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Purpose: Cervical chest pain (CCP) is an atypical symptom of cervical spine disease that often overlaps with other chest-related diseases but a type of noncardiogenic chest pain. The obvious relief of CCP after selective cervical nerve root block (SCNRB) near intervertebral disc herniation under ultrasound guidance should be considered to help identify the potential pathological source.The purpose of this study was to explore the application value of a positive ultrasound-guided SCNRB test before percutaneous cervical nucleoplasty (PCN) in the treatment of patients with CCP.
Methods: A retrospective analysis of 66 patients with CCP who underwent PCN was conducted. Patients were divided into a control group (PN group, n = 32) and an ultrasound-guided group (UPN group, n = 34) according to the absence or presence of ultrasound-guided SCNRB before surgery. The visual analogue scale (VAS) score, neck disability index (NDI), Pittsburgh Sleep Quality Index (PSQI), and proportion of patients taking oral analgesics before and at 1 week, 1 month, 3 months, and 6 months after surgery were recorded. The clinical effect according to the Odom criteria was recorded 6 months after surgery. The occurrence of adverse events was recorded to evaluate safety.
Results: Compared with baseline, both groups showed significant improvement in VAS score, NDI, and PSQI at 1 week, 1 month, 3 months, and 6 months after surgery (P < 0.05). The proportion of patients taking oral analgesics sharply decreased at each time point after surgery. The VAS score, NDI, and PSQI at 1 week, 1 month, 3 months, and 6 months after surgery in the UPN group were lower than those in the PN group, and the Odom criteria rate of excellent and good performance in the UPN group was 91.2%, which was significantly greater than that in the PN group at 75.0% (P < 0.05).
Conclusions: PCN can effectively alleviate the severity of chest pain, and improve sleep quality in patients with CCP. A positive ultrasound-guided SCNRB test before PCN can play a guiding role in identifying diseased nerves to improve the clinical efficacy of PCN in the treatment of CCP and can serve as a clinical reference.
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http://dx.doi.org/10.1007/s00586-025-08996-6 | DOI Listing |
J Am Coll Cardiol
September 2025
Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA; University of Missouri-Kansas City's Healthcare Institute for Innovations in Quality, Kansas City, Missouri, USA.
Background: Clinical trials typically report average health status outcomes by treatment at single points in time, as opposed to participants' trajectories (or journeys) over time. Although ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) demonstrated better mean health status at discrete times with an invasive treatment among those with baseline angina, the patterns of individual participants' angina over time are unknown.
Objectives: The purpose of this study was to identify patterns of individual participants' angina over time after invasive or conservative management strategies for chronic coronary disease.
Biol Psychiatry
September 2025
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA; Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 94304, USA. Electronic address: leawillia
Despite available treatments, major depressive disorder (MDD) remains one of the leading causes of disability across medical conditions. The current symptom-based diagnostic system groups patients with highly heterogeneous presentations, with no biomarkers to guide treatment-akin to diagnosing heart disease solely by chest pain, without imaging to reveal the underlying pathology. Lacking biological guidance, clinicians rely on trial-and-error prescribing.
View Article and Find Full Text PDFEur J Case Rep Intern Med
August 2025
Department of Gastroenterology and Hepatology, University of Balamand, Beirut, Lebanon.
Unlabelled: Aortic dissection is a life-threatening cardiovascular emergency, particularly Stanford type A, which typically necessitates urgent surgical intervention. Despite advances in surgical techniques and perioperative care, preoperative bleeding and coagulopathy remain significant challenges. Tranexamic acid, an antifibrinolytic agent, is widely used to minimize perioperative bleeding in cardiovascular surgeries; however, its role in the non-surgical, preoperative stabilization of aortic dissection has not been well established.
View Article and Find Full Text PDFEur J Case Rep Intern Med
August 2025
Cardiac Sciences Division, Department of Medicine, King Abdulaziz Hospital, Ministry of National Guard Health Affairs (MNGHA), Al Ahsa, Saudi Arabia.
Unlabelled: Anomalous origin of the coronary arteries is a rare congenital condition that can present as non-specific chest pain or shortness of breath or remain asymptomatic. Early identification is critical as certain variants are linked with a high risk of sudden cardiac death. Here, we report the case of a 53-year-old female with hypertension, hypothyroidism, obesity (class II) and a history of intermittent chest pain radiating to the left arm for two years.
View Article and Find Full Text PDFEur J Case Rep Intern Med
August 2025
Internal Medicine, University of California, Riverside School of Medicine, Riverside, USA.
Introduction: Pulmonary embolism (PE) is a life-threatening condition with well-defined management strategies; however, the presence of a clot-in-transit (CIT)-a mobile thrombus within the right heart-introduces a uniquely high-risk scenario associated with a significantly elevated mortality rate. While several therapeutic approaches are available-including anticoagulation, systemic thrombolysis, surgical embolectomy, and catheter-directed therapies-there is no established consensus on a superior treatment modality. Catheter-based mechanical thrombectomy has emerged as a promising, minimally invasive alternative that mitigates the bleeding risks of systemic thrombolysis and the invasiveness of surgery.
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