Sulfur-Engineered Second-Shell in Fe-N Catalysts: Dual Active Sites Harmonized Activity and Stability in Real Water Environment.

Single-atom catalysts (SACs) exhibit outstanding catalytic activity, yet their application in real complex environments is constrained by the single active sites and instabilities that are susceptible to inactivation. Extensive efforts have been made to regulate the metal coordination environment, but the catalytic role of nonmetal dopants, especially beyond the first shell, remains underexplored. Herein, S-engineered second-shell Fe single-atom catalysts (FeNSC) are reported, in which S sites not only function as additional nonmetallic active sites separated from Fe but also reinforce the stability of the catalysts.

Identification immune-related hub genes in diagnosing atherosclerosis with ischemic stroke through comprehensive bioinformatics analysis and machine learning.

Background: Atheroma plaques are major etiological factors in the pathogenesis of ischemic stroke (IS). Emerging evidence highlights the critical involvement of the immune microenvironment and dysregulated inflammatory responses throughout IS progression. Consequently, therapeutic strategies targeting specific immune-related markers or signaling pathways within this microenvironment hold significant promise for IS management.

Fast and accurate discrimination analysis of Angelicae Pubescentis Radix using non-targeted analytical profiles images and two-dimensional convolution neural network.

This study developed an effective approach for discriminating geographical origins of Duhuo samples using non-targeted UPLC chromatograms and UV-Vis spectrogram images combined with a two-dimensional convolution neural network (2D-CNN). For comparison, four machine learning methods-extreme gradient boosting (XGBoost), random forest (RF), partial least squares discriminant analysis (PLS-DA), and support vector machine (SVM) were applied to analyze UPLC, UV-Vis data matrix, and concentrations of seven target compounds. Enhanced by data augmentation, 2D-CNN demonstrated superior accuracy, with 98.

Integrated Headband for Monitoring Chloride Anions in Sweat Using Developed Flexible Patches.

Flexible wearable potentiometric ion sensors for continuous monitoring of electrolyte cations have made significant advances in bioanalysis for personal healthcare and diagnostics. However, less attention is paid to the most abundant extracellular anion, chloride ion (Cl) as a mark of electrolyte imbalance and an important diagnostic indicator of cystic fibrosis, which has important significance for accurate monitoring in complex biological fluids. An all-solid-state Cl-selective electrode is constructed utilizing oxygen vacancies reinforced vanadium oxide with a nitrogen-doped carbon shield as the solid contact (VO@NC/Cl-ISE).

Geographical origin discrimination of Chenpi using machine learning and enhanced mid-level data fusion.

Chenpi, or dried tangerine peel, is a traditional Chinese ingredient valued in medicine and edible for its digestive and respiratory benefits. The geographical origin of Chenpi is important, as it can impact its quality, active compounds and market value. This study develops a strategy to distinguish Chenpi samples on its origin.

Genome-Wide Study of Plant-Specific PLATZ Transcription Factors and Functional Analysis of in Regulating Caryopsis Development of Rice ( L.).

Plant A/T-rich sequence- and zinc-binding protein (PLATZ) is a type of plant-specific zinc-dependent DNA-binding protein that binds to A/T-rich DNA sequences. This family is essential for plant growth, development, and stress response. In this study, 15 were identified in the rice genome with complete PLATZ-conserved domains by CD-search, similar to those found in angiosperms.

A novel importance scores based variable selection approach and validation using a MIR and NIR dataset.

Variable selection is important in spectral analysis for improving interpretation quality and accuracy. This study introduces a novel variable selection process, named "VMHBSC", which consists of six steps, with each letter representing one step. To demonstrate its process and advantages, two datasets were employed, a mid-infrared spectral (MIR) dataset (234 × 7468, sample number × variables) of Chenpi samples (a traditional Chinese medicinal material derived from the dried peel of mature tangerines) and a near-infrared spectral (NIR) dataset (16000 × 256) for modeling competition.

Accurate and visualiable discrimination of Chenpi age using 2D-CNN and Grad-CAM++ based on infrared spectral images.

Dried tangerine peel ("Chenpi"), has numerous clinical and nutritional benefits, with its quality being significantly influenced by its storage age, referred to as "Chen Jiu Zhe Liang" in Chinese. Concequently, the rapid and accurate identification of Chenpi's age is important for consumers. In this study, Fourier transform infrared spectroscopy (FTIR) was employed to capture spectral images of Chenpi.

Assessment of metabolomic variations among individuals returning to plain areas after exposure to high altitudes: a metabolomic analysis of human plasma samples with high-altitude de-acclimatization syndrome.

Background: High altitude de-acclimatization (HADA) is gradually becoming a public health concern as millions of individuals of different occupations migrate to high-altitude areas for work due to economic growth in plateau areas. HADA affects people who return to lower elevations after exposure to high altitudes. It causes significant physiological and functional changes that can negatively impact health and even endanger life.

Robust Graphene-based Aerogel for Integrated 3D Asymmetric Supercapacitors with High Energy Density.

Three-dimensional asymmetric supercapacitors (3D ASC) have garnered significant attention due to their high operating window, theoretical energy density, and circularity. However, the practical application of 3D electrode materials is limited by brittleness and excessive dead volume. Therefore, we propose a controlled contraction strategy that regulates the pore structure of 3D electrode materials, eliminates dead volume in the 3D skeleton structure, and enhances mechanical strength.

Exploring the impact of high-altitude de-acclimatization on renal function: The roles of oxidative and endoplasmic reticulum stress in rat models.

Background: High-altitude de-acclimatization (HADA) significantly impacts physiological functions when individuals acclimatize to high altitudes return to lower altitudes. This study investigates HADA's effects on renal function and structure in rats, focusing on oxidative and endoplasmic reticulum stress as potential mechanisms of renal injury.

Objective: To elucidate the pathophysiological mechanisms of renal damage in HADA and evaluate the efficacy of antioxidants Vitamin C (Vit C) and tauroursodeoxycholic acid (TUDCA) in mitigating these effects.

Radioactive iodine therapy for follicular thyroid cancer: a 15 years follow-up study of Chinese patients.

Purpose: To identify long-term predictors of distant metastases (DM) and the overall survival (OS) of follicular thyroid cancer (FTC) patients who underwent radioactive iodine (RAI) therapy. And to expand the knowledge about the clinical course and experience of RAI treatment for FTC.

Materials: A total of 117 FTC patients who underwent RAI therapy at our institution from 2005 to 2020 were retrospectively studied.

Abdominal paracentesis drainage improves outcome of acute pancreatitis complicated with intra-abdominal hypertension in early phase.

Background: Intra-abdominal hypertension (IAH) is an important risk factor for organ dysfunction, and it occurs in the early phase of severe acute pancreatitis (SAP). We have reported a novel step-up approach and shown the benefit of performing abdominal paracentesis drainage (APD) ahead of percutaneous catheter drainage (PCD) when treating Patients with SAP with fluid collections. This study aimed to evaluate the efficacy of APD in Patients with SAP complicated with IAH in the early phase.

The effects of music therapy on peripherally inserted central catheter in hospitalized children with leukemia.

To explore the effect of music therapy on children with leukemia who have peripherally inserted central catheters (PICC). In this study, we divided 107 patients undergoing PICC into music group (47 cases) and control group (60 cases). The music group received music therapy during PICC, while the control group was given no complementary treatment.

Endoscopic-catheter-directed infusion of diluted (-)-noradrenaline for atypical hemobilia caused by liver abscess: A case report.

Background: Hemobilia occurs when there is a fistula between hepatic blood vessels and biliary radicles, and represents only a minority of upper gastrointestinal hemorrhages. Causes of hemobilia are varied, but liver abscess rarely causes hemobilia and only a few cases have been reported. Here, we present a case of atypical hemobilia caused by liver abscess that was successfully managed by endoscopic hepatobiliary intervention through endoscopic retrograde cholangiopancreatography (ERCP).

Effect of postoperative urinary retention in older patients with hip fracture on self-efficacy, resilience, and quality of life.

Background: Hip fracture (HF) is a major health problem for older patients. Postoperative urinary retention (POUR) is a common complication in HF patients. It extends the length of the hospital stay and affects the recovery of mobility.

Abdominal paracentesis drainage attenuates intestinal inflammation in rats with severe acute pancreatitis by inhibiting the HMGB1-mediated TLR4 signaling pathway.

Background: Our previous studies confirmed that abdominal paracentesis drainage (APD) attenuates intestinal mucosal injury in rats with severe acute pancreatitis (SAP), and improves administration of enteral nutrition in patients with acute pancreatitis (AP). However, the underlying mechanisms of the beneficial effects of APD remain poorly understood.

Aim: To evaluate the effect of APD on intestinal inflammation and accompanying apoptosis induced by SAP in rats, and its potential mechanisms.

Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress.

Background: Abdominal paracentesis drainage (APD) is a safe and effective strategy for severe acute pancreatitis (SAP) patients. However, the effects of APD treatment on SAP-associated cardiac injury remain unknown.

Aim: To investigate the protective effects of APD on SAP-associated cardiac injury and the underlying mechanisms.

Determination of the Oxidative Stability of Camellia Oils Using a Chemometrics Tool Based on H NMR Spectra and α-Tocopherol Content.

This study, for the first time, predicts oxidative stability in camellia oils by partial least squares (PLS) built with proton nuclear magnetic resonance (H NMR) and α-tocopherol content. The prediction models were established by the PLS method. Outlier detection, latent variables optimization, data pretreatment, and important variables selection were applied for models optimization.

Levels of miR-125a-5p are altered in Mycobacterium avium-infected macrophages and associate with the triggering of an autophagic response.

Macrophages are major pathogen-killing cells. Mycobacteria can represent a serious threat to human health, in particular Mycobacterium tuberculosis and, less so, the opportunistic Mycobacterium avium. They can cause disseminated infections because of their capacity to survive and proliferate within macrophage phagolysosomes.

Bile Acid Transporters Are Expressed and Heterogeneously Distributed in Rat Bile Ducts.

Background/aims: Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile acid transport proteins in cholangiocytes from normal rat liver and analyzed the possible pathophysiological significance.

Methods: Bile duct tissues of Sprague-Dawley rats were isolated by enzymatic digestion and mechanical isolation, and then divided into large and small bile duct tissues.

Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy.

The present study aimed to explore the correlation between the dynamic serum levels of phospholipase A2 receptor (PLA2R), aldose reductase (AR) and superoxide dismutase 2(SOD2) antibodies with disease activity and treatment response in patients with idiopathic membranous nephropathy (IMN). The present study included 56 patients with IMN who were diagnosed through a renal biopsy and presenting with nephrotic syndrome. The patients were divided into two treatment groups: One treated with cyclophosphamide (CTX) and one with tacrolimus (FK506).

Abdominal paracentesis drainage ameliorates severe acute pancreatitis in rats by regulating the polarization of peritoneal macrophages.

Aim: To investigate the role of peritoneal macrophage (PM) polarization in the therapeutic effect of abdominal paracentesis drainage (APD) on severe acute pancreatitis (SAP).

Methods: SAP was induced by 5% Na-taurocholate retrograde injection in Sprague-Dawley rats. APD was performed by inserting a drainage tube with a vacuum ball into the lower right abdomen of the rats immediately after the induction of SAP.