Case Report: A novel germline donor splicing site mutation of gene in a Chinese Tibetan pedigree with familial retinoblastoma.

Retinoblastoma (RB) is the most common primary intraocular malignancy in children and mostly initiates with biallelic inactivation of the gene. Hereditary retinoblastoma accounts for 40% of all cases, with only 6%-10% of patients having a positive family history. The proband, a Chinese Tibetan boy, was diagnosed with RB for leukocoria.

Prognostic value, biological role, and mechanisms of LCN2 in childhood acute lymphoblastic leukemia.

Resistance to glucocorticoids (GC) is associated with poor prognosis in childhood acute lymphoblastic leukemia (ALL). Lipocalin 2 (LCN2) plays a pro-tumorigenic role in solid tumors and chronic myeloid leukemia by promoting initiation, invasion, metastasis and drug resistance, and has gained increasing attentions as a therapeutic target. However, ALL cells show a low expression status of LCN2.

Low Muscularity as Assessed by Abdominal Computed Tomography on Intensive Care Unit Admission Is Associated With Mortality in a Critically Ill Asian Population.

Background: Low muscularity (LM) is associated with high mortality in the Caucasian critically ill population. Muscularity can be accurately measured by the skeletal muscle index (SMI; cm /m ) generated by computed tomography (CT). This study aimed to establish the overall and sex-specific cutoff values that predict hospital mortality in an Asian critically ill population.