Baichuan Baile Formula, a Promising Herbal Dietary Supplement, Exerts Antidepressant-Like Effects by Modulating the Serotoninergic System in Mouse Models.

Baichuan Baile (BCBL) is a novel formula that incorporates three herbs and a single food additive, all of which are widely used in ordinary or functional foods. It is a promising dietary supplement for the treatment of depression based on TCM principles and nutritional assessments. Our study was designed to explore BCBL's antidepressant-like effects and elucidate its underlying mechanisms.

Dual-Layer Flexible Liquid Metal Fiber for Plantar Pressure Monitoring and Synchronous Wound Electrotherapy.

Plantar wounds, particularly diabetic foot ulcers (DFUs), impose significant burdens on patients' quality of life and healthcare systems. Personalized wound management demands real-time monitoring of biomechanical parameters and effective therapeutic interventions to prevent exacerbations. Here, a dual-layer flexible liquid metal fiber (LMF) capable of simultaneous plantar pressure sensing and electrical stimulation for accelerated wound healing is presented.

A Seven-Gene Signature for the Diagnosis of Parkinson's Disease and Immune Infiltration Analysis.

The objective was to identify the predictive markers and develop a diagnostic model with predictive markers for Parkinson's disease (PD) and investigate the roles of immune cells in the disease pathology. Microarray datasets of PD and control samples were obtained from the Gene Expression Omnibus (GEO) database. We then performed a comprehensive analysis of differentially expressed genes (DEGs), functional enrichment, and protein-protein interactions to pinpoint a set of promising candidate genes.

Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating.

The mucosal barrier consisting of physicochemical, immune, and microbial components is the first line of defense against external stimuli. Breakdown of the mucosal barrier causes the occurrences of various diseases, while methods capable of multifacetedly restoring mucosal barrier functions have been rarely reported. Here, we describe the restoration of the physicochemical, immune, and microbial homeostasis of the mucosal barrier by in situ formation of a living-synthetic therapeutic coating (LSTC).

Possible transformation between half-metallic and metallic states of multiferroic MnGaSSe monolayers.

Multiferroic (MF) materials, exhibiting magnetic-electronic coupling properties, hold transformative potential for application in low-power spintronic devices. In this work, we investigate the structural, electronic and magnetic properties of a multiferroic MnGaSSe monolayer using first-principles calculations. Our results show that the -phase MnGaSSe (-MnGaSSe) monolayer exhibits a ferromagnetic (FM) semimetallic character with long-range magnetic order, while the -phase MnGaSSe (-MnGaSSe) monolayer adopts an FM metallic ground state.

Functional characterization of trehalases 1, 2, and 4 in Nosema bombycis (microsporidia).

Pebrine caused by Nosema bombycis infection is one of the most threatening diseases that affect sericulture. Trehalases play important roles in the lives of organisms, such as spore germination, insect flight, and stress resistance. The genome of N.

An evaluation of macrosomia risk factors in a cohort of Chinese women and neonates.

ObjectiveWe aimed to identify risk factors for macrosomia in women with high-risk pregnancies, which will allow for early identification and timely intervention and improve the health of mothers and infants.MethodsA retrospective case-control study was conducted of pregnant women and neonates born at Shenmu Hospital in China between 1 January 2020 and 31 December 2023. Cases comprised neonates with macrosomia (birth weight ≥4000 g), and controls comprised a group of normal-weight neonates (birth weight 2500-3999 g).

One-Year Outcomes After Intravenous Recombinant Tissue Plasminogen Activator for Ischemic Stroke: A Real-World Study.

Background: The longer-term benefits of intravenous recombinant tissue plasminogen activator (IV rt-PA) in Chinese acute ischemic stroke (AIS) patients remain lacking. We aimed to evaluate the 1-year clinical outcomes after IV rt-PA for Chinese AIS patients in a real-world setting.

Methods: Based on a prospective multicenter stroke registry in China, we analyzed the data of patients with AIS (aged ≥ 18 years) who arrived at hospital within 4.

Integrated horizontal convective PCR system for clinical diagnostics.

Rapid and accurate disease diagnosis in resource-limited settings is critical for optimizing medical resources and controlling epidemic outbreaks. However, developing a point-of-care detection system that is user-friendly, cost-effective, highly accurate, and exhibits strong specificity remains a formidable challenge. Here, we report an integrated horizontal convection PCR system (IHCS) for clinical point-of-care testing, capable of real-time fluorescence detection.

Aroma preserving analysis of Saperavi dry red wine by adding exogenous yeast derivatives.

Fruity and floral aromas in wine predominantly originate from esters, with higher alcohols as crucial precursors; however, both compound classes are susceptible to degradation during aging. This study investigated the efficacy of yeast mannoprotein, yeast polysaccharide, and glutathione-enriched inactivated yeast (G-IDYs) in preserving volatile aroma compounds (VAC) in Saperavi dry red wine over five months. At optimal dosages (0.

The Physicochemical Properties and Anti-Fatigue Efficacy of a Polysaccharide-Rich Fraction Derived From Millettia speciosa Champ.

The root of Millettia speciosa Champ has been traditionally and widely used for anti-fatigue properties in folk culture. However, the active components and underlying mechanisms of M. speciosa's anti-fatigue efficacy are still unclear.

Urolithin A Exhibits Antidepressant-like Effects by Modulating the AMPK/CREB/BDNF Pathway.

Background/objectives: Urolithin A (UA), a gut-derived metabolite of ellagitannins or ellagic acid, has recently gained attention for its potential benefits to brain health. The present research aimed to assess the antidepressant-like properties of UA in both in vitro and in vivo models and explored the molecular mechanisms underlying these effects.

Methods: We investigated the antidepressant effects and mechanisms of UA in a model of corticosterone-induced damage to PC12 cells and in a model of chronic socially frustrating stress.

Clinical outcomes of immunosuppressive therapy in patients with seronegative anti-PLA2R antibodies and PLA2R-related membranous nephropathy.

Background: The study aims to investigate the impact of immunosuppressive therapy on clinical outcomes in patients with baseline negative PLA2R antibody, providing new therapeutic insights for this patient population.

Methods: This study included 133 patients with positive histological PLA2R antigen and baseline serum anti-PLA2R antibody data. ELISA (enzyme-linked immunosorbent assay) was used to measure serum anti-PLA2R antibody levels.

C/EBPβ-VCAM1 axis in Kupffer cells promotes hepatic inflammation in MASLD.

Background & Aims: Kupffer cells (KCs) can promote hepatic inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD), but the underlying molecular mechanisms are not fully understood. C/EBPβ in macrophages can mediate metabolic and immune dysregulations. Therefore, we aimed to explore its role in KCs in MASLD pathogenesis.

A carrier-assisted strategy for accelerating aerobic granulation under low superficial gas velocity: Critical contributions of sediment biochar and camellia shell biochar carriers.

Long granulation time and instability limited the practical application of aerobic granular sludge (AGS) technology. This study presents a strategy for enhancing AGS formation by adding granular biochar carriers (camellia shell biochar and dredged sediment biochar) in two low-energy sequencing batch reactors (SBRs). Three SBRs were established, labeled R1 (no carriers added), R2 (dredged sediment biochar), R3 (camellia shell biochar added).

An Examination of the Relationship Between Spinal-Pelvic Morphology and Lower Lumbar Facet Joint Remodeling in Individuals with Mild Degenerative Lumbar Spondylolisthesis.

Objective: To examine the relationship between spinal-pelvic morphology based on pelvic incidence angle and facet joint characteristics in the lower lumbar spine of patients with mild degenerative lumbar spondylolisthesis.

Methods: The study involved 167 patients with mild degenerative lumbar spondylolisthesis and patients with 100 nonlumbar spondylolisthesis. Morphologic parameters of L4-5 and L5-S1 facet joints and intervertebral discs were assessed using 3D CT images, including facet joint angle, pedicle-facet angle, asymmetry, and osteoarthritis.

A ratiometric fluorescent sensor based on Eu -β-diketone functionalized covalent organic framework hybrid material-loaded in electrospun polyvinylidene fluoride film for ultra-sensitive and rapid detection of glyphosate.

The extensive application of glyphosate (Gly) presents significant environmental and health risks, underscoring the necessity for advanced sensors to monitor Gly levels. In this study, a novel ratiometric fluorescent sensor (Eu-TTA@COOH-COF) was developed by coordinating Eu³ ⁺ ions with carboxylated covalent organic frameworks (COOH-COF) and grafting 2-thenoyltrifluoroacetone (TTA) ligand to enhance Eu³ ⁺ sensitization. Gly detection relied on its energy competition with the COF, which quenched the characteristic red emission of Eu³ ⁺ (613 nm), and electron transfer to the COOH-COF matrix amplifying the intrinsic blue fluorescence emission (435 nm) of the COF.

Novel Edge-on-irradiated Si-based Photon-counting Detector CT for the Characterization of Cystic Renal Lesions.

Objective: To evaluate an edge-on-irradiated silicon-based photon-counting detector CT (Deep Si-PCD-CT) prototype for quantification of iodine concentration and stability of HU values, as well as detectability of subtle features in simulated kidney parenchyma.

Materials And Methods: A phantom, simulating moderately and strongly enhancing kidney parenchyma (at 180 and 240 HU) inside a small, medium, and large patient (23, 30, 37 cm diameter, respectively), was scanned on a Deep Si-PCD-CT. Centered in the kidney parenchyma was a water-equivalent rod at 0 HU and a rod of 0.

Homotypic biomimetic nanotheranostics enhance locoregional Cherenkov radiation-induced photodynamic therapy and ferroptosis in early bone metastases.

Theranostics for deep-seated and multifocal bone metastases using conventional nanoparticulate strategies face significant challenges due to limited targeting and insufficient spatial controllability within the lesions. Here, we developed a sophisticated nanocarrier (MC@MH) camouflaged with the homologous prostate cancer cell membrane and ferritin-homing peptide (HKN). Following systemic injection, the biomimetic nanotheranostics preferentially accumulated in bone metastases through a homotypic targeting mechanism.

Purification, structural characterization, and anti-ulcerative colitis activity of a novel pectin-like polysaccharide AH-H4-1 from Alhagi honey.

Alhagi honey (AH) has been employed in traditional medicine for treating intestinal diseases, demonstrating significant clinical efficacy. However, it remains unclear which components of AH play a role in the treatment of ulcerative colitis (UC). Here, high molecular weight polysaccharide (AH-H) and low molecular weight oligosaccharide (AH-L) were obtained from AH by dialysis.

Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations.

Acute ischemic stroke (AIS) in Asian populations presents unique epidemiological characteristics and challenges, which are of great significance for grasping the effect of intravenous thrombolysis (IVT) in the treatment process. IVT has proven efficacy in improving outcomes for AIS patients, but its application in Asia faces distinct barriers, such as delays in diagnosis, differences in healthcare infrastructure, and variations in patient characteristics. This review examines recent research on the use of IVT for AIS in Asia, comparing findings with Western populations to identify both commonalities and disparities.

Celastrol Induces Ferroptosis by Regulating CERKL to Exert Anti-Gastric Cancer Effect.

Gastric cancer is a significant global health issue. Celastrol, a natural compound, has shown antitumor potential, but its molecular mechanism in gastric cancer remains unclear. In this study, we treated HGC-27 cells with celastrol and employed CCK8, colony formation, and Transwell assays, revealing its inhibitory effect on cell proliferation and migration.