anti-Renal Fibrosis Potential from .

Trimeric phthalides in nature are rarely reported. This research successfully isolated three novel trimeric phthalides, triangesinenolides A-C (-), from . These compounds, derived from -ligustilide via diverse linkage patterns, display intricate polycyclic skeletons.

Confronting the anxiety of Generation Z: electroacupuncture therapy regulates oxidative stress and microglia activity in amygdala-basolateral of socially isolated mice.

Introduction: Anxiety disorders are prevalent mental health conditions characterized by significant impairments in daily functioning and social interactions. Despite the effectiveness of pharmacological treatments, challenges such as medication resistance, adverse side effects, and the high rate of relapse necessitate the exploration of alternative therapies. Recently, electroacupuncture (EA) has garnered attention as a promising non-pharmacological intervention for anxiety disorders; however, the mechanisms by which EA exerts its anxiolytic effects remain poorly understood.

G-protein coupled receptor GPR124 protects against podocyte senescence and injury in diabetic kidney disease.

Although emerging studies highlight the pivotal role of podocyte senescence in the pathogenesis of diabetic kidney disease (DKD) and aging-related kidney diseases, therapeutic strategies for preventing podocyte senescence are still lacking. Here, we identified a previously unrecognized role of GPR124, a novel adhesion G protein-coupled receptor, in maintaining podocyte structure and function by regulation of cellular senescence in DKD. Podocyte GPR124 was significantly reduced in db/db diabetic (a type 2 diabetic mouse model) and streptozocin-induced diabetic mice (a type 1 diabetic model), which was further confirmed in kidney biopsies from patients with DKD.

(T6) Peptaibols Inhibiting the Growth and Inducing Pear Fruit Resistance in Its Infection.

Pear fruit brown rot, caused by , affects pear fruit yields and quality. The present study determined T6 (T6) peptaibols as a biological control alternative to synthetic fungicides and assessed its efficacy against through dual plate culture and surface spraying at different concentrations. T6 peptaibols effectively inhibited growth, achieving an 85.

Ansofaxine suppressed NSCLC progression by increasing sensitization to combination immunotherapy.

Introduction: Depression negatively impacts the prognosis of various cancers, including lung cancer, by influencing antitumor immune responses and impairing immune cell function. Antidepressants may modulate the tumor immune microenvironment, enhancing immunotherapy efficacy. However, the specific mechanisms remain unclear.

Research on the Biogas Production Mechanism of Mudstone in the Qaidam Basin under Different CO Pressures.

Mudstone, a class of sedimentary rocks rich in organic matter, possesses considerable potential for biogas production. Mudstones possess a rich biological origin, which is conducive to refining the mechanisms and enrichment patterns of biogenic gas reservoirs. This has significant theoretical and practical implications for guiding the exploration and development of Quaternary mudstone gas reservoirs.