Electrocatalytic synthesis of methylamine from nitrate and carbon dioxide on a heterometallic polyphthalocyanine.

Electrocatalytic coreduction of nitrate and CO provides an opportunity for the synthesis of organonitrogen chemicals. The major challenge is to realize the simultaneous reduction of nitrate and CO into active intermediates for C-N bond formation. In this work, methylamine is synthesized from nitrate and CO on a polyphthalocyanine electrocatalyst with heterometal centers (CoCuPPc).

Predictors of Quality of Life in Myasthenia Gravis Patients from Southwestern China: Validation of Clinical and Socioenvironmental Determinants.

Introduction: Myasthenia gravis (MG) presents a substantial clinical burden, characterized by increased incidence of myasthenic crises, heterogeneity in treatment response, significant functional impairment, and gradually increasing mortality rates with marked geographical heterogeneity across China. While improving quality of life (QOL) is the focus of MG management, multifactorial determinants of QOL impairment remain unclear, especially in socioeconomically underrepresented regions, particularly Southwestern China. This study aimed to explore myasthenia-specific risk factors for QOL and develop a parsimonious prediction model.

Predictive Accuracy of Magnetocardiography for Diagnosing Myocardial Ischemia in NSTE-ACS Patients With Residual Post-PCI Angina.

Background: Post-percutaneous coronary intervention (PCI) angina affects 20% to 40% of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) survivors but remains a clinical challenge due to its unpredictable course.

Objectives: This study aimed to validate a rapid 90-second optically pumped magnetometer magnetocardiography (OPM-MCG) test for diagnosing post-PCI angina and develop a predictive model using dynamic MCG parameters.

Methods: NSTE-ACS patients who underwent pre- and post-PCI OPM-MCG scans were included.

Magnetocardiography's role in a recurrent angina patient following percutaneous coronary intervention - Case report.

Currently, there is a lack of convenient and effective methods for assessing recurrent angina following percutaneous coronary intervention (PCI). We documented the course of magnetocardiography's (MCG) changes in a 41-year-old man with recurrent angina throughout his visit to the clinic. The MCG suggested myocardial ischemia at the first visit.

Machine learning in diagnosing coronary artery disease via optical pumped magnetometer magnetocardiography: a prospective cohort study.

The potential of optical pumped magnetometer magnetocardiography (OPM-MCG) for diagnosing coronary artery disease (CAD) has been initially shown, yet lacks large-scale prospective research.Using invasive coronary angiography (ICA) as a reference, we constructed three feature sets for the development of machine learning (ML) models: a 'Heart' feature set consisting only of OPM-MCG features, a 'Clinical' feature set, and a 'Heart + Clinical' combined feature set. We assessed the performance of 11 ML models with 10-fold cross-validation and conducted a feature importance analysis.

Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway.

Background: Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions. While neuroendocrine-immune system dysfunction plays a crucial role in the development of autoimmune diseases, its involvement in MG remains largely unexplored. Kisspeptin, a neuropeptide hormone and endogenous ligand for GPR54 receptor, has been demonstrated to regulate antitumor immunity, antiviral immunity, and several autoimmune diseases.

Association of regional adiposity distribution with risk of autoimmune diseases.

Objective: To detect the association between regional adiposity distribution and the incidence of seven autoimmune diseases (ADs) in UK Biobank cohort and Mendelian randomization (MR) analyses.

Methods: We used Cox models to evaluate the associations between seven adiposity distribution measures and seven ADs (systemic lupus erythematosus [SLE], seropositive rheumatoid arthritis [PRA], psoriasis [PSO], multiple sclerosis [MS], myasthenia gravis [MG], Crohn's disease [CD] and ulcerative colitis [UC]) in cohort studies. In the MR analyses, we used the inverse variance-weighted MR method to estimate causal effects between adiposity distribution and obesity-related ADs in the cohort.

Determining water status of walnut orchards using the crop water stress index and canopy temperature measurements.

Background: Accurately evaluating the water status of walnuts in different growth stages is fundamental to implementing deficit irrigation strategies and improving the yield of walnuts. The crop water stress index (CWSI) based on the canopy temperature is one of the most commonly used tools for current research on plant water monitoring. However, the suitability and effectiveness of using the CWSI as an indicator of the walnut water status under field conditions are still unclear.

Improved evaluation of coronary artery diseases from patients with coronary calcification utilizing FFR: a comparative study against CCTA.

Objective: This multicenter study evaluated the diagnostic accuracy of coronary computed tomography angiography (CCTA) and computed tomography-derived fractional flow reserve (FFR) in diagnosing coronary artery disease (CAD), focusing on the impact of coronary calcification, using invasive coronary angiography (ICA) as the reference.

Methods: The study analyzed 4172 patients from 3 centers who underwent CCTA and FFR between August 2021 and August 2022. Exclusion criteria included the absence of ICA within 90 days after CCTA, left main disease, previous coronary revascularization, or unmeasurable Agatston score (AS).

Unveiling soil-borne antibiotic resistome and their associated risks: A comparative study of antibiotic and non-antibiotic pharmaceutical factories.

Antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB) are extensively documented within antibiotic pharmaceutical factories. Notably, non-antibiotic pharmaceuticals also represent a significant portion of the pharmaceuticals market. However, the comparative analyses of soil-borne ARG profiles and associated risks in different categories of pharmaceutical factories remain limited.

Development and validation of a clinical diagnostic model for myocardial ischaemia in borderline coronary lesions based on optical pumped magnetometer magnetocardiography: a prospective observational cohort study.

Objectives: To develop and validate a clinical diagnostic model based on optical pumped magnetometer magnetocardiography (OPM-MCG) for the detection of myocardial ischaemia in patients with borderline coronary lesions prior to invasive coronary angiography (ICA).

Design: Prospective observational cohort study.

Setting: Single centre of the China National Clinical Research Centre for Cardiovascular Disease (NCCMRC).

Parametrization of lower limit temperature in crop water stress index model: A case study of plantation.

The lower limit temperature in the crop water stress index (CWSI) model refers to the canopy temperature () or the canopy-air temperature differences () under well-watered conditions, which has significant impacts on the accuracy of the model in quantifying plant water status. At present, the direct estimation of lower limit temperature based on data-driven method has been successfully used in crops, but its applicability has not been tes-ted in forest ecosystems. We collected continuously and synchronously and meteorological data in a plantation at the southern foot of Taihang Mountain to evaluate the feasibility of multiple linear regression model and BP neural network model for estimating the lower limit temperature and the accuracy of the CWSI indicating water status of the plantation.

Engineering a solar formic acid/pentose (SFAP) pathway in Escherichia coli for lactic acid production.

Microbial CO fixation into lactic acid (LA) is an important approach for low-carbon biomanufacturing. Engineering microbes to utilize CO and sugar as co-substrates can create efficient pathways through input of moderate reducing power to drive CO fixation into product. However, to achieve complete conservation of organic carbon, how to engineer the CO-fixing modules compatible with native central metabolism and merge the processes for improving bioproduction of LA is a big challenge.

Double-layer horizontal cross sutures for intra-atrial mitral valve implantation: An effective surgical method for severe mitral annular calcification.

Objective: Severe mitral annular calcification (MAC) can make prosthetic implantation extremely difficult. Although intra-atrial mitral valve prosthesis implantation without annular decalcification offers a simpler approach, it poses a potential rupture risk due to high left ventricular pressure. We developed a double-layer (DL) horizontal cross-suture technique, which ensures close proximity of the valve prosthesis to the calcified annulus and segregates the left atrial wall from the left ventricle.

Single-cell mapping reveals dysregulation of immune cell populations and VISTA+ monocytes in myasthenia gravis.

The pathogenesis and progression of myasthenia gravis (MG), an autoimmune disease, involve abnormal function and composition of several immune cell populations. However, details of this dysregulation remain unclear. We performed a cross-section analysis using cytometry time-of-flight on blood samples from 12 generalized MG without glucocorticoid or other immunosuppressant treatment, and 10 sex- and age-matched healthy controls.

Recent advances in separation applications of polymerized high internal phase emulsions.

Polymerized high internal phase emulsions as highly porous adsorption materials have received increasing attention and wide applications in separation science in recent years due to their remarkable merits such as highly interconnected porosity, high permeability, good thermal and chemical stability, and tailorable chemistry. In this review, we attempt to introduce some strategies to utilize polymerized high internal phase emulsions for separation science, and highlight the recent advances made in the applications of polymerized high internal phase emulsions for diverse separation of small organic molecules, carbon dioxide, metal ions, proteins, and other interesting targets. Potential challenges and future perspectives for polymerized high internal phase emulsion research in the field of separation science are also speculated at the end of this review.

Quantifying aircraft emissions of Shanghai Pudong International Airport with aircraft ground operational data.

The air traffic growth at Shanghai Pudong International Airport (PVG) has attracted much concern over the potential impacts on local air quality and human health; however, the emission contributions due to aircraft activities, impact on air quality and health effects remain unclear. In this study, the ground operational data derived from the Aircraft Communication Addressing and Reporting System (ACARS) dataset are newly utilized to obtain the PVG-specific emission parameters of 10 distinct aircraft-engine combinations during the taxi-in and taxi-out phases of the landing and take-off (LTO) cycle. The resulting emission parameters, together with PVG-specific operational conditions, are applied to quantify the annual emissions in 2017 for main engines and auxiliary power units (APUs) at PVG, emission variations caused by mixing layer height, sensitivity of black carbon (BC) emissions to the estimation method and sensitivity of PM emissions to the fuel sulfur content (FSC).

Controllable Surface Reorganization Engineering on Cobalt Phosphide Nanowire Arrays for Efficient Alkaline Hydrogen Evolution Reaction.

Developing highly efficient hydrogen evolution reaction (HER) catalysts in alkaline media is considered significant and valuable for water splitting. Herein, it is demonstrated that surface reorganization engineering by oxygen plasma engraving on electocatalysts successfully realizes a dramatically enhanced alkaline HER activity. Taking CoP nanowire arrays grown on carbon cloth (denoted as CoP NWs/CC) as an example, the oxygen plasma engraving can trigger moderate CoO species formation on the surface of the CoP NWs/CC, which is visually verified by the X-ray absorption fine structure, high-resolution transmission electron microscopy, and energy-dispersive spectrometer (EDS) mapping.

Promoting Active Species Generation by Electrochemical Activation in Alkaline Media for Efficient Electrocatalytic Oxygen Evolution in Neutral Media.

In this study, by using dicobalt phosphide nanoparticles as precatalysts, we demonstrated that electrochemical activation of metallic precatalysts in alkaline media (comparing with directly electrochemical activation in neutral media) could significantly promote the OER catalysis in neutral media, specifically realizing a 2-fold enhanced activity and meanwhile showing a greatly decreased overpotential of about 100 mV at 10 mA cm. Compared directly with electrochemical activation in neutral media, the electrochemical activation in harsh alkaline media could easily break the strong Co-Co bond and promote active species generation on the surface of metallic CoP, thus accounting for the enhancement of neutral OER activity, which is also evidenced by HRTEM and the electrochemical double-layer capacitance measurement. The activation of electrochemical oxidation of metallic precatalysts in alkaline media enhanced neutral OER catalysis could also be observed on CoP nanoparticles and NiP nanoparticles, suggesting this is a generic strategy.

[Correction of whistle deformity in bilateral cleft lip with lower lip bipedicle orbicularis oris musculomucosal island flap].

Objective: To explore a new method to correct the whistle deformity in bilateral cleft lip.

Methods: A lower lip bipedicle orbicularis oris musculomucosal island flap was designed to repair the upper vermilion defect.The pedicle of this flap was deepidermidalized and then embedded into the upper lip.