Amlodipine overdose rescued with extracorporeal membrane oxygenation: A case report.

Rationale: Amlodipine, a calcium channel blocker, is widely prescribed for managing hypertension through vascular smooth muscle relaxation. However, severe amlodipine toxicity can lead to profound hypotension and refractory shock, often unresponsive to conventional treatments.

Patient Concerns: In this report, we reported a 32-year-old female case of amlodipine overdose who was admitted to our hospital on March 1, 2024, due to intentionally ingesting approximately 84 tablets of amlodipine (5 mg each).

Elevation from Binary to Ternary Resistive Switching Behaviors by Graphitizing Transformation from Nanodiamond to Onion-like Carbon in Their Chitosan Composites.

The development of green high-density memristors is urgent for the coming big-data era. In this work, the graphitization degree of the nanodiamond (ND) was modulated by thermal annealing at different temperatures. Consequently, the graphitizing transformation from the ND structure to partial onion-like carbon (OLC-1) and complete OLC-2 was achieved, which has been validated by increased sp/sp ratios and carbonyl contents.

Kampo medicine in the management of menopausal symptoms: A narrative review of therapeutic potential.

Menopausal symptoms primarily result from ovarian dysfunction and declining estrogen levels, leading to multisystem disorders. Although hormone therapy remains the most effective treatment, its long-term use is associated with significant risks, prompting interest in alternative options. Kampo medicine, a traditional Japanese system derived from Chinese herbal medicine, has gained renewed attention as a complementary and personalized therapeutic approach to menopausal health.

Traditional Chinese medicine for intractable and rare diseases: Research progress and future strategies.

Rare diseases have become a global public health challenge due to their low prevalence, difficult diagnosis, and limited treatment options. Intractable diseases are more common but often involve complex mechanisms, treatment with limited efficacy, and high medical costs, placing a heavy burden on patients and healthcare systems. In recent years, traditional Chinese medicine (TCM) has demonstrated unique advantages in the treatment of intractable and rare diseases and has gradually become an important complementary treatment.

Synthesis, characterization and induction of ferroptosis of iridium(III) complexes against B16 melanoma cells.

The synthesis of the ligand 2-(2-methyl-4-hydroxyl)phenyl-1-imidazo[4,5-][1,10]phenanthroline (MHIP) and its corresponding new iridium(III) complexes [Ir(ppy)(MHIP)]PF (ppy = 2-phenylpyridine, 9a), [Ir(bzq)(MHIP)]PF (bzq = benzo[]quinolone, 9b) and [Ir(piq)(MHIP)]PF (piq = 1-phenylisoquinoline, 9c) was reported. The antiproliferative activity of compounds 9a-9c on HepG2, B16, and A549 cancer cells as well as on normal NIH 3T3 cells was tested using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. It was found that the three complexes showed moderate cytotoxicity in A549 and B16 cells.

Intrinsic Flame-Retardant Solid-Solid Organic Phase Change Materials for High-Security Thermal Management.

Organic phase change materials (PCMs) provide great potential for zero-energy thermal management thanks to superior thermal storage cyclability, stable phase change temperature, and low supercooling behavior. However, liquid leakage and flammability are long-standing defects that limit their practical utilization in thermal management. Here, an intrinsic flame-retardant solid-solid organic phase change material synthesis strategy is realized by a facile multicomponent reaction (MCR) from dimethyl phosphite, benzaldehyde, and alcohol under mild conditions.

A Relay-Type Solid-State Macrocyclic Host-Guest System for Selective Isomer Adsorption, Controlled Release, and Turn-On Colorimetric Sensing of 1-/2-Bromoalkanes.

Macrocycle-based adaptive crystals have gained significant attention for their precise adsorption and separation capabilities. However, achieving controlled analyte release under nonthermal stimuli remains a major challenge. Here, a relay-type solid-state host-guest system based on a fluorinated pillararene derivative, EtFLP6, is presented, which enables selective adsorption of 1-/2-bromoalkane isomers, room-temperature-controlled desorption, and turn-on colorimetric sensing.

Clinical effect of psychological nursing and nutritional intervention in radiopharmaceutical therapy of patients with thyroid carcinoma.

Objective: To investigate the clinical value of psychological nursing and nutritional intervention in radiopharmaceutical therapy of patients with thyroid carcinoma.

Methods: This was retrospective study. One hundred and twenty patients with thyroid carcinoma were included at Baoding No.

Glycodiversification of gentamicins through glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity.

Aminoglycosides (AGs) are a class of antibiotics with a broad spectrum of activity. However, their use is limited by safety concerns associated with nephrotoxicity and ototoxicity, as well as drug resistance. To address these issues, semi-synthetic approaches for modifying natural AGs have generated new generations of AGs, however, with limited types of modification due to significant challenges in synthesis.

An Ultra-stable Supramolecular Framework Based on Consecutive Side-by-side Hydrogen Bonds for One-step CH/CH Separation.

The one-step efficient separation of high-purity CH from CH/CH mixtures by hydrogen-bonded organic frameworks (HOFs) faces two problems: lack of strategies for constructing stable pores in HOFs and how to obtain high CH selectivity. Herein, we have developed a microporous Mortise-Tenon-type HOF (MTHOF-1, MT is short for Mortise-Tenon structure) with a new self-assembly mode for CH/CH separation. Unlike previous HOFs which usually possess discrete head-to-head hydrogen bonds, MTHOF-1 is assembled by unique consecutive side-by-side hydrogen bonds, which result in mortise-and-tenon pores decorated with orderly arranged amide groups and benzene rings.

Water-Stable Microporous Bipyrazole-Based Framework for Efficient Separation of MTO Products.

Recently, methanol-to-olefins (MTO) technology has been widely used. The development of new adsorbents to separate MTO products and obtain high-purity ethylene (CH) and propylene (CH) has become an urgent task. Herein, an exceptionally highly water-stable metal-organic framework (MOF), [Cu(OH)(MeBPZ)]·(solvent) () (HMeBPZ = 3,3'-dimethyl-1,1'-4,4'-bipyrazole) with hexagonal pores, has been elaborately designed and constructed.

Highly Stable Metal-Organic Framework with Redox-Active Naphthalene Diimide Core as Cathode Material for Aqueous Zinc-Ion Batteries.

Recently, metal-organic frameworks (MOFs) as the cathode materials for aqueous zinc-ion batteries (ZIBs) received growing attention. Herein, a novel MOF, Ni-Ndi-trz (Ndi-trz=2,7-di(4H-1,2,4-triazol-4-yl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone) was synthesized through a solvothermal method. Its rational design using a naphthalene diimide (Ndi) core allowed the formation of a four-fold interpenetrated pcu (primitive cubic) topology.

Rational Pore Design of a Cage-like Metal-Organic Framework for Efficient CH/CO Separation.

Considering the importance of CH in industry, it is of great significance to develop porous materials for efficient CH/CO separation. Besides the high selectivity, the CH adsorption capacity is another vital factor in CH/CO separation. However, the "trade-off" between these two factors is still perplexing.

Stable Fluorinated Hybrid Microporous Material for the Efficient Separation of C-C Alkyne/Alkene Mixtures.

The separation of C-C alkyne/alkene mixtures is important but difficult work thanks to their similar physical and chemical properties. Crystalline porous materials with high alkyne adsorption and prominent separation selectivity of alkyne/alkene mixtures have been extensively investigated because of their energy-saving merits. Herein, we report a fluorinated hybrid microporous material (FJI-W1) that exhibits unexpected water and thermal stability.

Geological Control of Irreducible Water Within the Coal Matrix and Its Quantified Evaluation Model.

This paper adopts the measurement of mercury intrusion porosimetry and nuclear magnetic resonance (NMR) to analyze the pore system and the pore structure of coal samples, and the measurement of maceral group composition, scanning electron microscopy, and energy dispersive X-ray spectroscopy to obtain the organic/inorganic composition of coal samples. Gravimetric and NMR methods are both used to calculate irreducible water saturation of the samples, and qualitative and quantitative research studies are therefore conducted. The following knowledge is obtained.

Genome-Wide Assessment of Avocado Germplasm Determined from Specific Length Amplified Fragment Sequencing and Transcriptomes: Population Structure, Genetic Diversity, Identification, and Application of Race-Specific Markers.

Genomic data is a powerful tool. However, the phylogenetic relationships among different ecological races of avocado remain unclear. Here, we used the results from specific length amplified fragment sequencing (SLAF-seq) and transcriptome data to infer the population structure and genetic diversity of 21 avocado cultivars and reconstructed the phylogeny of three ecological races and two interracial hybrids.

Arbuscular mycorrhiza fungi increased the susceptibility of to powdery mildew caused by .

Powdery mildew caused by is a major factor that affects the growth of standing milkvetch (). As arbuscular mycorrhizal fungi (AMF) have shown to be enhancing the resistance of plants to biotrophic pathogens such as powdery mildew, a study was carried out to look at the effects of three AMF, either singularly or in combination, on the growth of standing milkvetch and susceptibility to . The results showed that the presence of AMF enhanced the growth of standing milkvetch even though their presence in the roots increased susceptibility to this foliage pathogen compared with plants having no AMF.

Synergistic Effects of Bacillus amyloliquefaciens (GB03) and Water Retaining Agent on Drought Tolerance of Perennial Ryegrass.

Water retaining agent (WRA) is widely used for soil erosion control and agricultural water saving. Here, we evaluated the effects of the combination of beneficial soil bacterium strain GB03 and WRA (the compound is super absorbent hydrogels) on drought tolerance of perennial ryegrass ( L.).

Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy.

Background: Depression has most often been diagnosed in patients with temporal lobe epilepsy (TLE), but the mechanism underlying this association remains unclear. In this study, we report that indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in epilepsy-associated depressive-like behavior.

Methods: Rats which develop chronic epilepsy following pilocarpine status epilepticus exhibited a set of interictal disorders consistent with depressive-like behavior.