The effect of pre-transplant dialysis duration on the relationship between delayed graft function and recipient death.

The aim of this study was to evaluate the effect of delayed graft function (DGF) on recipient death after kidney transplant from donors after brain death (DBD) stratified by pre-transplant dialysis duration. Using a retrospective database, this study collected clinical data from 1,311 patients who underwent DBD kidney transplantation. Univariate and multivariate Cox regression analyses were performed to assess the relationship between the DGF and recipient death.

Hydroxysafflower yellow A mitigates renal ischemia-reperfusion injury by inhibiting the CCR4-mediated apoptosis pathway.

Background: Renal ischemia-reperfusion injury (RIRI) is a major contributor to acute kidney injury (AKI), associated with high mortality in intensive care units. Hydroxysafflower yellow A (HSYA), with known anti-inflammatory and antioxidant properties, may protect against AKI caused by RIRI.

Purpose: This study investigates HSYA's mechanisms in AKI protection through transcriptome sequencing and functional validation.

Recombinant probiotic Escherichia coli delivers the polymeric protein of swine influenza virus for protection.

Swine influenza virus invades the host through the respiratory mucosa, which severely restricts the development of the pig breeding industry. To construct monomeric and trimeric vaccines, we developed recombinant Escherichia coli Nissle 1917 (EcN) strains that express the receptor binding site (RBS) of the hemagglutinin (HA) antigen from H1N1 swine influenza virus. After the mucosal immunization of mice, we found that probiotics activated CD40 and CD86 in DCs and increased the levels of IL-4 and IFN-γ secretion by T cells.

The investigation of the interaction of warangalone with transferrin as a therapeutic biological macromolecule and the formation of a protein-ligand nanocomplex with superior anticancer activity against lung cancer cells.

Though warangalone has shown anticancer properties against breast cancer cells, its colloidal stability and therapeutic index ought to be improved using a potential strategy, especially via protein-based (nano)carriers. In this research, transferrin was used as a plasma protein for the development of the warangalone-transferrin NPs. To investigate the mechanism underlying the formation of this complex, the interaction between warangalone and transferrin, as well as transferrin NPs, was analyzed using spectroscopic methods.

Effect of laterality on the postoperative survival of non-small cell lung cancer patients undergoing pneumonectomy.

Background: Pneumonectomy is one of the important surgical methods for non-small cell lung cancer (NSCLC). This study evaluated the effects of laterality on the short- and long-term survival of NSCLC patients undergoing pneumonectomy.

Methods: We reviewed the Surveillance, Epidemiology, and End Results database to retrieve the data of patients who underwent pneumonectomy for stage I-III NSCLC from 2004 to 2015.

[Evaluation and Optimization of Rural Sewage Treatment Technologies in the Middle Reaches of the Yangtze River Based on Group Decision Making and Analytic Hierarchy Process].

Rural sewage treatment in the Yangtze River basin is an important link to achieve the great protection of the Yangtze River, but the existing treatment technologies are difficult to choose and have various techniques and a lack of evaluation. Therefore, this study researched and collected the case information of rural sewage treatment projects in the middle reaches of the Yangtze River, analyzed the application of each treatment technology under different collection modes and discharge standards, constructed the evaluation index system of rural sewage treatment technologies, and then conducted a classification evaluation of processing technologies for each application scenario based on group decision making and the Analytic Hierarchy Process. The results showed that:the collection modes of rural sewage in the middle reaches of the Yangtze River were mainly single village or small-scale joint village, the treatment scale was mainly concentrated below 200 m·d, the treatment technology was most applied by the anaerobic+ecological process (28.

Total knee arthroplasty exhibits satisfactory long-term clinical efficacy in the treatment of hemophilia patients with stiff knees.

Objective: This study aimed to (1) determine the long-term clinical efficacy of total knee arthroplasty (TKA) in the treatment of hemophilia patients with stiff knessknees, (2) assess the 5- and 10-year prosthesis survival in hemophilia, and (3) determine whether the severity of preoperative stiffness would affect postoperative clinical outcomes and complication rates.

Methods: The clinical data of 71 patients (78 knees) with hemophilia and concomitant knee stiffness who had undergone TKA between September 2007 and June 2018 were retrospectively analyzed. All patients were male, their mean age at the time of surgery was 38.

The prevalence of obesity-related hypertension among middle-aged and older adults in China.

Objective: The aim of our study was to assess the prevalence and geographic variation of obesity-related hypertension in China among adults aged 45 years or older.

Methods: Data were derived from the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2015. Stratified sample households covered 150 counties/districts and 450 villages/urban communities from 28 provinces by using household questionnaires, clinical measurements, and blood-based bioassays.

[Effects of management on the content and spectral characteristics of soil dissolved organic carbon in a subtropical forest].

The differences of artificial measures, such as logging residue management, between assisted natural regeneration and afforestation may change the content and structure of soil dissolved organic carbon (DOC) and affect forest carbon cycle. In this study, we investigated the effects of managements on the content and spectral characteristics of DOC in a subtropical forest, which contained the forest of assisted natural regeneration (Ⅱ), and the plantation (Ⅲ), both were converted from mature secondary forests (Ⅰ). Results showed that DOC content in the 0-10 cm soil layer was significantly decreased by 21% and 50% in Ⅱ and Ⅲ, respectively, compared with that in Ⅰ.

Roles of conserved residues in the receptor binding sites of human parainfluenza virus type 3 HN protein.

Human parainfluenza virus type 3 (hPIV-3) entry and intrahost spread through membrane fusion are initiated by two envelope glycoproteins, hemagglutinin-neuraminidase (HN) and fusion (F) protein. Binding of HN protein to the cellular receptor via its receptor-binding sites triggers conformational changes in the F protein leading to virus-cell fusion. However, little is known about the roles of individual amino acids that comprise the receptor-binding sites in the fusion process.

[Nitrogen Distribution and Inorganic Nitrogen Diffusion Flux in a Shallow Lake During the Low Temperature Period: A Case Study of the Baiyangdian Lake].

The distribution of inorganic nitrogen across the sediment-water interface in Baiyangdian Lake, the largest shallow lake in North China, was examined during the low temperature period. Furthermore, the influence of inorganic nitrogen diffusion flux in sediment porewater on the overlying water quality was analyzed. The results showed that the mean TN concentration in the surface water ranged from 4.

Research on removal algorithm of EOG artifacts in single-channel EEG signals based on CEEMDAN-BD.

Single-channel electroencephalography (EEG) signals are more susceptible to electro-oculography (EOG) interference, which could be attributed to the acquisition device of the single-channel. To realize EOG artifacts separation in this paper, the blind deconvolution (BD) model was investigated based on complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN). The CEEMDAN method was firstly used to decompose the EEG data contained artifacts into several intrinsic mode functions (IMF).

[Currency Survey and Influencing Factors Analysis on the Knowledge and Behavior Related to Brucellosis among Occupational Workers in Jianyang City].

Objective: To investigate the status and influencing factors of the knowledge and behavior related to brucellosis among occupational workers in Jianyang city, and to provide basic information for developing regional specific strategies for brucellosis prevention and control.

Methods: With multistage cluster random sampling, occupational workers aged ≥18 yr. who had been in contact with sheep and their products were interviewed through a questionnaire about demographic characteristic, knowledge, and behavior related to brucellosis.

Liraglutide ameliorates beta-cell function, alleviates oxidative stress and inhibits low grade inflammation in young patients with new-onset type 2 diabetes.

Background: The prevalence of type 2 diabetes in youth is escalating rapidly. We aimed to evaluate the effects of liraglutide on beta-cell function, metabolic productions of oxidative stress, low grade inflammation compared with metformin in young patients with recent onset type 2 diabetes mellitus.

Methods: Sixty patients were randomly assigned to receive 8-week liraglutide or metformin treatment.

Application of modified primary closure of the pelvic floor in laparoscopic extralevator abdominal perineal excision for low rectal cancer.

Aim: To introduce a novel, modified primary closure technique of laparoscopic extralevator abdominal perineal excision (LELAPE) for low rectal cancer.

Methods: We retrospectively analyzed data from 76 patients with rectal cancer who underwent LELAPE from March 2013 to May 2016. Patients were classified into the modified primary closure group (32 patients) and the biological mesh closure group (44 patients).

Liraglutide suppresses non-esterified free fatty acids and soluble vascular cell adhesion molecule-1 compared with metformin in patients with recent-onset type 2 diabetes.

Background: It has been suggested that liraglutide could have an impact on glucose and lipid metabolism disorder and adhesion molecule activation, which may play important roles in the vascular damage of diabetes. In this study, we examined the effects of liraglutide versus metformin on non-esterified free fatty acids, beta-cell insulin secretion, and adhesion molecule levels in patients with recent-onset type 2 diabetes mellitus.

Methods: In this study, 60 patients newly diagnosed with type 2 diabetes mellitus (mean age 33.

Comparing the Intramedullary Nail and Extramedullary Fixation in Treatment of Unstable Intertrochanteric Fractures.

Treatment options for unstable intertrochanteric fractures include intramedullary nail and extramedullary fixation, although evidence regarding the most appropriate treatment for such fractures remains controversial. Our hypothesis was that there would be no obvious differences in mortality rates, functional outcomes and complications between the two groups. We therefore conducted a meta-analysis to compare the relative advantages of intramedullary nail and extramedullary fixation.

Contribution of 3CD Region to the Virulence of Enterovirus 71.

Enterovirus 71 is a neuroinvasive virus that is associated with severe neurological complications. We had earlier suggested that the replication capacity of a severe strain was higher than that of a mild strain. The recombinant 3CRV and 3CDRV virus strains were successfully rescued in our previous study.