Correction: The composition and predictive function of the fecal microbiota in female donkeys across different reproductive cycles.

[This corrects the article DOI: 10.3389/fmicb.2025.

Neurofibromatosis type 2 misdiagnosed as amblyopia-a case report and literature review.

Neurofibromatosis type 2 (NF2) is characterized by bilateral vestibular schwannomas, and approximately 40-70% of affected children show ophthalmological involvement. Ophthalmological features may be the first sign of NF2; however, the symptoms associated with ocular lesions are diverse. The onset of NF2 is often obscure, resulting in missed or misdiagnosed cases.

Risk factors and predictive model for mortality in acute myocardial infarction with ventricular septal rupture at high altitudes.

Background: Acute myocardial infarction (AMI) combined with ventricular septal perforation (VSR) is still a highly fatal condition in the era of reperfusion therapy. The incidence rate has decreased to 0.2%-0.

In Silico Identification of Novel Compounds as Anthelmintics Against Through Inhibiting β-Tubulin Isotype 1 and Glutathione S-Transferase.

Haemonchosis caused by the parasitic worm is a major threat to cattle and other ruminants and imposes significant economic losses in the livestock industry. Different medications have been reported; however, these are not reliable now due to mass drug resistance. The current study investigates potential inhibitors of two proteins: glutathione S-transferase (GST) and beta-tubulin isotype 1.

Anti-inflammatory and gut modulating effects of donkey whey protein in dextran sodium sulfate-induced colitis mice: Insights from the various processing methods.

Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), presents therapeutic challenges due to the limitations and side effects of current treatments, creating a need for safer and more effective alternatives. Despite several studies on the health benefits of donkey milk, its specific impact on UC remains unsolved. This study investigates the therapeutic potential of donkey whey protein (DWP), a bioactive-rich functional food, in alleviating UC symptoms in a mouse model of dextran sodium sulfate-induced colitis.

The composition and predictive function of the fecal microbiota in female donkeys across different reproductive cycles.

The microorganisms residing in the gastrointestinal tract of monogastric herbivores play a vital role in nutrient absorption and maintaining the host's health. However, the quantitative and functional establishment of these microorganisms in female donkeys across different reproductive cycles has not yet been examined. Knowledge regarding the composition and function of gut microbiota in female donkeys during different reproductive cycles remains limited.

Biomechanical Analysis and Clinical Study of Augmented Versus Conventional Endoscopic Orbital Decompression for Dysthyroid Optic Neuropathy.

Dysthyroid optic neuropathy (DON) represents a severe ocular complication in thyroid eye disease (TED) that can lead to vision loss. Although surgical decompression is a well-established treatment modality, the optimal decompression area remains controversial in orbital decompression surgery. This study aims to develop and validate a finite element analysis (FEA) model of DON to compare the biomechanical behavior between patients undergoing conventional or augmented orbital decompression surgery, with potential clinical implications for surgical planning.

Radiotherapy-induced changes in corneal morphology and biomechanics in myopathic thyroid eye disease.

Purpose: To assess differences in corneal morphology and biomechanics between patients with myopathic thyroid eye disease (TED) and normal controls (NCs), as well as to evaluate these changes following radiotherapy.

Methods: Patients with active myopathic TED and age-, sex-, and spherical equivalent-matched NCs were enrolled in this study. All patients underwent radiotherapy and were followed up for 6 months post-treatment.

Large-scale survey, animal models, and computational modeling identify histological neurodegenerative biomarkers for traumatic optic neuropathy.

BACKGROUNDTraumatic optic neuropathy (TON) is a leading cause of blindness following closed traumatic brain injury, with no effective treatments available. Previous interventional clinical trials were complicated by its low prevalence, variability in neurodegenerative severity, and unavailability of reliable biomarkers.METHODSWe analyzed data from 1,226 patients enrolled in the prospective National Multi-Center Collaborative Clinical Research Program of China (2017-2024) to establish a clinical profile and identify noninvasive biomarkers for neurodegenerative severity.

Investigation of the structural, functional, and digestive properties of beta-casein from cow, goat, and donkey milk.

This study aimed to investigate the genotypes, structures, physicochemical properties, in vitro antioxidants, and digestive properties of isolated goat, donkey, and cow β-casein (β-CN). The β-CN genotypes of goats and donkeys are not cow type A1 β-CN, avoiding the unfavorable effects on intestinal digestion of BCM-7, a peptide fragment produced by the digestion of cow type A1 β-CN from bovine milk. Goat and donkey β-CN exhibited a smaller particle size, a more stable solution system, a looser secondary structure, and better solubility than cow β-CN.

Grapefruit Extracellular-Vesicle-Derived Nanodrug Loading Three-Functional Platinum(IV) Conjugates with Enhanced Targeting and TME Modulating Properties.

Grapefruit extracellular vesicle (GEVs) derived nanodrug Tf-GEVs@Pt(IV) loading novel three-functional platinum(IV) conjugates was developed, which was effective in modulating the inflammatory, fibrotic, and immunosuppressive tumor microenvironment (TME). The GEVs enhanced the penetration of Tf-GEVs@Pt(IV) into tumor tissues, while the transferrin (Tf) moiety further improved the tumor-targeting capabilities. The active ingredient, platinum(IV) conjugate, was released in a sustained manner within the TME, which was easily reduced to platinum(II), aspirin (ASP), and captopril (CTP) fragments.

Fermented banana feed and nanoparticles: a new eco-friendly, cost-effective potential green approach for poultry industry.

The quest for sustainable, alternative, and cost-effective biofeed resources has been driven by the increasing costs and environmental concerns linked to conventional poultry feed. The banana plant (Musa spp.), traditionally valued for its fruit, is gaining recognition as a versatile and sustainable resource for the livestock and poultry industry.

Characterization and Discrimination of Volatile Compounds of Donkey and Horse Meat Based on Gas Chromatography-Ion Mobility Spectrometry.

The production of high-quality specialty meats has emerged as a prominent research focus within the livestock industry, under the broader concept of big food. However, the composition and variances of volatile compounds (VOCs) in donkey meat (DM) and horse meat (HM) remain unclear, which complicates their effective identification. In the present study, the VOCs of DM and HM were analyzed using gas chromatography-ion mobility spectrometry (GC-IMS) in combination with a multivariate analysis.

Methionine Alters the Fecal Microbiota and Enhances the Antioxidant Capacity of Lactating Donkeys.

This study looked at how methionine (Met) affects on serum biochemical indicators, antioxidant indicators, and the fecal microbiota of lactating donkeys. A total of 18 healthy donkeys at the mid-lactation stage were used in this study. They were given concentrate meals with varying concentrations of Met after being randomly split into three groups: Met group I (M1) received 5 g/d of Met, Met group II (M2) received 15 g/d of Met, and the control group (C) received 0 g/d of Met.

The Milk Compositions and Blood Parameters of Lactating Dezhou Donkeys Changes With Lactation Stages.

The aim of this study was to investigate the changes in milk compositions and blood parameters of Dezhou donkeys during the lactation. Milk and serum samples from six lactating Dezhou donkeys were collected at 1, 30, 60, 90, 120, 150 and 180 days of lactation. The results displayed that the milk yield during the lactation first increased and then gradually decreased, with the peak milk production period of 30-60 days after parturition.

Exploring cytochrome P450 under hypoxia: potential pharmacological significance in drug metabolism and protection against high-altitude diseases.

High-altitude hypoxia affects the human respiratory, central nervous, cardiovascular, and endocrine systems. These outcomes affect the expression of cytochrome P450 (CYP), the most important family of metabolic enzymes in the body that is involved in the metabolism of both exogenous and endogenous substances (such as arachidonic acid, vitamins, and steroids). Hypoxia influences CYP expression and activity, mediating changes in drug and endogenous substance metabolism, with endogenous metabolites playing a significant role in controlling high-altitude diseases.

Pharmacokinetics of Midazolam in Plasma and Brain Tissue of Rats after Exposure to Acute and Chronic High Altitude Hypoxia.

Tian, Lu, Guiqin Liu, Qin Zhao, Junjun Han, Yue Lin, Qian Wang, Qiangqiang Jia, Delong Duo, Duan Yabin, Zhu Junbo, and Li Xiangyang. Pharmacokinetics of midazolam in plasma and brain tissue of rats after exposure to acute and chronic high altitude hypoxia. 26:273-282, 2025.

Aflatoxin B1-Induced Apoptosis in Donkey Kidney via EndoG-Mediated Endoplasmic Reticulum Stress.

Aflatoxin B1 (AFB1) is a prevalent environmental and forage contaminant that poses significant health risks to both humans and livestock due to its toxic effects on various organs and systems. Among its toxicological effects, nephrotoxicity is a hallmark of AFB1 exposure. However, the precise mechanisms underlying AFB1-induced kidney damage in donkeys remain poorly understood.

Artificial intelligence-assisted enhancement of prostate volume metrics in the diagnosis of clinically significant prostate cancer: a retrospective analysis.

Background: Although artificial intelligence (AI) algorithms provide reliable prostate volume (PV) measurements across various magnetic resonance imaging devices, their impact on prostate cancer risk stratification for patients with a Gleason score of 6 remains unclear. This study aimed to evaluate the benefits of integrating AI-derived PV and transitional or peripheral zone volume (TZV/PZV) measurements with clinical factors to improve prostate-cancer risk stratification.

Methods: Our retrospective cohort included 560 patients with biopsy-confirmed Gleason score 6, stratified based on the outcome of radical prostatectomy as clinically significant prostate cancer (csPC) and clinically insignificant prostate cancer (insPC).

Equine Herpesvirus-1 Induced Respiratory Disease in Dezhou Donkey Foals: Case Study from China, 2024.

Equine herpesvirus-1 (EHV-1) is a significant pathogen that causes substantial economic losses in the equine industry worldwide, which leads to severe respiratory diseases and abortions in horses. However, reports of EHV-1 infection in donkeys are limited, particularly in China. This case study reported an EHV-1-induced respiratory disease in Dezhou donkey foals in Shandong Province, China, in July 2024.

Pullulan fermented by Aureobasidium melanogenum TZ-FC3 for the preparation of self-healing, adhesive, injectable and antibacterial pullulan/PVA/borax hydrogel.

Natural polymer hydrogels, such as pullulan-based hydrogels, offer significant advantages over synthetic materials due to their thermal stability, film-forming capacity, solubility, adhesiveness, and antioxidant properties. In this study, the strain Aureobasidium melanogenum TZ-FC3, which produces a high level of pullulan, was successfully isolated from the mangrove ecosystems of Guangdong Province, China. 66.

Fermented residue improved milk performance of lactating donkeys by enhancing antioxidant capacity and regulating metabolism.

The fermented residue (FCPR) has a promoting effect on animal health, but it has not been studied in livestock feed. This study investigated the effects of FCPR addition on the milk performance, milk metabolites, and blood biochemical parameters and metabolites of lactating donkeys. Twelve healthy multiparous lactating Dezhou donkeys were randomly divided into two groups (with 6 donkeys in each group): control group (without FCPR, C) and FCPR group (200 g of FCPR per head per day, FF).

Causal correlations between inflammatory proteins and heart failure: A two-sample Mendelian randomization analysis.

Aims: Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation-related proteins and HF risk remains unclear. This study aims to investigate the genetically supported causality between inflammatory proteins and HF using a two-sample Mendelian randomization (MR) analysis.

Effects of Methionine on Milk Performance and Milk Constituents of Lactating Donkeys.

This study investigated the effects of adding methionine (Met) in milk production and the milk and blood metabolites of lactating donkeys. Eighteen healthy multiparous donkeys in early-stage lactation were selected for this study. The donkeys were randomly divided into three groups and fed diets with different levels of Met: control group (C, Met 0 g/d), Met group I (M1, Met 5 g/d), and Met group II (M2, Met 15 g/d).