Exploring the determinants of unhealthy dietary behaviors among pregnant women in China using the Theory of Planned Behavior-a cross-sectional study.

Background: Pregnant women in China are at risk of malnutrition due to an interplay of physiological, psychosocial, and environmental factors. Understanding the factors influencing dietary behaviors in pregnant women is vital for promoting maternal and infant health. This study explores the determinants of dietary behaviors among pregnant women in China based on the Theory of Planned Behavior (TPB).

Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation.

Atherosclerosis (AS) is a major contributor to cardiovascular disease. In traditional Chinese medicine, Tribulus terrestris L., or Baijili (BJL), has shown therapeutic effects on inflammation and cardiovascular issues.

Prevalence and Clinical Characteristics of Dark Without Pressure Retinal Changes in a Chinese Hospital-Based Population.

Introduction: This study investigates the clinical characteristics and prevalence of dark without pressure (DWP) retinal changes in a hospital-based Chinese population and evaluates its association with common fundus diseases.

Methods: This cross-sectional study analyzed data from 6787 eligible patients recruited from the Ophthalmology Department of Peking University First Hospital between April and July 2023. All participants underwent ultra-wide-field color fundus photography (UWF CFP) for the detection of DWP.

One-Month Changes in Choroidal Vascularity Index of Medium Vessel Layer in Children with Myopia Wearing Orthokeratology Lenses: a Predictor for One-Year Changes in Axial Length.

Introduction: Orthokeratology (ortho-K) is an established intervention for myopia control in children, yet the vascular mechanisms within the choroidal sublayers underlying its efficacy remain unclear. This study aims to investigate the changes in the choroidal vascularity index (CVI) of choroid sublayers after ortho-K treatment, the association between 1-month CVI changes and 1-year axial length (AL) elongation, and the role of CVI responses in predicting the 1-year control efficacy of ortho-K treatment.

Methods: A prospective cohort study was conducted, enrolling 257 children with myopia aged 7-16 years.

Effects of Salinity Fluctuation on Antimicrobial Resistance and Virulence Factor Genes of Low and High Nucleic Acid-Content Bacteria in a Marine Environment.

Salinity, as one of the critical environmental factors in marine ecosystems, has complex and wide-ranging biological effects. However, the effects of salinity fluctuation on antibiotic resistance genes (ARGs) and virulence factor genes (VFGs) in the marine environment are not well understood. In this study, metagenomic sequencing analysis was used to reveal the response of ARGs and VFGs, hosted by low and high nucleic acid-content bacteria (HNA and LNA bacteria), to salinity, as it decreased from 26‱ to 16‱.

Deubiquitinase OTUD4 Stabilizes SLC5A2 to Promote Pancreatic Cancer Proliferation and Migration Through Enchaining Glycolysis-Mediated Autophagy.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by its insidious onset, rapid progression, and poor treatment outcomes. Sodium glucose transporter 2 (SLC5A2) is the predominant sodium-glucose transporter. Our study reveals that SLC5A2 interacted with ovarian tumor family deubiquitinase 4 (OTUD4) to stabilize and increase its expression in PDAC.

Association between weight-adjusted-waist index and retinopathy among American adults: a cross-sectional study and mediation analysis.

Background: Retinopathy, a microvascular complication linked to obesity and metabolic dysfunction, is characterized by the absence of reliable anthropometric predictors. The weight-adjusted waist index (WWI), incorporating waist circumference and weight, may better capture visceral adiposity and its pathological impact. This study investigates the association between WWI and retinopathy in U.

Contrast-enhanced CT-Derived extracellular volume fraction predicts survival in postoperative pancreatic cancer patients.

Objective: To evaluate the prognostic value of extracellular volume (ECV) fraction derived from contrast-enhanced computed tomography (CECT) in predicting survival outcomes of resectable pancreatic ductal adenocarcinoma (PDAC).

Methods: The study cohort included a total of 166 patients with resectable PDAC who underwent CECT before operative excision between Jan 2018 and Mar 2021. Tumor CT-derived ECV fractions were calculated from unenhanced and equilibrium-phase CT images.

Enhanced BDE-47 biotransformation via cross-feeding in an aerobic-facultative anaerobic bacterial synthetic community.

2,2',4,4'-tetrabromodiphenyl ether (BDE-47) is a persistent organic pollutant that poses significant environmental challenges. Microbial transformation plays a crucial role in removing BDE-47. While most studies to date have focused on its degradation using single microbial strains under specific conditions, research on combined degradation approaches remains limited.

Nailfold capillary morphology changes in patients with retinal vein occlusion.

Aim: To investigate the changes in the morphology of nailfold capillaries in patients with retinal vein occlusion (RVO) and their relationship with retinal vessel density (RVD).

Methods: This cross-sectional study, included 30 patients with RVO and 30 normal controls. Nailfold capillaroscopy was used to evaluate the morphology of the nailfold capillaries, and optical coherence tomography angiography was used to evaluate RVD.

Pre-eclampsia, gestational hypertension, and lipid levels during pregnancy: a systematic review and meta-analysis.

Background: Gestational hypertension (GH) and pre-eclampsia (PE) are common high-risk complications of pregnancy, and are also one of the important causes of global maternal mortality and perinatal mortality. It has been suggested that abnormal lipid metabolism may play a key role in the pathogenesis of GH and PE. However, the results of different studies are controversial and lack of systematic quantitative analysis.

Advances in layer manganese dioxide for energy conversion and storage: mechanisms, strategies and prospects.

Layer manganese dioxide with its special structure, low price and large theoretical specific capacitance/capacity is considered a competitive candidate for various energy conversion and storage devices, such as supercapacitors and batteries (Li-ion, Na-ion, and Zn-ion) However, challenges such as low electronic/ionic conductivity, sluggish diffusion kinetics, and structural collapse during cycling are still the main factors limiting its practical application. A solid understanding of the correlation between structure and performance will greatly promote the performance and the further application of layer manganese dioxide. In this review, the energy storage mechanism of layer manganese dioxide in different energy storage devices is discussed in detail.

Gestational Diabetes Mellitus Rats Induce Anxiety-Depression-Like Behavior in Offspring: Association with Neuroinflammation and NF-κB Pathway.

The gestational diabetes mellitus (GDM) rat model was established through a combination of high-fat diet and streptozotocin. GDM is a common disease during pregnancy with high morbidity, which is associated with a high risk of neurological changes in the offspring. Neuroinflammation plays an important role in the development of anxiety-depression-like behavior.

27-hydroxycholesterol impairs placental development via p53/p21/Cdk6 pathway: Implications for nutrient transport and cellular senescence.

Aberrant placental development and function contribute to various pregnancy complications. 27-hydroxycholesterol (27-OHC), a recognized mediator linking hypercholesterolemia and metabolic diseases, has an undefined role in placental development. This study investigates the impact of 27-OHC on placental development and its underlying mechanisms, particularly in relation to cellular senescence.

Single staged repair of an anastomotic tracheal fistula following Mckeown esophagectomy via cervical incision: a case report.

Background: The incidence of tracheoesophageal fistula (TEF) following esophagectomy is less than 3%, but it often leads to severe complications and can even be life-threatening to patients. Surgical repair methods for TEF include muscle or omental flap support, biologic patch repair, and sleeve resection. In recent years, there has been an increasing number of case reports on primary closure via a cervical incision, with a rising success rate and a lower incidence of postoperative complications.

Interfacial Engineering of Liquid Metals in Thermal Science and Technology.

Liquid metals (LMs), with their unique metallic and fluidic properties at room temperature, show promising potential in advanced thermal-related applications. Nevertheless, challenges, such as high surface tension, limited wettability, phase separation, leakage, and corrosion, limit their integration into broader applications. In this Perspective, we overview the interfacial engineering approaches in enhancing the compatibility and stability of LMs in complex application environments.

Immune-Related Adverse Event of Immunotherapy: Diabetes.

Background: The development of immunotherapy has led to a paradigm shift in the treatment of malignant tumors. Immune checkpoint inhibitors (ICIs) function by blocking the receptors and ligands of T cells from binding one another, empowering them to target and attack cancer cells. ICIs along with other immunotherapy treatments, have seen a significant increase in usage in recent years.

Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation.

The PIWI-interacting RNA (piRNA) pathway plays a crucial role in protecting animal germ cells by repressing transposons. However, the mechanism of piRNA-guided heterochromatin formation and its relationship to transcriptional termination remains elusive. Through RNA interference screening, we discovered Pcf11 and PNUTS as essential for piRNA-guided silencing in Drosophila germ line.

LEDGF/p75 promotes transcriptional pausing through preventing SPT5 phosphorylation.

SPT5 exhibits versatile functions in RNA Pol II promoter proximal pausing, pause release, and elongation in metazoans. However, the mechanism underlying the functional switch of SPT5 during early elongation has not been fully understood. Here, we report that the phosphorylation site-rich domain (PRD)/CTR1 and the prion-like domain (PLD)/CTR2, which are situated adjacent to each other within the C-terminal repeat (CTR) in SPT5, play pivotal roles in Pol II pausing and elongation, respectively.

Anomalous drainage of lingular vein into left inferior pulmonary vein during thoracoscopic lung cancer surgery.

Background: The intricate anatomical variations in lung structure often perplex thoracic surgeons, and the accurate identification of these variations is closely associated with favorable surgical outcomes.

Case Presentation: A 53-year-old female patient who underwent computed tomography (CT) examination due to chest discomfort, revealing the presence of a partial solid nodule highly suspected of early-stage lung cancer, measuring approximately 2.8 × 2.

Integrative development of a concise screening questionnaire for early detection of pregnant women at risk for dystrophy.

Background: Maintaining a healthy diet during pregnancy is vital for reducing the risk of adverse birth outcomes. However, conventional methods of assessing the dietary behavior of pregnant women, such as the FFQ, are often time-consuming. This study aims to develop a concise nutritional screening questionnaire tailored for pregnant women, empowering prenatal healthcare providers to quickly identify key adverse dietary behaviors and provide targeted guidance.

Clinical Study on the Effects of Total Hip Arthroplasty Assisted by Virtual Planning Combined With Intraoperative Navigation Templates.

Objectives: Although total hip arthroplasty (THA) effectively alleviates pain and restores joint function in the end-stage hip disease, challenges remain in achieving precise osteotomy and minimizing subjective dependency on prosthesis positioning. This study aims to evaluate the efficacy and safety of preoperative virtual planning and navigation templates compared to conventional techniques, providing new methods to enhance the precision and personalization of THA.

Methods: During the period from 2022 to 2023, we conducted a retrospective case-control study on 74 patients who underwent THA surgery at our hospital, based on the inclusion and exclusion criteria.

ALKBH5 controlled autophagy of peripheral blood mononuclear cells by regulating NRG1 mRNA stability in ankylosing spondylitis.

Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease which is characterized by pathological osteogenesis. N6-methyladenosine (m6A) RNA modification is pivotal in immunity and inflammation. In this study, the peripheral blood mononuclear cells (PBMCs) were isolated from healthy or AS patients blood samples in Fuyang People's Hospital, which was utilized to clarify the role of m6A modification in AS pathogenesis.

Elevated serum cholesterol levels during pregnancy as predictors for postpartum hypercholesterolemia: A prospective cohort study.

Objective: To identify the associations between gestational cholesterol levels and the risk of postpartum hypercholesterolemia, and to establish trimester-specific reference values.

Methods: Serum lipids at gestational weeks 6-8, 16, 24, and 36, and 42 days postpartum were derived from 905 pregnant women of a prospective cohort. The major outcome was postpartum hypercholesterolemia.

Choroidal Optical Coherence Tomography Angiography: Noninvasive Choroidal Vessel Analysis via Deep Learning.

The choroid is the most vascularized structure in the human eye, associated with numerous retinal and choroidal diseases. However, the vessel distribution of choroidal sublayers has yet to be effectively explored due to the lack of suitable tools for visualization and analysis. In this paper, we present a novel choroidal angiography strategy to more effectively evaluate vessels within choroidal sublayers in the clinic.