The relationship between online risk exposure and depression among college students: the multiple mediating effects of emotional security and Suppress Happiness.

Background: The relationship between online risk exposure and depression among college students has aroused great attention in academic and educational circles. This study constructs a structural equation model to examine the role of emotional security and Suppress Happiness in the relationship between online risk exposure and depression among college students.

Methods: A total of 986 Chinese college students (M = 19.

Increased peripheral CD4 lymphocytes promote ketamine-induced abnormal behaviors in mice.

Ketamine (Ket) is a globally widely used injectable anesthetic and recreational drug that can lead to persistent behavioral deficits and induce psychotic states. Immune pathogenesis is believed to play a pivotal role in psychological symptoms and abnormal behavior. However, the role of the immune system, particularly peripheral immune changes, in ketamine-induced behavioral deficits and even psychotic symptoms remains largely elusive.

Frequency and phase noise analysis in the 1550 nm external cavity diode laser with a cat-eye reflector.

A 1550 nm narrow linewidth external cavity diode laser with a cat-eye reflector has been demonstrated. Two silicon etalons are used as spectral filters, and a cat-eye reflector is used to suppress the frequency noise. The linewidth and noise characteristics of the laser are evaluated by using the delayed self-heterodyne interferometer.

Trio Exome Sequencing Reveal Paternal Transmission Bias and Novel Gene Loci in Recurrent Spontaneous Abortion.

To systematically evaluate the contributions of parental and fetal genetic factors in recurrent spontaneous abortion (RSA) through trio-based exome sequencing and transmission disequilibrium test (TDT). We conducted whole-exome sequencing on 31 trios (mother, father, and miscarried fetus) affected by RSA, collected from Nanjing Drum Tower Hospital between March 2021 and December 2023. Using TDT, we analyzed common genetic variants to identify associations with RSA and performed parent-of-origin analysis to assess the independent contributions of paternal and maternal alleles.

Preparation of Highly Antibacterial MXene Nanofiltration Membranes and Investigation of Their Separation Performance.

In this study, polyethersulfone (PES)/sulfonated polyethersulfone (SPES) composite nanofiltration membranes doped with different contents of monolayer titanium carbide nanosheets (TiCT) were prepared by the nonsolvent induced phase inversion (NIPS) method. The effects of TiCT on membrane structure, separation performance and antibacterial activity were investigated systematically. The results demonstrated that the viscosity of the casting solution increased significantly with the increasing content of TiCT.

Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.

Background: The survival of decidual stromal cells (DSCs) at the maternal-fetal interface is critical for maintaining pregnancy. Dysfunction of DSCs is a significant contributor to recurrent spontaneous abortion (RSA), though the precise regulatory mechanisms remain elusive. Here, we report a marked downregulation of fatty acid-binding protein 5 (FABP5) in decidual tissues and DSCs from RSA donors, suggesting its potential role in RSA pathogenesis.

Gene Variants Related to Primary Familial Brain Calcification: Perspectives from Bibliometrics and Meta-Analysis.

The genetic role and specific effects of primary familial cerebral calcification (PFBC) are still unclear. We aim to analyze bibliometric features in studies related to PFBC, investigate variant detection rates in patients with brain calcifications, and examine the phenotypic characteristics of PFBC patients. A comprehensive search of studies on the genetic effects of PFBC up until December 31, 2024, was conducted across Web of Science, PubMed, Embase, and Scopus.

The regulatory role of protein lactylation in various diseases: Special focus on the regulatory role of non-histone lactylation.

Lactylation, an emerging form of post-translational modification derived from lactate, plays a pivotal role in numerous cellular processes such as tumor proliferation, metabolism, inflammation, and embryonic development. However, the precise molecular mechanisms by which lactylation controls these biological functions in both physiological and pathological contexts remain elusive. This review summarizes the latest reported regulatory mechanisms of protein lactylation in various diseases since 2024, introducing the latest research progress regarding the regulatory functions of protein lactylation in pathological processes, with particular attention to the regulatory mechanisms of non-histone lactylation modification in diseases.

Bro p 3, an nsLTP1: The first major allergen identified in Broussonetia papyrifera pollen.

Background: Broussonetia papyrifera pollen is an important cause of allergy worldwide, yet its key allergenic components remain unclear. This study aims to identify and characterize the major allergen of B.papyrifera pollen.

Nanosecond vs Microsecond Pulsed Field Ablation: Lesion Durability and Muscle Contraction in a Canine Model.

Background: A nanosecond pulsed field generator and a circular multielectrode catheter have been introduced.

Objectives: The aim of this study was to compare the durability, safety, and muscle contraction of ablation via microsecond or nanosecond pulsed field ablation (PFA) in canines.

Methods: Under general anesthesia without muscle relaxants, 24 canines were subjected to isolation of the superior vena cava (SVC) and pulmonary veins (PVs) using nanosecond or microsecond PFA.

Molecular mechanism of programmed cell death in drug-induced neuronal damage: A special focus on ketamine-induced neurotoxicity.

In recent years, the abuse of ketamine as a recreational drug has been growing, and has become one of the most widely abused drugs. Continuous using ketamine poses a risk of drug addiction and complications such as attention deficit disorder, memory loss and cognitive decline. Ketamine-induced neurotoxicity is thought to play a key role in the development of these neurological complications.

Ligand Engineering Regulation toward Zn Ions and Zn Substrate for All-Climate Zn Metal Batteries.

The regulation of artificial interphase for advanced Zn anode is an effective solution to achieve superior electrochemical performance for aqueous batteries. However, the deployment of atomically precise architectures and ligand engineering to achieve functionalization-oriented regulatory screening is lacking, which is hindered by higher requirements for synthetic chemistry and structural chemistry. Herein, we have first performed ligand engineering which selected zinc ion trapping ligands (-CH) based on the coordination effect, and zinc substrate binding ligands (-N=N-CH) based on the electrostatic interaction.

Self-Healing Flexible Fiber Optic Sensors for Safe Underwater Monitoring.

The advancement of underwater monitoring technologies has been significantly hampered by the limitations of traditional electrical sensors, particularly in the presence of electromagnetic interference and safety concerns in aquatic environments. Fiber optic sensors are therefore nowadays widely applied to underwater monitoring devices. However, silicon- and polymer-based optical fibers often face challenges, such as rigidity, susceptibility to environmental stress, and limited operational flexibility.

[Application of mind mapping-assisted flipped classroom in clinical endodontics teaching].

Purpose: To explore the application effect of mind mapping-assisted flipped classroom in clinical endodontics teaching.

Methods: A total of 41 fifth-year undergraduates majoring in stomatology from School of Stomatology, Tongji University, finishing their clinical internship at Departments of Endodontics from October 2023 to March 2024, were randomly divided into control group (traditional teaching group, n=21) and experimental group (flipped classroom teaching group, n=20). Theoretical assessments were conducted on the day of entering the department and at the end of eight weeks in the department.

The role of the immune system in Parkinson's disease pathogenesis: A focus on Th17 cells - A systematic review and meta-analysis.

Background: Parkinson's disease (PD) has been linked to T helper 17 (Th17) cells in prior investigations, but the evidence remains inconclusive. To gain a deeper understanding of this potential connection, we conducted a systematic review and meta-analysis.

Methods: A comprehensive search for relevant studies published up to July 8, 2023, was performed across PubMed, EMBASE, and Cochrane Library databases.

Assessment of the efficacy of autologous blood preparations in maxillary sinus floor elevation surgery: a systematic review and meta-analysis.

Objective: This study aimed to evaluate the efficacy of autologous blood preparations, namely Platelet-Rich Plasma (PRP), Platelet-Rich Fibrin (PRF), and Concentrated Growth Factor (CGF), in maxillary sinus floor elevation surgery. The focus was on their impact on new bone formation, maxillary sinus floor height, and soft tissue healing.

Methods: A systematic search was conducted across PubMed/MEDLINE, Web of Science, Embase, and Scopus databases up to April 2024.

Forensic toxicological studies of acute glufosinate poisoning: A case series.

Glufosinate is a widely and increasingly used non-selective, broad-spectrum herbicide. Although cases of glufosinate poisoning are frequently reported, they are rarely documented in forensic case reports, particularly in fatal instances. The present study examined six cases of glufosinate poisoning, including a fatal case involving a 25-year-old female found deceased by the roadside, with an empty 1000 mL bottle labeled "glufosinate" by her side.

Accuracy of expanded noninvasive prenatal testing for maternal copy number variations: A comparative study with CNV-seq of maternal lymphocyte DNA.

Objective: To evaluate the accuracy of expanded noninvasive prenatal testing (NIPT) for maternal copy number variations.

Materials And Methods: Expanded NIPT was used to detect CNVs ≥2 Mb at a whole-genome scale. The threshold of maternal deletion was copy numbers (CN) ≤ 1.

Associations of serum lead, cadmium, and mercury concentrations with all-cause and cause-specific mortality among individuals with cardiometabolic multimorbidity.

Epidemiological evidence indicates an association between exposure to toxic metals and the occurrence of cardiometabolic diseases (CMDs). However, the impact of exposure to harmful metallic elements, such as lead (Pb), cadmium (Cd), and mercury (Hg), on mortality in individuals with cardiometabolic multimorbidity (CMM) remains uncertain. Therefore, in this study, we analyzed data from 4139 adults diagnosed with CMM from the National Health and Nutrition Examination Survey 1999-2016.

The role of serum chloride ion in the prognosis of COPD.

Background: As exacerbations of chronic obstructive pulmonary disease (COPD) are one of the leading causes of hospitalization and are associated with significant mortality, it is particularly important to accurately assess the risk of exacerbations in COPD. Most of the current clinical biomarkers are related to inflammation and few consider how ion levels affect COPD. Chloride ion, the second most abundant serum electrolyte, has been shown to be associated with poor prognoses in several diseases, but their relationship with COPD remains unclear.