A-to-I edited SNHG3 promotes non-small cell lung cancer metastasis by promoting fatty acid oxidation and resisting ferroptosis.

Adenosine-to-inosine (A-to-I) RNA editing is a critical post-transcriptional modification that enhances tumor genome diversity and contributes to cancer progression. In non-small cell lung cancer (NSCLC), while specific A-to-I editing events have been identified, their functional mechanisms and clinical relevance remain poorly understood. Here, through whole-transcriptome analysis of NSCLC specimens, we discovered a hyper-editing event at position c.

A Suppression Method for Random Errors of IFOG Based on the Decoupling of Colored Noise-Spectrum Information.

In high-precision inertial navigation systems, suppressing the random errors of a fiber-optic gyroscope is of great importance. However, the traditional rule-based autoregressive moving average modeling method, when applied in Kalman filtering considering colored noise, presents inherent disadvantages in principle, including inaccurate state equations and difficulties in state dimension expansion. To this end, the noise characteristics in the fiber-optic gyroscope signal are first deeply analyzed, a random error model form is clarified, and a new model-order determination criterion is proposed to achieve the high-precision modeling of random errors.

Fiber Optic Gyro Random Error Suppression Based on Dual Adaptive Kalman Filter.

The random error of fiber optic gyros is a critical factor affecting their measurement accuracy. However, the statistical characteristics of these errors exhibit time-varying properties, which degrade model fidelity and consequently impair the performance of random error suppression algorithms. To address these issues, this study first proposes a recursive dynamic Allan variance calculation method that effectively mitigates the poor real-time performance and spectral leakage inherent in conventional dynamic Allan variance techniques.

Thermodynamic mechanism in colored glass substrates of interference filters under continuous-wave laser irradiation.

The ablation perforation damage of double-sided coated narrow-band filters based on RG-850 colored glass under out-of-band laser irradiation is investigated. A temperature-triggered nonlinear absorption mechanism is identified where substrate absorption sharply increases beyond a critical temperature. To quantify the resulting energy deposition dynamics, the multiple reflection model is employed, revealing the absorption enhancement by partial-transmission/high-reflection coatings.

Rule-adaptive lane-changing trajectory planning method for autonomous vehicles driven by dynamic risk information.

Rapid advancements in autonomous driving technology have highlighted the challenges of ensuring vehicle safety and driving efficiency in complex dynamic traffic environments. Current approaches typically define potential risks as safety constraints for compliance and use them in trajectory planning. However, the risks predefined in these constraints are often fixed, reducing driving efficiency.

High-entropy Prussian blue analogues-mediated flexible field-effect transistor for wearable sweat dopamine monitoring.

Wearable sensor offers a non-invasive platform for continuous monitoring of biomarkers, but their application remains challenging due to low target level and stability issue in sweat. Here, we proposed a wearable sensing system comprising a flexible field-effect transistor (FET) integrated with a microfluidic sweat collection channel for real-time monitoring of dopamine in sweat. By functionalizing the recognition layer of FET using high-entropy Prussian blue analogues (HEPBAs), the sensor not only enables direct and selective catalysis of dopamine but also amplifies the response signal for trace dopamine determination.

Nonseeded linewise temperature measurements by resonantly ionized photoemission thermometry in a Mach 4 Ludwieg tube.

A one-dimensional (1D) thermometry using oxygen-tagging resonantly ionized photoelectron thermometry ( RIPT) was employed to investigate thermal gradients within a Mach 4 Ludwieg tube. The Ludwieg tube is pulsed with a test duration of approximately 100 ms, providing a cold supersonic flow at Mach 4 ideal for studying aerothermal effects. This study focused on measuring freestream temperatures, capturing shock-induced heating behind a detached bow shock from a blunt cylinder, and resolving sharp temperature variations across a bow shock generated by a cylinder.

HO absorption spectroscopy via focused laser differential interferometry.

A modification of focused laser differential interferometry (FLDI) is demonstrated with an infrared tunable diode laser (TDL) to achieve simultaneous absorption spectroscopy (AS) measurements. Measurements from this absorbing-FLDI (A-FLDI) are shown for a Hencken burner plume. Initial comparison measurements are recorded using TDLAS and an electrical hygrometer.

Applications of Lignin-Dervied Carbon Quantum Dots: Current Status and Challenges.

In recent years, lignin has attracted substantial attention from researchers because of its diverse sources, low cost, and renewability. The effective functionalization and enhanced value-added utilization of lignin have successfully addressed the challenges associated with biomass resource waste, low utilization rate, high material cost, and underwhelming performance in energy, environmental protection, and medical applications. The emergence of lignin carbon quantum dots (LCQDs) has opened new avenues for the development and utilization of lignin by offering exciting opportunities for their applications.

Application value of Ultrasound-Guided cervical nerve root block test before percutaneous nucleoplasty in the treatment of patients with cervical chest pain: A retrospective study.

Purpose: Cervical chest pain (CCP) is an atypical symptom of cervical spine disease that often overlaps with other chest-related diseases but a type of noncardiogenic chest pain. The obvious relief of CCP after selective cervical nerve root block (SCNRB) near intervertebral disc herniation under ultrasound guidance should be considered to help identify the potential pathological source.The purpose of this study was to explore the application value of a positive ultrasound-guided SCNRB test before percutaneous cervical nucleoplasty (PCN) in the treatment of patients with CCP.

A facile dual-drug delivery system using cellulose-based microgel/hydrogel for enhanced gastric cancer therapy.

Gastric cancer remains a significant clinical challenge due to its high incidence, elevated mortality, frequent recurrence, and increasing chemotherapy resistance. To address these issues, we developed a thiolated carboxymethyl cellulose (CMC-SH) microgel system co-loaded with 5-fluorouracil (5-FU) and curcumin (Cur), further embedded in an injectable gelatin and dialdehyde cellulose hydrogel. Leveraging the distinct solubility profiles of 5-FU (hydrophilic) and Cur (hydrophobic), this dual-drug microgel achieved sustained drug release over four days, effectively overcoming 5-FU resistance while amplifying anticancer efficacy.

Mitochondria-targeting natural product rhein conjugated with dichloroacetate as the dual inhibitor of glycolysis and oxidative phosphorylation to off energize cancer cells and induce ROS storm.

Metabolic reprogramming emerges as a remarkable hallmark of cancer cells and exhibits potential in the development of metabolic modulators. Numerous small-molecule inhibitors mainly target reversing the dominant-glycolysis pathway. However, energy metabolic adaptation that facilitates the alternation of metabolic phenotypes from glycolysis to oxidative phosphorylation (OXPHOS) undermines treatment efficacy.

Novel Isatin-Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation.

Neuroinflammation is considered a significant factor in triggering numerous neurodegenerative diseases. Hence, the development of effective anti-inflammatory drugs is of utmost urgency. In this study, three series of new isatin-chalcone hybrid derivatives were successfully designed and synthesized, and their anti-neuritis activities were explored using BV2 microglial cells.

Semi-supervised temporal attention network for lung 4D CT ventilation estimation.

Computed tomography (CT)-derived ventilation estimation, also known as CT ventilation imaging (CTVI), is emerging as a potentially crucial tool for designing functional avoidance radiotherapy treatment plans and evaluating therapy responses. However, most conventional CTVI methods are highly dependent on deformation fields from image registration to track volume variations, making them susceptible to registration errors and resulting in low estimation accuracy. In addition, existing deep learning-based CTVI methods typically have the issue of requiring a large amount of labeled data and cannot fully utilize temporal characteristics of 4D CT images.

In-Motion Initial Alignment Method Based on Multi-Source Information Fusion for Special Vehicles.

To address the urgent demand for autonomous rapid initial alignment of vehicular inertial navigation systems in complex battlefield environments, this study overcomes the technical limitations of traditional stationary base alignment methods by proposing a robust moving-base autonomous alignment approach based on multi-source information fusion. First, a federal Kalman filter-based multi-sensor fusion architecture is established to effectively integrate odometer, laser Doppler velocimeter, and SINS data, resolving the challenge of autonomous navigation parameter calculation under GNSS-denied conditions. Second, a dual-mode fault diagnosis and isolation mechanism is developed to enable rapid identification of sensor failures and system reconfiguration.

Prior knowledge-based multi-task learning network for pulmonary nodule classification.

The morphological characteristics of pulmonary nodule, also known as the attributes, are crucial for classification of benign and malignant nodules. In clinical, radiologists usually conduct a comprehensive analysis of correlations between different attributes, to accurately judge pulmonary nodules are benign or malignant. However, most of pulmonary nodule classification models ignore the inherent correlations between different attributes, leading to unsatisfactory classification performance.

High-Voltage-Resistant Highly Stable Solid Polymer Electrolyte via In Situ Integrated Construction with Fast Ion Migration.

Electric aircraft such as electric aircraft and electric vehicles play a key role in the future electric aviation industry, but they put forward huge requirements for battery energy density. However, the current high-energy-density lithium battery technology still needs to be broken through. Herein, through the molecular structure design of the polymer electrolyte, a strategy of a fast migration channel and wide electrochemical window is proposed to fabricate high-voltage-resistant solid polymer electrolyte (HVPE) via in situ polymerization.

Changes of soil organic carbon and aggregate stability along elevation gradient in Cunninghamia lanceolata plantations.

Exploring the components of soil organic carbon (SOC) and aggregate stability across different elevations is crucial to assessing the stability of SOC in subtropical forest ecosystems under climate change. In this study, we investigated the spatial variation of active carbon (C) compositions, aggregate distribution, and stability in Chinese fir (Cunninghamia lanceolata) plantations across an elevation gradient from 750 to 1150 m a.s.

A physical crosslinked pH-sensitive hydrogel based on hemicellulose/graphene oxide for controlled oral drug delivery.

The design of innovative pH-sensitive hydrogels for oral drug delivery is particularly promising for the treatment of intestinal diseases. The traditional pH-responsive hydrogels still have some problems such as low biocompatibility, complex preparation process and poor therapeutic effect, so a new method needs to be developed to solve these problems. Here, a pH-sensitive hemicellulose/graphene oxide (HC/GO) composite hydrogel (HGCH) was prepared through a one-step strategy.

High-Efficiency Gold Nanoaggregates for NIR LED-Driven Sustained Mild Photothermal Therapy Achieving Complete Tumor Eradication and Immune Enhancement.

For millennia, humans have harnessed thermal energy to treat cancer. However, delivering energy to tumor tissues in traditional hyperthermia remains a significant challenge. Nanotechnology has revolutionized this approach, enabling nanomaterials to target tumors precisely and act as internal heat sources.

Pulmonary CT Registration Network Based on Deformable Cross Attention.

Current Transformer structure utilizes the self-attention mechanism to model global contextual relevance within image, which makes an impact on medical image registration. However, the use of Transformer in handling large deformation lung CT registration is relatively straightforwardly. These models only focus on single image feature representation neglecting to employ attention mechanism to capture the across image correspondence.

An Automated Sprinkler Cooling System Effectively Alleviates Heat Stress in Dairy Cows.

(1) Background: Heat stress detrimentally restricted economic growth in dairy production. In particular, the cooling mechanism of the spraying system effectively reduced both environmental and shell temperatures. This study was designed to investigate the underlying modulatory mechanism of an automatic cooling system in alleviating heat-stressed dairy cows.