Aqueduct-fourth ventricle-cisterna magna shunting as a prophylactic procedure for postoperative hydrocephalus in selective fourth ventricular tumors: A retrospective study.

Surgery for fourth ventricular tumors (FVT) is plagued by potential CSF blockage after the tumor removal due to a plethora of reasons. Thus, we explored the use of aqueduct-fourth ventricle-cisterna magna (AFVCM) shunting as prophylactic procedure for postoperative hydrocephalus after FVT resection. We retrospectively gathered the data of patients who underwent surgery of the fourth ventricle tumor between January 2019 and December 2021 at the Department of Neurosurgery in West China Hospital of Sichuan University.

Non-invasive and sensitive MRI assessment of radiation-induced cognitive dysfunction via voxel-based morphological and functional connectivity.

Background: Radiotherapy inevitably cause cognitive dysfunction. We aim to explore a non-invasive, sensitive strategy for assessing radiation-induced cognitive dysfunction, using voxel-based morphometry (VBM) and functional connectivity (FC), and to clarify the potential mechanisms from behavioral, histological, and molecular perspectives.

Methods: We employed a multimodal cross-validation strategy to evaluate cognitive dysfunction of C57BL/6j mice exposed to a single dose of 5 Gy or 15 Gy using a Co γ radiation source.

Recent advances in the study of reproductive function in pediatric patients with brain tumors.

In recent years, pediatric brain tumors have emerged as one of the most common malignant tumors among children. The site of tumor growth and the selected treatment modalities can potentially have a profound and significant impact on the reproductive function of pediatric patients, which is intimately associated with the physical and psychological health of children during their developmental process. Current research studies have demonstrated that pediatric patients diagnosed with germ cell tumors, craniopharyngiomas, and medulloblastomas commonly present with reproductive dysfunction.

Kampo medicine in the management of menopausal symptoms: A narrative review of therapeutic potential.

Menopausal symptoms primarily result from ovarian dysfunction and declining estrogen levels, leading to multisystem disorders. Although hormone therapy remains the most effective treatment, its long-term use is associated with significant risks, prompting interest in alternative options. Kampo medicine, a traditional Japanese system derived from Chinese herbal medicine, has gained renewed attention as a complementary and personalized therapeutic approach to menopausal health.

Traditional Chinese medicine for intractable and rare diseases: Research progress and future strategies.

Rare diseases have become a global public health challenge due to their low prevalence, difficult diagnosis, and limited treatment options. Intractable diseases are more common but often involve complex mechanisms, treatment with limited efficacy, and high medical costs, placing a heavy burden on patients and healthcare systems. In recent years, traditional Chinese medicine (TCM) has demonstrated unique advantages in the treatment of intractable and rare diseases and has gradually become an important complementary treatment.

Clinical Nomogram Model for Predicting the Prognosis of Patients with Brainstem Glioma : A Population-based Study.

Objective: The current understanding and clinical prediction of brainstem glioma (BSG) are still limited. This study aimed to conduct a large-scale population-based study to construct a clinical predictive model.

Methods: Patients with BSG diagnosed histologically from 1973 to 2016 were identified using the SEER database.

Potential drug targets for Neuromyelitis optica spectrum disorders (NMOSD): A Mendelian randomization analysis.

Background: Certain peripheral proteins are involved in the development of Neuromyelitis optica spectrum disorders (NMOSD), such as IL-6, complement proteins, and MHC class II molecules. However, the roles of other new protein biomarkers are unclear. Current NMOSD treatments (e.

Validation of measurement of body composition by dual-energy X-ray absorptiometry and bioelectrical impedance analysis and body composition's profiling in Tibetan's adults.

Objective: We aimed to validate in-body bioelectrical impedance analysis (BIA) measures with dual-energy X-ray absorptiometry (DXA) as reference and describe the body composition (BC) profiling of Tibetan adults.

Design: This cross-sectional study included 855 participants (391 men and 464 women). Correlation and Bland-Altman analyses were performed for method agreement of in-body BIA and DXA.

Compounds from sea buckthorn and their application in food: A review.

Sea buckthorn is a fruit rich in many bioactive compounds and shows the benefits of antioxidant, anti-inflammatory, anti-obesity, hepatoprotective, anti-tumor, and immunomodulatory properties, etc. The main bioactive compounds extracted and characterized in sea buckthorn are polyphenols, carotenoids, and functional lipids, which could provide health benefits by scavenging free radicals, regulating enzyme activities, and modulating signaling pathways, etc. Although there are many studies focused on the values of sea buckthorn, a comprehensive review on its chemical composition, functional mechanism and food application are still lacking.

Protocatechuic acid/sodium alginate multilayer coating induced by metal ion enhanced the ulcerative colitis alleviations of Lactiplantibacillus plantarum.

Oral intake of probiotics is a promising approach to alleviate colitis. However, environmental sensitivity of the gastrointestinal tract and poor adhesion of probiotics to the intestine hamper the remedial effects. In this study, a simple yet effective novel probiotic multilayer coating consisting of Fe-protocatechuic acid (PCA) crosslinked network and Ca-induced sodium alginate (SA) for arming Lactiplantibacillus plantarum (LP) was developed.

In vitro digestion and fermentation of the whole goji berry: Bioactive ingredients change and impacts on human gut microbiota.

Goji berry (Lycium barbarum L.) is a nutrient-rich fruit and has received enormous interest for its health benefits. The beneficial effects of goji berry are linked to the absorption of bioactive compounds within the gastrointestinal digestion process and colon fermentation.

Recent developments in delirium after oral and maxillofacial free-flap reconstruction.

Postoperative delirium (POD), a common complication following surgery and anesthesia, is particularly prone to occur after reconstruction surgery in the oral and maxillofacial region. The occurrence of POD seriously affects the incidence of postoperative complications, the survival of free flaps, the length of hospital stays, and brings great pain to patients and their families, and even increases perioperative mortality. Currently, a large number of studies have reported on the risk factors for POD after oral and maxillofacial free-flap reconstruction.

Sodium alginate-based indicator film with enhanced physicochemical properties induced by cellulose nanocrystals and monitor the freshness of chilled meat.

Intelligent indicator films with colorimetric pH indicator properties were developed, incorporating black soybean seed coat anthocyanin (BA), cellulose nanocrystals (CNC), and sodium alginate (SA) to monitor meat freshness. The effect of different CNC additions on the microstructure, water barrier properties of the films, and BA release kinetics were comprehensively investigated. The results showed that with the increasement of CNC addition, the mechanical properties of SA/BA/CNC films were improved, the water contact angle significantly increased from 51.

Tumor treating fields for newly diagnosed high-grade glioma based on the criteria of 2021 WHO CNS5: A retrospective analysis of Chinese patients in a single center.

Background And Objective: High-grade glioma (HGG) is known to be characterized by a high degree of malignancy and a worse prognosis. The classical treatment is safe resection supplemented by radiotherapy and chemotherapy. Tumor treating fields (TTFields), an emerging physiotherapeutic modality that targets malignant solid tumors using medium-frequency, low-intensity, alternating electric fields to interfere with cell division, have been used for the treatment of new diagnosis of glioblastoma, however, their administration in HGG requires further clinical evidence.

Effect of hawthorn polyphenol extracts on the physicochemical properties and digestibility of corn starch.

To investigate the effect of hawthorn polyphenols on the physicochemical properties and digestibility of corn starch, different proportions (1%, 2%, 3%, and 4% [w/w]) of hawthorn polyphenol extracts (HPEs) were mixed with corn starch, and their physicochemical properties and digestive properties were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Rapid Visco Analysis, differential scanning calorimetry, and in vitro/in vivo analysis. Results indicated that small V-type crystal starch tended to be formed in the samples, and the addition of HPEs reduced the viscosity, prolonged the gelatinization temperature of corn starch, and increased the proportion of slowly digestible starch and resistant starch of the corn starch, which accounted for 36.32% ± 1.

Enhance the resistance of probiotics by microencapsulation and biofilm construction based on rhamnogalacturonan I rich pectin.

Microcapsules were always used as functional material carriers for targeted delivery and meanwhile offering protection. However, microcapsule wall materials with specific properties were required, which makes the choice of wall material a key factor. In our previous study, a highly branched rhamnogalacturonan I rich (RG-I-rich) pectin was extracted from citrus canning processing water, which showed good gelling properties and binding ability, indicating it could be a potential microcapsule wall material.

Pectin from Marc. Alleviates Glucose and Lipid Metabolism by Regulating the Gut Microbiota and Metabolites.

The effects of pectin from Marc. on glycolipid metabolism, the morphologies of the pancreas and epididymal fat, the gut microbiota, and the metabolites of short-chain fatty acids (SCFAs) in db/db mice were investigated in this study. The results indicated that pectin reduced the levels of fasting blood glucose, glycated serum protein, triglycerides, total cholesterol, and low-density lipoprotein cholesterol while increasing the levels of high-density lipoprotein cholesterol.

FAM20C: A key protein kinase in multiple diseases.

Family with sequence similarity 20 C (FAM20C) is a Golgi protein kinase that phosphorylates the serine residue in the S-x-E/pS motif of target proteins. FAM20C phosphorylates most secreted proteins, which play important roles in multiple biological processes, including cancer progression, biomineralization, and lipid homeostasis. Numerous studies have documented the potential contribution of FAM20C to the growth, invasion, and metastasis of glioma, breast cancer, and other cancers, as well as to the mineralization process of teeth and bone.

Deep Learning for the Prediction of the Survival of Midline Diffuse Glioma with an H3K27M Alteration.

Background: The prognosis of diffuse midline glioma (DMG) patients with H3K27M (H3K27M-DMG) alterations is poor; however, a model that encourages accurate prediction of prognosis for such lesions on an individual basis remains elusive. We aimed to construct an H3K27M-DMG survival model based on DeepSurv to predict patient prognosis.

Methods: Patients recruited from a single center were used for model training, and patients recruited from another center were used for external validation.

Clinical outcomes and prognostic factors in the surgical treatment of spinal dural arteriovenous fistulas: a retrospective study of 118 patients.

Spinal dural arteriovenous fistulas (SDAVFs) are the most common type of spinal vascular malformations (AVMs), constituting approximately 70% of all spinal AVMs. The impact of various clinical and radiologic features on the outcomes in patients with SDAVFs is still controversial. The purpose of the study is to investigate the clinical outcomes and prognostic factors in patients with surgically treated SDAVFs in a single center.

Regulating the physicochemical, structural characteristics and digestibility of potato starch by complexing with different phenolic acids.

The effects of ferulic acid (FA), protocatechuic acid (PA), and gallic acid (GA) on the physicochemical characteristics, structural properties, and in vitro digestion of gelatinized potato starch (PS) were investigated. Rapid viscosity analysis revealed that the gelatinized viscosity parameters of PS decreased after complexing with different phenolic acids. Dynamic rheology results showed that phenolic acids could reduce the values of G' and G″ of PS-phenolic acid complexes, demonstrating that the addition of phenolic acids weakened the viscoelasticity of starch gel.

Blood-Blister Aneurysms of the Internal Carotid Artery in Tibetan and Han Populations : A Retrospective Observational Study.

Objective: Blood-blister aneurysms (BBAs) of the internal carotid artery (ICA) are challenging lesions with high morbidity and mortality rates. Although research on BBAs is well documented in different populations, the study of BBAs in the Tibetan population is extremely rare. This study aimed to evaluate the characteristics of BBAs and analyze the treatment modalities and long-term outcomes in the Tibetan population in comparison with the Han population.