Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objectives: The primary goal of this research was to design a useful and biocompatible nanofilm system (CNF) encapsulating chlorhexidine acetate (CHX) for wounds that is endowed with antibacterial and anti-inflammatory activities and promotes wound healing.
Methods: The nanofilm system was developed on the basis of the successful preparation of its nanoemulsion and PVA-CS film system and then important properties of the nanofilm system, including its morphological and physicochemical characteristics, stability and safety, its antimicrobial efficacy against was also evaluated and . The antibacterial effect, wound healing effect and inflammatory factor change were evaluated.
Results: These results of this nanofilm system revealed a good particle size (59.27 nm) and stable zeta potential (-15.2 mV) that are suitable for wound healing applications. Additionally, it was stable, exhibited long-term stability (24 months) and sustained release in simulated wound fluid. Results showed that this nanofilm does not induce dose-related toxic effects and displays a better antibacterial effect that occurs more quickly, two times greater than that of CHX . This safe nanofilm enhances antibacterial activity against for 14 days, modulates the immune response, and accelerates skin wound healing .
Conclusions: These insights into multifunctional nanofilm designs for improved antibacterial effects and sustained release suggest promising clinical applications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015611 | PMC |
| http://dx.doi.org/10.3389/fmicb.2025.1548106 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Circularly Polarized Light Emission From Single Chiral Hedgehog Particles Coated with Nanofilms of Achiral Perovskites.
Adv Mater
September 2025
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Metal-halide perovskites are known for their strong and tunable luminescence. However, the synthesis of perovskite-based particles with circularly polarized light emission (CPLE) remains challenging due to the complex interplay of metal-ligand chemistries, crystallization patterns, and chirality transfer mechanisms. Achiral perovskites can be deposited on chiral "hedgehog" particles (CHIPs) with twisted spikes, producing chiroptically active materials with spectroscopic bands specific to the perovskite and chirality specific to the template CHIPs.
View Article and Find Full Text PDFPrussian blue nanofilm-sensitized plasmonic electrochemical microscopy for spatially resolved detection of the localized delivery of hydrogen peroxide.
Sens Actuators Rep
December 2024
Department of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, CA, USA.
Hydrogen peroxide (HO) sensing has been widely investigated using various electrochemical methods, yet the challenge of finding an imaging technique capable of real-time, spatially resolved detection remains. Addressing this, we introduce a Prussian blue (PB) nanofilm-sensitized plasmonic electrochemical microscopy (PEM) technique that successfully visualizes the localized delivery of HO. The PB nanofilm was carefully characterized, and its sensing capability towards HO was demonstrated in amperometric mode.
View Article and Find Full Text PDFVibrational sum frequency generation spectroscopy reveals the inertness of chromium oxide (001) surfaces.
J Colloid Interface Sci
August 2025
Pacific Northwest National Lab, Physical and Computational Sciences Directorate, Richland, WA 99354, United States. Electronic address:
Nanoengineered metal oxides such as Cr(III)-oxide (chromia) films have diverse potential applications in corrosion inhibition, remediation, energy generation, catalysis, data storage, and biological and environmental systems. Concerns about material degradation or oxidation to toxic chromate necessitate an understanding of chromia/aqueous interfaces, beginning with their hydroxylation and hydration behavior. Vibrational sum-frequency generation spectroscopy (vSFG) provides specific molecular-level information about water at the oxide/aqueous junction with high surface selectivity.
View Article and Find Full Text PDFHigh-Frequency Electric Field-Induced Polarization Response in Barium Titanate Thin Films.
ACS Appl Mater Interfaces
August 2025
Department of Materials Science and Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
We used molecular dynamics simulations to investigate the frequency-dependent polarization-electric field (-) response of BaTiO nanofilms for in-plane and out-of-plane field/film orientation. Our study reveals that the polarization direction (in-plane or out-of-plane) of thin films profoundly impacts polarization-switching behavior across a broad frequency range. Out-of-plane polarized films exhibit rather distinct behavior at all frequencies compared to in-plane polarized films and bulk BaTiO.
View Article and Find Full Text PDFMultifunctional Amyloid-Like Porous Nanofilm-Decorated Transistor-Based Biosensor for Accurate Detection of Alzheimer's Disease Biomarker.
Anal Chem
August 2025
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China.
The high sensitivity of field-effect transistor (FET) biosensors has made them a valuable tool for detecting low abundance biomarkers in AD diagnosis, but it faces ongoing challenges, particularly in their susceptibility to interference from complex sample matrices. Here, an amyloid-like nanofilm was introduced as an intermediate layer to enhance the antifouling ability and sensitivity of FET biosensors in complex systems. This nanofilm serves a dual purpose: due to the size-selective mechanism of the amyloid-like nanofilm, which prevents interference from nonspecific proteins, the proposed biosensor exhibited enhanced stability and antifouling capability in complex samples (nonspecific response of less than 5%).
View Article and Find Full Text PDF