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Article Abstract
Pyrrolidine aminal skeletons are found in many natural products and biologically active compounds. Therefore, the development of a new methodology for rapid access to this core is of high importance. Herein, we first reported results of a Pd(0)-catalyzed three-component hydroamidation/Heck/Tsuji-Trost reaction to afford fluorinated 3-pyrroline aminal derivatives based on β-CF-1,3-enynamides.
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Synthesis of Fluorinated 3-Pyrroline Aminals by a Pd(0)-Catalyzed Three-Component Hydroamidation/Heck/Tsuji-Trost Reactions.
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Pyrrolidine aminal skeletons are found in many natural products and biologically active compounds. Therefore, the development of a new methodology for rapid access to this core is of high importance. Herein, we first reported results of a Pd(0)-catalyzed three-component hydroamidation/Heck/Tsuji-Trost reaction to afford fluorinated 3-pyrroline aminal derivatives based on β-CF-1,3-enynamides.
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