Simplified Assessment of Acetylcholinesterase Inhibition by Environmental Organophosphorus Pesticides.

Environmental contaminants, such as pesticides, can inhibit the enzymatic activity of acetylcholinesterase (AChE), an enzyme necessary for neurotransmission. The inhibitory effects of structurally diverse pesticides on AChE may result from either reversible or covalent interactions. Therefore, assessing their potency typically requires different assay design to determine either dissociation constants or rate constants, respectively.

Ligand- and tissue-specific differences in the activation of the aryl hydrocarbon receptor by flavonoids: A focus on baicalein and scutellarein.

Flavonoids are natural dietary modulators of the aryl hydrocarbon receptor (AHR) with considerable therapeutic potential. However, their safety and efficacy remain difficult to predict due to the complex, ligand- and tissue-specific differences of AHR. In this study, we combined transcriptional and protein-level experiments with computational methods, including molecular docking and R-based RNA-seq analyses, to elucidate the patterns of cell type-specific activation of AHR by structurally similar flavonoids.

Pan-cancer analysis of acetylcholinesterase (AChE) expression by a data-driven approach: future directions of AChE in cancer neuroscience.

There is evidence that the expression of acetylcholinesterase (AChE) is associated with the development of certain cancers. However, there are still insufficient studies to reveal the correlation between AChE expression and cancer development and prognosis from the perspective of pan-cancer. In this study, a comprehensive bioinformatics analysis of the pan-cancer expression signature of AChE was conducted through a data-driven approach.

Astrocytes Respond to Environment-Relevant Doses TCDD in a Specific Manner Which Is Different from the Endogenous AhR Ligand (FICZ).

Astrocytes play an important role in the nervous system's response to external stimulation. Environmental pollutants could activate astrocytes into A1 (toxic) or A2 (protective) types and induce different effects. Meanwhile, the aryl hydrocarbon receptor (AhR) is an environmental molecule sensor in the body and has various ligands.

The best anthropometric indices to predict colon cancer.

Background: Colon cancer is one of the most prevalent malignancies globally. Anthropometric data are widely accessible. However, numerous anthropometric indicators exist, and no study has identified the most reliable predictor for colon cancer.

Uneven effects of global trade on transportation industry sustainability.

The global trade in transportation industry has complex socio-economic, resource, and environmental (SRE) footprints. Linking these footprints with sustainability frameworks is crucial for driving transportation industry sustainability (TI-S). Here, we analyze these footprints and develop a TI-S assessment system with 26 SRE indicators for 16 TI-S targets.

Dioxin-like effects of an emerging contaminant 1,3,6,8-tetrabromocarbazole on the myogenic differentiation of mouse C2C12 cells.

1,3,6,8-Tetrabromocarbazole (1368-BCZ) has been proposed as an emerging environmental contaminant which has aryl hydrocarbon receptor (AhR) activating properties analogous to those of dioxins. Skeletal muscle development is a critical target of dioxin toxicity. However, the impact of 1368-BCZ on muscle development is inadequately understood.

Unprejudiced Training Auxiliary Tasks Makes Primary Better: A Multitask Learning Perspective.

Human beings can leverage knowledge from relative tasks to improve learning on a primary task. Similarly, multitask learning (MTL) methods suggest using auxiliary tasks to enhance a neural network's performance on a specific primary task. However, previous methods often select auxiliary tasks carefully but treat them as secondary during training.

The Effects of a 6-Week Plyometric and Sprint Interval Training Intervention on Soccer Player's Physical Performance.

Despite the well-documented benefits of sprint interval training (SIT) and plyometric training (PT) in improving the physical fitness of soccer players, it remains unclear which of these training methods is superior for enhancing players' aerobic and anaerobic performance. Therefore, this study aimed to compare the effects of SIT and PT on physical performance measures of male soccer players. Thirty male soccer players were randomly assigned to PT (n = 10), SIT (n = 10), and an active control group (CON, n = 10).

A comprehensive city-level final energy consumption dataset including renewable energy for China, 2005-2021.

The role of China is increasingly pivotal in climate change mitigation, and the formulation of energy conservation and emission reduction policies requires city-level information. The effectiveness of national policy implementation is contingent upon the support and involvement of local governments. Accurate data on final energy consumption is vital to formulate and implement city-level energy transitions and energy conservation and emission reduction policies.

Exploring the adverse effects of 1,3,6,8-tetrabromo-9H-carbazole in atherosclerotic model mice by metabolomic profiling integrated with mechanism studies in vitro.

Given its wide distribution in the environment and latent toxic effects, 1,3,6,8-tetrabromo-9H-carbazole (1368-BCZ) is an emerging concern that has gained increasing attention globally. 1368-BCZ exposure is reported to have potential cardiovascular toxicity. Although atherosclerosis is a cardiovascular disease and remains a primary cause of mortality worldwide, no evidence has been found regarding the impact of 1368-BCZ on atherosclerosis.

Carbon emission reduction effects of renewable energy technological innovation in China: New insights into the intellectual property rights protection.

Renewable energy technological innovation (RETI) is of great significance in reducing carbon emissions. A deeper understanding of the impact of intellectual property rights (IPR) protection on the carbon reduction effect of RETI can provide policymakers with more specific information. Using the dataset from 30 provinces in China during 2007-2018, we provide a detailed analysis of the moderating role of IPR protection in RETI's impact on carbon emissions.

China's ambitious low-carbon goals require fostering city-level renewable energy transitions.

Cities in China, as elsewhere, are increasingly playing a crucial role in mitigating climate change. We developed a panel dataset on renewable energy transition in Chinese cities, and assessed the CO emissions reduction of city-level renewable energy transition. We found that city-level renewable energy transition only reduced 446 million tonnes of CO emissions from 2005 to 2019.

Genomic insights into local adaptation and future climate-induced vulnerability of a keystone forest tree in East Asia.

Rapid global climate change is posing a substantial threat to biodiversity. The assessment of population vulnerability and adaptive capacity under climate change is crucial for informing conservation and mitigation strategies. Here we generate a chromosome-scale genome assembly and re-sequence genomes of 230 individuals collected from 24 populations for Populus koreana, a pioneer and keystone tree species in temperate forests of East Asia.

Effects of the emerging contaminant 1,3,6,8-tetrabromocarbazole on the NF-κB and correlated mechanism in human hepatocellular carcinoma cells.

1,3,6,8-Tetrabromocarbazole (1368-BCZ) is identified as an emerging contaminant that exerts angiogenic effects. Multiple studies indicated there was a positive correlation between angiogenesis and nuclear factor kappa B (NF-κB) activation. While the role of NF-κB in inflammation and apoptosis has been well known, the potential biological effects of 1368-BCZ on NF-κB signaling and related mechanism remain unclear.

Comprehensive Evaluation of College Students' Physical Health and Sports Mode Recommendation Model Based on Decision Tree Classification Model.

Nowadays, more and more college students' physical health is getting worse because of their living habits and self-consciousness. In order to improve the physical quality of college students as much as possible, the experiment uses the improved iterative dichotomiser III (ID3) decision tree to make decisions on the physical condition of some college students and the corresponding sports mode recommendation, and compares the results with the traditional ID3 algorithm. In the experimental results, the information entropy ratio of the improved ID3 algorithm is 89.

Uncertainty-Aware Contrastive Distillation for Incremental Semantic Segmentation.

A fundamental and challenging problem in deep learning is catastrophic forgetting, i.e., the tendency of neural networks to fail to preserve the knowledge acquired from old tasks when learning new tasks.

HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant.

The dioxin-like substances polyhalogenated carbazoles (PHCZs) may trigger the aryl hydrocarbon receptor (AhR) signaling pathway. Although the crosstalk between AhR and the hypoxia inducible factor-1 (HIF-1) pathways is generally believed to occur, the exact mechanisms of the HIF-1 pathway in PHCZ toxicity have not been determined. We aimed to elucidate the effect of PHCZs on the HIF-1 pathway and its involvement in the regulation of target genes of HIF-1.

How does biased technological progress affect haze pollution? Evidence from APEC economies.

Biased technological progress is the act of energy conservation and emission reduction by changing the marginal rate of substitution. In this study, we introduced renewable energy into a production function, and proposed a method of identifying biased characteristics of technological progress, based on marginal productivity theory. A panel dataset for the Asia-Pacific Economic Cooperation (APEC) economies from 2000 to 2017 was analyzed to explore the effect of biased technological progress in reducing particulate matter (PM).

Variational Structured Attention Networks for Deep Visual Representation Learning.

Convolutional neural networks have enabled major progresses in addressing pixel-level prediction tasks such as semantic segmentation, depth estimation, surface normal prediction and so on, benefiting from their powerful capabilities in visual representation learning. Typically, state of the art models integrate attention mechanisms for improved deep feature representations. Recently, some works have demonstrated the significance of learning and combining both spatial- and channel-wise attentions for deep feature refinement.

Construction of 2D/2D MoS/g-CN Heterostructures for Photoreduction of Cr (VI).

2D/2D MoS/g-CN (MCN) surface heterostructures were created by second thermal polymerization of bulk g-CN and the reaction of thiourea and MoO at 670 °C. MoS networks grew vertically along the (002) facet on superior thin g-CN nanosheets. The layered heterostructures drastically improved the Cr(VI) removal ability.

Sl-lncRNA15492 interacts with Sl-miR482a and affects Solanum lycopersicum immunity against Phytophthora infestans.

Long non-coding RNAs (lncRNAs) are involved in the resistance of plants to infection by pathogens via interactions with microRNAs (miRNAs). Long non-coding RNAs are cleaved by miRNAs to produce phased small interfering RNAs (phasiRNAs), which, as competing endogenous RNAs (ceRNAs), function as decoys for mature miRNAs, thus inhibiting their expression, and contain pre-miRNA sequences to produce mature miRNAs. However, whether lncRNAs and miRNAs mediate other molecular mechanisms during plant resistance to pathogens is unknown.

Does environment-biased technological progress reduce CO emissions in APEC economies? Evidence from fossil and clean energy consumption.

Environment-biased technological progress plays a critical role in carbon reduction, while the association among environment-biased technological progress, energy consumption, and carbon emissions has not been paid enough attention. Working with a unique spatial panel dataset of APEC economies spanning the 2000-2017 period, we employed the nonspatial panel model and the spatial panel model to investigate the role of fossil energy (FE) and clean energy (CE) consumption in carbon dioxide (CO) abatement through environment-biased technological progress (EBTP). We decomposed EBTP into both emission-reducing biased technological progress (ErBTP) and energy-saving biased technological progress (EsBTP).

Tomato lncRNA23468 functions as a competing endogenous RNA to modulate genes by decoying miR482b in the tomato interaction.

Our previous studies indicated that tomato miR482b could negatively regulate the resistance of tomato to and the expression of miR482b was decreased after inoculation with . However, the mechanism by which the accumulation of miR482b is suppressed remains unclear. In this study, we wrote a program to identify 89 long noncoding RNA (lncRNA)-originated endogenous target mimics (eTMs) for 46 miRNAs from our RNA-Seq data.