Identification of submergence tolerance QTLs/genes during seed germination in 432 rice varieties by GWAS.

Background: Submergence stress is a major obstacle limiting the application of direct seeding in rice cultivation. Therefore, understanding the genetic basis of submergence tolerance in rice is of great significance for identifying favorable genes and developing superior rice varieties. However, few studies have focused on submergence tolerance during seed germination; thus, the genetic basis of submergence tolerance at this stage deserves more attention.

Characterization of IS26-bracketed bla resistance module on IncI1 and IncX1 plasmids in Escherichia coli ST224 isolated from a chicken in China.

Antimicrobial resistance (AMR) poses a significant global health threat, particularly due to increasing bacterial resistance to β-lactam and aminoglycoside antibiotics, primarily mediated by extended-spectrum β-lactamases (ESBLs) and 16S rRNA methylases in Enterobacteriaceae. In this study, a multidrug resistant (MDR) E. coli strain HN257 isolated from chicken belonging to ST224 and serotype O88:H23 was characterized.

Multi-omics analysis of the biological mechanism of the pathogenesis of non-alcoholic fatty liver disease.

Background: Non-alcoholic fatty liver disease (NAFLD) is a type of liver metabolic syndrome. Employing multi-omics analyses encompassing the microbiome, metabolome and transcriptome is crucial for comprehensively elucidating the biological processes underlying NAFLD.

Methods: Hepatic tissue, blood and fecal samples were obtained from 9 NAFLD model mice and 8 normal control mice.

Energy-saving targets and carbon neutrality: A perspective on carbon emissions and carbon substitution in 288 Chinese cities.

Environmental protection is a shared task among nations. In pursuit of its commitment to achieve carbon neutrality by 2060, China has implemented more robust energy-saving targets. This study utilizes panel data from 288 Chinese cities spanning from 2006 to 2020 to examine the policy effects of energy-saving targets on carbon neutrality.

Lactoferrin Is a Potential Activator of the Vitamin D Receptor in Its Regulation of Osteogenic Activities in C57BL/6J Mice and MC3T3-E1 Cells.

Background: Lactoferrin (LF) has been shown to promote bone anabolism, and the vitamin D receptor (VDR) mediates the effects of vitamin D on bone. We hypothesized that LF improves bone health by increasing VDR expression.

Objectives: We sought to determine the role of VDR activation in LF-induced osteogenic activity in vivo and in vitro and the underlying molecular mechanisms.