Adefovir dipivoxil-associated Fanconi syndrome combined with peripheral neuropathy: a case report and literature review.

Long-term use of low-dose adefovir dipivoxil (ADV) has been increasingly associated with Fanconi syndrome; however, cases of Fanconi syndrome combined with peripheral neuropathy remain rare. Here, we report a 67-year-old man who developed progressive limb weakness and sensory abnormalities after approximately 6 years of treatment with 10 mg ADV. He was diagnosed with ADV-associated Fanconi syndrome accompanied by peripheral neuropathy.

Enhancing microbe-disease association prediction via multi-view graph convolution and latent feature learning.

Microbes play a crucial role in the onset, progression, and treatment of diseases. To address the challenges of missing information and insufficient feature fusion in microbe-disease association prediction, this paper proposes an innovative computational model named MVGCVAE. MVGCVAE is the first model to synergistically integrate multi-view graph convolutional networks (GCNs), variational autoencoders (VAEs), and dynamic kernel matrix weighting for microbe-disease association (MDA) prediction.

Elucidating the Effects of Electrolytes on a Robust MOF Interface for Enhanced CO Electroreduction to C Products.

Elucidating the role of electrolytes in steering CO electroreduction toward C products is critical, yet impeded by dynamic electrocatalyst reconstruction during the CORR. Herein, we successfully prepared a novel Cu-based metal-organic framework (Cu-BDP, BDP = 1,4-benzenedipyrazolate) with robust Cu-N coordination. Bode phase analysis and contact angle measurements demonstrate that Cs cations facilitate interfacial charge transfer and establish local hydrophobic microenvironments to suppress hydrogen evolution reactions.

HydroWrap for T2DM-Related Fractures: A smart HS-delivery controller modulating Macrophage senescence.

Impaired fracture healing in type 2 diabetes mellitus (T2DM) poses a significant clinical challenge, primarily due to a compromised bone microenvironment driven by senescent macrophages and their amplifying effects. Reduced hydrogen sulfide (HS) levels are a critical contributor to this pathology. To address this, we developed HydroWrap, an advanced HS-delivery controller designed to modulate distinct stages of macrophage senescence.

exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs.

Introduction: Sepsis is a life-threatening condition that often leads to organ dysfunction and systemic inflammation, with gut microbiota dysbiosis playing a crucial role in its pathogenesis. The role of (), a potentially pathogenic bacterium, in sepsis remains unclear.

Methods: We first assessed the abundance of in the feces of septic mice and patients using qPCR.

Omic AI reveals new autophagy regulators from the Atg1 interactome in .

In , Atg1 is a core autophagy-related (Atg) protein kinase (PK) in regulating macroautophagy/autophagy, by physically interacting with numerous other proteins, or by phosphorylating various substrates. It is unclear how many Atg1-interacting partners and substrates are also involved in regulating autophagy. Here, we conducted transcriptomic, proteomic and phosphoproteomic profiling of Atg1-dependent molecular landscapes during nitrogen starvation-triggered autophagy, and detected 244, 245 and 217 genes to be affected by in the autophagic process at mRNA, protein, and phosphorylation levels, respectively.

How does the upgraded domestic emission control area policy affect PM concentrations in port cities of China?

Ship emissions are significant sources of air pollution in coastal areas. To mitigate the impacts of these emissions, China implemented the Domestic Emission Control Area (DECA) policy, which was upgraded to DECA 2.0 in late 2018, aiming at improving air quality in port cities.

Hybrid gabor attention convolution and transformer interaction network with hierarchical monitoring mechanism for liver and tumor segmentation.

Liver and tumor segmentation is an important technology for the diagnosis of hepatocellular carcinoma. However, most existing methods struggle to accurately delineate the boundaries of the liver and tumor due to significant differences in their shapes, sizes, and distributions, which leads to unclear segmentation of the liver contour and incorrect delineation of the lesion area. To address this gap, we propose a hybrid gabor attention convolution and transformer interaction network with hierarchical monitoring mechanism for liver and tumor segmentation, named HyborNet.

GPSD: a hybrid learning framework for the prediction of phosphatase-specific dephosphorylation sites.

Protein phosphorylation is dynamically and reversibly regulated by protein kinases and protein phosphatases, and plays an essential role in orchestrating a wide range of biological processes. Although a number of tools have been developed for predicting kinase-specific phosphorylation sites (p-sites), computational prediction of phosphatase-specific dephosphorylation sites remains to be a great challenge. In this study, we manually curated 4393 experimentally identified site-specific phosphatase-substrate relationships for 3463 dephosphorylation sites occurring on phosphoserine, phosphothreonine, and/or phosphotyrosine residues, from the literature and public databases.

Driving factors of ship-induced nitrogen dioxide concentrations over coastal seas of China: Implications for ship emission management.

Ships generate large amounts of air pollutants, including nitrogen dioxide (NO) that profoundly impacts air quality and poses serious threats to human health. It is crucial to understand the dynamics and drivers of ship-induced NO concentrations in China to support the prevention and control of fine particulate matter (PM) and ozone (O) pollution. This study built Generalized Additive Models (GAMs) to reveal the nonlinear effects of meteorological factors and ship emissions on ship-induced NO concentrations based on the Tropospheric Monitoring Instrument (TROPOMI) satellite data, AIS based emission model and meteorological data.

Elevated EBF2 in mouse but not pig drives the progressive brown fat lineage specification via chromatin activation.

Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis, but it is absent in some mammals, including pigs. During development, BAT progenitors are derived from paired box 7 (Pax7)-expressing somitic mesodermal stem cells, which also give rise to skeletal muscle. However, the intrinsic mechanisms underlying the fate decisions between brown fat and muscle progenitors remain elusive across species.

Oxygen Vacancy Engineering and Constructing Built-In Electric Field in Fe-g-CN/BiMoO Z-Scheme Heterojunction for Boosting Photo-Fenton Catalytic Degradation Performance of Tetracycline.

A novel Fe-g-CN/BiMoO (FCNB) Z-scheme heterojunction enriched with oxygen vacancy is constructed and employed for the photo-Fenton degradation of tetracycline (TC). The 2% FCNB demonstrates prominent catalytic performance and mineralization efficiency for TC wastewater, showing activity of 8.20 times greater than that of pure photocatalytic technology.

Metabolomics reveals the importance of metabolites in Mussaenda pubescens for antioxidant properties and quality traits.

Mussaenda pubescens (Mp) is a valuable medicinal plant that has traditionally been used for medicinal purposes or as a tea substitute. However, there are few studies on the comprehensive and dynamic evaluation of Mp metabolites. This study used an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach and biochemical analysis to investigate substance changes in leaves at three different stages and elucidate the relationship between metabolites and antioxidant capacity.

Strain Engineering for Electrocatalytic Overall Water Splitting.

Strain engineering is a novel method that can achieve superior performance for different applications. The lattice strain can affect the performance of electrochemical catalysts by changing the binding energy between the surface-active sites and intermediates and can be affected by the thickness, surface defects and composition of the materials. In this review, we summarized the basic principle, characterization method, introduction strategy and application direction of lattice strain.

Effects of emission control areas on sulfur-oxides concentrations--Evidence from the coastal ports in China.

The setting of Sulfur limitations in Emission Control Areas (ECAs) is a crucial action of marine environmental governance at the international regulatory levels. In this study, the overall and structural impacts of the two rounds of ECA policies on SOx concentrations were quantified using synthetic control method (SCM) based on time-series data from Chinese coastal ports from 2005 to 2020. From the outcomes, the 1st round of ECA policy announced in 2015 intensified the competition between ECA and non-ECA ports and provided strong support for ECA expansion and enhanced regulation in 2019.

Dexmedetomidine alleviates hippocampal neuronal loss and cognitive decline in rats undergoing open surgery under sevoflurane anaesthesia by suppressing CCAAT/enhancer-binding protein beta.

Dexmedetomidine (Dex) may exert neuroprotective effects by attenuating inflammatory responses. However, whether Dex specifically improves postoperative cognitive dysfunction (POCD) by inhibiting microglial inflammation through what pathway remains unclear. In this study, the POCD model was constructed by performing open surgery after 3 h of continuous inhalation of 3% sevoflurane to rats, which were intraperitoneally injected with 25 μg/kg Dex .

Tuning the interface of MM(OH)F@MMS (M: Ni, Co; M: Co, Fe) by atomic replacement strategy toward high performance overall water splitting.

Constructing heterostructure is considered as one of the most promising strategies to reveal high efficiency hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) performance. Nevertheless, it is highly challenging to obtain stable interfaces and sufficient active sites via conventional method. In addition, Ni, Co and Fe elements share the valence electron structures of 3d4s, the appropriate integration of these metals to induce synergistic effect in multicomponent electrocatalysts can enhance electrochemical activity.

Novel Strain Engineering Combined with a Microscopic Pore Synergistic Modulated Strategy for Designing Lattice Tensile-Strained Porous VC-MXene for High-Performance Overall Water Splitting.

Transition metal carbon/nitride (MXene) holds immense potential as an innovative electrocatalyst for enhancing the overall water splitting properties. Nevertheless, the re-stacking nature induced by van der Waals force remains a significant challenge. In this work, the lattice tensile-strained porous VC-MXene (named as TS-P-VC) is successfully constructed via the rapid spray freezing method and the following hydrothermal treatment.

Double-Shelled Porous g-C N Nanotubes Modified with Amorphous Cu-Doped FeOOH Nanoclusters as 0D/3D Non-Homogeneous Photo-Fenton Catalysts for Effective Removal of Organic Dyes.

Graphite phased carbon nitride (g-C N ) has attracted extensive attention attributed to its non-toxic nature, remarkable physical-chemical stability, and visible light response properties. Nevertheless, the pristine g-C N suffers from the rapid photogenerated carrier recombination and unfavorable specific surface area, which greatly limit its catalytic performance. Herein, 0D/3D Cu-FeOOH/TCN composites are constructed as photo-Fenton catalysts by assembling amorphous Cu-FeOOH clusters on 3D double-shelled porous tubular g-C N (TCN) fabricated through one-step calcination.

Liquid nitrogen quenching inducing lattice tensile strain to endow nitrogen/fluorine co-doping FeO nanocubes assembled on porous carbon with optimizing hydrogen evolution reaction.

In this work, the lattice tensile strain of nitrogen/fluorine co-doping ferroferric oxide (FeO) nanocubes assembled on chrysanthemum tea-derived porous carbon is induced through a novel liquid nitrogen quenching treatment (named as TS-NF-FO/PC-Y, TS: Tensile strain, NF: Nitrogen/Fluorine co-doping, FO: FeO, PC: Porous carbon, X: The weight ratio of KOH/carbon, Y: The adding amount of porous carbon). Besides, the electrocatalytic activity influenced by the adding amount of porous carbon, the type of dopant, and the introduction of lattice tensile strain is systematically studied and explored. The interconnected porous carbon could improve electrical conductivity and prevent FeO nanocubes from aggregating.

Spatiotemporal variations of NO and its driving factors in the coastal ports of China.

Nitrogen Dioxide (NO) is one of the major air pollutants in coastal ports of China. Understanding the spatiotemporal varying effects of driving factors of NO is vital for the implementation of differentiated air pollution control measures for different port areas. Based on the Ozone Monitoring Instrument (OMI) satellite data, we adopted a Geographically and Temporally Weighted Regression (GTWR) model to explore the influences of meteorological and socioeconomic factors on the NO Vertical Column Concentrations (VCDs) in coastal ports of China from 2015 to 2021.

PRDX3 promotes resistance to cisplatin in gastric cancer cells.

Objective: This study aims to investigate peroxiredoxin 3 (PRDX3) expression in gastric cancer tissue and its effects on cisplatin resistance in gastric cancer cells and its possible mechanism.

Methods: PRDX3 expression in human gastric cancer tissue microarrays was detected via immunohistochemistry. The PRDX3 small interfering RNA (siPRDX3 group) and the negative control siNC (siNC group) were transfected into AGS and MKN-74 cell lines, respectively, whereas a blank control group was set up.