A novel organoid model retaining the glioma microenvironment for personalized drug screening and therapeutic evaluation.

Glioma is an aggressive brain tumor with a poor prognosis. Establishing an in vitro culture model that closely replicates the cellular composition and microenvironment of the original tumor has been challenging, limiting its clinical applications. Here, we present a novel approach to generate glioma organoids with a microenvironment (GlioME) from patient-derived glioma tissue.

Effects of a novel Mg-C micro-electrolysis system for phenolic wastewater degradation: material characterization, influencing factors, and model optimization.

This study investigated a novel magnesium carbon micro-electrolysis (Mg-C ME) system for strengthening the removal of phenolic compounds in wastewater. The effects of the Mg/C mass ratio, aeration intensity, initial pH and reaction time on the degradation of three phenolic compounds and the COD removal efficiency in the simulated wastewater were evaluated using one-factor-at-a-time (OFAT) method. The optimum values obtained for the Mg/C mass ratio, aeration intensity, initial pH and reaction time were 3:1, 4.

Apcin inhibits the growth and invasion of glioblastoma cells and improves glioma sensitivity to temozolomide.

Glioblastoma (GBM) is the most common malignant primary brain tumor, and GBM patients have a poor overall prognosis. CDC20 expression is increased in a variety of tumors and associated with temozolomide (TMZ) resistance in glioma cells. Apcin specifically binds to CDC20 to inhibit APC/C-CDC20 interaction and exhibits antitumor properties.

Prognosis of synchronous colorectal carcinoma compared to solitary colorectal carcinoma: a matched pair analysis.

Background: Synchronous colorectal carcinoma (CRC) is a specific and rare type of colorectal malignancy. The data on the impact of synchronous CRC are controversial. This study aimed to compare the characteristics and prognosis between synchronous CRC and solitary CRC.

Associations between the HLA-A/B/DRB1 polymorphisms and aplastic anemia: evidence from 17 case-control studies.

Objective: To estimate the associations between HLA-A/B/DRB1 polymorphisms and aplastic anemia (AA), we carried out the meta-analysis.

Methods: In this meta-analysis, all publications in English and Chinese were considered up to 30 September 2015. The electronic databases we searched were Pubmed, Science Direct, Embase, Web of Science, CNKI, Wanfang Data and VIP.

Antiangiogenic drugs used with chemotherapy for patients with recurrent ovarian cancer: a meta-analysis.

Objective: The value of antiangiogenic inhibitors for patients with recurrent ovarian cancer has not been completely affirmed. Therefore, we aimed to assess the effectiveness and toxicities of various antiangiogenic drugs for the treatment of recurrent ovarian cancer.

Methods: In this meta-analysis, we searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials databases for complete randomized controlled trials.