Risk factors and outcomes of asparaginase-associated pancreatitis in pediatric patients with ALL.

Asparaginase-associated pancreatitis (AAP) is a significant complication in acute lymphoblastic leukemia (ALL) therapy, often leading to treatment delays or discontinuation. This study aimed to identify AAP risk factors, assess outcomes after first and second episodes, and evaluate the impact of asparaginase rechallenge. We retrospectively analyzed 7,640 patients (aged 1 month-18 years) treated under the Chinese Children Cancer Group ALL 2015 protocol.

Patterns and risks of microplastic release during primary oral care in Chinese residents.

This study characterized microplastics (MPs) generated from the toothpaste and toothbrushes commonly used in China based on a survey of oral care product usage. The study examined the time-dependent trend of MPs released from toothbrushes and evaluated the risk of microplastic exposure through oral products in a Chinese population. MPs in the toothpaste were composed of translucent and irregularly fragmented polyethylene (22 %) and polyethylene-vinyl acetate (78 %).

Polylactic acid microplastics and earthworms drive cadmium bioaccumulation and toxicity in the soil-radish health community.

Recent studies underscored the toxicity of microplastics (MPs) as vectors for cadmium (Cd) in soil-plant systems, yet the driven potential of soil fauna in real-world environments remains overlooked. This study examined the interactive effects of earthworms and polylactic acid (PLA) MPs (0.5 % w/w) on rhizosphere biochemistry and Cd (2 mg/kg)-induced phytotoxicity in radish.

Regulation strategies of microplastics with different particle sizes on cadmium migration processes and toxicity in soil-pakchoi system.

It is still unclear whether there are differences in the effects of microplastics with different particle sizes on the environmental behavior of cadmium (Cd) in the soil-crop system. By introducing the polystyrene microplastics (PS-MPs) with 0.2, 2, and 20 μm, this study explored the regulation strategies of different-sized MPs on the migration and toxicity of Cd in the soil-pakchoi system.

Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1 Macrophages for Infectious Bone Defect Regeneration.

Infectious bone defects pose significant clinical challenges due to persistent infection and impaired bone healing. Icam1 macrophages were identified as crucial and previously unrecognized regulators in the repair of bone defects, where impaired oxidative phosphorylation within this macrophage subset represents a significant barrier to effective bone regeneration. To address this challenge, dual-responsive iron-doped barium titanate (BFTO) nanoparticles were synthesized with magnetic and ultrasonic properties.

Risk factors and a prediction model of severe asparaginase-associated pancreatitis in children.

We aimed to investigate whether early clinical indicators were associated with eventual disease severity, and to develop a predictive model for severe asparaginase-associated pancreatitis (AAP). Seventy-five acute lymphoblastic leukaemia (ALL) cases with AAP admitted to Shanghai Children's Medical Center from March 2013 to August 2023 were divided into non-severe (n = 44) and severe (n = 31) groups based on Atlanta diagnostic and AAP grading criteria. We compared essential information, asparaginase(ASP) dosage form, cumulative dose, clinical characteristics and laboratory tests between the groups.

Therapeutic drug monitoring of posaconazole delayed-release tablets and injections in pediatric patients.

This study aimed to investigate the dose and trough concentration () of posaconazole delayed-release tablets and injections, and their correlation with efficacy and safety in pediatric patients. Patients younger than 18 years old received posaconazole delayed-release tablets or injections for prophylaxis or treatment of invasive fungal disease (IFD). Blood samples were collected to determine the plasma s, and dose regimen adjustments were made if necessary.

Effects of asparaginase-associated pancreatitis in children with haematological tumours.

Background: Asparaginase-associated pancreatitis (AAP) is a major challenge for continuing asparaginase therapy. We aimed to investigate the acute and long-term complications and survival rates related to first and second AAP episodes in Chinese children with haematological malignancies.

Methods: We retrospectively analysed clinical data of children with pancreatitis who received asparaginase chemotherapy for acute lymphoblastic leukaemia (ALL), acute mixed cell leukaemia, and non-Hodgkin's lymphoma at Shanghai Children's Medical Center from November 2013 to November 2023.

Association between plant microbiota and cadmium uptake under the influence of microplastics with different particle sizes.

Plant microbiota are an important factor impacting plant cadmium (Cd) uptake. However, little is known about how plant microbiota affects the Cd uptake by plants under the influence of microplastics (MPs) with different particle sizes. In this study, bacterial structure and assembly in the rhizosphere and endosphere in pakchoi were analyzed by amplicon sequencing of 16S rRNA genes under the influence of different particle sizes of polystyrene microplastics (PS-MPs) combined with Cd treatments.

Phthalate monoesters accumulation in residential indoor dust and influence factors.

Phthalate monoesters (mPAEs) possess biological activity that matches or even exceeds that of their parent compounds, phthalate esters (PAEs), negatively impacting humans. Indoor dust is the main carrier of indoor pollutants. In this study, indoor dust samples were collected from 46 households in Changchun City, Jilin Province, in May 2019, and particulate and flocculent fibrous dust was used as the research target to analyze the concentration and compositional characteristics of mPAEs, primary metabolites of five significant PAEs.

Enhanced immobilization of cadmium and lead in contaminated soil using calcium alginate-modified HAP biochar: Improvements in soil health and microbial diversity.

A novel adsorbent, calcium alginate-modified HAP (Hydroxyapatite)-wood ear mushroom sticks biochar (CA-HAP), was synthesized to enhance the immobilization of Cd and Pb in soil. Over 150 days, applying CA-HAP at concentrations of 0%-3% in contaminated soils from Chenzhou City in Hunan Province (CZ) and Shenyang City in Liaoning Province (SY) resulted in decreased effective concentrations of Cd and Pb. Specifically, in CZ soil, Cd and Pb decreased by 30.

Optimizing Surface State Electrons of Topological Semi-Metal by Atomic Doping for Enhanced Hydrogen Evolution Reaction.

Topological materials carrying topological surface states (TSSs) have extraordinary carrier mobility and robustness, which provide a new platform for searching for efficient hydrogen evolution reaction (HER) electrocatalysts. However, the majority of these TSSs originate from the sp band of topological quantum catalysts rather than the d band. Here, based on the density functional theory calculation, it is reported a topological semimetal PdSn carrying TSSs mainly derived from d orbital and proposed that optimizing surface state electrons of PdSn by introduction heteroatoms (Ni) can promote hybridization between hydrogen atoms and electrons, thereby reducing the Gibbs free energy (ΔG) of adsorbed hydrogen and improving its HER performance.

Exploration the interaction of cadmium and copper toxic effects in pakchoi (Brassica chinensis L) roots through combinatorial transcriptomic and weighted gene co-expression network analysis.

The interaction between cadmium(Cd) and copper(Cu) during combined pollution can lead to more complex toxic effects on humans and plants.However, there is still a lack of sufficient understanding regarding the types of interactions at the plant molecular level and the response strategies of plants to combined pollution. To assess this, we investigated the phenotypic and transcriptomic patterns of pakchoi (Brassica chinensis L) roots in response to individual and combined pollution of Cd and Cu.

Immunophenotypic clustering in paediatric acute myeloid leukaemia.

Acute myeloid leukaemia (AML) is a highly heterogeneous disease, exhibiting diverse subtypes according to the characteristics of tumour cells. The immunophenotype is one of the aspects acquired routinely through flow cytometry in the diagnosis of AML. Here, we characterized the antigen expression in paediatric AML cases across both morphological and molecular genetic subgroups.

Demographic and clinical characteristics associated with failure of physical therapy in chronic low back pain: a secondary analysis from a randomized controlled trial.

Background: The effect of physical therapy on pain and disability alleviation in patients with chronic low back pain (cLBP) has been demonstrated, but the risk factors for treatment failure remain unknown.

Aim: To explore the associations of baseline demographic and clinical characteristics with treatment failure after physical therapy intervention for cLBP.

Design: A secondary analysis of a single-blind randomized clinical trial.

Multi-source exposure and health risks of phthalates among university students in Northeastern China.

The endocrine disruptor phthalates (PAEs) are widely used as important chemical additives in a variety of areas around the globe. PAEs are toxic to reproduction and development and may adversely affect the health of adolescents. Risk assessments of exposure to PAEs from different sources are more reflective of actual exposure than single-source assessments.

Porous Titanium Scaffolds with Mechanoelectrical Conversion and Photothermal Function: A Win-Win Strategy for Bone Reconstruction of Tumor-Resected Defects.

Bone metastases severely threaten the lives of patients. Although surgical treatment combined with adjuvant chemotherapy significantly improves the survival rate of patients, tumor recurrence, or metastasis after surgical resection and bone defects caused by surgical treatment remain major challenges for clinicians. Given the abovementioned clinical requirements, barium titanate-containing iron-coated porous titanium alloy scaffolds have been proposed to promote bone defect repair and inhibit tumor recurrence.

Comprehensive assessment of phthalates in indoor dust across China between 2007 and 2019: Benefits from regulatory restrictions.

China is the largest producer and consumer of phthalates in the world. However, it remains unclear whether China's phthalate restrictions have alleviated indoor phthalate pollution. We extracted the concentrations of dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP), benzyl butyl phthalate (BBP), and bis(2-ethylhexyl) phthalate (DEHP) in indoor dust at 2762 sites throughout China between 2007 and 2019 from the published literature.

Exploring the effect of CH/FBr ( = 0-3) passivating agent on surface properties at different termination ends: first principles.

To prevent further decomposition of organic-inorganic hybrid perovskite by defects, in this work density functional theory was applied to explore the electronic properties, carrier surface mobility and theoretical photoelectric conversion efficiency (PCE) of passivating molecules with different fluorine atom content at the symmetric site of the benzene ring at different termination ends of MAPbI, which shed light on the control of perovskite surface passivation by different element atoms in the same molecule. We found that the same molecule acts as a different passivation agent at different termination faces. Passivating molecules on the surface termination end by MAI play a Lewis acid role, with molecules with stronger dipole moments narrowing the band gap from the original 1.