Synergizing Ferroptosis Suppressor Protein 1 Gene Silencing and Photodynamic Therapy Based on Photosensitive Lipid Nanoparticles for Colon Cancer Immunotherapy.

Metastasis and immune escape play crucial roles in the progression of colon cancer. Current chemotherapy and immunotherapy treatments have limited effectiveness in reversing the immunologically cold microenvironment. Therefore, it is essential to investigate efficient strategies to enhance the antitumor immunity.

Harnessing the Immunomodulation of UV-Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment.

Sunbathing excessively heightens the risk of skin carcinogenesis due to ultraviolet (UV)-mediated immunosuppression. Keratinocytes, the primary cells in epidermis, play a pivotal role in orchestrating the UV-induced immunosuppressive response by releasing platelet-activating factor (PAF) upon UV exposure. Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV-irradiated keratinocytes.

OsNAL11 and OsBURP12 Affect Rice Seed Germination at Low Temperature.

Cold stress is one of the major disasters that severely affect agricultural production. Heat shock protein 40 (HSP40) and BURP proteins are involved in the cold stress response. However, the physiological and molecular mechanisms of heat shock proteins and BURP family proteins regulating seed germination at low temperature are rarely reported.

IR783-Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation.

Immune evasion and metastasis are the leading causes of poor prognosis in triple-negative breast cancer treatment. Since current standard immunotherapies have limited efficacy due to immunologically cold microenvironment, it is crucial to explore new strategies to sensitize anticancer immune response. In this study, it is found that incorporating β-lapachone-based oxidation therapy with CUDC101-initiated epigenetic regulation results in synergistic antitumor effects and potent immune activation.

Exploring the mechanism of vitamin C on the co-expressed genes of papillary thyroid carcinoma and Epstein-Barr virus based on bioinformatics, network pharmacology and molecular docking analysis.

Objective: The study aims to evaluate the role and mechanism of action of vitamin C as an anti- Epstein-Barr virus (EBV) and papillary thyroid carcinoma (PTC) therapeutic agent.

Methods: The PTC/EBV-associated genes were obtained by intersection and further screen out hub genes to construct a prognostic model. The relationship between PTC/EBV-related genes and core genes and immune infiltration was analyzed, respectively.

Photosensitive Hybrid γδ-T Exosomes for Targeted Cancer Photoimmunotherapy.

Melanoma is the most aggressive type of skin cancers. Traditional chemotherapy and radiotherapy have limited effectiveness and can lead to systemic side effects. Photodynamic therapy (PDT) is a photoresponsive cancer therapy based on photosensitizers to generate reactive oxygen species (ROS) to eradicate tumor cells.

Correction to "Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy".

[This corrects the article DOI: 10.1021/acsptsci.1c00230.

Sport training of axial rotation affects spatial ability: Evidence from behavior and fNIRS.

The present study investigated the spatial ability of adolescent athletes with different sport expertise of axial rotation, providing the cognitive characteristics from both behavior and functional near-infrared spectroscopy (fNIRS) tests. 16 basketball and soccer players, 15 freestyle athletes and 15 runners were selected for spatial ability testing with a three-factor mixed experimental design of 3 (sport type: open high-spatial sport, closed high-spatial sport, closed low-spatial sport) × 2 (rotation angle: 45°, 90°) × 3 (rotation axis: horizontal, vertical, longitudinal). Repeated-measures ANOVA was performed to evaluate the behavioral and fNIRS data of the mental rotation test.

Axial rotation affects the cognitive characteristics of spatial ability.

Purpose: To test spatial ability in athletes with different axial rotation experience and analyze their behavioral data to explain the cognitive mechanisms of spatial ability in athletes.

Methods: Experiment 1: A total of 147 athletes were selected for the paper-and-pencil mental rotation test (MRT). The athletes were separated according to three sport types: open high-spatial (OH) sport, closed high-spatial (CH) sport, closed low-spatial (CL) sport.

Molecular-level insights into the leachates released from ultraviolet-aged biodegradable and conventional commercial microplastics and their mechanism of toxicity toward Chlorella pyrenoidosa.

Understanding the harmful effects of microplastics (MPs) and their derivatives is a priority in environmental study. However, the characteristics and toxic effects of leachates from MPs at the molecular-level remain unclear. Herein, two conventional commercial MPs [polystyrene (PS) and polyethylene (PE)] and two biodegradable commercial MPs [polylactic acid (PLA) and polybutylene adipate-co-terephthalate/PLA (PBAT/PLA)] were subjected to leaching under ultraviolet-irradiation, and their leachates were investigated.

and Regulate the Low-Temperature Germination of Rice Seeds by Affecting GA Content.

Low temperatures cause serious threat to rice seed emergence, which has become one of the main limiting factors in the production of direct seeding rice. It is of great importance to study the genes controlling low-temperature tolerance during seed germination and to mine the possible regulatory mechanism for developing new rice varieties with immense low-temperature germination ability. In the current research study, two types of mutants of and , derived from the WT (wild type) ZH11, were used for the analysis of low-temperature germinability.

Enhancing Coleoptile Length of Rice Seeds under Submergence through Knockout.

Submergence stress challenges direct seeding in rice cultivation. In this study, we identified a heat shock protein, , with a DnaJ domain, which can regulate the length of rice coleoptiles under flooded conditions. Through bioinformatics analyses, we identified -regulatory elements in its promoter, making it responsive to abiotic stresses, such as hypoxia or anoxia.

Precise In Situ Delivery of a Photo-Enhanceable Inflammasome-Activating Nanovaccine Activates Anticancer Immunity.

A variety of state-of-the-art nanovaccines (NV) combined with immunotherapies have recently been developed to treat malignant tumors, showing promising results. However, immunosuppression in the tumor microenvironment (TME) restrains cytotoxic T-cell infiltration and limits the efficacy of immunotherapies in solid tumors. Therefore, tactics for enhancing antigen cross-presentation and reshaping the TME need to be explored to enhance the activity of NVs.

Integrating mTOR Inhibition and Photodynamic Therapy Based on Carrier-Free Nanodrugs for Breast Cancer Immunotherapy.

Conventional photodynamic therapy (PDT) in cancer treatment needs to utilize oxygen to produce reactive oxygen species to eliminate malignant tissues. However, oxygen consumption in tumor microenvironment exacerbates cancer cell hypoxia and may promote vasculature angiogenesis. Since the mammalian target of rapamycin (mTOR) signaling pathway plays a vital role in endothelial cell proliferation and fibrosis, mTOR inhibitor drugs hold the potential to reverse hypoxia-evoked angiogenesis for improved PDT effect.

Targeted protein delivery based on stimuli-triggered nanomedicine.

Protein-based drugs have shown unique advantages to treat various diseases in recent years. However, most protein therapeutics in clinical use are limited to extracellular targets with low delivery efficiency. To realize targeted protein delivery, a series of stimuli-triggered nanoparticle formulations have been developed to improve delivery efficiency and reduce off-target release.

Development of Multifunctional Catalysts for the Direct Hydrogenation of Carbon Dioxide to Higher Alcohols.

The direct hydrogenation of greenhouse gas CO to higher alcohols (COH) provides a new route for the production of high-value chemicals. Due to the difficulty of C-C coupling, the formation of higher alcohols is more difficult compared to that of other compounds. In this review, we summarize recent advances in the development of multifunctional catalysts, including noble metal catalysts, Co-based catalysts, Cu-based catalysts, Fe-based catalysts, and tandem catalysts for the direct hydrogenation of CO to higher alcohols.

Track Irregularity Identification Method of High-Speed Railway Based on CNN-Bi-LSTM.

Track smoothness has become an important factor in the safe operation of high-speed trains. In order to ensure the safety of high-speed operations, studies on track smoothness detection methods are constantly improving. This paper presents a track irregularity identification method based on CNN-Bi-LSTM and predicts track irregularity through car body acceleration detection, which is easy to collect and can be obtained by passenger trains, so the model proposed in this paper provides an idea for the development of track irregularity identification method based on conventional vehicles.

Numerical calculation of streaming potential around osteocytes under human gait loading.

Streaming potential is a type of stress-generated potential in bone that affects the electrical environment of osteocytes and may play a role in bone remodeling. Because the electrical environment around osteocytes has been difficult to measure experimentally until now, a numerical solid-liquid-streaming potential coupling method was proposed to analyze the streaming potential generated by bone deformation in the lacunae and canaliculus network (LCN) of the bone. Using this method, the cellular shear stress caused by liquid flow on the osteocyte surface was first calculated, and the results were consistent with those reported in the literature.

Apoptotic Extracellular Vesicles Derived from Human Umbilical Vein Endothelial Cells Promote Skin Repair by Enhancing Angiogenesis: From Death to Regeneration.

Purpose: The promotion of angiogenesis is an effective strategy for skin wound repair. While the transplantation of endothelial cells has shown promise in vascularization, the underlying mechanism remains unclear. Recent studies have suggested that transplanted cells undergo apoptosis in a short period and release apoptotic extracellular vesicles (ApoEVs) that may have therapeutic potential.

Comparative analysis of permeability model construction and risk fields evaluation by roof cutting along the gob in a coal mine.

The productivity of coal mines is seriously threatened by the combined disasters of gas and coal spontaneous combustion, which have become a common disaster mode. It is unclear how the gas and coal spontaneously combusted in the roof cutting along gob working face. The goal of this study is to identify the distinctive features of combined disasters in gob from two different types of roof cutting along working faces.

Construction and validation of a nomogram for predicting the prognosis of patients with lymph node-positive invasive micropapillary carcinoma of the breast: based on SEER database and external validation cohort.

Background: Invasive micropapillary carcinoma (IMPC) of the breast is a rare subtype of breast cancer with high incidence of aggressive clinical behavior, lymph node metastasis (LNM) and poor prognosis. In the present study, using the Surveillance, Epidemiology, and End Results (SEER) database, we analyzed the clinicopathological characteristics and prognostic factors of IMPC with LNM, and constructed a prognostic nomogram.

Methods: We retrospectively analyzed data for 487 breast IMPC patients with LNM in the SEER database from January 2010 to December 2015, and randomly divided these patients into a training cohort (70%) and an internal validation cohort (30%) for the construction and internal validation of the nomogram, respectively.

regulates heading date in rice.

Unlabelled: Heading date is a critical agronomic trait that determines crop yield. Although numerous genes associated with heading date have been identified in rice, the mechanisms involving family have not been elucidated. In this study, the biological function of several genes was initially investigated using the CRISPR- technology in the Japonica cultivar Zhonghua11 (ZH11) background.

Photo-Enhanced Synergistic Induction of Ferroptosis for Anti-Cancer Immunotherapy.

Ferroptosis as programmed cell death received considerable attention in cancer research. Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because PDT promotes glutathione (GSH) deletion, glutathione peroxidase 4 (GPX4) degradation, and lipid peroxide accumulation. However, PDT-induced ferroptosis may be potentially prevented by ferroptosis suppressor protein 1 (FSP1).

[Pollution Characteristics and Source Apportionment of Heavy Metals in Farmland Soils Around the Gangue Heap of Coal Mine Based on APCS-MLR and PMF Receptor Model].

To analyze the pollution characteristics and source apportionment of heavy metal pollution in soil of farmland surrounding the Gangue Heap of Coal Mine in Nanchuan, Chongqing, the Nemerow pollution index and Muller index were used. Meanwhile, to investigate the sources and contribution rate of heavy metals in the soil, absolute principal component score-multiple linear regression receptor modeling (APCS-MLR) and positive matrix factorization (PMF) were employed. The results showed higher amounts of Cd, Hg, As, Pb, Cr, Cu, Ni, and Zn in the downstream area than those in the upstream area, and only Cu, Ni, and Zn showed significantly higher amounts in the downstream area than those in upstream area (<0.