Sulfur-Engineered Second-Shell in Fe-N Catalysts: Dual Active Sites Harmonized Activity and Stability in Real Water Environment.

Single-atom catalysts (SACs) exhibit outstanding catalytic activity, yet their application in real complex environments is constrained by the single active sites and instabilities that are susceptible to inactivation. Extensive efforts have been made to regulate the metal coordination environment, but the catalytic role of nonmetal dopants, especially beyond the first shell, remains underexplored. Herein, S-engineered second-shell Fe single-atom catalysts (FeNSC) are reported, in which S sites not only function as additional nonmetallic active sites separated from Fe but also reinforce the stability of the catalysts.

Prognostic value of baseline body composition parameters from F-FDG PET/CT in angioimmunoblastic T-cell lymphoma patients.

This retrospective study investigated preliminarily the prognostic value of body composition parameters derived from baseline F-FDG PET/CT in angioimmunoblastic T-cell lymphoma (AITL) patients. We included 94 treatment-naïve AITL patients diagnosed by histopathology. Based on the axial CT images of the third lumbar vertebra, the areas of skeletal muscle (SM), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) were semi-automatically delineated and standardized to finally obtain SM index (SMI), VAT index (VATI), and SAT index (SATI).

Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer's disease progression.

Objective: Develop a multimodal biomarker framework integrating DTI-ALPS (Diffusion Tensor Imaging along the Perivascular Space), hippocampal diffusivity, and CSF profiles for staging Alzheimer's disease (AD) progression across the HC → MCI → AD continuum.

Methods: Cross-sectional analysis of 60 age-matched participants [18 healthy controls (HC), 20 with mild cognitive impairment (MCI), and 22 with Alzheimer's disease (AD)] combining 3 T MRI-derived biomarkers (bilateral hippocampal fractional anisotropy (FA) and mean diffusivity (MD), and DTI-ALPS). Cerebrospinal fluid (CSF) analysis (Aβ42, p-tau181, t-tau), and cognitive assessments (MMSE, MoCA).

Additive-Free EDA Photochemical Arylative Trifluoromethylation of Enamides with Trifluoromethyl Benzothiazole Sulfones.

An additive-free trifluoromethylation-heteroarylation of enamides with trifluoromethyl heteroaryl sulfones via EDA photochemistry is reported. Under visible-light irradiation, diverse enamides and sulfones undergo efficient difunctionalization to afford CF-heteroaryl amides in moderate to excellent yields, without the need for photocatalysts or additives. Mechanistic studies support the formation of a photoexcited EDA complex that triggers C-S bond cleavage, generating CF and heteroaryl anions.

Identification of variants in SWI/SNF complex genes associated with neurodevelopmental disorders.

Introduction: Neurodevelopmental disorder (NDDs) such as intellectual disability, developmental delay encompasses a diverse group of conditions caused by the disruptions in the central nervous system (CNS) during development. Variants in the SWItch/Sucrose non-fermentable (SWI/SNF) complex genes are significant contributors to NDDs. ARID2, ARID1B, and SMARCC2 are important subunits of the SWI/SNF complex, and their variants can also result in Coffin-Siris syndrome (CSS), a type of NDDs characterized by CNS disorders, global developmental delay, visual/hearing impairment, distinct facial features, and congenital heart disease (CHD).

Personalized three-dimensional dose calculation method based on multi-modal images in dosimetry assessment of prostate cancer with skull metastasis: a Monte Carlo simulation study.

Background: The nuclear medicine treatment based on Lu-PSMA-617 has achieved excellent therapeutic effects on Prostate cancer (PCa), but there is a lack of three-dimensional dosimetry analysis of organs at risk (OARs) and distant metastatic lesions.

Results: This work establishes an accurate and personalized three-dimensional dose calculation method based on Monte Carlo simulation and multi-modal images of PCa patients with skull metastasis, and analyzes the three-dimensional dose distribution of metastatic lesions and OARs in the brain. Results show that due to the targeting characteristics of Lu-PSMA-617, metastatic brain lesions of all patients can receive high radiation doses with the average dose of 0.

A fluorescent probe for ultra-wide range detection of SO in food, traditional Chinese medicine, organisms and environment.

Sulfur dioxide (SO) has long been recognized as a hazardous environmental pollutant, and excessive intake of SO and its derivatives (HSO/SO) may be harmful to human health. A fluorescent probe capable of quantitative sulfite detection (0.755 μM - 500 μM), named RPB-R, was developed to exhibit chromogenic and red fluorescence turn-on responses.

Advancing anesthesiology trainee proficiency in airway management simulation-based training: a non-hypoxic apnea duration approach.

Background: Effective airway management training for anesthesiology trainees remains crucial for patient safety. While simulation-based education has shown promise, incorporating physiological parameters into training scenarios could enhance learning outcomes.

Objective: To evaluate the impact of incorporating non-hypoxic apnea duration awareness in simulation-based airway management education for anesthesiology trainees.

A novel 1,8-naphthalimide-based fluorescent sensor for ultrafast, portable, ratiometric detection of uranyl ions in seawater, seafood, soil, and living cells.

The uranyl ion (UO) poses notable risks to the ecological environment and human health owing to its intense radioactivity and high chemical toxicity. Consequently, we need to develop an effective straightforward method for detecting UO. This study presents an innovative ratiometric fluorescent probe, referred to as Nap-HBT, conveniently fabricated through the amalgamation of 4-hydroxynaphthalimide (Nap) and 2-(2-hydroxyphenyl) benzothiazole (HBT).

Identification immune-related hub genes in diagnosing atherosclerosis with ischemic stroke through comprehensive bioinformatics analysis and machine learning.

Background: Atheroma plaques are major etiological factors in the pathogenesis of ischemic stroke (IS). Emerging evidence highlights the critical involvement of the immune microenvironment and dysregulated inflammatory responses throughout IS progression. Consequently, therapeutic strategies targeting specific immune-related markers or signaling pathways within this microenvironment hold significant promise for IS management.

A biocompatible chitosan-based nanosensor for dual-functional detection and removal of mercury ion and its application in living cells and environmental systems.

Chitosan has been widely utilized due to its biodegradable, environmentally friendly, and extensive resources properties. The modification of chitosan has garnered significant attention as a promising approach for detecting and removing heavy metal contaminants. Herein, we presented a novel dual-functional fluorescent nanoprobe Nano-NAP for the effective detection and absorption of Hg, which could be conveniently fabricated by self-assembling a small-molecule Hg fluorescent probe into a carrier of chitosan-based fluorophore (CS-MeO).

Preparation of Chiral Stationary Phase Co-Modified With Homochiral Secondary Amine Molecular Cages and Amylose and Its Enantiomeric Separation Performance.

In this study, reduced porous organic cages with homochiral secondary amine structure were immobilized on a silica gel surface, and a derivative of 3,5-dimethyl phenyl carbamate of amylose was coated onto the molecular cage-modified silica sphere to prepare a chiral stationary phase co-modified with amylose and homochiral secondary amine molecular cages. The prepared chiral stationary phase was characterized using techniques such as scanning electron microscopy, infrared spectroscopy, and thermogravimetric analysis. The results confirmed the successful preparation of the amylose and homochiral secondary amine molecular cages co-modified silica gel chiral stationary phase.

Lumican as a potential biomarker for diabetic nephropathy.

Objective: We employed bioinformatics to identify potential biomarkers for diabetic nephropathy (DN) and investigate the role of the key gene lumican in its molecular processes.

Methods: We analyzed the GSE96804 and GSE30528 DN datasets from the Gene Expression Omnibus (GEO). GO and GSEA-KEGG enrichment analyses were used to identify key biological functions and related pathways.

From contemplation to serenity: how yoga meditation improves the mental health of female college students?

Objective: This study aims to investigate the impact of yoga meditation on the mental health of female college students, focusing on how meditation improves emotional regulation, alleviates stress and strengthens psychological resilience.

Methods: Employing a combination of quantitative assessment and qualitative analysis, the study measured participants' emotional states, stress levels, and psychological resilience across multiple time points to track participants' mental health changes dynamically. In-depth interviews and analysis of meditation journals were also conducted.

Study on Spatiotemporal Variation in Internal Temperature Field in Quartz Flexible Accelerometer.

Quartz flexible accelerometers (QFAs) are a type of temperature-sensitive sensor, whereby a change in temperature will cause the key parameters of the accelerometer to drift and cause stability errors. Due to the absence of effective methods for sensing the temperature of internal accelerometer components, existing temperature error correction approaches primarily rely on shell temperature measurements to establish correction models. Consequently, most correction methods achieve higher accuracy during the steady-state heat conduction phase of the accelerometer, whereas the correction error markedly increases during the transient heat conduction phase.

Relationship of prenatal ambient air pollutants exposure with childhood asthma risk and underlying mechanism: Ma'anshan Birth Cohort study.

Introduction: Association between prenatal exposure to particulate matter speciation and childhood asthma was limited, and study of sensitive exposure window was needed.

Methods: Among 1807 children from Ma'anshan Birth Cohort, childhood asthma information was obtained by standardized questionnaire. Family address was collected at birth and in 7 years old and used to assess trimester-specific ambient air pollutants (AAPs) exposure.

Integrated Headband for Monitoring Chloride Anions in Sweat Using Developed Flexible Patches.

Flexible wearable potentiometric ion sensors for continuous monitoring of electrolyte cations have made significant advances in bioanalysis for personal healthcare and diagnostics. However, less attention is paid to the most abundant extracellular anion, chloride ion (Cl) as a mark of electrolyte imbalance and an important diagnostic indicator of cystic fibrosis, which has important significance for accurate monitoring in complex biological fluids. An all-solid-state Cl-selective electrode is constructed utilizing oxygen vacancies reinforced vanadium oxide with a nitrogen-doped carbon shield as the solid contact (VO@NC/Cl-ISE).

Cyclobutrifluram Resistance in : Molecular Mechanisms and Detection Strategies.

The resistance risk and mechanisms of cyclobutrifluram in are unclear. The baseline sensitivity of 111 isolates to cyclobutrifluram was 0.10 ± 0.

A triphenylamine-based aggregation-induced emission active fluorescent probe for fluorescent ink, fingerprint powder, and visual detection of salmon freshness.

Background: Multifunctional fluorescent probes have attracted much attention due to their wide range of applications and high utilization. In this study, a multifunctional fluorescent probe (E)-3-(4-(7-(4-(diphenylamino)phenyl)benzo[c] [1,2,5]thiadiazol-4-yl)phenyl)acrylic acid (TBAC) based on triphenylamine was designed and synthesized.

Results: The TBAC probe provided excellent aggregation-induced emission (AIE) performance and could be used as a fluorescent ink for printing.

Colorimetric and fluorescent probe assisted by smartphone app for monitoring fish freshness.

In this study, a novel "OFF-ON" fluorescent probe MPZ ((E)-5-((10-ethyl-2-methoxy-10H-phenothiazin-3-yl)methylene)thiazolidine-2,4-dione) based on phenothiazine is synthesized, which can rapidly (7 s) detect biogenic amines (BAs) through deprotonation, utilizing both colorimetric and fluorescent dual channels. An app for visual portable detection of fish freshness, named "Visual Evaluation", is independently developed. This app integrates several functions, including image capture, editable scanning of red, green, and blue (RGB) values, data analysis fitting, data storage, and verification.

Genome-Wide Study of Plant-Specific PLATZ Transcription Factors and Functional Analysis of in Regulating Caryopsis Development of Rice ( L.).

Plant A/T-rich sequence- and zinc-binding protein (PLATZ) is a type of plant-specific zinc-dependent DNA-binding protein that binds to A/T-rich DNA sequences. This family is essential for plant growth, development, and stress response. In this study, 15 were identified in the rice genome with complete PLATZ-conserved domains by CD-search, similar to those found in angiosperms.

A near-infrared amine/HSO probe with colorimetric and fluorescent ultrafast response and its application in food samples and visual evaluation of salmon freshness.

A multifunctional near-infrared fluorescent probe (Sycy) is synthesized by the one-step condensation reaction of syringaldehyde and tricyanofuran. Sycy can detect HSO within 150 s in the red wine and sugar samples with a low detection limit of 3.5 μM.

Effects of double data extraction on errors in evidence synthesis: a crossover, multicenter, investigator-blinded, randomized controlled trial.

Objectives: The objective was to investigate the role of double extraction in reducing data errors in evidence synthesis for pharmaceutical and non-pharmaceutical interventions.

Design: Crossover randomized controlled trial (RCT).

Setting: University and hospital with teaching programs in evidence-based medicine.

Construction of a Dual-Mode Sensing Platform for Ultra-fast Detection of Bisulfite in Food and Environmental Systems.

Sulfur dioxide (SO) is widely used in food processing to extend the shelf life of food. However, excessive intake of SO and its derivatives (HSO and SO) can cause oxidative damage to the body, and result in several diseases. How to construct probes for rapid real-time detection of HSO in the field is beneficial to the developmental needs of practical applications, but it is also very challenging.