Formation of neutrophil extracellular traps in the early stages exacerbate the healing process by regulating macrophage polarization in Achilles tendon-bone injury.

The influence of neutrophils and of neutrophil extracellular traps (NETs) on post-traumatic tendon-to-bone healing was studied in a murine model. The impact of neutrophil infiltration on macrophage polarization and peritendinous fibrosis in early-stage Achilles tendon injury is reported. Mice underwent Achilles tendon-bone injury and divided into four groups: sham operation, tendon injury (TI) treated with acetylcellulose (vehicle control), TI treated with a Protein arginine deiminase-4 (PAD4) inhibitor GSK484, and TI treated with a neutrophil elastase inhibitor Sivelestat.

Changes in source contribution to particle number concentrations during the 2022 COVID-19 Lockdown on southern edge of North China Plain.

The COVID-19 lockdown was a typical example of extreme emission reduction, providing an opportunity to study the impact of lockdown measures on air pollution. Particle number concentrations (PNC) originate from direct emissions or through new particle formation events. However, their variations during the lockdown period are under investigation.

[Emission Characteristics of Polycyclic Aromatic Hydrocarbons and Their Derivatives from Exhaust PM of China Ⅴ and China Ⅵ Diesel Trucks Based on On-road Measurements].

Exhaust emissions from diesel vehicles are one among the major sources of PM and polycyclic aromatic hydrocarbons （PAHs） emitted by diesel vehicles are of concern due to their notable impact on health. To better understand the toxicity of diesel vehicle emissions, we used an on-road sampling system to collect PM samples from four light-duty diesel trucks （LDDTs） and two heavy-duty diesel trucks （HDDTs） under the China Ⅴ and China Ⅵ emission standard. Further, 16 polycyclic aromatic hydrocarbons （pPAHs）, 18 nitro-polycyclic aromatic hydrocarbons （NPAHs）, and five oxygenated polycyclic aromatic hydrocarbons （OPAHs） were analyzed by GC-MS, and mileage-based emission factors were calculated.

[Characteristics and Sources of Volatile Organic Compounds （VOCs） in Luohe City During Summer].

Luohe City is an important node city in the Central Plains Urban Agglomeration in China, where the atmospheric ozone （O） pollution situation has been serious in recent years. In order to provide a scientific basis for O pollution control, the online filed observation of O precursor volatile organic compounds （VOCs） was carried out in Luohe City in July 2022 to understand their variation characteristics and sources. The mean ratio of （TVOCs） during the observation period was （16.

Perioperative Dexamethasone Split Between Two Doses Further Reduced Early Postoperative Nausea and Vomiting Than Single-Dose Dexamethasone: A Randomized Blinded Placebo-Controlled Trial.

Background: We investigated whether two doses of dexamethasone are more effective than a single dose in reducing early postoperative nausea and vomiting (PONV) during total knee arthroplasty (TKA).

Methods: A total of 150 patients between June 2021 and June 2022 were randomized into 3 groups: two doses of normal saline (group A), a single dose of 10 mg dexamethasone before surgery and normal saline after surgery (group B), and two doses of 5 mg dexamethasone during the perioperative period (group C). Primary outcomes were incidences and severity of PONV within 24 hours after surgery, the number and consumption of patients requiring morphine and metoclopramine, and visual analog scale scores for nausea and vomiting at 2, 4, 6, and 24 hours after surgery.

The role of mitochondrial quality control mechanisms in chondrocyte senescence.

Chondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs the health of the cartilage. The primary factor contributing to the deterioration of cartilage structure and function is chondrocyte senescence. In hypoxia and hypodextrose environment, chondrocytes heavily rely on glycolysis for energy metabolism.

Tissue adhesive, ROS scavenging and injectable PRP-based 'plasticine' for promoting cartilage repair.

Platelet-rich plasma (PRP) that has various growth factors has been used clinically in cartilage repair. However, the short residence time and release time at the injury site limit its therapeutic effect. The present study fabricated a granular hydrogel that was assembled from gelatin microspheres and tannic acid through their abundant hydrogen bonding.

Carbamazepine regulates USP10 through miR-20a-5p to affect the deubiquitination of SKP2 and inhibit osteogenic differentiation.

Background: Antiepileptic drugs (AEDs) harm bone health and are significantly associated with osteoporosis development. In this study, we aimed to explore the mechanisms involved in carbamazepine (CBZ) and microRNA (miR)-20a-5p/ubiquitin-specific peptidase 10 (USP10)/S-phase kinase-associated protein 2 (SKP2) axis in osteoporosis.

Methods: Human bone marrow mesenchymal stem cells (BMSCs) were treated with different concentrations of CBZ.