Multimodal sensing system based on phenylboric acid-COF/RhB ratio fluorescence: highly sensitive detection of ovarian cancer biomarker, smartphone-assisted field analysis and information encryption and anti-counterfeiting integration.

It is essential to develop an innovative technology with high sensitivity and real-time detection for the early diagnosis of ovarian cancer. The cross-disciplinary application of multifunctional materials represents a significant trend in contemporary sensing research. In this paper, a ratio-type fluorescence sensing platform RhB/TFBBPY-COF@PBA was constructed from the covalent organic framework (COF) co-functionalized by phenylboric acid and rhodamine B (RhB).

A ratiometric fluorescent sensor based on Eu -β-diketone functionalized covalent organic framework hybrid material-loaded in electrospun polyvinylidene fluoride film for ultra-sensitive and rapid detection of glyphosate.

The extensive application of glyphosate (Gly) presents significant environmental and health risks, underscoring the necessity for advanced sensors to monitor Gly levels. In this study, a novel ratiometric fluorescent sensor (Eu-TTA@COOH-COF) was developed by coordinating Eu³ ⁺ ions with carboxylated covalent organic frameworks (COOH-COF) and grafting 2-thenoyltrifluoroacetone (TTA) ligand to enhance Eu³ ⁺ sensitization. Gly detection relied on its energy competition with the COF, which quenched the characteristic red emission of Eu³ ⁺ (613 nm), and electron transfer to the COOH-COF matrix amplifying the intrinsic blue fluorescence emission (435 nm) of the COF.

An artificial neural network model based on CDs@MOF/COF composites for the ultra-sensitive fluorescence detection of glyphosate.

Glyphosate (Gly) overuse threatens public health and ecosystems, necessitating highly sensitive detection. This work developed a novel ratiometric fluorescent probe, CDs@Cu-MOF/TMTA-COF, by integrating carbon dots (CDs), metal organic frameworks (MOFs), and covalent organic frameworks (COFs). We encapsulated CDs within Cu-MOF in-situ grown onto sp‑carbon conjugated TMTA-COF.

Deep machine learning-assisted MOF@COF fluorescence/colorimetric dual-mode intelligent ratiometric sensing platform for sensitive glutathione detection.

Glutathione (GSH) levels have been linked to aging and the pathogenesis of various diseases, highlighting the necessity for the development of sensitive analytical methods for GSH to facilitate disease diagnosis and treatment. In this study, we synthesized a novel core-shell material, UiO@TBTA, by in-situ growing TFPB-TAPA COF on UiO-66-NH through a Schiff base reaction. The resulting composite capitalize on the advantages of both materials, demonstrating excellent stability, large specific surface area, and abundant active functional groups while preserving superior crystallinity.

Carbon dots for efficient detection of water content in organic solvents.

The trace amount of water in organic solvents can affect the progress of chemical reactions, which will adversely affect chemical production in many industries, resulting in a doubling of costs. In this work, carbon dots (CDs) with abundant polar groups were synthesized by a simple one-step hydrothermal method. The prepared CDs showed superior dispersibility and fluorescence performance compared to the CDs that have been reported for the detection of water content in organic solvents.

Covalent post-synthetic modification of MOFs as a fluorescent sensor for the efficient detection of the biomarker of cystinuria.

Cystinuria is a genetic disorder, and in severe cases, it might lead to kidney failure. As an important biomarker for cystinuria, the level of arginine (Arg) in urine is a vital indicator for cystinuria screening. Therefore, it is urgently needed to detect Arg with high selectivity and sensitivity.

Fluorescent sensor based on bismuth metal-organic frameworks (Bi-MOFs) mimic enzyme for HO detection in real samples and distinction of phenylenediamine isomers.

Although peroxidase-like nano-enzymes have been widely utilized in biosensors, nano-enzyme based biosensors are seldom used for both quantitative analysis of HO and differentiation of isomers of organic compounds simultaneously. In this study, a dual-functional mimetic enzyme-based fluorescent sensor was constructed using metal-organic frameworks (Bi-MOFs) with exceptional oxidase activity and fluorescence properties. This mimetic enzyme sensor facilitated quantitative analysis of HO and accurate discrimination of phenylenediamine isomers.

Eu-Modified Covalent Organic Frameworks for the Detection of a Vinyl Chloride Monomer Exposure Biomarker.

The vinyl chloride monomer (VCM), a common raw material in the plastics industry, is one of the environmental pollutants to which humans are mostly exposed. Thiodiglycolic acid (TDGA) in human urine is a specific biomarker of its exposure. TDGA plays an important role in understanding the relationships between exposure to the VCM and the identification of subgroups that are at increased risk for disease diagnosis.

Highly crystalline polyimide covalent organic framework as electrochemical sensing platform for the ultrasensitive detection of purine bases in DNA.

It is of great significance to propose simple methods to detect DNA bases sensitively for biological analysis and medical diagnosis. Herein, a highly crystalline polyimide covalent organic framework (TAPM-COF) has been successfully synthesized via a solvothermal route using pyromellitic dianhydride (PMDA) and tris(4-aminophenyl) amine (TAPA), which possessed large specific surface area (2286 m g) and excellent thermal stability. Intriguingly, the crystallinity of the TAPM-COF improved significantly with the increase of water content in the reaction medium.

A novel electrochemical sensing platform based on double-active-center polyimide covalent organic frameworks for sensitive analysis of levofloxacin.

The development of a simple and sensitive electrochemical sensing platform for levofloxacin (LVF) analysis is of great significance to human health. In this work, a covalent organic framework (TP-COF) was in situ grown on the surface of Sn-MoC nanospheres with nanoflower-like morphology through a one-pot method to obtain the TP-COF@Sn-MoC composite. The prepared composite was used to modify a glassy carbon electrode (GCE) to realize the sensitive detection of levofloxacin.