Assessment of clinical efficacy and safety of sublingual immunotherapy for house dust mite-induced allergic pharyngitis with rhinitis.

Background: Sublingual immunotherapy (SLIT) has been widely established as a disease-modifying treatment for allergic airway diseases. However, its efficacy and safety in allergic pharyngitis (AP) remain insufficiently investigated and require further clinical validation.

Methods: In this retrospective study, 100 patients diagnosed with house dust mite (HDM)-induced AP concomitant with allergic rhinitis (AR) were enrolled.

Ecological presence and functional role of bacteriophages in fermented vegetables.

Fermented vegetables are widely favored by consumers for their distinctive flavors and nutritional value, with their quality attributes being closely associated with microbiome dynamics. Recent advances in high-throughput sequencing technologies have revealed abundant bacteriophage resources within the fermented vegetable microbiome. These viral components significantly influence fermentation processes and product characteristics by modulating microbial community structure and function.

Trends in the global burden of aortic valve calcification disease in the working-age population from 1992 to 2021.

Background: Calcific aortic valve disease (CAVD) is a degenerative condition marked by aortic valve thickening and calcification, leading to stenosis or regurgitation, with rising prevalence in developed countries.

Objectives: This study aimed to analyze the epidemiological trends and disease burden of CAVD in the global working-age population (defined in this study as the age group of 15 to 64 years) from 1992 to 2021. It further examined differences by Sociodemographic Index (SDI) regions and gender, providing insights for public health strategies.

Assessment of modified textbook outcomes following gastrectomy based on survival benefits: a multicenter observational study.

Background: Textbook outcome (TO) is an increasingly utilized metric for evaluating perioperative treatment quality. However, a standardized and universally accepted definition of TO in gastrectomy has not yet been established. This multicenter study aimed to evaluate the incidence of a modified definition of TO (mTO) and its association with long-term oncologic survival following gastrectomy.

Bacterial microbiome and their assembly processing in two sympatric desert rodents ( and ) from different geographic sources.

The microbiome of mammals has profound effects on host fitness, but the process, which drives the assembly and shift of mammalian microbiome remains poorly understood. To explore the patterns of small mammal microbial communities across host species and geographical sites and measure the relative contributions of different processes in driving assembly patterns, 2 sympatric desert rodent species ( and ) were sampled from 2 geographically distant regions, which differed in the environment, followed by 16S rRNA gene sequencing. The microbiomes differed significantly between and , and linear mixed modeling (LMM) analysis revealed that microbial diversity was mostly affected by species rather than the environment.

Phase-interface-anchored cadmium single-atom catalysts for efficient methanol steam reforming.

Employing interface engineering to design innovative single-atom catalysts (SACs) for effective methanol steam reforming (MSR) presents an attractive yet formidable challenge. Here, we report phase-interface confined Cd/P25 SACs, where Cd atoms are stably anchored at the phase interface between anatase (101) and rutile (110) facets. The Cd-O-Ti phase interface sites formed exhibit asymmetric geometric and electronic properties that enable 100% methanol conversion, a low CO concentration (~0.

In Situ Reconstruction of Bimetallic MOFs to Form Copper-Cobalt Relay Catalysis for Efficient Nitrate Reduction to Ammonia.

The electrochemical nitrate reduction reaction (eNORR) is hindered by poor selectivity and sluggish kinetics due to competing hydrogen evolution and complex multi-electron/proton transfers. Here, a bimetallic CuCo-MOF （Metal-Organic Framework） is reported catalyst that undergoes in situ electrochemical reconstruction to form copper nanoparticles embedded within a cobalt-MOF matrix, establishing spatially coupled active sites for tandem catalysis. Mechanistic investigations reveal that the in situ-generated Cu nanoparticles selectively catalyze the nitrate-to-nitrite conversion, while the adjacent cobalt sites in the MOF framework facilitate water dissociation to provide reactive hydrogen species (*H) for subsequent nitrite hydrogenation to ammonia.

Management of patients with cancer pain: an evaluation of AGREE II-based clinical practice guidelines.

Objective: To systematically evaluate the clinical practice guidelines for cancer pain management published during 2014-2024, analyze the quality characteristics and recommendations of existing guidelines, and provide an evidence-based basis for the development and implementation of standardized clinical practice guidelines for pain management.

Methods: A systematic search of PubMed, OVID, Cochrane Library, China National Knowledge, and other databases was performed to include guidelines related to the management of cancer pain patients. The Appraisal of Guidelines for Research and Evaluation Tool (AGREE II) was used to evaluate the quality of the literature that met the inclusion criteria and to determine the guideline recommendation level.

Self-management needs of adolescents with type 1 diabetes on transition to adult health care: a qualitative study.

Unlabelled: This study is to explore the self-management needs of adolescents with type 1 diabetes from the perspective of those who are currently undergoing or have recently completed the period of healthcare transition. One-on-one in-depth interviews were conducted with 13 adolescents between July 2024 and September 2024. Participants were recruited through purposive sampling at a tertiary hospital in Wenzhou, Zhejiang Province, China.

Isolation, Characterization, and Preliminary Application of Staphylococcal Bacteriophages in Sichuan Fermentation.

Sichuan , a microbial food predominantly fermented by lactic acid bacteria and hosting a complex and diverse microbial ecosystem, serves as an ideal habitat for bacteriophages. However, relatively few studies have been conducted on isolating bacteriophages from fermented vegetables and their application in vegetable fermentation. In this study, three staphylococcal bacteriophages, ΦSx-2, ΦSs-1, and ΦSs-2, were isolated and purified from Sichuan using the spot test method.

Exclusive Encapsulation Adhesive in a Neutral-Plane Model for Ultrahigh Mechanical Stability of Flexible Perovskite Solar Cells.

The functional layers of flexible perovskite solar cells (FPSCs) are subjected to significant stress during bending, causing structural failure and declining power conversion efficiency. To alleviate stress, a neutral plane (NP) is introduced by positioning the functional layers at the center of the device, with top metal electrode encapsulated by a protective layer. However, adhesive detachment remains a critical issue during multiple bending cycles, and the underlying mechanism remains unclear.

Integrated serum pharmacochemistry and network pharmacology to reveal the kernel material basis and underlying mechanisms of the fuzi-lizhong pill for ulcerative colitis.

Background: In traditional Chinese medicine, Fuzi-Lizhong pill (FLZP) has been used for millennia as a treatment for the Spleen-Kidney-Yang-deficiency (SKYD) diseases. FLZP has increasingly been employed in the clinic as a therapeutic option for ulcerative colitis with SKYD syndrome (SKYD-UC). In the present study, we revealed the kernel material basis and underlying mechanisms of the FLZP for treating SKYD-UC.

Effectiveness of sarcopenia screening indicators in predicting death in older patients with chronic heart failure.

Objective: This study investigated the associations between multiple sarcopenia screening indicators and the risk of mortality, both overall and within 30 days of discharge, in older patients with chronic heart failure (CHF).

Materials And Methods: This retrospective study enrolled inpatients aged ≥ 60 years diagnosed with CHF in a teaching hospital in western China. The general data of the patients between January 1, 2017 and July 7, 2022 were collected from the electronic medical record system, and information on mortality was obtained through telephonic follow-up from July 31, 2022 to August 1, 2022.

Influence of disaccharide and mixed starter cultures on the fermentation process in earthen jar of factory-produced Sichuan paocai.

Four Lactiplantibacillus plantarum strains, each possessing distinct characteristics, were employed as a mixed starter culture for a 28-day Sichuan paocai fermentation process, both in the presence and absence of disaccharides. The physicochemical properties, bacterial community composition, and metabolite profiles during Sichuan paocai fermentation were systematically analyzed. The results indicated that the pH value of brine in the mixed starter fermented group without disaccharide addition reached 3.

Optimizing aortic arch branch cannulation in acute type A dissection surgery: a minimally invasive approach.

Background: The optimal cannulation strategy for acute type A aortic dissection (ATAAD) surgery via a minimally invasive approach remains a topic of debate. This study aimed to compare the feasibility and safety of different aortic arch branch cannulation techniques using a single upper hemisternotomy.

Methods: A retrospective analysis was performed on 207 patients with ATAAD who underwent total arch replacement combined with frozen elephant trunk techniques between December 2019 and July 2023.

Metabolomic Profiling of Tomato Root Exudates Induced by Strains of Different Pathogenicity: Screening for Metabolites Conferring Bacterial Wilt Resistance.

Tomato is one of the most widely cultivated and consumed vegetables in the world, and its production is severely threatened by bacterial wilt. Bacterial wilt caused by , is one of the most devastating plant diseases. is a complex species with both virulent and avirulent strains.

Case Report: Heavy metal poisoning and acute liver failure following use of a folk remedy in a child with a burn.

Introducion: Folk remedies for the treatment of burns are widely used in China, often due to the belief that they can prevent scarring. However, these remedies may contain complex and unregulated ingredients that can worsen wound conditions, increase infection risk, and lead to systemic heavy metal poisoning.

Methods: We report the case of a 1-year-and-8-month-old boy with a burn injury who received treatment with a folk remedy.

Cancer driver topologically associated domains identify oncogenic and tumor-suppressive lncRNAs.

Cancer long noncoding RNAs (lncRNAs) have been identified by experimental and in silico methods. However, current approaches for identifying cancer lncRNAs are not sufficient and effective. To uncover them, we focus on the core cancer driver lncRNAs, which directly interact with cancer driver protein-coding genes (PCGs).

Protein phosphatase SCP4 regulates temporomandibular joint cartilage development via glucose metabolism.

Objective: Despite the growing evidence supporting the regulatory role of small carboxy-terminal domain (CTD) phosphatase 4 (SCP4) in metabolic pathways, limited knowledge exists concerning its involvement and molecular basis in temporomandibular joint (TMJ) cartilage growth, development, and homeostasis maintenance. Therefore, this study aims to investigate the role of SCP4 in chondrogenesis in condylar cartilage.

Methods: We generated chondrocyte-specific SCP4 conditional knockout mice (SCP4).

Carboxylesterase-activated hepatocyte-targeting fluorescent probe for drug-induced liver injury diagnosis.

In this study, a novel fluorescent probe DCI-Gal-Bz toward CEs was developed. DCI-Gal-Bz exhibits excellent sensitivity and selectivity toward CEs, which is not disturbed by physiologically relevant interferences. DCI-Gal-Bz could specifically distinguish hepatocytes from A549, HeLa, and SGC-7901 cells, showing good hepatocyte-targeting potential, which is because the terminal galactose of DCI-Gal-Bz can be selectively recognized by HepG2 cells overexpressing ASGPR.

Lysionotin promoted apoptosis of hepatocellular carcinoma cells via inducing autophagy.

Background: Hepatocellular carcinoma is a prevalent malignant tumor with a high mortality rate. Natural plants hold promise for its treatment, however, the mechanism of lysionotin induced apoptosis in liver cancer cells unclearly. This study aims to investigate the microenvironment alterations and the efficacy of lysionotin in liver cancer.

Benzoyl Chloride Derivatization Coupled With Liquid Chromatography-Mass Spectrometry for the Simultaneous Quantification of Molnupiravir and Its Metabolite β-d-N-hydroxycytidine in Human Plasma.

A sensitive and efficient method for simultaneous quantifying molnupiravir and its active metabolite β-d-N-hydroxycytidine in human plasma was developed by combining chemical derivatization with liquid chromatography-tandem mass spectrometry. Through benzoyl chloride chemical derivatization, the analytes exhibited improved mass spectral responses and enhanced chromatographic retention. Besides, the fragmentation patterns were optimized to identify analyte-specific fragments, enhancing detection specificity beyond the common benzoyl fragments.

Gut microbiota dysbiosis orchestrates vitiligo-related oxidative stress through the metabolite hippuric acid.

Background: Vitiligo, a depigmenting autoimmune skin disease characterized by melanocyte dysfunction or death, is known to be associated with an imbalance in gut microbiota. Oxidative stress plays a critical role in the pathogenesis of vitiligo. However, the complex promising interaction between abnormal accumulation of reactive oxygen species (ROS) in the skin and gut microbiota has remained unclear.