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Article Abstract
Glioma, the most common malignant tumor of the central nervous system, is regulated by long non-coding ribonucleic acids (lncRNAs). This study reported that linc01811 is expressed at low levels in gliomas and inhibits glioma tumorigenesis by regulating the miR-4635-nuclear transcription factor Y subunit beta (NF-YB) axis. MiR-4635 is identified as a direct target of linc01811 and can specifically target the 3' untranslated region of NF-YB and consequently downregulate its expression. As a transcription factor, NF-YB binds to the linc01811 promoter, thereby activating its expression. Overall, this study identified a tumor suppressor lncRNA that inhibits glioma progression via the miR-4635/NF-YB feedback loop, highlighting a potential axis for diagnostic and therapeutic targeting in glioma.
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| http://dx.doi.org/10.1016/j.bbrc.2025.152167 | DOI Listing |
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