Publications by authors named "Bing-Jing Sun"
Noggin Combined With Human Dental Pulp Stem Cells to Promote Skeletal Muscle Regeneration.
Stem Cells Int
December 2024
Article Synopsis
- Dental pulp stem cells (DPSCs) show promise for muscle injury repair, but their ability to differentiate into muscle cells is currently limited.
- Treating DPSCs with Noggin, which inhibits bone morphogenetic protein (BMP) signals, enhances myogenic differentiation, increases myogenic markers, and generates satellite-like cells, improving muscle regeneration.
- Implanting Noggin-treated DPSCs in a mouse model of muscle loss resulted in significant reductions in defect size and scar tissue, indicating that BMP/Smad signaling regulation by Noggin effectively promotes muscle repair.
Objective: Obesity can affect periodontal tissues and exacerbate periodontitis. Pyroptosis, a newly identified type of inflammatory cell death, is involved in the development of periodontal inflammation. The saturated fatty acid palmitic acid (PA) is elevated in obese patients.
View Article and Find Full Text PDFHIF-1α activator DMOG inhibits alveolar bone resorption in murine periodontitis by regulating macrophage polarization.
Int Immunopharmacol
October 2021
Periodontitis is initiated by serious and sustained bacterial infection and ultimately results in chronic immune-mediated inflammation, tissue destruction, and bone loss. The pathogenesis of periodontitis remains unclear. Host immunological responses to periodontal bacteria ultimately determine the severity and mechanisms governing periodontitis progression.
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