[Clinical study on hemodynamics and analgesic effect of local infiltration anesthesia in the treatment of severe early childhood caries under general anesthesia].

Objectives: This study aimed to explore the clinical efficacy of severe early childhood caries (SECC) treatment combined with local anesthesia under general anesthesia.

Methods: A total of 108 children under 6 years old who underwent SECC dental treatment under general anesthesia at the Department of Pediatric Dentistry, Third Affiliated Hospital of Air Force Medical University from March to December 2023 were selected as the study subjects, with American Society of Anesthesiologists (ASA) classification of classⅠor Ⅱ. The study subjects were divided into a control group (=54) and an experimental group (=54) by retrieving intraoperative cases and postoperative follow-up records.

Wastewater-based epidemiology of influenza A virus in Shenzhen: baseline values and implications for multi-pathogen surveillance.

Influenza A virus (IAV) has become increasingly unpredictable in its seasonal patterns following the COVID-19 pandemic. A key challenge remains identifying optimal moments for public health interventions to inform evidence-based decisions. Real-time PCR was employed to quantify IAV concentrations in wastewater samples from 38 treatment plants in Shenzhen, China (n = 2,764), collected weekly from March 2023 to March 2024.

Enhanced Photoluminescence and Imaging Applications of Sb-Doped CsCdCl and CsCdCl Driven by Structure-Property Relationships.

Ruddlesden-Popper phases CsCdCl and CsCdCl are widely used in experimental research of optoelectronics due to their excellent doping matrix properties, but their optoelectronic mechanisms have not been fully explored. This study uses first-principles calculations and experiments to analyze the differences in point defect crystal growth and optoelectronic properties caused by Sb doping of these two materials. Sb tends to replace the position of Cd in both structures.

Asynchronous Boundary Stabilization of Stochastic Markovian Reaction-Diffusion Neural Networks With Mode-Dependent Delays.

This article tackles asynchronous control issue for a class of stochastic Markovian reaction-diffusion neural networks with mode-dependent delays (MDDs). Taking into account the spatio-temporal distribution of such networks, we propose a boundary control (BC) scheme combined with asynchronous control to reduce control implementation cost and overcome environmental constraint. By incorporating a hidden Markov model to manage the mode asynchrony, we develop an integral asynchronous boundary controller for Neumann boundary conditions, as well as an innovative one for Dirichlet boundary conditions.

Enhanced Nonlinear Optical Response and Self-Powered CPL Detection in Unique Triangular-Tetrahedral Chiral Copper(I) Halides.

The low-coordination polyhedral architecture of Cu(I)-based chiral metal halides induces significant structural distortions, endowing these materials with remarkable circularly polarized light (CPL) activity and exceptional nonlinear optical (NLO) performance. However, achieving highly selective CPL detection with large dissymmetry factors (g) in Cu(I)-based chiral metal halides remains a significant challenge. Herein, we prepared 1D chiral (R/S)-MPZCuCl (where MPZ is 2-methylpiperazine) halides with the unique triangular-tetrahedral configuration in the noncentrosymmetric cubic P111 space group, resulting in substantial structural distortions, which significantly impact nonlinear susceptibility.

Magneto-Chiroptical Hybrid Perovskites with Anomalous Photovoltaic Effect for High-Performance Self-Driven Photodetectors.

Organic-inorganic hybrid perovskites show promising applications in photodetectors due to their high absorption coefficients and outstanding optoelectronic properties. However, most hybrid perovskites exhibit centrosymmetric structures, requiring external electric fields for photodetection. Herein, 2D chiral hybrid perovskite (R/S)-3BrMBAPbBr is synthesized, which exhibits broadband circularly polarized luminescence with a luminescence asymmetry factor of 1.

Elucidating the Effects of Electrolytes on a Robust MOF Interface for Enhanced CO Electroreduction to C Products.

Elucidating the role of electrolytes in steering CO electroreduction toward C products is critical, yet impeded by dynamic electrocatalyst reconstruction during the CORR. Herein, we successfully prepared a novel Cu-based metal-organic framework (Cu-BDP, BDP = 1,4-benzenedipyrazolate) with robust Cu-N coordination. Bode phase analysis and contact angle measurements demonstrate that Cs cations facilitate interfacial charge transfer and establish local hydrophobic microenvironments to suppress hydrogen evolution reactions.

Rhodium catalysts supported on phosphorus-rich covalent organic polymers for sustainable hydrosilylation of alkynes.

Heterogeneous rhodium catalysts supported on phosphorus-rich covalent organic polymers provide a sustainable solution to the scarcity of Rh resources in the chemical industry. We synthesized COP-PPh by utilizing triphenylphosphine as monomers and then supported rhodium on COP-PPh to generate the heterogeneous Rh catalyst COP-PPh-RhCl. This catalyst demonstrated excellent catalytic activity and substrate adaptability in alkyne hydrosilylation reactions.

Effects of different polysaccharide contents on the gel properties of transglutaminase-induced ultrasonic-assisted peanut isolate proteins-corn silk polysaccharide products and their influence on riboflavin release behavior.

The effects of ultrasonic-assisted glycosylation technology on the gel properties of transglutaminase-induced peanut protein isolate (PPI) and its influence on the release behavior of riboflavin were investigated. The mechanism of the glycosylation action and polysaccharide content on the gel properties of PPI were preliminarily explored. The results showed that glycosylation action made the structural unfolding of PPI, enhanced the molecular interactions between molecules, and formed a more compact gel network structure.

Zengmian Yiliu formula suppresses cell cycle in immune-rich ovarian cancer patient-derived organoids.

Background: Ovarian cancer, often diagnosed at advanced stages, has a 5-year survival rate below 50%, indicating a critical need for innovative treatments. The Zengmian Yiliu (ZMYL) formula, a Traditional Chinese Medicine (TCM) prescription, has shown potential in enhancing chemotherapy efficacy and improving patients' quality of life, PURPOSE: To investigate the effects of the ZMYL formula on ovarian cancer organoids, focusing on its impact on organoid phenotypes and underlying mechanisms, and to explore its potential as an immunotherapeutic agent.

Methods: Ovarian cancer organoids were established from surgical tissues and treated with the ZMYL formula at varying concentrations.

The Unexploring Optoelectronic Features in Organic Trans-Dimensional Materials of Gridofluorenes at the Nanoscale.

Organic grido-architectures offer not only state-of-the-art models for exploring the complex relationships of multicarrier coherence among excitons, charges, photons, electrons, and phonons but also organic high-dimensional nanomaterials for flexible electronics and organic intelligence. Herein, we initiate the fundamental progress and perspective on gridofluorene-based zero-, one-, two-, and three-dimensional nanomolecules and their optoelectronic features. From the future point of view, the sterically trans-dimensional and hierarchically cross-scale effects of these covalent frameworks and nanostructures are discussed on their photophysical, electrical, mechanical and thermal properties.

Exploration of the Interrelationship Between Serum Uric Acid, Gout, and Cardiac, Renal, and Metabolic Conditions in Middle Aged and Older People.

Background: Cardiac, renal, and metabolic (CRM) conditions are major causes of morbidity and mortality globally. This study aims to explore the relationship between serum uric acid (SUA), hyperuricemia, gout, and CRM conditions in middle-aged and elderly populations.

Methods: Sample 1 included participants from CHARLS (China Health and Retirement Longitudinal Study, n=9341), and Sample 2 from NHANES (National Health and Nutrition Examination Survey, unweighted n=17 913; weighted n=115 646 390).

Encapsulation of Monoterpene Phenols in Protein-Stabilized Nanoemulsions for Improved Wound Healing.

Monoterpene phenols have antibacterial, antioxidant, anticancer, antihypertensive, and antidiabetic properties, but their natural volatility and hydrophobicity limit their biomedical applications. In this work, we developed an oil-in-water nanoemulsion (NE) stabilized by proteins (i.e.

Ultrasound-assisted preparation of shikonin-loaded emulsions for the treatment of bacterial infections.

Bacteria can encapsulate themselves in a self-generated matrix of hydrated extracellular polymeric substances such as polysaccharides, proteins, and nucleic acids, thereby forming bacterial biofilm infections. These biofilms are drug resistant and will diminish the efficacy of antimicrobial agents, rendering treatment of such infections challenging. Herein, an innovative strategy is proposed to synergistically degrade bacterial biofilms and eradicate the entrapped bacteria through integrating α-amylase (α-Amy), shikonin (SK) and epigallocatechin gallate (EGCG) within an emulsion.

The role of LNK in mitigating hypertension: inhibition of vascular smooth muscle proliferation and JAK-STAT pathway.

The lymphocyte adaptor protein LNK is predominantly found in endothelial and hematopoietic cells and is linked to cardiovascular and autoimmune diseases. LNK functions as a negative regulator of cytokine signaling and cell proliferation, but its impact on hypertensive vascular smooth muscle cells (HVSMC) remains unclear. This study aimed to explore the influence of LNK on HVSMC function.

The exploration of the relationship between hyperuricemia, gout and vitamin D deficiency.

Our study aims to provide evidence concerning the relationship between hyperuricemia, gout and Vitamin D deficiency by analyzing data from Peking Union Medical College Hospital (PUMCH), the National Health and Nutrition Examination Survey (NHANES) database, and through Mendelian randomization (MR) analyses. Sample 1 involved patients from PUMCH (n = 13,532), and sample 2 involved participants from NHANES (Unweighted n = 22,860; weight n = 182,829,142). Logistic regression and restricted cubic spline analyses were applied to assess above relationship.

Site-Specific for CO Photoreduction with Single-Atom Ni on Strained TiO Derived from Bimetallic Metal-Organic Frameworks.

The photocatalytic reduction of CO in water to produce fuels and chemicals is promising while challenging. However, many photocatalysts for accomplishing such challenging task usually suffer from unspecific catalytic active sites and the inefficient charge carrier's separation. Here, a site-specific single-atom Ni/TiO catalyst is reported by in situ topological transformation of Ni-Ti-EG bimetallic metal-organic frameworks.

Quercetin Promote the Chemosensitivity in Organoids Derived from Patients with Breast Cancer.

Aim: The study aimed to culture organoids from tissues of patients with breast cancer (BC) and use the organoids to measure the sensitivity to quercetin and its combination with chemotherapeutic agents.

Methods: Four patient-derived organoids (PDOs) of BC were cultured. The proliferative activity and morphology of PDOs were evaluated on different generations and after resuscitation.

Associations between serum uric acid and risk of depressive symptoms in East Asian populations.

Background: Despite the fact that observational studies have reported associations between serum uric acid (SUA) and depressive symptoms risk in East Asian populations, there is a lack of evidence demonstrating a causal relationship between them. This study aimed to perform a comprehensive assessment of the relationship between SUA and depressive symptoms.

Methods: This study included two cohort studies and a two-sample Mendelian randomization study.

secretory protein VceA promotes FOXO1 entry into the nucleus to shift host cell metabolism toward glycolysis.

Increased glycolytic metabolism is a key step in the reproduction of and the induction of brucellosis, however, little is known about how this process is regulated during infection. Forkhead box protein O1 (FOXO1) is a transcription factor that regulates energy metabolism. In this study, we employ the yeast two-hybrid system (Y2H) and immunoprecipitation (Co-IP) to reverse screen for the FOXO1 for the first time and identify interactions between FOXO1 and the secretory protein VceA.

Effect of Internet-Based Cognitive Behavioral Therapy on Psychological Distress and Quality of Life Among Breast Cancer Survivors: A Meta-Analysis of Randomized Controlled Trials.

Objectives: This meta-analysis was to critically evaluate the effectiveness of Internet-based Cognitive Behavioral Therapy (ICBT) on psychological distress and quality of life in breast cancer survivors.

Methods: A search was conducted across eleven databases (PubMed, Web of Science, Embase, Cochrane Library, Scopus, ProQuest, CINAHL, CBM, CNKI, VIP and Wanfang) to identify relevant randomized controlled trials (RCTs) published from databases inception to September 2023. Two reviewers independently conducted study screening, data extraction, and quality assessment of the included studies.

Dental pulp stem cells promote genioglossus repair and systemic amelioration in chronic intermittent hypoxia.

Obstructive sleep apnea (OSA) leads to chronic intermittent hypoxia (CIH) and is not well addressed by current therapies. The genioglossus (GG) is the largest upper airway dilator controlling OSA pathology, making its repair a potential treatment. This study investigates dental pulp stem cells (DPSCs) in repairing GG injury in a CIH mouse model.