Inhibition of c-Abl suppresses the proliferation, invasion and migration of glioma cells.

Background: The proto-oncogene c-Abl has been implicated in tumor progression across multiple cancer types, but its role in glioma remains poorly understood. This study aimed to investigate the function of c-Abl in glioma progression and assess its potential as a therapeutic target.

Methods: High-throughput RNA sequencing was conducted on U-87 glioma cells following c-Abl knockdown.

Quantitative Analysis of the Formation and Evolution of Underpressure in Tight Sandstone Reservoirs in the Craton Basin: The Chang 7 Member in the A Area of the Ordos Basin.

The Ordos Basin is a typical craton basin. Underpressure exists in the tight sandstone reservoirs of the Chang 7 member of the Upper Triassic Yanchang Formation in the Yishan slope of the basin. However, overpressure was verified in these reservoirs during the Early Cretaceous period, and the evolution process from overpressure to underpressure is still unclear.

Autonomous All-in-One Patch for Closed-Loop Diagnosis-Therapy of Melanoma.

Early diagnosis, long-term monitoring, and precise therapy of melanoma are hampered by insufficient medical resources, significantly impacting the reduction of melanoma mortality rates and the mitigation of therapy-induced side effects. As an ideal autonomous all-in-one patch for long-term precision medicine on melanoma, several units, including sensing, drug delivery, power supply, and smart control, are required. Here, a microneedle-based sensing and drug release unit, a flexible printed-circuit board (FPCB)-based smart control platform, and a flexible Zn-air battery are integrated as an autonomous diagnosis-therapy system.

Nighttime sleep duration and the prevalence of hyperuricemia: a systematic review and network meta-analysis.

Objective: According to clinical observation and recent studies, there is a significant association between night sleep duration and hyperuricemia. In this study, systematic review and network meta-analysis were performed to evaluate the risk of hyperuricemia associated with different nighttime sleep durations.

Methods: Seven databases were searched from database inception to March 2020.

Engineering Light-Element Modified LaFeSi Compounds Enables Tunable Giant Magnetocaloric Effect.

Magnetocaloric refrigeration is one of the most promising next-generation solid-state caloric techniques to revolutionize the traditional air-compression technique. The La(Fe,Si)-based materials are recognized as candidates with potential for practical applications. However, flexible strategies to improve the Curie temperature (T) and further achieve the tunable giant magnetocaloric effect (GMCE) still need to be developed.

NIR-responsive CuSe@Fc nanoparticles for photothermal- ferroptosis combination therapy in esophageal cancer.

Esophageal cancer (EC) represents a highly recurrent and aggressive malignancy within the digestive system. However, conventional therapeutic strategies exhibit notable limitations in their clinical applications. Photothermal therapy (PTT), combined with ferroptosis, has attracted considerable attentions, emerging as a promising novel strategy for EC treatment.

A Redox-Sensitive Green Fluorescent Protein (roGFP) Sensing Strategy for Dynamic Analysis of Metal Oxide Nanoparticle-Induced Oxidative Stress.

The induction of oxygen radicals and oxidative stress are major pathways through which nanomaterials cause adverse health effects. Dynamic monitoring of redox processes in living cells exposed to nanomaterials is currently limited due to the inadequacy of conventional methods. Herein, we construct a Grx1-roGFP2 (glutaredoxin 1 fused with redox-sensitive Green Fluorescent Protein 2) protein sensor expressed in Madin-Darby Canine Kidney (MDCK) cells that allows dynamic analysis of metal oxide (MOx) nanoparticle-induced oxidative stress.

Genetic dissection of maize grain moisture content and dehydration rate using high-density bin mapping in a recombinant inbred line population.

Maize (Zea mays L.) grain moisture content (GMC) at harvest is a key determinant of seed preservation, grain quality, and drying costs, with the grain dehydration rate (GDR) playing a critical role in determining GMC. This study focused on understanding the genetic basis of GDR by utilizing a recombinant inbred line population of 310 lines derived from PB80 and PHJ65, assessed across three environments with high-density SNP markers.

Amelioration of metabolic syndrome in high-fat diet-fed mice by total sesquiterpene lactones of chicory modulation of intestinal flora and bile acid excretion.

Chicory ( L.) is a commonly used vegetable in Europe and is also regarded as a plant for both medicinal and edible uses in China. Chicory exhibits a substantial abundance of sesquiterpene lactone compounds within its composition.

Alteration of intestinal microbiota-intestinal barrier interaction interferes with intestinal health after microcystin-LR exposure in Lithobates catesbeianus tadpoles.

There remains uncertainty regarding the influence of microcystin-leucine arginine (MC-LR) on amphibian intestinal health, specifically how MC-LR interferes with intestinal microbiota following exposure to environmental concentrations. In this study, Lithobates catesbeianus tadpoles were exposed to varying MC-LR concentrations (0, 0.5, and 2 µg/L) over a 30-day period.

Relationship between controlling nutritional status (CONUT) and surgical site infection (SSI) following elective foot and ankle surgery.

This study aims to examine whether the preoperative controlling nutritional status (CONUT) score was associated with SSI following elective foot and ankle surgeries. This study retrospectively reviewed adult undergoing elective foot and ankle surgeries in a tertiary university-affiliated hospital between January 2019 and May 2023, and identified who subsequently developed an SSI within 12 months postoperative. CONUT score was calculated from serum albumin, lymphocyte count, and toral cholesterol concentration, and its optimal cut-off value for differentiating SSI risk was determined by the receiver operating characteristic curve.

Comparative analysis of triplanar Chevron osteotomy (TCO) and Chevron osteotomy (CO) for treating mild to moderate hallux valgus via computer simulation and 3D printing: An observational study.

Hallux valgus (HV) deformity, which is characterized by lateral deviation and pronation of the metatarsophalangeal joint, demonstrates complex 3-dimensional challenges, thus prompting the development of various surgical approaches, including traditional Chevron osteotomy (CO) and novel triplanar Chevron osteotomy (TCO). The objective of this study is to determine TCO at various tilt angles by employing 3D printing for ex vivo osteotomy angle simulations and computer modeling to correct deformities across 3 planes, thus aiming to enhance surgical outcomes by preserving or even increasing the length of the first metatarsal and thereby overcoming the limitations of CO. In this study, we collected and analyzed non-weight-bearing CT data from 55 patients (61 feet) with mild-to-moderate hallux valgus, plantar callosities and metatarsalgia from June 2019 to June 2020.

Nano-tentacled interconnected channels organic gel for rapid uranium extraction from seawater.

Due to dwindling terrestrial uranium resources and escalating ecological pressures, the long-term viability of uranium supply has become a critical concern. The immense uranium reserves in seawater present a potential solution, yet extraction technology faces dual challenges of efficiency and adaptability to complex marine environments. Current interconnected porous adsorbents, despite their high flux properties, are limited by low specific surface area and weak mechanical strength, which constrain their effectiveness.

Surface Electromyography-Based Recognition of Electronic Taste Sensations.

Taste sensation recognition is a core for taste-related queries. Most prior research has been devoted to recognizing the basic taste sensations using the Brain-Computer Interface (BCI), which includes EEG, MEG, EMG, and fMRI. This research aims to recognize electronic taste (E-Taste) sensations based on surface electromyography (sEMG).

Dual roles of CD11bCD33HLA-DRCD14 myeloid-derived suppressor cells with a granulocytic morphology following allogeneic hematopoietic stem cell transplantation: from inflammation promoters to immune suppressors within 90 days.

Introduction: Granulocytic myeloid-derived suppressor cells (G-MDSCs) show fast recovery following allogeneic hematopoietic stem cell transplantation (allo-HSCT) constituting the major part of peripheral blood in the early phase. Although G-MDSCs mediate immune suppression through multiple mechanisms, they may also promote inflammation under specific conditions.

Methods: G-MDSCs were isolated from 82 patients following allo-HSCT within 90 days after allo-HSCT, and their interactions with autologous CD3 T-cells were examined.

Investigating the therapeutic mechanism of Jiedu-Quyu-Ziyin Fang on systemic lupus erythematosus through the ERα-miRNA-TLR7 immune axis.

Jiedu-Quyu-Ziyin Fang (JQZF) is a formula that has been empirically used for the treatment of SLE in clinical practice. JQZF has become an approved hospital prescription in China. Fifteen MRL/lpr mice were randomly divided into three groups: Model, JQZF, and JQZF + GC, with five mice in each group.

Highly radioiodine gas capture by 2-mercaptobenzimidazole-functionalized Bi/Mg oxide and effective iodine waste immobilization by etidronic-BiO complex.

The present work prepared a novel BiMgO-2MBD (X = 0.42) material for iodine vapor capture in temperature conditions related to spent nuclear fuel reprocessing and nuclear accidents. BiMgO-2MBD (X = 0.

Comparison of the clinical efficacy of bone grafting and bone grafting combined with guided tissue regeneration in periodontal regenerative therapy: a meta-analysis.

Objective: This study aims to compare the clinical efficacy of simple bone grafting and bone grafting combined with guided tissue regeneration (GTR) in periodontal regenerative therapy.

Methods: The authors systematically searched PubMed, the Web of Science, The National Library of Medicine, the China National Knowledge Infrastructure database and the Wanfang database and collected randomized controlled trials relating to bone graft co-guided tissue regeneration. The retrieval was conducted between January 1990 and December 2022.

Efficacy and safety of lenalidomide in the treatment of B-cell non-Hodgkin lymphoma.

Background: The combination of rituximab and chemotherapy is a first-line treatment for patients with B-cell non-Hodgkin lymphoma. Lenalidomide is an immunomodulatory drug that has shown promising properties and activity in a variety of hematological malignancies. This study evaluated the efficacy and safety of lenalidomide-based regimens in the treatment of B-cell non-Hodgkin lymphoma.

Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair.

Drugs targeting the DNA damage response (DDR) are widely used in cancer therapy, but resistance to these drugs remains a major clinical challenge. Here, we show that SYCP2, a meiotic protein in the synaptonemal complex, is aberrantly and commonly expressed in breast and ovarian cancers and associated with broad resistance to DDR drugs. Mechanistically, SYCP2 enhances the repair of DNA double-strand breaks (DSBs) through transcription-coupled homologous recombination (TC-HR).