Genotype clinical phenotype analysis of 35 cases of hereditary spherocytosis in children.

Objective: Hereditary spherocytosis (HS) is a common red blood cell membrane disease. It is currently clear that mutations in genes such as ANK1, SPTB, SPTA1, SLC4A1, EPB4.2 can cause the loss of their corresponding encoded proteins.

BRD4 Mediates Transforming Growth Factor-β-Induced Smooth Muscle Cell Differentiation from Mesenchymal Progenitor Cells.

Smooth muscle cell (SMC) differentiation plays a crucial role in angiogenesis and vasculogenesis during embryonic development. The underlying mechanisms controlling SMC differentiation, especially progenitor-specific regulation, however, remain largely unclear. In this study, we identified bromodomain-containing protein 4 (BRD4) as a novel regulator for SMC differentiation.

A multicenter single-arm clinical study of Chinese children's cancer group-acute promyelocytic leukemia-2017 (CCCG-APL-2017) protocol.

The Realgar-Indigo Naturalis formula (RIF) is a proprietary Chinese medicine, which is one of the important drugs in the treatment of pediatric acute promyelocytic leukemia (APL). However, the dose of RIF in clinical application is not uniform and the long-term effectiveness and safety of combining RIF with all-trans retinoic acid (ATRA) in a larger population of pediatric APL patients remains undocumented. We conducted a multicenter single-arm clinical trial (ChiCTR-OIC-16010014) in China.

Total flavonoids of L. alleviate cognitive impairment via TNF-α/NF-κB p65 signaling pathway in vascular dementia rats.

Objective: This study aims to elucidate the neuroprotective effects and underlying mechanisms of total flavonoids of (TFDM) in VaD by using network pharmacology and validation.

Methods: The network pharmacology was used to explore the mechanism of TFDM to improve VaD. A rat model of VaD was established using permanent bilateral common carotid artery occlusion (2VO).

Unexpected richness and distinct patterns of () species diversity in Chongqing, a notable "Furnace City": unveiling rich diversity in hot regions.

species, commonly known as true morels and being cold-preferring fungi, are esteemed for their distinctive flavor as well as significant economic and prominent research value. Chongqing, located in southwestern China and renowned as the "Furnace City" due to its distinctive climate and extremely high summer temperatures, spans an area of 82,400 square kilometers with complex geographical topography, yet has lacked a comprehensive survey of true morels () so far. From 2017 to 2024, we conducted extensive field surveys across 13 districts and counties within Chongqing, resulting in the collection of over 1,000 wild morel samples.

Never too late to start musical instrument training: Effects on working memory and subcortical preservation in healthy older adults across 4 years.

Studies have shown the beneficial effects of musical instrument on memory and executive function in healthy aging. However, few studies investigated these long-term benefits. In this regard, the current study tracked a cohort of older adults (n = 53) over 4 years after they have initially participated in a musical instrument training program.

Cost-effective enhancement of SPR performance via spectral shaping techniques.

Surface plasmon resonance (SPR) technology has been widely applied in various fields, such as biosensing, environmental monitoring, food safety, and drug screening. However, the signal-to-noise ratio (SNR) of SPR sensors varies with wavelength and greatly affects their performance due to the fact that optics and sensors work differently for varying wavelengths of light. To address this issue, this paper proposes a simple and effective spectral shaping method based on a multi-field-of-view spectrometer combined with a mask.

Risk factors and outcomes of asparaginase-associated pancreatitis in pediatric patients with ALL.

Asparaginase-associated pancreatitis (AAP) is a significant complication in acute lymphoblastic leukemia (ALL) therapy, often leading to treatment delays or discontinuation. This study aimed to identify AAP risk factors, assess outcomes after first and second episodes, and evaluate the impact of asparaginase rechallenge. We retrospectively analyzed 7,640 patients (aged 1 month-18 years) treated under the Chinese Children Cancer Group ALL 2015 protocol.

Lysosome-hijacking inhalable nanomimosa enhances ferroptosis for lung cancer therapy.

Ferroptosis therapy shows potential for lung tumor treatment, but precise accumulation of reactive oxygen species (ROS) remains a challenge. A lysosome-hijacking strategy was developed, aiming to induce ROS spread from lysosomes to the entire cell. The key is delivering a ROS inducer to the lysosome for rapid and targeted ROS generation.

Neural dynamics impairments in amyotrophic lateral sclerosis patients and their associations with clinical characteristics: An observational cohort study.

Background And Purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the central nervous system. It remains unclear whether pathological changes in ALS can lead to abnormalities in neural dynamics and how these abnormalities relate to key clinical characteristics of ALS.

Methods: Nonlinear neural dynamics analyses of electroencephalography (EEG) sensorimotor channels were conducted using recurrence quantification analysis (RQA), permutation Lempel-Ziv complexity (PLZC), shannon entropy (ShannonE) and permutation entropy (PermEn).

CPN2 alleviates cryptorchidism by inhibiting the NF-κB pathway and regulating immune responses.

Cryptorchidism, a common male reproductive disorder characterized by undescended testes, is associated with infertility and increased cancer risk. While its etiology remains incompletely understood, accumulating evidence suggests that immune-inflammatory responses contribute to disease progression. This study investigated the role of carboxypeptidase N subunit 2 (CPN2) in modulating immune activation and testicular pathology via the NF-κB signaling pathway.

Direct sequencing of DNA 5-methylcytosine by engineered dioxygenase NTET-assisted eNAPS.

DNA methylation (5-methylcytosine, 5mC) represents the most prevalent modification in mammals, which is closely linked to disease pathogenesis and cancer development. Single-base resolution sequencing and quantitative analysis of 5mC are essential for elucidating its biological functions. However, current methods are still limited by resolution, sequencing bias, and false positives.

A sodium superionic chloride electrolyte driven by paddle wheel mechanism for solid state batteries.

Halides are promising solid electrolytes due to their high ionic conductivity and high oxidation potential. Here we report a superionic chloride material, NaTaCl, which exhibits a high ionic conductivity of 3.3 mS cm at 27 °C, being two-orders of magnitude higher than that of NaNbCl (0.

DFN-YOLO: Detecting Narrowband Signals in Broadband Spectrum.

With the rapid development of wireless communication technologies and the increasing demand for efficient spectrum utilization, broadband spectrum sensing has become critical in both civilian and military fields. Detecting narrowband signals under broadband environments, especially under low-signal-to-noise-ratio (SNR) conditions, poses significant challenges due to the complexity of time-frequency features and noise interference. To this end, this study presents a signal detection model named deformable feature-enhanced network-You Only Look Once (DFN-YOLO), specifically designed for blind signal detection in broadband scenarios.

A causal relationship between functional connectivity of brain networks and cardiovascular disease: A Mendelian randomization study.

Dysfunction in the brain's resting-state functional networks is strongly connected with mental illness and cognitive impairment, while cardiovascular disease (CVD) is accepted as a risk factor for cognitive dysfunction. Growing interest exists in the correlation between brain and heart diseases. However, the causality between resting-state functional networks and CVD remains uncertain.

The mediating effect of BMI in serum vitamin D related sleep deprivation based on the NHANES database.

Background: Sleep deprivation are a widespread condition globally, posing significant risks to individuals' physical and mental health. Existing studies have explored the associations between sleep deprivation, vitamin D, and obesity. However, there is limited research on the combined effects of serum vitamin D and obesity.

Adverse Events of Tunneled Central Venous Catheters versus Totally Implantable Venous Access Devices in Pediatric Oncology: A Systematic Review and Meta-analysis.

Purpose: To evaluate the adverse events associated with tunneled central venous catheters (CVCs) and totally implantable venous access device (TIVAD) in patients of pediatric oncology undergoing chemotherapy.

Materials And Methods: A comprehensive search was retrospectively conducted using PubMed, Embase, Web of Science, and the Cochrane Library to identify studies. Cohort studies and randomized controlled trials comparing tunneled CVCs with TIVAD in patients of pediatric oncology were included.

PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1 mice.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motor neuron death. Dysregulated energy metabolism is implicated in ALS pathogenesis, yet the role of pyruvate kinase M2 (PKM2), a key glycolytic enzyme, remains elusive. Here, we demonstrated that PKM2 expression was upregulated in the spinal neurons of SOD1 mice during early stages of disease.

Erratum: The inhibition of YTHDF3/mA/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer: Erratum.

[This corrects the article DOI: 10.7150/ijbs.87203.

Case Report: A novel germline donor splicing site mutation of gene in a Chinese Tibetan pedigree with familial retinoblastoma.

Retinoblastoma (RB) is the most common primary intraocular malignancy in children and mostly initiates with biallelic inactivation of the gene. Hereditary retinoblastoma accounts for 40% of all cases, with only 6%-10% of patients having a positive family history. The proband, a Chinese Tibetan boy, was diagnosed with RB for leukocoria.

Bisulfite-free whole-genome mapping of 5-methylcytosine at single-base resolution by NTD-seq.

5-Methylcytosine (5mC) is a crucial epigenetic modification which plays a significant role in the regulation of gene expression. Accurate and quantitative detection of 5mC at single-base resolution is essential for understanding its epigenetic functions within genomes. In this study, we develop a novel Naegleria TET-assisted deaminase sequencing (NTD-seq) method for the base-resolution and quantitative detection of 5mC in genomic DNA.

Prognostic value, biological role, and mechanisms of LCN2 in childhood acute lymphoblastic leukemia.

Resistance to glucocorticoids (GC) is associated with poor prognosis in childhood acute lymphoblastic leukemia (ALL). Lipocalin 2 (LCN2) plays a pro-tumorigenic role in solid tumors and chronic myeloid leukemia by promoting initiation, invasion, metastasis and drug resistance, and has gained increasing attentions as a therapeutic target. However, ALL cells show a low expression status of LCN2.

Achieving Uniform Phase Structure for Layer-by-Layer Processed Binary Organic Solar Cells with 20.2% Efficiency.

Layer-by-layer (LBL) deposition has become a facile and promising method to fabricate highly efficient organic solar cells (OSCs). However, characterization and optimization of 3D morphology remain a grand challenge for LBL-processed active layers, and their correlation with photovoltaic properties of OSC devices is not clear to date. Here, to address this issue, the morphology and its formation mechanisms of LBL-processed active layer based on the classical D18/L8-BO blend were investigated systematically.