Efficacy and Safety Analysis of Transarterial Chemoembolization Combined with Sintilimab Plus Bevacizumab Biosimilar in the Treatment of Unresectable Hepatocellular Carcinoma.

Background: Transarterial chemoembolization (TACE) remains a cornerstone for unresectable hepatocellular carcinoma (uHCC) but is limited by tumor progression. Combining TACE with systemic therapies may enhance efficacy. Notably, sintilimab combined with bevacizumab biosimilar has shown synergistic effects in tumor control and has been incorporated into the first-line treatment regimen in China.

Combined use of vitamin C and antifolates induces cuproptosis-like bacterial death.

Combined use of antimicrobial agents is a key strategy to combat antimicrobial resistance. After several decades of approval, clinical application of the classical combination co-trimoxazole has gradually become limited, mainly due to the prevalence of resistance. Vitamin C is a natural antimicrobial and redox agent.

Association of a Serum Uric Acid-Related Dietary Pattern with Metabolic Syndrome Among Guangzhou Children Aged 9-17 Years: A Cross-Sectional Study.

Childhood metabolic syndrome (MetS) represents a growing public health concern in China, with diet emerging as a critical modifiable risk factor. Although numerous studies have explored the relationship between dietary patterns and MetS, the specific influence of dietary patterns associated with serum uric acid (SUA) levels in the young population remains poorly understood. The purpose of this study is to investigate the relationship between an SUA-related dietary pattern and MetS risk among children aged 9-17 years in Guangzhou, China.

Stepwise degradation of bisphenol A into various monocyclic aromatic hydrocarbons by a P450 enzyme BisdB in Sphingobium yanoikuyae GDP.

Bisphenol A (BPA) is a frequently used endocrine-disrupting chemical widely distributed in the environment, necessitating effective removal strategies. This study aimed to isolate and characterize a highly efficient BPA-degrading bacterial strain, Sphingobium yanoikuyae GDP, and to elucidate the enzymatic degradation pathways of BPA mediated by the P450 enzyme BisdB, including the identification of novel metabolites using C stable isotope-assisted untargeted liquid chromatography-tandem mass spectrometry. In this study, a BPA-degrading microbial community, D45, was isolated from contaminated soil and degraded 400 mg L of BPA within 24 h.

Whether Adjuvant TACE Plus TKI Therapy is More Effective Than TACE Alone in HCC Patients at High Risks of Recurrence Following Radical Hepatectomy.

Purpose: To compare the efficacy and safety of postoperative adjuvant therapy with transarterial chemoembolization (TACE) plus tyrosine kinase inhibitor (TKI) (TPT) versus TACE alone in hepatocellular carcinoma (HCC) patients at high risks of recurrence after radical hepatectomy.

Patients And Methods: We retrospectively analyzed 264 HCC patients who underwent radical hepatectomy (R0 resection) between August 2016 and August 2023. To mitigate selection bias, propensity score matching (PSM) was employed.

Roles of inflammatory cytokines in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure and CAR-T therapy.

Objective: To investigate the association between inflammatory cytokines and liver function indices in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients and chimeric antigen receptor (CAR) T therapy recipients, with the aim of identifying prognostic biomarkers and elucidating the pathophysiological roles of inflammatory cytokines in HBV-ACLF.

Methods: This retrospective cohort study analyzed clinical data from three groups: 68 patients with confirmed HBV-ACLF, 30 patients with pre-HBV-ACLF, and 372 hematologic malignancy patients receiving CAR-T therapy with preserved liver function at the First Affiliated Hospital of Soochow University.

Results: Serum interleukin (IL)-10 levels demonstrated a progressive increase across the groups [healthy controls: 0.

Current Trends and Research Hot Spots in Traumatic Birth: A Bibliometric Analysis.

The identification of traumatic birth is becoming a major global health concern. Evaluating the existing research can help shape future directions for traumatic birth studies. This study aimed to provide a comprehensive and up-to-date summary of research articles on traumatic birth.

Sidt2 inhibits islet β-cell dedifferentiation by regulating insulin secretion.

β-cell dedifferentiation plays an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). SID1 transmembrane family member 2 (Sidt2) is a lysosomal membrane protein known to regulate hepatic steatosis and lipid metabolism. However, its role in pancreatic β-cell dedifferentiation remains unclear.

Global Disease and Economic Burden of Noncommunicable Diseases Attributable to Hepatitis B Infection: A Health Economic Evaluation Study.

Hepatitis B virus (HBV) infection remains a significant global public health challenge, contributing to both hepatic and extrahepatic disease burdens. This study aims to estimate the global disease and economic burden of HBV-attributable noncommunicable diseases (NCDs). The study included hepatic NCDs (cirrhosis and other chronic liver diseases [CCLDs] and hepatocellular carcinoma [HCC]) and nonhepatic NCDs (NHNCDs).

Synergistic and antagonistic effects of ZnO/Zn species and Brønsted/Lewis acid sites variations on the catalytic conversion of polyethylene to aromatics.

The catalytic pyrolysis of polyethylene for aromatic production is a promising method for waste plastic disposal and resource recovery. This study investigated the nature of metal species and the distribution of acidic sites in low-density polyethylene (LDPE) scission-aromatization reactions using metal-loaded zeolite catalysts. Under the influence of the 1.

Rapid and efficient low-temperature nitrate reduction in aquaculture wastewater by a recombinant nitrate reductase: Biochemical characterization and applied insights.

Heterotrophic nitrification aerobic denitrification represents an exceptionally efficient biological process for nitrogen removal, where nitrate reductase plays a pivotal role as the initial step. Using a crude enzyme solution, AtNR01 was able to degrade 80 % of 1 mg/mL NO-N within 20 min. Notably, AtNR01 can maintain robust performance over a wide range of temperatures and pH levels.

Cognitive characteristics and ischemic prognosis of quantitative white matter hyperintensities in adult moyamoya disease.

Background: White matter hyperintensities (WMHs) are associated with long-term stroke and cognitive decline in the elderly population but differ from the young and middle-aged populations, especially for those with moyamoya disease (MMD). The aim of this study was to modify the Fazekas grade and quantitatively analyze the effects of WMHs on multiple cognitive domains and 2-year clinical ischemic events in adult MMD patients.

Methods: Adult MMD patients and healthy controls were recruited for a comprehensive cognitive assessment.

Impact of kindergarten structures on the dynamics of hand, foot, and mouth disease and the effects of intervention strategies: an agent-based modeling study.

Background: Hand, foot, and mouth disease (HFMD) poses an unignorable threat to the health of kindergarten children. Kindergarten structures (i.e.

Electrocatalytic Upcycling of Plastic Waste to Organonitrogen Chemicals via Intercepting Carbon Intermediates.

Transforming and repurposing plastic waste into valuable commodity chemical products is a sustainable strategy, which is beneficial for not only managing plastic waste but also fostering a circular plastic economy. Herein, we reported an electrocatalytic polyethylene terephthalate (PET) plastic waste upcycling to organonitrogen chemicals strategy over a MnO (MnO/CFP) catalyst. The MnO/CFP catalyst is capable of mildly oxidizing PET plastic-waste-derived ethylene glycol (EG) to electrophilic carbon intermediates under near-neutral conditions, in which the in situ formed carbon intermediates were stabilized and further attacked by nitrogenous nucleophiles, leading to the successful formation of amides.

Highly enantioselective synthesis controlled by spin-exchange interaction.

We present a strategy to achieve absolute asymmetric catalysis that is effectively controlled by an external magnetic field via a spin-exchange reaction leveraging the chirality-induced spin selectivity effect. Using an external magnetic field to achieve asymmetric synthesis has long been desired. Here, we demonstrate 90% enantiomeric excess (ee) in [3 + 2] cycloadditions and 89% ee in aldol reactions, where the handedness of the product is determined by the ~±150 mT external magnetic polarization of a ferromagnet (FM).

A Strongly Coupled Cluster Heterostructure with Pt-N-Mo Bonding for Durable and Efficient H Evolution in Anion-Exchange Membrane Water Electrolyzers.

Creating strongly coupled heterostructures with favorable catalytic activities is crucial for promoting the performance of catalytic reactions, especially those involve multiple intermediates. Herein, we fabricated a strongly coupled platinum/molybdenum nitrides nanocluster heterostructure on nitrogen-doped reduced graphene oxide (Pt/Mo₂N-NrGO) for alkaline hydrogen evolution reaction. The well-defined Pt-containing Anderson-type polyoxometalates promote strong interfacial Pt-N-Mo bonding in Pt/MoN-NrGO, which exhibits a remarkably low overpotential, high mass activity, and exceptional long-term durability (> 500 h at 1500 mA cm⁻) in an anion-exchange membrane water electrolyzer (AEMWE).

Patterns of sleep problems and associated factors in older people living with HIV: A latent class analysis.

BackgroundTo identify sleep subtypes and associated factors in older people living with HIV (PLWH).MethodsA cross-sectional study was conducted to recruit older PLWH in Wuxi, China. Sleep quality was assessed using the Pittsburgh Sleep Quality Index.

Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin.

Background: Since the discovery of streptomycin in the 1940s, more than a dozen drugs have been continuously introduced into tuberculosis (TB) therapy. However, limited attention has been paid to the collateral effects of drug resistance evolution in Mycobacterium tuberculosis (Mtb). Recently, we observed a clear discordance between the capreomycin (CAP) susceptibility of rifampicin-resistant (RR) Mtb clinical isolates and the adverse outcomes associated with CAP treatment, indicating potential collateral effects between rpoB mutations and CAP.

Discovery of CYP1A1 Inhibitors for Host-Directed Therapy against Sepsis.

Bacterial sepsis remains a leading cause of death globally, exacerbated by the rise of multidrug resistance (MDR). Host-directed therapy (HDT) has emerged as a promising nonantibiotic approach to combat infections; thus, multiple HDT targets have been identified. However, the translation of HDT targets into therapeutic drugs, particularly small-molecule drugs, remains rare.

Coagulation functions and factors correlated with central nervous system infection in herpes zoster patients.

Objective: Reports on central nervous system (CNS) infection caused by varicella-zoster virus (VZV) reactivation are increasing, but its pathogenesis remains unclear, which causes delayed diagnosis and treatment. Some studies suggested that hypercoagulability is involved in the pathogenesis of CNS infection of VZV. This study investigated the coagulation parameters of herpes zoster (HZ) and their correlations with the VZV-related CNS infection, and provided a reference for the early diagnosis and treatment.

BMI trajectories, changes and their potential associations with the risk of depression during adulthood: A cross-sectional study from NHANES 2005-2018.

Background: Body mass index (BMI) levels have been proven to have a significant relationship with depression. However, there is limited evidence regarding the impact of BMI trajectories and the average annual changes among adults aged 40-74 years on the risk of developing depression.

Methods: In this cross-sectional study, participants aged 40-74 were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2005-2018.

Intracellular acetyl phosphate modulates pyruvate metabolism.

Lysine acetylation has been shown to be an abundant and vital post-translational modification (PTM) that utilizes acetyl phosphate (AcP) as one of the acetyl group donors in bacteria. The pyruvate dehydrogenase (PDH) complex catalyzes the conversion from pyruvate to acetyl coenzyme A (acetyl-CoA). Thus far, the connection between lysine acetylation and pyruvate metabolism has not been thoroughly investigated.

Expression profile of Chchd10 gene during testicular development.

Chchd10 protein is crucial for sustaining mitochondrial dynamics, physiology and functions, and has been reported to be most abundantly in myocardial cells and skeletal muscle. However, nothing is known for the expression pattern of Chchd10 in gonadal development. Here, we characterized the expression patterns of Chchd10 gene during embryonic gonad development and postnatal testis development in mice, as well as the expression pattern of Chchd10 gene in human puberty testis and young adult testis using publicly available datasets.

Quantifying the loss of healthy life expectancy due to population ageing: health benefit estimation from a global perspective.

Study Objective: Investing in health to improve healthy life expectancy (HLE) is fundamental to create a demographic dividend. However, how dramatic population ageing affects HLE remains unknown. This study aims to quantify and project the major diseases and injuries attributed to changes in population size and age structure that contributed to substantial losses in HLE.

Multi-Knowledge Graph and Multi-View Entity Feature Learning for Predicting Drug-Related Side Effects.

Computational prediction of potential drug side effects plays a crucial role in reducing health risks for clinical patients and accelerating drug development. Recent methods have constructed heterogeneous graphs that represent drugs and their side effects, utilizing graph learning strategies such as graph convolutional networks to predict associations between them. However, existing approaches fail to fully exploit the diverse topologies and semantics present in multiple knowledge graphs.