Fucoidan-driven Bacteroides xylanisolvens HS-1 alleviates hyperuricemia by promoting intestinal uric acid excretion via the PPARγ/ABCG2 signaling pathway.

The rising prevalence of hyperuricemia and associated complications present a substantial global health challenge. Fucoidan, a natural sulfate-rich polysaccharide degraded by gut microbiota, is under investigation as a potential therapeutic agent for reducing uric acid levels. However, the precise mechanism underlying its effects remains unclear.

A nomogram for predicting non-curative resection in patients with early gastric cancer based on white light imaging.

Endoscopic submucosal dissection (ESD) is an effective treatment with minimal invasiveness for early gastric cancer (EGC). However, cases undergoing non-curative resection (NCR) may still undergo additional surgical procedures. We aimed to analyze the features of NCR under white light imaging (WLI), and develop a prediction model to assess the risk of NCR before ESD.

Advances in multibending endoscope: A paradigm shift in minimally invasive diagnostics and therapeutics.

Digestive endoscopy has been widely used in the diagnosis and treatment of digestive diseases. However, the anatomical complexity of specific lesions increases the difficulty of these operations, resulting in complications or treatment failure. Although various strategies, such as floss traction and the application of transparent caps, have been explored, their effectiveness remains limited due to individual differences in patients' anatomical characteristics.

Efficacy and safety of triple therapy with vonoprazan for eradication: A multicenter, prospective, randomized controlled trial.

Background: () is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach, damaging the gastric mucosa through various mechanisms and leading to various digestive disorders. Accurate assessment and precise treatment are essential in initial intensive therapy.

Aim: To investigate the efficacy and safety of a vonoprazan (VPZ)-based triple regimen for first-line eradication of in China.

Diagnosis model for gastric submucosal tumor based on multiple decision trees comprising endoscopic and endoscopic ultrasonography features.

Background: The clinical course and manifestations of subepithelial lesions (SEL) patients tend to vary from different pathological types, therefore the accurate diagnosis of SEL would undoubtedly be beneficial to the treatment and prognosis of SEL patients. Based on the decision tree method, we developed a novel classification model for SELs by combining endoscopy with endoscopic ultrasound (EUS).

Methods: We retrospectively collected data from 469 patients hospitalized in the Affiliated Hospital of Qingdao University between January 2017 to November 2021 for endoscopic resection.

A case report of Castleman disease variant of POEMS syndrome presenting with prominent polyserositis and renal impairment.

Background: POEMS syndrome is a rare hematologic disorder related to plasma cell dyscrasia. The Castleman disease variant of POEMS syndrome is extremely rare and often misdiagnosed. In this study, we aim to present a noteworthy case of POEMS syndrome mainly manifested as multiple pleural effusion and renal impairment without M protein.

A Decentralized Actor-Critic Algorithm With Entropy Regularization and Its Finite-Time Analysis.

Decentralized actor-critic (AC) is one of the most dominant algorithms for dealing with multiagent reinforcement learning (MARL) problems. However, exploration-efficient, sample-efficient, and communication-efficient are difficult to achieve simultaneously by existing decentralized AC methods. For this reason, this article develops a decentralized multiagent AC algorithm by incorporating entropy regularization to improve exploration with theoretical guarantees, referred to as multi-agent AC algorithm with entropy regularization (MACE).

A case report of rare pancreatic lymphoma: wide range of diffuse large B-cell lymphoma located in the body and tail of pancreas.

Background: Pancreatic lymphoma is a rare pancreatic malignancy that is challenging to differentiate from diseases such as pancreatic cancer (PC). Although pathological examination of specimens obtained through surgery or endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) can aid in diagnosis, factors such as the occasional need for surgery and the variability in specimen quality from EUS-FNA complicate the diagnostic process. Misdiagnosis of pancreatic lymphoma as PC often leads to unnecessary surgery.

Alginate ameliorates hyperuricemia in mice by restoring hyperuricemia-induced renal and intestinal dysfunctions.

Alginate, a bioactive polysaccharide fermentable by gut microbiota, has been shown to effectively reduce serum uric acid levels. However, its mechanisms and the role of gut microbiota remain unclear. In this study, we explored the effects of alginate with two different molecular weights on hyperuricemia mice.

Dual chemical crosslinking strategy to fabricate lightweight, flame-retardant, high-modulus and hydrophobic cellulose cryogel.

Cellulose cryogel shows great application potential as a thermal insulation material because of its eco-friendliness, lightweight, high porosity and highly-efficient thermal insulation property. However, the high flammability and hydrophilicity have become bottlenecks to restrict its application in the thermal insulation field. Herein, we synthesized an amylose derivative with ammonium phosphate groups (AM), and reported a dual chemical crosslinking strategy to fabricate lightweight, flame-retardant, high-modulus and hydrophobic cellulose cryogel with AM and methyltrimethoxysilane (MTMS) via baking-crosslinking and chemical vapor deposition techniques.

Anti-Markovnikov hydroallylation reaction of alkenes via scandium-catalyzed allylic C‒H activation.

Compared with rare-earth (RE)…heteroatom interaction, RE…π interaction, frequently used in facilitating regio- and stereoselectivity of olefin polymerizations, is seldomly used to trigger catalytic C - H functionalization. Here, we describe a direct anti-Markovnikov hydroallylation reaction of styrene derivatives with 1-aryl-2-alkyl alkenes and α-alkenes by use of RE…π interaction. This protocol provides a straightforward and atom-efficient route for the synthesis of valuable chain elongated internal alkenes (65 examples, up to 99% yield, > 19:1 E/Z ratio).

The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases.

CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. The CCL2/CCR2 signaling pathway plays a crucial role in the development of fibrosis across multiple organ systems by modulating the recruitment and activation of immune cells, which in turn influences the progression of fibrotic diseases in the liver, intestines, pancreas, heart, lungs, kidneys, and other organs. This paper introduces the biological functions of CCL2 and CCR2, highlighting their similarities and differences concerning fibrotic disorders in various organ systems, and reviews recent progress in the diagnosis and treatment of clinical fibrotic diseases linked to the CCL2/CCR2 signaling pathway.

Association between dietary mineral intake and new onset diabetes/pre-diabetes after chronic pancreatitis.

Background And Aims: As the main type of pancreatic diabetes, patients with new diabetes after chronic pancreatitis are often difficult to manage and have poor prognosis. This study aimed to figure out the association between dietary mineral intake and glucose metabolism with chronic pancreatitis.

Method: The study included 114 patients with chronic pancreatitis, who were grouped based on the sequence of onset for chronic pancreatitis and diabetes: normoglycaemia after chronic pancreatitis (NCP), type 2 diabetes (T2DM), and new-onset diabetes or pre-diabetes after chronic pancreatitis (NODCP).

Effects of Temporary Rearing on the Muscle Flavor Quality of .

, a special economic aquaculture species in China, is valued highly for its medicinal and nutritional benefits. However, the muscle of farmed exhibits a strong off-flavor, resulting in poor flavor quality. To enhance the flavor quality of the meat, this study examined the volatile compounds in muscle by establishing identification methods for these volatile odor compounds and comparing the differences between the two aquaculture modes.

The risk factors of lymph node metastasis in early colorectal cancer: a predictive nomogram and risk assessment.

Purpose: Endoscopic procedures and surgery are common treatments for early colorectal cancer (CRC). However, only approximately 10% of patients who undergo surgery have lymph node metastases (LNM) detected on postoperative pathology, which often leads to overtreatment. This study aims to comprehensively analyze the risk factors for LNM in early CRC patients, establishing a predictive model to aid in treatment decisions.

Lightweight, ultrahigh-strength and flame-retardant cellulose aerogel crosslinked with a reactive P/N-rich curdlan derivative.

Cellulose aerogel, recognized for its eco-friendliness, bio-sustainability and excellent thermal insulation property, holds immense potential as an insulation material. However, the application of cellulose aerogel has been hindered by its inherent drawbacks, particularly its low strength and flammability. In this study, a reactive P/N-rich curdlan derivative (NT) was synthesized and characterized.

Feasibility and safety of endoscopic full-thickness resection for submucosal tumors in the upper gastrointestinal tract, including predominantly extraluminal submucosal tumors (with video).

Objectives: Endoscopic full-thickness resection (EFTR) for submucosal tumors (SMTs) has been technically challenging. This retrospective study aimed to evaluate the feasibility, safety, and efficacy of EFTR for upper gastrointestinal (GI) SMTs, including extraluminal lesions.

Methods: We retrospectively investigated 232 patients with SMTs who underwent EFTR from January 2014 to August 2023.

Dose-response relationship between body mass index and hypertension: A cross-sectional study from Eastern China.

Background: A high body mass index (BMI) increases the risk of hypertension. However, little is known about the dose-dependent association between BMI and hypertension. Therefore, this study investigated the prevalence of hypertension in 7568 subjects from the Jiangsu Province, Eastern China, and analyzed the dose-response relationship between BMI and hypertension risk.

Process evaluation of an mHealth-based school education program to reduce salt intake scaling up in China (EduSaltS): a mixed methods study using the RE-AIM framework.

Background: An mHealth-based school health education platform (EduSaltS) was promoted in real-world China to reduce salt intake among children and their families. This progress evaluation explores its implementation process and influencing factors using mixed methods.

Methods: The mixed-methods process evaluation employed the RE-AIM framework.

A case report of interstitial pneumonia induced by vedolizumab in a patient with ulcerative colitis.

Rationale: The interstitial pneumonia (IP) linked to vedolizumab (VDZ) in patients with ulcerative colitis (UC) is rare. Prompt diagnosis and treatment can improve patient outcomes.

Patient Concerns: A 39-year-old man with UC who received VDZ as sole therapy developed symptoms such as chest tightness, cough, and suffocation.

Effect of Gut Microbiota-Mediated Tryptophan Metabolism on Inflammaging in Frailty and Sarcopenia.

Frailty syndrome refers to the nonspecific state of increased body vulnerability and decreased antistress and recovery abilities after stress during aging. Sarcopenia is the major component of frailty and is characterized by the gradual loss of muscle mass, strength, and function with age. Inflammaging is the gradual increase in inflammatory status during aging, and it disrupts immune tolerance, causes physiological changes in tissues, organs, and normal cells, and is related to frailty and sarcopenia.

Effects of Aminomethylphosphonic Acid on the Transcriptome and Metabolome of Red Swamp Crayfish, .

Red swamp crayfish, (), is an important model crustacean organism used in many types of research. However, the effects of different doses of aminomethylphosphonic acid (AMAP) on the transcriptome and metabolites of have not been explored. Thus, this study investigated the molecular and metabolic mechanisms activated at the different exposure dosages of AMAP in to provide new insights into the strategies of in response to the high concentrations of AMAP in the environment.

Application of artificial intelligence in endoscopic gastrointestinal tumors.

With an increasing number of patients with gastrointestinal cancer, effective and accurate early diagnostic clinical tools are required provide better health care for patients with gastrointestinal cancer. Recent studies have shown that artificial intelligence (AI) plays an important role in the diagnosis and treatment of patients with gastrointestinal tumors, which not only improves the efficiency of early tumor screening, but also significantly improves the survival rate of patients after treatment. With the aid of efficient learning and judgment abilities of AI, endoscopists can improve the accuracy of diagnosis and treatment through endoscopy and avoid incorrect descriptions or judgments of gastrointestinal lesions.