In situ ischemic postconditioning for acute ischemic stroke: preliminary exploratory study.

Background: Endovascular therapy within 24 hours of stroke onset is effective and safe, but successful recanalization does not always give favorable outcomes. Ischemic postconditioning (IPostC), a reperfusion strategy with potential neuroprotective effects, has been extensively studied in preclinical models, but its impact in humans remains unclear. Building on a previous dose escalation study, we aimed to investigate the effect of in situ IPostC on infarct volume in patients with acute ischemic stroke following mechanical thrombectomy.

Improved preoperative planning for endovascular therapy: High-resolution vessel wall magnetic resonance imaging shows promise in identifying proximal occlusion site and distal boundary of the occlusion of acute ischemic stroke.

Background And Purpose: Detecting the proximal occlusion site (POS) and distal boundary of the occlusion (DBO) of arterial occlusion is very important for the prognosis of endovascular treatment. Recent studies have shown that magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) are also beneficial for preoperative patient selection for endovascular therapy. High-resolution vessel wall MRI (HRVW-MRI) for intraluminal detection of arterial largevessel occlusions (LVOs) is receiving increasing attention.

Mo-doped and vacancy-rich NiP@NC anode: A dual-strategy approach to high-capacity and long cycle life sodium-ion batteries.

The development of high-performance anode materials for sodium-ion batteries (SIBs) remains critical to overcome the limitations of lithium-ion technologies. In this work, Mo-doped NiP encapsulated in nitrogen-doped carbon (Mo-NiP@NC) SIB anodes with nanosheet-stacked porous architectures through a solvothermal and chemical vapor deposition (CVD) approach were synthesized. X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses confirmed lattice expansion due to Mo substitution.

Comparing Multi-Value Diffusion MRI Models for Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer.

Background Multi-value diffusion MRI models have been used to predict pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) for breast cancer. However, there is a lack of longitudinal comparative research. Purpose To compare the performance of various diffusion MRI-derived longitudinal parameters during NAC for prediction of pCR in breast cancer.

Construction of Ultrafine Bimetallic Mn-Fe Phosphide Embedded in Nitrogen-Doped 3D Carbon Shells and the Excellent Na-Ion Storage Performance.

Transition-metal phosphides (TMPs) possess high theoretical capacity and voltage, which make them promising candidates for anode materials in sodium-ion batteries (SIBs). However, TMP anode materials face challenges such as significant volume expansion and poor conductivity. In this study, we synthesized nanobimetallic manganese-iron phosphide (MnFeP@NC) encapsulated in hollow nitrogen-doped carbon shells using a two-step method.

MXene-Supported Ru-Ni: A Common Active Site for Hydrolysis, Hydrogen Oxidation, and Hydrogenation.

Insights into the activation and conversion of hydrogen using a single-mode catalyst are crucial for advancing fuels and fine chemical production. In this paper, the activation and conversion of H molecules in hydrogen production and application were investigated on RuM (M = Ni, Co, Cu, Fe)-MXene catalysts. RuM (M = Ni, Co, Cu, Fe) bimetallic nanoclusters were uniformly distributed on TiC MXene.

Protocol for a prospective 1-year follow-up investigation on normobaric hyperoxia in conjunction with endovascular treatment for acute ischemic stroke (OPENS-2L) trial.

Introduction: Ongoing research endeavors seek to identify neuroprotective drugs capable of mitigating brain cell necrosis and reperfusion injury by protecting the ischemic penumbra. Despite these efforts, the quest for effective neuroprotective agents remains elusive. Encouragingly, preliminary investigations, including basic experiments and single-center exploratory studies, have demonstrated the neuroprotective properties of normobaric hyperoxia (NBO).

Outcomes of Endovascular Treatment in Patients With Vertebrobasilar Artery Occlusion Beyond 24 Hours.

Importance: The efficacy and safety of endovascular thrombectomy (EVT) plus best medical treatment (BMT) for vertebrobasilar artery occlusion beyond 24 hours remain uncertain.

Objective: To evaluate outcomes associated with EVT in patients treated beyond 24 hours after last known well time due to vertebrobasilar artery occlusion.

Design, Setting, And Participants: This multicenter, prospective cohort study enrolled patients between 2019 and 2024 from 11 comprehensive stroke centers across China.

Co-Based Dual-Metal Phosphides on P-Activated Nickel Foam for Enhanced Hydrogen Generation from Ammonia Borane.

Cobalt-based monolithic phosphides are an attractive approach due to their stability and corrosion resistance properties for catalytic reactions. Herein, phosphourous -induced Co-based dual active sites phosphides (CoP-NiP-NC) are fabricated on phosphourous-activated nickel foam (P-NF) through the phosphorization method. The results confirm the uniform growth of CoP-NiP nanoparticles (NPs) with octahedral morphology embedded in the carbon-nitrogen matrix.

Nickel-iron alloy films electrodeposited from metal salt-l-serine deep eutectic solvent for alkaline oxygen evolution reaction.

Active and stable electrocatalysts for oxygen evolution reaction (OER) is crutial in the widespread application of hydrogen production from water electrolyzers. Here, deep eutectic solvents formed from metal chlorides and l-serine are utilized as the electrolyte to deposit metal films (Ni, Fe, and Ni-Fe alloys) under potentiostatic conditions onto nickel foam (NF) substrate. The deposited films are characterized, and the Ni-Fe alloy films constituting of nanometer-sized crystalline regions.

The Mechanism of Traditional Chinese Medicine and Natural Medicine in Treating Chronic Obstructive Pulmonary Disease.

Ethnopharmacological Relevance: Chronic obstructive pulmonary disease (COPD) is one of the crucial chronic diseases that seriously endangers the health of residents in China. There is a complex mechanism of the pathogenesis of COPD, and no specific drugs are currently available to reverse the progressive decline in lung function during the natural course of COPD. Traditional Chinese Medicine (TCM) not only alleviates clinical symptoms, but also leads to fewer adverse reactions.

Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.

Introduction: Adenovirus (Ad) vectors are widely used for gene delivery, and some of them have been approved for vaccine development. In particular, the recombinant COVID-19 vaccine for inhalation, which was developed using adenovirus type 5 (Ad5), represents a milestone in respiratory immunization. Owing to the high pre-existing immunity (PEI) to Ad5, the development of an adenoviral vector with lower PEI and higher immunogenicity has been explored.

Improved antibacterial activity of a sustained-release biocompatible nanofilm for treating wound infection and .

Objectives: The primary goal of this research was to design a useful and biocompatible nanofilm system (CNF) encapsulating chlorhexidine acetate (CHX) for wounds that is endowed with antibacterial and anti-inflammatory activities and promotes wound healing.

Methods: The nanofilm system was developed on the basis of the successful preparation of its nanoemulsion and PVA-CS film system and then important properties of the nanofilm system, including its morphological and physicochemical characteristics, stability and safety, its antimicrobial efficacy against was also evaluated and . The antibacterial effect, wound healing effect and inflammatory factor change were evaluated.

Lignocellulose-Derived Energy Materials and Chemicals: A Review on Synthesis Pathways and Machine Learning Applications.

Lignocellulose biomass, Earth's most abundant renewable resource, is crucial for sustainable production of high-value chemicals and bioengineered materials, especially for energy storage. Efficient pretreatment is vital to boost lignocellulose conversion to bioenergy and biomaterials, cut costs, and broaden its energy-sector applications. Machine learning (ML) has become a key tool in this field, optimizing pretreatment processes, improving decision-making, and driving innovation in lignocellulose valorization for energy storage.

Salt-free clean dyeing of cotton fabrics by reactive dye/cationic nanoparticle to obtain dark-coloured fabrics.

The conventional dyeing processes employed to obtain dark-coloured fabrics necessitate the utilisation of substantial quantities of dyes, a limitation that is further compounded by the existence of dyeing saturation. To address these issues, a novel reactive dye/cationic nanoparticle is proposed. The effects of the synthesis process of reactive dyes/cationic nanoparticle on particle size, zeta potential, dispersion stability and K/S value were investigated.

The Effects of Testosterone on Cervicovaginal Cytology in Transgender and Gender-Diverse Individuals.

Background: The Papanicolaou (Papanicolaou) test is an effective and widely used cervical cancer screening procedure. Recommendations for cervical cancer screening do not incorporate patients' gender identities nor gender-affirming hormone statuses in determining screening surveillance intervals and interpreting test results. This study assessed the association between testosterone and rates of abnormal Papanicolaou specimens and specimen adequacy by comparing testosterone-associated Papanicolaou specimens and nontestosterone Papanicolaou specimens among transgender and gender-diverse (TGD) patients.

Electrodeposited P-Doped CuNi Alloy from Deep Eutectic Solvent for Efficient and Selective Nitrate-to-Ammonia Electroreduction.

Electrochemical nitrate reduction reaction (NORR) offers a promising alternative for ammonia production using electricity generated from renewable energy sources. Active electrocatalysts with high selectivity and high yield are required to selectively catalyze NORR to ammonia. Here, P-doped CuNi alloy thin films are electrodeposited from a deep eutectic solvent of choline chloride-ethylene glycol (ChCl/EG).

A comprehensive study on the impact of L. fruit polysaccharide on myocardial fibrosis through animal experiments, network pharmacology and molecular docking.

Background: Myocardial fibrosis (MF) is a prevalent pathological condition associated with various heart diseases, such as heart failure and arrhythmias, which disrupt electrical signals and reduce pumping efficiency. This research explored the therapeutic effects and potential mechanisms of L. fruit polysaccharide (LVFP) on MF.

Monomolecule Coupled to Oxygen-Doped Carbon for Efficient Electrocatalytic Hydrogen Peroxide Production.

The electrocatalytic production of hydrogen peroxide (HO) is an ideal alternative for the industrial anthraquinone process because of environmental friendliness and energy efficiency, depending on the activity and selectivity of catalysts. Carbon-based materials possess prospects as candidate catalysts for the production of HO. Herein, cedar-derived monolithic carbon catalysts modified with coupling oxygen doping and phthalocyanine molecules are synthesized.

Challenges and Prospects of Catalyst Design and Environmental Applications for On-Site Hydrogen Peroxide Production via Diverse (Photo)Electrochemical Reaction Pathways.

Hydrogen peroxide (HO) is an environmentally friendly and efficient oxidant with diverse applications in the chemical industry, medicine, energy, and environmental protection. While the anthraquinone oxidation process has traditionally dominated industrial HO production, its complexity and high pollution levels present significant challenges. In response, alternative methods such as electrochemical, photochemical, and photoelectrochemical pathways have emerged, providing greener and more sustainable solutions.

Normobaric hyperoxia combined with endovascular treatment for acute ischaemic stroke in China (OPENS-2 trial): a multicentre, randomised, single-blind, sham-controlled trial.

Background: Endovascular treatment improves the recanalisation rate for patients with acute ischaemic stroke; however, even with endovascular treatment, approximately half of patients do not have a favourable functional outcome. We aimed to evaluate the effect of normobaric hyperoxia combined with endovascular treatment on functional outcomes up to 90 days after treatment in patients who had an acute ischaemic stroke with large-vessel occlusion.

Methods: In this multicentre, randomised, single-blind, sham-controlled trial, patients aged 18-80 years presenting within 6 h of acute ischaemic stroke attributed to large-vessel occlusion in anterior circulation, who were candidates for endovascular treatment, were recruited from 26 comprehensive stroke centres in China.

Risk of All-Cause Mortality in Mild Chronic Obstructive Pulmonary Disease: Evidence From the NHANES III and 2007-2012.

Background: It is unclear whether patients with Global Initiative for Chronic Obstructive Lung Disease stage 1 (mild) chronic obstructive pulmonary disease (COPD) have a higher risk of all-cause mortality than participants with normal spirometry results.

Methods: We used the data from the National Health and Nutrition Examination Survey (NHANES) III and 2007-2012, which included participants aged 20-79 years, to investigate whether patients with mild COPD (whole population and subgroups) have a higher risk of all-cause mortality than participants with normal spirometry. Mild COPD was defined as prebronchodilator forced expiratory volume in 1 second /forced vital capacity <0.

Methods for modeling gestational weight gain: empirical application using electronic health record data from a safety net population.

Background: Understanding the risks and effects of gestational weight gain (GWG) is a prominent area of perinatal research but approaches for quantifying GWG are evolving and remain underdeveloped, especially in clinical settings for underserved demographic subgroups. To fill this gap, we demonstrated and compared six GWG metrics across pre-pregnancy BMI classifications: total GWG, trimester-specific linear rate of GWG, adherence to total and trimester-specific recommendations, area under the curve, and GWG for gestational age z-scores.

Methods: We used clinical data on 44,801 pregnant people from community-based health care organizations with extensive longitudinal measures and substantial representation of understudied subgroups.

Lipoprotein(a) is Associated with Sarcopenia in Patients with Type 2 Diabetes: A cross-Sectional Study.

Background: The association between lipoprotein(a) (Lp(a)) and sarcopenia in T2DM patients of general age is unclear, and whether this association differs by sex remains uncertain. We intend to analyze the association between Lp(a) and sarcopenia in patients with type 2 diabetes mellitus (T2DM) and whether this association differs by sex.

Methods: T2DM patients between December 2021 and December 2022 were consecutively enrolled.

Chromium Oxide Nanoparticles Anchored in Hydrogel-Derived Three-Dimensional N-Doped Porous Carbon Anode Materials as Lithium-Ion Batteries.

Transition metal oxides (TMOs) have been identified as the most promising anode materials for lithium-ion batteries (LIBs). However, these materials tend to undergo volumetric expansion during battery operation, which disrupts their internal structure and ultimately leads to a degradation of battery performance. CrO/N-doped porous carbon (CrO@NC) composites were successfully synthesized through high-temperature calcination using CrO-containing hydrogels as precursors.