Genome-Wide Association Study and Candidate Gene Identification for Girth Traits in Rubber Tree.

As a key tropical economic tree species, the girth of the rubber tree () not only reflects its growth rate and timber yield but also determines tapping schedules and non-productive periods. This trait critically influences both the species' economic value and latex production potential. Despite recent advances in genetic analyses of girth driven by genomic technologies, the number of identified key genes remains insufficient to support molecular breeding programs.

How policymakers value end-of-life treatments for rare and common diseases in China: evidence from a contingent valuation study.

Background: Understanding policymakers' value judgements in reimbursement decisions is essential for promoting equity and guiding informed healthcare decision-making. This study aimed to estimate and compare Chinese policymakers' willingness-to-pay (WTP) per quality-adjusted life year (QALY) specifically in end-of-life treatment scenarios involving life-threatening common and rare diseases.

Methods: We conducted a contingent valuation study employing single-bounded dichotomous-choice questions among 120 experts formally appointed by China's National Healthcare Security Administration to serve on the National Reimbursement Drug List Expert Committee in recent years.

Tumor Stiffness-Enhanced Room Temperature Phosphorescence Imaging Using Dual-Ligand Nanoprobes.

Organic room temperature phosphorescence (RTP) materials offer high tumor-to-background imaging contrast owing to their long afterglow and minimal autofluorescence interference. In this work, a targeted phosphorescent nanoprobe is prepared based on a pyrene/benzophenone (PyBP) guest-host system and further functionalized it with folic acid and cyclic Arg-Gly-Asp peptide for enhanced tumor specificity. In oral squamous cell carcinoma (OSCC) xenograft models, this dual-ligand nanoprobe can help achieve a four-fivefold increase in the tumor signal over the background.

Machine learning based on pangenome-wide association studies reveals the impact of host source on the zoonotic potential of closely related bacterial pathogens.

Variations in host species significantly impact bacterial growth traits and antibiotic resistance, making it essential to consider host origin when evaluating the zoonotic potential of pathogens. This study focuses on multiple Brucella species, which share highly similar genetic material, to explore the relationship between host origin and zoonotic potential by integrating pan-genome-wide association studies (pan-GWAS) with machine learning (ML). Our results present an open pangenome of Brucella spp.

Evaluation of the total antioxidant capacity of Anchusa italica retz using carbon fiber microelectrode modified by Au-Ag alloy urchin-like nanostructures.

Anchusa italica Retz, a plant rich in bioactive compounds, has garnered considerable attention for its antioxidant properties and associated health benefits. However, the traditional methods for assessing antioxidant capacity often suffer from limited sensitivity and operational complexity. To overcome these challenges, gold-silver alloy urchin-like nanostructures (AAA-UNs) were synthesized using an ascorbic acid reduction method and electrodeposited onto a carbon fiber microelectrode (CFME) to form a highly sensitive electrochemical sensor (AAA-UNs/CFME).

Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration.

Age-related macular degeneration (AMD) is the leading cause of central vision impairment among the elderly. Geographic atrophy is a defining characteristic of AMD, but the detailed mechanism for massive loss of retinal pigment epithelium (RPE) cells is not fully understood. In this study, we found that Z-DNA binding protein 1 (ZBP1), a sensor for dsDNA, is able to induce RPE cell PANoptosis.

Phase Equilibrium Regulation in ZIF-67-Derived Electrocatalysts: Degradation Mechanism and Stability Enhancement for Oxygen Evolution Reaction.

Metal-organic frameworks (MOFs) like ZIF-67 are promising electrocatalysts due to their tunable structures and porosity, but their instability in aqueous electrolytes requires a deeper understanding. This study investigates the structural evolution and degradation mechanism of ZIF-67 during the oxygen evolution reaction (OER) in alkaline media. Using atomic-resolution identical-location transmission electron microscopy, we reveal its transformation pathway: ZIF-67 first converts to Co(OH), then progressively evolves into catalytically active CoOOH and inactive CoO species, ultimately establishing a dynamic three-phase equilibrium under operational conditions.

Sub-Nano Ir-Based Alloy Clusters by Hierarchical Confinement Effect for Water Splitting.

The synthesis of sub-nanoscale noble metal catalysts is pivotal for enhancing electrocatalytic performance, yet achieving precise control over particle size at this scale remains a critical challenge. In this work, we propose a hierarchical confinement strategy which combines spatial confinement at nanoscale and anchoring confinement at atomic scale, to overcome the size limitations imposed by high-temperature sintering. Using this strategy, a series of uniformly sized (∼1 nm) Ir-based alloy clusters, including IrMn, IrFe, IrCo and IrNi, are successfully fabricated.

The haplotype-resolved telomere-to-telomere genome and OMICS analyses reveal genetic responses to tapping in rubber tree.

Rubber tree (Hevea brasiliensis) is the primary source of natural rubber and economically important. We present the haplotype-resolved, telomere-to-telomere, gap-free genome assembly of the cultivar CATAS 7-33-97, with both haplotypes containing complete telomeric and centromeric regions. Structural variations, including a 32.

Resolving the Ambiguity of Complete-to-Partial Point Cloud Registration for Image-Guided Liver Surgery with Patches-to-Partial Matching.

In image-guided liver surgery, the initial rigid alignment between preoperative and intraoperative data, often represented as point clouds, is crucial for providing sub-surface information from preoperative CT/MRI images to the surgeon during the procedure. Currently, this alignment is typically performed using semi-automatic methods, which, while effective to some extent, are prone to errors that demand manual correction. Alternatively, correspondence-based point cloud registration methods further offer a promising fully automatic solution.

Multimodal Model for Non-Invasive Detection of DRD2, SSTR2 and ESR1 Receptor Profiling in Pituitary Neuroendocrine Tumors: A Retrospective Study.

: The dopamine receptor D2 (DRD2), somatostatin receptor 2 (SSTR2), and oestrogen receptor 1 (ESR1) have been demonstrated to play a critical role in determining treatment response in pituitary neuroendocrine tumors (PitNETs). However, the identification of these receptors preoperative presented a significant challenge. The objective of this study was to develop a predictive model that employs both radiomics and deep learning features in conjunction with conventional magnetic resonance imaging (MRI) to predict the expression of these three receptors in PitNETs in a retrospective study.

Meta-analysis of erector spinae plane block efficacy in managing postoperative pain following cardiac surgery.

Cardiac surgery is associated with significant postoperative pain, necessitating effective multimodal analgesia to reduce opioid-related morbidity. This systematic review and meta-analysis evaluated the analgesic efficacy of erector spinae plane block (ESPB) in adult cardiac surgery. Twenty-three randomized controlled trials (1,612 patients) were included.

NF-YB-driven expression of long non-coding RNA linc01811 inhibiting glioma tumorigenesis by regulating miR-4635/NF-YB axis: A positive feedback loop.

Glioma, the most common malignant tumor of the central nervous system, is regulated by long non-coding ribonucleic acids (lncRNAs). This study reported that linc01811 is expressed at low levels in gliomas and inhibits glioma tumorigenesis by regulating the miR-4635-nuclear transcription factor Y subunit beta (NF-YB) axis. MiR-4635 is identified as a direct target of linc01811 and can specifically target the 3' untranslated region of NF-YB and consequently downregulate its expression.

IDNet: An inception-like deformable non-local network for projection compensation over non-flat textured surfaces.

Projector compensation on non-flat, textured surfaces represents a formidable challenge in computational imaging, with conventional convolution-based methods frequently encountering critical limitations, especially in image edge regions characterized by complex geometric transformations. To systematically address these persistent challenges, we introduce IDNet, an innovative framework distinguished by its multi-scale receptive feature extraction modules. Central to our approach are multi-scale deformable convolution modules that dynamically adapt to geometric distortions through intelligently flexible sampling positions and precise offset mechanisms, which significantly enhance processing capabilities in intricate distortion regions.

Patient-specific guided Deep Circumflex Iliac Artery free flap for mandibular reconstruction in an ameloblastoma case. Case report and insights on the current state of customized surgery in H&N reconstruction in China.

This article presents a case of recurrent mandibular ameloblastoma treated with customized reconstructive surgery using a microvascularized DCIA bone flap. Virtual surgical planning and customized surgery, which has become increasingly adopted in head and neck reconstruction, enhances precision in tumor resection, flap design, and fixation, leading to superior functional and aesthetic outcomes. The patient, initially treated with curettage in China (2017) and Japan (2021), presented with recurrence upon relocating to Shanghai.

Omic AI reveals new autophagy regulators from the Atg1 interactome in .

In , Atg1 is a core autophagy-related (Atg) protein kinase (PK) in regulating macroautophagy/autophagy, by physically interacting with numerous other proteins, or by phosphorylating various substrates. It is unclear how many Atg1-interacting partners and substrates are also involved in regulating autophagy. Here, we conducted transcriptomic, proteomic and phosphoproteomic profiling of Atg1-dependent molecular landscapes during nitrogen starvation-triggered autophagy, and detected 244, 245 and 217 genes to be affected by in the autophagic process at mRNA, protein, and phosphorylation levels, respectively.

Architecting Three-Dimensional Porous Energy Harvesters with Bamboo-Like Filaments for Enhanced Piezoelectric Performance.

Three-dimensional (3D) poly(vinylidene fluoride) (PVDF)-based piezoelectric energy harvesters (PEHs) offer exceptional electromechanical conversion capabilities due to their flexible structures and customizable designs. However, how to design and construct such structures with enhanced strain for a higher piezoelectric output remains a complex challenge. This study presents a novel approach by combining the versatility of 3D printing with solvent exchange to create a unique 3D porous bamboo-structured PVDF/MXene PEH, allowing for a tailored hollow structure by adjusting the temperature and solvent concentration.

Vascular Endothelial Growth Factor-Mimetic Peptide and Mitochondria-Targeted Antioxidant-Loaded Hydrogel System Improves Repair of Myocardial Infarction in Mice.

Myocardial infarction (MI) is a pathological state characterized by persistent ischemia of the heart. Following MI, the structural and functional remodeling of the myocardium and vasculature involves oxidative stress and mitochondrial dysfunction, which exacerbate myocardial injury. Currently, there are limited effective treatments available to alleviate MI-induced damage.

The calcium-sensitive receptor in the pathogenesis of sepsis.

Sepsis is an organ dysfunction caused by the body's dysfunctional response to infection, which is one of the most important causes of death in critically ill patients. It is characterized by high morbidity, high mortality, and high treatment costs. Currently, the treatment of sepsis relies mainly on supportive therapy, and there is a lack of targeted intervention ways.

INR Smooth: Interframe noise relation-based smooth video synthesis on diffusion models.

The text-to-video generation task can provide people with rich and diverse video content, but it also has some typical issues, such as content inconsistency between video frames or text alignment failure, which degrade the smoothness of video. And in the process of improving the video smoothing problems, the background texture and artistic expression are often lost because of the excessive smoothing. Based on the above problems, this paper proposes INR Smooth, a type of video smoothing strategy based on the relationship between interframe noise, which can improve the smoothness of most T2V generation tasks.

Transcriptome analysis of nitrogen assimilation preferences in sp. M6-3 and sp. M7-15.

Introduction: Ammonium (NH ) and nitrate (NO ) are the two main forms of inorganic nitrogen (N) that exist in soil and both can be absorbed and utilized by plants. As a vast and crucial biome, soil microorganisms are responsible for mediating the inorganic N assimilation process and enhancing nitrogen use efficiency. Understanding how these microorganisms assimilate different forms of inorganic nitrogen is crucial.

Effects of resistance training on breast cancer-related arm lymphedema: a systematic review and dose-response meta-analysis.

Purposes: This meta-analysis aims to (1) examine how resistance training affects lymphedema and muscle strength; and (2) evaluate the extent of improvement in lymphedema with different exercise dosages in breast cancer patients.

Methods: Eight English and Chinese electronic databases were searched from their inception up to April 7, 2024. A dose-response meta-analysis was performed with R software.

Integrative Proteomic and Phosphoproteomic Profiling Reveals Molecular Mechanisms of Hypoxic Adaptation in Brandt's Voles () Brain Tissue.

Rapid ascent to high altitudes by unacclimatized individuals significantly increases the risk of brain damage, given the brain's heightened sensitivity to hypoxic conditions. Investigating hypoxia-tolerant animals can provide insights into adaptive mechanisms and guide prevention and treatment of hypoxic-ischemic brain injury. In this study, we exposed Brandt's voles to simulated altitudes (100 m, 3000 m, 5000 m, and 7000 m) for 24 h and performed quantitative proteomic and phosphoproteomic analyses of brain tissue.

Inferring kinase-phosphosite regulation from phosphoproteome-enriched cancer multi-omics datasets.

Phosphorylation in eukaryotic cells plays a key role in regulating cell signaling and disease progression. Despite the ability to detect thousands of phosphosites in a single experiment using high-throughput technologies, the kinases responsible for regulating these sites are largely unidentified. To solve this, we collected the quantitative data at the transcriptional, protein, and phosphorylation levels of 10 159 samples from 23 tumor datasets and 15 adjacent normal tissue datasets.