Self-referenced ratiometric electrochemical biosensor based on covalent organic framework assembled MXene for stain-resistance and sensitive sensing of dopamine.

Dopamine (DA) is not only an important neurotransmitter involving in the regulation of life activities, but also a typical biomarker of neurodegenerative diseases. Accurate detection of DA content is of great significance for early diagnosis and treatment of related illness. Herein, a ratio electrochemical sensing platform was constructed based on covalent organic framework (COF) assembled MXene composite nanomaterials for sensitive, selective and accurate detection of DA.

Construction of an electrochemical sensor based on N-COF@MWCNT-COOH/Tri-AgNPs for sensitive detection of tyrosine in biological fluids.

A sensitive electrochemical sensor was constructed for tyrosine detection by collaborating a highly conductivity, excellent electrocatalysis and large surface of nitrogen-rich porous covalent organic framework in situ grown on three-dimensional conductive carboxylated multi-walled carbon nanotubes network and catalytic activity of triangular silver nanosheets. The prepared electrochemical sensing platform exhibited satisfactory results for detection of tyrosine with a wide linear range of 0.6-280 μM and a low detection limit of 0.

Protein Ubiquitination Modification in Pulmonary Fibrosis.

Pulmonary fibrosis (PF) is a chronic, progressive fibrotic interstitial lung disease characterized by a high incidence and mortality rate, which encompasses features, such as diffuse alveolar inflammation, invasive fibroblast activation, and uncontrolled extracellular matrix (ECM) deposition. Beyond the local pathological processes, PF can be better understood in light of interorgan communication networks that are involved in its progression. Notably, pulmonary inflammation can affect cardiovascular, renal, hepatic, and neural functions, highlighting the importance of understanding these systemic interactions.

A rapid on-site fluorescence sensing platform for malachite green in an aqueous phase based on lanthanide-functionalized MOF.

The residue of malachite green (MG) in water has serious toxic effects on the human body, so it is very important to establish a highly sensitive and convenient method for MG detection. In this study, a novel double-emission lanthanide MOF fluorescence probe (Eu-Zn-MOF) was designed for monitoring MG in water by post-synthetic modification (PSM) to Zn-MOF synthesized by a simple hydrothermal method. Eu-Zn-MOF exhibits excellent photoluminescence properties, making it suitable as a ratiometric fluorescence sensor (I/I) for the sensitive detection of MG.

Analysis of coupled coordination and spatial interaction effects between digital and tourism economy in the Yangtze River Delta region.

The coupled and coordinated development of the digital economy and tourism economy has become an inevitable choice for achieving high-quality development in both sectors. This paper proposes a conceptual index system using entropy weight method and coupling coordination degree model for analysis of the coupling coordination relationship between digital economy and tourism economy. After that, the paper introduces the Moran's Index to examines the spatial heterogeneous effects of coupling coordination degree.

Imine-linked covalent organic framework with high crystallinity for constructing sensitive purine bases electrochemical sensor.

In this work, a covalent organic framework (TADM-COF) with high crystallinity and large specific surface area (2597 m g) has been successfully synthesized using 1,3,5-(4-aminophenyl) benzene (TAPB) and 2,5-dimethoxy-p-phenyldiformaldehyde (DMTP). The COF was grown in situ on oxide particles to form core-shell nanocomposites (SiO@TADM COF, FeO@TADM COF and CoO@TADM COF) to realize its function as a shell material. Among them, the CoO@TADM COF with the highest electrochemical response to purine bases was further cross-linked with multi-walled carbon nanotubes (MWCNT) to construct a novel electrochemical sensor (CoO@TADM COF/MWCNT/GCE) for detection of purine bases.

Eu-Modified Covalent Organic Frameworks for the Detection of a Vinyl Chloride Monomer Exposure Biomarker.

The vinyl chloride monomer (VCM), a common raw material in the plastics industry, is one of the environmental pollutants to which humans are mostly exposed. Thiodiglycolic acid (TDGA) in human urine is a specific biomarker of its exposure. TDGA plays an important role in understanding the relationships between exposure to the VCM and the identification of subgroups that are at increased risk for disease diagnosis.

Highly crystalline polyimide covalent organic framework as electrochemical sensing platform for the ultrasensitive detection of purine bases in DNA.

It is of great significance to propose simple methods to detect DNA bases sensitively for biological analysis and medical diagnosis. Herein, a highly crystalline polyimide covalent organic framework (TAPM-COF) has been successfully synthesized via a solvothermal route using pyromellitic dianhydride (PMDA) and tris(4-aminophenyl) amine (TAPA), which possessed large specific surface area (2286 m g) and excellent thermal stability. Intriguingly, the crystallinity of the TAPM-COF improved significantly with the increase of water content in the reaction medium.

A novel electrochemical sensing platform based on double-active-center polyimide covalent organic frameworks for sensitive analysis of levofloxacin.

The development of a simple and sensitive electrochemical sensing platform for levofloxacin (LVF) analysis is of great significance to human health. In this work, a covalent organic framework (TP-COF) was in situ grown on the surface of Sn-MoC nanospheres with nanoflower-like morphology through a one-pot method to obtain the TP-COF@Sn-MoC composite. The prepared composite was used to modify a glassy carbon electrode (GCE) to realize the sensitive detection of levofloxacin.

The analysis and optimization of thermal sensation of train drivers under occupational thermal exposure.

Introduction: Prolonged exposure of train drivers to thermal discomfort can lead to occupational safety and health (OSH) risks, causing physical and mental injuries. Traditional method of treating human skin as a wall surface fail to observe accurate skin temperature changes or obtain human thermal comfort that adapts to the thermal environment.

Methods: This study employs the Stolwijk human thermal regulation model to investigate and optimize the thermal comfort of train drivers.

Psychological Capital on College Teachers' and Students' Entrepreneurial Performance and Sports Morality Under Social and Political Education.

The aim of this study was to improve the entrepreneurial performance (EP) and sports morality of college teacher-and-student entrepreneurs (i.e., college entrepreneurs).

Mitochondrial heat-shock cognate protein 70 contributes to auxin-mediated embryo development.

In Arabidopsis thaliana, mitochondrial-localized heat-shock cognate protein 70-1 (mtHSC70-1) plays an important role in vegetativegrowth. However, whether mtHSC70-1 affects reproductive growth remains unknown. Here, we found that the mtHSC70-1 gene was expressed in the provascular cells of the embryo proper from the early heart stage onward during embryogenesis.

Depression Following COVID-19 Lockdown in Severely, Moderately, and Mildly Impacted Areas in China.

The Coronavirus Disease 2019 (COVID-19) pandemic has led to overwhelming levels of distress as it spread rapidly from Wuhan, Hubei province to other regions in China. To contain the transmission of COVID-19, China has executed strict lockdown and quarantine policies, particularly in provinces with the highest severity (i.e.

The effects of antimony on Alzheimer's disease-like pathological changes in mice brain.

We have previously identified antimony (Sb) as a newly nerve poison which leads to neuronal apoptosis. However, the relationship between Sb exposure and Alzheimer's disease (AD) process lacks direct evidence. HE staining and Nissl staining showed significant nerve damage after Sb exposure.

Tsinghua facial expression database - A database of facial expressions in Chinese young and older women and men: Development and validation.

Perception of facial identity and emotional expressions is fundamental to social interactions. Recently, interest in age associated changes in the processing of faces has grown rapidly. Due to the lack of older faces stimuli, most previous age-comparative studies only used young faces stimuli, which might cause own-age advantage.