Publications by authors named "Xingxu Yan"

Rapid advancements in autonomous driving technology have highlighted the challenges of ensuring vehicle safety and driving efficiency in complex dynamic traffic environments. Current approaches typically define potential risks as safety constraints for compliance and use them in trajectory planning. However, the risks predefined in these constraints are often fixed, reducing driving efficiency.

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Monolayer MoS is attractive for future photonics and optoelectronics for its direct-gap excitons with ultrahigh binding energies. However, the atomically thin structure is prone to nonradiative defects, challenging to scale for large-area production, and inherently limited in optical cross-section, all hindering technological integration. Stacking monolayers to increase the optical cross-section results in multilayers with diminished photoluminescence activity.

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Tailoring magnetic ordering in solid-state materials is essential for emerging spintronics. However, substitutional lattice doping in magnetic semiconductors is often constrained by the low solubility of magnetic elements, limiting the maximum achievable doping concentration (for example, less than 5%) and ferromagnetic ordering temperature. The intercalation of magnetic elements in layered two-dimensional atomic crystals (2DACs) without breaking in-plane covalent bonds offers an alternative approach to incorporate a much higher concentration of magnetic atoms (for example, up to 50%) beyond the typical solubility limit.

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Transforming and repurposing plastic waste into valuable commodity chemical products is a sustainable strategy, which is beneficial for not only managing plastic waste but also fostering a circular plastic economy. Herein, we reported an electrocatalytic polyethylene terephthalate (PET) plastic waste upcycling to organonitrogen chemicals strategy over a MnO (MnO/CFP) catalyst. The MnO/CFP catalyst is capable of mildly oxidizing PET plastic-waste-derived ethylene glycol (EG) to electrophilic carbon intermediates under near-neutral conditions, in which the in situ formed carbon intermediates were stabilized and further attacked by nitrogenous nucleophiles, leading to the successful formation of amides.

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Proton exchange membrane fuel cells feature considerable scalability advantages over lithium-ion batteries for heavy-duty-vehicle applications. The different driving behaviours and operating conditions of heavy-duty vehicles pose challenging requirements, particularly on fuel cell lifetime and efficiency. Here we report the design of a graphene-nanopocket-protected, pore-confined and electrochemically accessible Pt nanocatalyst supported on Ketjenblack carbon for heavy-duty-vehicle applications.

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Unlabelled: Growing evidence suggests that dietary herbs can prevent stroke by regulating the composition and structure of gut microbiota. The components of dietary herbs can also be metabolized or converted into bioactive molecules for treating stroke by gut microbiota, and exert therapeutic effects by inhibiting inflammation, oxidative stress, apoptosis, and other processes caused by stroke. A deep understanding of the mechanism of gut microbiota-mediated dietary herbal intervention in stroke is of great significance for the treatment and drug screening of stroke diseases.

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There are abundant natural products resources and extensive clinical use experience in China. However, the active components of natural products generally have problems such as poor water solubility and low bioavailability, which limit their druggability. Carrier-free nanoparticles, such as nanocrystals, self-assembled nanoparticles, and extracellular vesicles derived from both animal and plant sources, have great application potential in improving the safety and efficacy of drugs due to their simple and flexible preparation methods, high drug loading capacity and delivery efficiency, as well as long half-life in blood circulation.

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Current studies have clearly shown that aristolochic acid (AA) exposure can induce a variety of diseases, such as kidney disease, liver cancer, and urinary tract cancer (UTC). However, no studies have systematically analyzed and integrated these results. Therefore, we aimed to elucidate the association between AA exposure and the risk of safety outcomes for AA-related overall disease and different types of disease it causes.

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  • * Researchers used advanced electron energy loss spectroscopy to identify new optical phonon modes that strongly interact with electrons, which are primarily due to vibrations of oxygen atoms in the interface layers.
  • * The results indicate a direct relationship between the strength of electron-phonon coupling and the distance between FeSe and the TiO-layer in SrTiO, offering insights into improving superconductivity in similar materials.
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  • The study investigates early identification and diagnosis of liver cirrhosis (LC) through a meta-analysis of metabolite levels in patients with various types of liver diseases.
  • A total of 55 studies involving 8,266 participants were analyzed, uncovering significant alterations in metabolites related to bile acid biosynthesis, amino acids, and fatty acids associated with LC.
  • Findings highlight key biomarkers that could enhance early diagnosis and treatment monitoring of liver cirrhosis, potentially improving patient outcomes.
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Postconsumer plastics are generally perceived as valueless with only a small portion of plastic waste being closed-loop recycled into similar products while most of them are discarded in landfills. Depositing plastic waste in landfills not only harms the environment but also signifies a substantial economic loss. Alternatively, constructing value-added chemical feedstocks via mining the waste-derived intermediate species as a carbon (C) source under mild electrochemical conditions is a sustainable strategy to realize the circular economy.

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Upcycling plastic wastes into value-added chemicals is a promising approach to put end-of-life plastic wastes back into their ecocycle. As one of the polyesters that is used daily, polyethylene terephthalate (PET) plastic waste is employed here as the model substrate. Herein, a nickel (Ni)-based catalyst was prepared via electrochemically depositing copper (Cu) species on Ni foam (NiCu/NF).

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  • The study focuses on Diabetic Kidney Disease (DKD), a significant complication of diabetes leading to severe renal issues, aiming to identify key metabolic markers for diagnosis and prediction of the disease.
  • Researchers analyzed 34 clinical metabolomics studies, comparing metabolite levels in 1875 DKD patients and 4503 controls, finding 60 differential metabolites, including 5 essential ones that are significantly altered in DKD.
  • The identified metabolites indicate disturbances in amino acid, lipid, and pyrimidine metabolism in DKD patients, suggesting potential biomarkers for disease management and targets for new therapies.
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Background: Mycotoxins have been reported to be present in medicinal plants. With the growing usage of medicinal plants, contamination of mycotoxins has emerged as one of the biggest threats to global food hygiene and ecological environment, posing a severe threat to human health.

Purpose: This study aimed to determine the mycotoxin prevalence and levels in medicinal plants and conduct a risk assessment by conducting a systematic review and meta-analysis.

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Ulcerative colitis (UC) represents an inflammatory disease characterized by fluctuations in severity, posing substantial challenges in treatment. The gut microbiota plays a pivotal role in the pathogenesis of UC. This study sought to identify drugs specifically targeting the gut microbiota to mitigate UC.

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  • Single-atom catalysts (SACs) utilize metals more efficiently and show different reactivity compared to traditional metal nanoparticles.
  • The study reveals that platinum SACs (Pt SAs) on anatase TiO support display different coordination environments depending on which surface (001 or 101) they are on, affecting their reactivity.
  • Findings indicate that Pt SAs beneath the (001) surface have lower reactivity due to reduced access to gas, highlighting the importance of understanding heterogeneous coordination environments in the development of SACs.
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  • The study addresses the issue of underdiagnosis and poor treatment of rheumatoid arthritis (RA) by examining its metabolic characteristics.
  • It involved a review of 49 studies and a meta-analysis of 6 studies to investigate the link between 28 metabolites and RA.
  • Key findings show that levels of histidine, asparagine, methionine, and glycine are significantly lower in RA patients, whereas hypoxanthine levels are higher, suggesting these metabolites may serve as potential biomarkers for the disease.
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Photocatalytic plastic waste upcycling into value-added feedstock is a promising way to mitigate the environmental issues caused by the nondegradable nature of plastic waste. Here, we developed a MoS/g-CN photocatalyst that can efficiently upcycle poly(ethylene terephthalate) (PET) into valuable organic chemicals. Interestingly, the conversion mechanism is concentration-dependent.

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Fructus Psoraleae (FP), one of the important traditional Chinese medicines, is widely used in clinic and has been reported to be hepatotoxic. However, there is no report on the mechanism of FP-induced hepatotoxicity based on the theory of You Gu Wu Yun. In this study, plasma samples of rats with different kidney deficiency syndromes were investigated using a lipidomics approach based on UPLC/Q-TOF-MS technique.

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  • The introduction of platinum-group metals (PGMs) to cerium oxide (CeO) enhances redox surface reactions, particularly hydrogen (H) dissociation and surface reduction, which are important in heterogeneous catalysis.
  • Research utilized various methods, including temperature-programmed reduction (TPR) and in situ spectroscopy, to investigate how platinum (Pt) nanoclusters and single atoms affect H reactions on Pt/CeO powder catalysts.
  • Key findings indicate that Pt significantly speeds up H consumption rates even on small fractions of CeO, alters the mechanism for H activation, and leads to localized changes in Ce distribution at CeO boundaries, ultimately improving H reaction efficiency compared to pure CeO.
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  • Electrocatalytic reduction of waste nitrates to ammonia offers a carbon-neutral and decentralized approach to ammonia synthesis, utilizing metal-nitrogen-carbon (M-N-C) catalysts that exhibit high activity and selectivity for mono-nitrogen products.
  • A study presents 14 different M-N-C catalysts from various metal groups, highlighting a strong correlation between their activity in reducing nitrates and selectivity for ammonia production.
  • The research delves into the reaction mechanisms of nitrate reduction, particularly the role of the nitrate intermediate, and explores pathways for the adsorption of nitrate on the catalysts, paving the way for future designs of multi-element systems.
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  • Defect engineering in perovskite thin films allows for atom-level modifications, creating new nanostructures for advanced nanodevices.
  • Unlike three-dimensional structures, one- or two-dimensional nanostructures can handle large misfit strains without causing instability in the thin films.
  • The study reports the creation of edge-type misfit dislocation-assisted BiMnO nanochannels within perovskite thin films, which show diode-like current behavior, indicating potential for innovative nanoscale electronic applications.
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  • Atomically dispersed catalysts, particularly single-atom catalysts, are promising for oxidizing methane to produce valuable compounds like acetic acid and methanol, but they usually have low active site loading, resulting in low product yield.
  • The study introduces a method using metal-organic frameworks with porphyrin linkers to enhance rhodium concentrations, achieving a high loading of 5 wt% with excellent dispersity.
  • When tested for acetic acid production, this new catalyst reached a performance benchmark of 23.62 mmol·g·h and demonstrated sensitivity to light, allowing for different selectivity between acetic acid and methanol based on illumination conditions.
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Synopsis of recent research by authors named "Xingxu Yan"

  • - Xingxu Yan's recent research spans diverse areas, primarily focusing on catalysis and its applications, including the upcycling of plastic waste using innovative single-atom and heterogeneous catalysts, highlighting the potential for sustainable practices in chemical production.
  • - Another significant area of his work includes clinical metabolomics, where he investigates metabolic profiles in various diseases, such as diabetic kidney disease and liver cirrhosis, aiming to identify biomarkers for early diagnosis and understanding drug interactions through systematic reviews and meta-analyses.
  • - Yan also explores the dynamics of catalyst efficiency and interactions at the atomic level, particularly involving precious metals like platinum and rhodium, to enhance catalytic reactions for environmental remediation and energy conversion processes.