Oxidant-Modulated Synthesis of Polycrystalline MoS on SiO/Si with Near-Single-Crystal Mobility.

MoS, a 2D semiconductor, has emerged as an ideal channel material for transistors in the post-Moore era due to its atomic thickness, high mobility, and excellent gate control capability. The direct growth of 2D MoS films on SiO/Si is crucial for ensuring compatibility with complementary metal-oxide-semiconductor (CMOS) processes while avoiding the damage and defects often associated with transfer processes. However, 2D MoS polycrystalline films grown on SiO/Si suffer from small grain sizes, high grain boundary densities, and poor electrical performance.

Association between dietary vitamin intake and all-cause mortality in ovarian cancer patients: a prospective cohort study.

Background: While various lifestyle factors have been implicated in cancer prognosis, the role of dietary vitamins in ovarian cancer survival is not well understood. This study aimed to investigate the association between dietary vitamin intake and all-cause mortality in ovarian cancer patients, presenting a potential modifiable avenue for improving outcomes.

Methods: Data were obtained from 7 consecutive National Health and Nutrition Examination Survey (NHANES) cycles between 2003 and 2016, including 108 ovarian cancer patients.

High-sensitivity hybrid MoSe/AgInGaS quantum dot heterojunction photodetector.

Zero-dimensional (0D)-two-dimensional (2D) hybrid photodetectors have received widespread attention due to their outstanding photoelectric performances. However, these devices with high performances mainly employ quantum dots that contain toxic elements as sensitizing layers, which restricts their practical applications. In this work, we used eco-friendly AgInGaS quantum dots (AIGS-QDs) as a highly light-absorbing layer and molybdenum diselenide (MoSe) as a charge transfer layer to construct a 0D-2D hybrid photodetector.

Necroptosis-related regulatory pattern and scoring system for predicting therapeutic efficacy and prognosis in ovarian cancer.

Background: Ovarian cancer is difficult to treat and is, therefore, associated with a high fatality rate. Although targeted therapy and immunotherapy have been successfully used clinically to improve the diagnosis and treatment of ovarian cancer, most tumors become drug resistant, and patients experience relapse, meaning that the overall survival rate remains low.

Aims: There is currently a lack of effective biomarkers for predicting the prognosis and/or outcomes of patients with ovarian cancer.

SLC11A2: a promising biomarker and therapeutic target in ovarian cancer.

Ovarian cancer has the highest mortality rate among gynecologic tumors, with a 5-year survival rate of less than 25%. There is an urgent need for early diagnosis and new drugs to reduce the disease burden of ovarian cancer. The aim of this study was to investigate the effectiveness of SLC11A2 as a therapeutic target and marker for ovarian cancer.

A novel necroptosis-related lncRNA signature for predicting prognosis and anti-cancer treatment response in endometrial cancer.

Background: Necroptosis, a form of programmed cell death, underlies tumorigenesis and the progression of cancers. Anti-cancer strategies targeting necroptosis have increasingly been shown to present a potential cancer therapy. However, the predictive utility and anticancer sensitivity value of necroptosis-related lncRNAs (NRLs) for endometrial cancer (EC) are currently unknown.

Dualistic classification of high grade serous ovarian carcinoma has its root in spatial heterogeneity.

Introduction: Widespread intra-peritoneal metastases is a main feature of high grade serous ovarian carcinoma (HGSOC). Recently, the extent of tumour heterogeneity was used to evaluate the cancer genomes among multi-regions in HGSOC. However, there is no consensus on the effect of tumour heterogeneity on the evolution of the tumour metastasis process in HGSOC.

Protein Panel of Serum-Derived Small Extracellular Vesicles for the Screening and Diagnosis of Epithelial Ovarian Cancer.

Although ovarian cancer, a gynecological malignancy, has the highest fatality rate, it still lacks highly specific biomarkers, and the differential diagnosis of ovarian masses remains difficult to determine for gynecologists. Our study aimed to obtain ovarian cancer-specific protein candidates from the circulating small extracellular vesicles (sEVs) and develop a protein panel for ovarian cancer screening and differential diagnosis of ovarian masses. In our study, sEVs derived from the serum of healthy controls and patients with cystadenoma and ovarian cancer were investigated to obtain a cancer-specific proteomic profile.

Therapeutic potential of helminths in autoimmune diseases: helminth-derived immune-regulators and immune balance.

Helminths have accompanied human throughout history by releasing immune-evasion molecules that could counteract an aberrant immune response within the host. In the past decades, helminth infections are becoming less prevalent possibly due to the developed sanitation. Meanwhile, the incidence of autoimmune diseases is increasing, which cannot be exclusively explained by the changes of susceptibility genes.

Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types.

Cancer-testis (CT) genes represent the similarity between the processes of spermatogenesis and tumorigenesis. It is possible that their selective expression pattern can help identify driver genes in cancer. In this study, we integrate transcriptomics data from multiple databases and systematically identify 876 new CT genes in 19 cancer types.